메뉴 건너뛰기




Volumn , Issue , 2012, Pages 229-252

Addressing the interactions between opioid ligands and their receptors: Classic and nonclassic cases

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84884213687     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b12279     Document Type: Chapter
Times cited : (3)

References (113)
  • 1
    • 0022051507 scopus 로고
    • Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma-glioma hybrid cell line (NG 108-15)
    • Akiyama, K., Gee, K. W., Mosberg, H. I., Hruby, V. J., Yamamura, H. I. 1985. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma-glioma hybrid cell line (NG 108-15). Proc. Natl. Acad. Sci. USA. 82: 2543-7.
    • (1985) Proc. Natl. Acad. Sci. USA. , vol.82 , pp. 2543-2547
    • Akiyama, K.1    Gee, K.W.2    Mosberg, H.I.3    Hruby, V.J.4    Yamamura, H.I.5
  • 2
    • 68249140053 scopus 로고    scopus 로고
    • Peptide kappa opioid receptor ligands: Potential for drug development
    • Aldrich, J. V., McLaughlin, J. P. 2009. Peptide kappa opioid receptor ligands: potential for drug development. AAPS J. 11: 312-22.
    • (2009) AAPS J. , vol.11 , pp. 312-322
    • Aldrich, J.V.1    McLaughlin, J.P.2
  • 4
    • 65549163531 scopus 로고    scopus 로고
    • Recent advances in structure-based virtual screening of G-protein coupled receptors
    • Ananthan, S., Zhang, W., Hobrath, J. V. 2009. Recent advances in structure-based virtual screening of G-protein coupled receptors. AAPS J. 11: 178-85.
    • (2009) AAPS J. , vol.11 , pp. 178-185
    • Ananthan, S.1    Zhang, W.2    Hobrath, J.V.3
  • 5
    • 0033828942 scopus 로고    scopus 로고
    • Optically active aromatic amino acids. Part VI. Synthesis and properties of (Leu5)-enkephalin analogues containing O-methyl-L-tyrosine1 with ring substitution at position 3'
    • Arnold, Z. S., Schiller, P. W. 2000. Optically active aromatic amino acids. Part VI. Synthesis and properties of (Leu5)-enkephalin analogues containing O-methyl-L-tyrosine1 with ring substitution at position 3'. J. Pept. Sci. 6: 280-9.
    • (2000) J. Pept. Sci. , vol.6 , pp. 280-289
    • Arnold, Z.S.1    Schiller, P.W.2
  • 6
    • 77957830877 scopus 로고    scopus 로고
    • Peripheral antinociceptive effects of the cyclic endomorphin-1 analogue c[YpwFG] in a mouse visceral pain model
    • Bedini, A., Baiula, M., Gentilucci, L., Tolomelli, A., De Marco, R., Spampinato, S. 2010. Peripheral antinociceptive effects of the cyclic endomorphin-1 analogue c[YpwFG] in a mouse visceral pain model. Peptides. 31: 2135-40.
    • (2010) Peptides. , vol.31 , pp. 2135-2140
    • Bedini, A.1    Baiula, M.2    Gentilucci, L.3    Tolomelli, A.4    De Marco, R.5    Spampinato, S.6
  • 7
    • 19544363413 scopus 로고    scopus 로고
    • Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues
    • Beguin, C., Richards, M. R., Wang, Y., et al. 2005. Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues. Bioorg. Med. Chem. Lett. 15: 2761-5.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2761-2765
    • Beguin, C.1    Richards, M.R.2    Wang, Y.3
  • 8
    • 0037433589 scopus 로고    scopus 로고
    • 2D conformationally sampled pharmacophore: A ligand-based pharmacophore to differentiate δ opioid agonists from antagonists
    • Bernard, D., Coop, A., MacKerell, A. D. Jr. 2003. 2D conformationally sampled pharmacophore: a ligand-based pharmacophore to differentiate δ opioid agonists from antagonists. J. Am. Chem. Soc. 125: 3101-7.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 3101-3107
    • Bernard, D.1    Coop, A.2    MacKerell, A.D.3
  • 9
    • 70449651677 scopus 로고    scopus 로고
    • Endogenous opiates and behaviour: 2008
    • Bodnar, R. J. 2009. Endogenous opiates and behaviour: 2008. Peptides. 30: 2432-79.
    • (2009) Peptides. , vol.30 , pp. 2432-2479
    • Bodnar, R.J.1
  • 10
    • 74649085205 scopus 로고    scopus 로고
    • Structural comparison of mu-opioid receptor selective peptides confirmed four parameters of bioactivity
    • Borics, A., Toth, G. 2010. Structural comparison of mu-opioid receptor selective peptides confirmed four parameters of bioactivity. J. Mol. Graph. Model. 28: 495-505.
    • (2010) J. Mol. Graph. Model. , vol.28 , pp. 495-505
    • Borics, A.1    Toth, G.2
  • 12
    • 14644392876 scopus 로고    scopus 로고
    • Opioids in chronic non-cancer pain, indications and controversies
    • Breivik, H. 2005. Opioids in chronic non-cancer pain, indications and controversies. Eur. J. Pain. 9: 127-30.
    • (2005) Eur. J. Pain. , vol.9 , pp. 127-130
    • Breivik, H.1
  • 13
    • 0033590274 scopus 로고    scopus 로고
    • Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA
    • Burden, J. E., Davis, P., Porreca, F., Spatola, A. F. 1999. Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA. Bioorg. Med. Chem. Lett. 9: 3441-6.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 3441-3446
    • Burden, J.E.1    Davis, P.2    Porreca, F.3    Spatola, A.F.4
  • 14
    • 1442350415 scopus 로고    scopus 로고
    • SNC 80 and related delta opioid agonists
    • Calderon, S. N., Coop, A. 2004. SNC 80 and related delta opioid agonists. Curr. Phar. Des. 10: 733-42.
    • (2004) Curr. Phar. Des. , vol.10 , pp. 733-742
    • Calderon, S.N.1    Coop, A.2
  • 15
    • 0034684771 scopus 로고    scopus 로고
    • Synthesis and binding activity of endomorphin-1 analogues containing β-amino acids
    • Cardillo, G., Gentilucci, L., Melchiorre, P., Spampinato, S. 2000. Synthesis and binding activity of endomorphin-1 analogues containing β-amino acids. Bioorg. Med. Chem. Lett. 10: 2755-8.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 2755-2758
    • Cardillo, G.1    Gentilucci, L.2    Melchiorre, P.3    Spampinato, S.4
  • 16
    • 0037030643 scopus 로고    scopus 로고
    • Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhance enzymatic hydrolysis resistance
    • Cardillo, G., Gentilucci, L., Qasem, A. R., Sgarzi, F., Spampinato, S. 2002. Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhance enzymatic hydrolysis resistance. J. Med. Chem. 45: 2571-8.
    • (2002) J. Med. Chem. , vol.45 , pp. 2571-2578
    • Cardillo, G.1    Gentilucci, L.2    Qasem, A.R.3    Sgarzi, F.4    Spampinato, S.5
  • 17
    • 0141853255 scopus 로고    scopus 로고
    • Conformational analysis and µ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent
    • Cardillo, G., Gentilucci, L., Tolomelli, A., Qasem, A. R., Spampinato, S., Calienni, M. 2003. Conformational analysis and µ-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent. Org. Biomol. Chem. 1: 3010-14.
    • (2003) Org. Biomol. Chem. , vol.1 , pp. 3010-3014
    • Cardillo, G.1    Gentilucci, L.2    Tolomelli, A.3    Qasem, A.R.4    Spampinato, S.5    Calienni, M.6
  • 18
    • 4744353375 scopus 로고    scopus 로고
    • Synthesis and evaluation of the affinity toward l-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]
    • Cardillo, G., Gentilucci, L., Tolomelli, A., et al. 2004. Synthesis and evaluation of the affinity toward l-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]. J. Med. Chem. 47: 5198-203.
    • (2004) J. Med. Chem. , vol.47 , pp. 5198-5203
    • Cardillo, G.1    Gentilucci, L.2    Tolomelli, A.3
  • 21
    • 0036382880 scopus 로고    scopus 로고
    • The structure of an endomorphin analogue incorporating 1-aminocyclohexane-1-carboxlylic acid for proline is similar to the β-turn of Leu-enkephalin
    • Doi, M., Asano, A., Komura, E., Ueda, Y. 2002. The structure of an endomorphin analogue incorporating 1-aminocyclohexane-1-carboxlylic acid for proline is similar to the β-turn of Leu-enkephalin. Biochem. Biophys. Res. Commun. 297: 138-42.
    • (2002) Biochem. Biophys. Res. Commun. , vol.297 , pp. 138-142
    • Doi, M.1    Asano, A.2    Komura, E.3    Ueda, Y.4
  • 22
    • 2942615372 scopus 로고    scopus 로고
    • (4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands
    • Dolle, R. E., Machaut, M., Martinez-Teipel, B., et al. 2004. (4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands. Bioorg. Med. Chem. Lett. 14: 3545-8.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3545-3548
    • Dolle, R.E.1    Machaut, M.2    Martinez-Teipel, B.3
  • 24
    • 33644982587 scopus 로고    scopus 로고
    • Steric interactions and the activity of fentanyl analogs at the l-opioid receptor
    • Dosen-Micovic, L., Ivanovic, M., Micovic, V. 2006. Steric interactions and the activity of fentanyl analogs at the l-opioid receptor. Bioorg. Med. Chem. 14: 2887-95.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 2887-2895
    • Dosen-Micovic, L.1    Ivanovic, M.2    Micovic, V.3
  • 25
    • 1242314868 scopus 로고    scopus 로고
    • Advances in selective opioid receptoragonists and antagonists
    • Eguchi, M. 2004. Advances in selective opioid receptoragonists and antagonists. Med. Res. Rev. 24: 182-212.
    • (2004) Med. Res. Rev. , vol.24 , pp. 182-212
    • Eguchi, M.1
  • 26
    • 0037187386 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: Enkephalin and endomorphin mimetics
    • Eguchi, M., Shen, R. Y., Shea, J. P., Lee, M. S., Kahn, M. 2002. Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics. J. Med. Chem. 45: 1395-8.
    • (2002) J. Med. Chem. , vol.45 , pp. 1395-1398
    • Eguchi, M.1    Shen, R.Y.2    Shea, J.P.3    Lee, M.S.4    Kahn, M.5
  • 27
    • 9944222055 scopus 로고    scopus 로고
    • Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position
    • Fichna, J., do-Rego, J.-C., Kosson, P., Costentin, J., Janecka, A. 2005. Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position. Biochem. Pharmacol. 69: 179-85.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 179-185
    • Fichna, J.1    do-Rego, J.-C.2    Kosson, P.3    Costentin, J.4    Janecka, A.5
  • 28
    • 33847366597 scopus 로고    scopus 로고
    • The endomorphin system and its evolving neurophysiological role pharmacological reviews
    • Fichna, J., Janecka, A., Costentin, J., do-Rego. J.-C. 2007. The endomorphin system and its evolving neurophysiological role pharmacological reviews. Pharmacol. Rev. 59: 88-123.
    • (2007) Pharmacol. Rev. , vol.59 , pp. 88-123
    • Fichna, J.1    Janecka, A.2    Costentin, J.3    do-Rego, J.-C.4
  • 29
    • 0036997276 scopus 로고    scopus 로고
    • Structural models for dimerization of G-protein coupled receptors: The opioid receptor homodimers
    • Filizola, M. Weinstein, H. 2002. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers. 66: 317-25.
    • (2002) Biopolymers. , vol.66 , pp. 317-325
    • Filizola, M.1    Weinstein, H.2
  • 30
    • 10844246435 scopus 로고    scopus 로고
    • Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints
    • Fowler, C. B., Pogozheva, I. D., Lomize, A. L., LeVine, H., III, Mosberg, H. I. 2004. Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints Biochemistry. 43: 15796-810.
    • (2004) Biochemistry. , vol.43 , pp. 15796-15810
    • Fowler, C.B.1    Pogozheva, I.D.2    Lomize, A.L.3    LeVine III, H.4    Mosberg, H.I.5
  • 31
    • 15044364083 scopus 로고    scopus 로고
    • Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2
    • Gao, Y., Liu, X., Wei, J., Zhu, B., Chena, Q., Wang, R. 2005. Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg. Med. Chem. Lett. 15: 1847-50.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 1847-1850
    • Gao, Y.1    Liu, X.2    Wei, J.3    Zhu, B.4    Chena, Q.5    Wang, R.6
  • 32
    • 2142658722 scopus 로고    scopus 로고
    • New trends in the development of opioid peptide analogues as advanced remedies for pain relief
    • Gentilucci, L. 2004. New trends in the development of opioid peptide analogues as advanced remedies for pain relief. Curr. Topics Med. Chem. 4: 19-38.
    • (2004) Curr. Topics Med. Chem. , vol.4 , pp. 19-38
    • Gentilucci, L.1
  • 33
    • 78649852683 scopus 로고    scopus 로고
    • Chemical modifications designed to improve peptide stability: Incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization
    • Gentilucci, L., De Marco, R., Cerisoli, L. 2010. Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization. Curr. Pharm. Des. 16: 3185-203.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 3185-3203
    • Gentilucci, L.1    De Marco, R.2    Cerisoli, L.3
  • 34
    • 33846004812 scopus 로고    scopus 로고
    • Re-discussion of the importance of ionic interactions in stabilizing ligand-opioid receptor complex and in activating signal transduction
    • Gentilucci, L., Squassabia, F., Artali, R. 2007. Re-discussion of the importance of ionic interactions in stabilizing ligand-opioid receptor complex and in activating signal transduction. Curr Drug Targets. 8: 185-96.
    • (2007) Curr Drug Targets. , vol.8 , pp. 185-196
    • Gentilucci, L.1    Squassabia, F.2    Artali, R.3
  • 35
    • 42449132536 scopus 로고    scopus 로고
    • Investigation of the interaction between the atypical agonist c[YpwFG] and MOR
    • Gentilucci, L., Squassabia, F., De Marco, R., et al. 2008. Investigation of the interaction between the atypical agonist c[YpwFG] and MOR. FEBS J. 275: 2315-37.
    • (2008) FEBS J. , vol.275 , pp. 2315-2337
    • Gentilucci, L.1    Squassabia, F.2    De Marco, R.3
  • 36
    • 33845973404 scopus 로고    scopus 로고
    • Topological exploration of cyclic endomorphin-1 analogues, structurally defined models for investigating the bioactive conformation of MOR agonists
    • Gentilucci, L., Tolomelli, A., Squassabia, F. 2007. Topological exploration of cyclic endomorphin-1 analogues, structurally defined models for investigating the bioactive conformation of MOR agonists. Prot. Pept. Lett. 14: 51-6.
    • (2007) Prot. Pept. Lett. , vol.14 , pp. 51-56
    • Gentilucci, L.1    Tolomelli, A.2    Squassabia, F.3
  • 38
    • 0019395141 scopus 로고
    • Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors
    • Handa, B. K., Land, A. C., Lord, J.A., Morgan, B. A., Rance, M. J., Smith, C. F. 1981. Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors. Eur. J. Pharm. 70: 531-40.
    • (1981) Eur. J. Pharm. , vol.70 , pp. 531-540
    • Handa, B.K.1    Land, A.C.2    Lord, J.A.3    Morgan, B.A.4    Rance, M.J.5    Smith, C.F.6
  • 39
    • 22744432397 scopus 로고    scopus 로고
    • Neoclerodane diterpenes as a novel scaffold for µ opioid receptor ligands
    • Harding, W. W., Tidgewell, K., Byrd, N., et al. 2005. Neoclerodane diterpenes as a novel scaffold for µ opioid receptor ligands. J. Med. Chem. 48: 4765-71.
    • (2005) J. Med. Chem. , vol.48 , pp. 4765-4771
    • Harding, W.W.1    Tidgewell, K.2    Byrd, N.3
  • 40
    • 70349134354 scopus 로고    scopus 로고
    • New and emerging analgesics and analgesic technologies for acute pain management
    • Heitz, J. W., Witkowski, T. A., Viscusi, E. R. 2009. New and emerging analgesics and analgesic technologies for acute pain management. Curr. Opin. Anaesthesiol. 22: 608-17.
    • (2009) Curr. Opin. Anaesthesiol. , vol.22 , pp. 608-617
    • Heitz, J.W.1    Witkowski, T.A.2    Viscusi, E.R.3
  • 41
    • 0035687436 scopus 로고    scopus 로고
    • Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice
    • Honda, M., Okutsu, H., Matsuura, T., Miyagi, T., Yamamoto, Y., Hazato, T., Ono, H. 2001. Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn. J. Pharmacol. 87: 261-7.
    • (2001) Jpn. J. Pharmacol. , vol.87 , pp. 261-267
    • Honda, M.1    Okutsu, H.2    Matsuura, T.3    Miyagi, T.4    Yamamoto, Y.5    Hazato, T.6    Ono, H.7
  • 42
    • 0034450970 scopus 로고    scopus 로고
    • Endomorphin-1 and endomorphin-2: Pharmacology of the selective endogenous mu-opioid receptor agonists
    • Horvath, G. 2000. Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists. Pharmacol. Ther. 88: 437-63.
    • (2000) Pharmacol. Ther. , vol.88 , pp. 437-463
    • Horvath, G.1
  • 43
    • 0033495881 scopus 로고    scopus 로고
    • Conformation-activity relationships of opioid peptides with selective activities at opioid receptors
    • Hruby, V. J., Agnes, R. S. 1999. Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers. 51: 391-410.
    • (1999) Biopolymers. , vol.51 , pp. 391-410
    • Hruby, V.J.1    Agnes, R.S.2
  • 44
    • 0033851469 scopus 로고    scopus 로고
    • Conformational and Topographical considerations in designing agonist peptidomimetics from peptide leads
    • Hruby, V. J., Balse, P. M. 2000. Conformational and Topographical considerations in designing agonist peptidomimetics from peptide leads. Curr. Med. Chem. 7: 945-70.
    • (2000) Curr. Med. Chem. , vol.7 , pp. 945-970
    • Hruby, V.J.1    Balse, P.M.2
  • 45
    • 26244446907 scopus 로고    scopus 로고
    • Structural function of C-terminal amidation of endomorphin. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid, studied by 1H-NMR spectroscopy, molecular calculation, and X-ray crystallography
    • In, Y., Minoura, K., Tomoo, K., et al. 2005. Structural function of C-terminal amidation of endomorphin. Conformational comparison of mu-selective endomorphin-2 with its C-terminal free acid, studied by 1H-NMR spectroscopy, molecular calculation, and X-ray crystallography. FEBS J. 272: 5079-97.
    • (2005) FEBS J. , vol.272 , pp. 5079-5097
    • In, Y.1    Minoura, K.2    Tomoo, K.3
  • 46
    • 0042261466 scopus 로고    scopus 로고
    • Structure-activity relationship, conformation and pharmacology studies of morphiceptin analogues-selective mu-opioid receptor ligands
    • Janecka, A., Fichna, J., Mirowski, M., Janecki, T. 2002. Structure-activity relationship, conformation and pharmacology studies of morphiceptin analogues-selective mu-opioid receptor ligands. Mini Rev. Med. Chem. 2: 565-72.
    • (2002) Mini Rev. Med. Chem. , vol.2 , pp. 565-572
    • Janecka, A.1    Fichna, J.2    Mirowski, M.3    Janecki, T.4
  • 47
    • 14544294044 scopus 로고    scopus 로고
    • Conformationally restricted peptides as tools in opioid receptor studies
    • Janecka, A., Kruszynski, R. 2005. Conformationally restricted peptides as tools in opioid receptor studies. Curr. Med. Chem. 12: 471-81.
    • (2005) Curr. Med. Chem. , vol.12 , pp. 471-481
    • Janecka, A.1    Kruszynski, R.2
  • 50
    • 15244351034 scopus 로고    scopus 로고
    • Buprenorphine: Considerations for pain management
    • Johnson, R. E., Fudala, P. J., Payne, R. 2005. Buprenorphine: considerations for pain management. J. Pain Sympt. Manag. 29: 297-326.
    • (2005) J. Pain Sympt. Manag. , vol.29 , pp. 297-326
    • Johnson, R.E.1    Fudala, P.J.2    Payne, R.3
  • 51
    • 0035993849 scopus 로고    scopus 로고
    • Non-peptide opioid receptor ligands-recent advances. Part I-agonists
    • Kaczor, A., Matosiuk, D. 2002. Non-peptide opioid receptor ligands-recent advances. Part I-agonists. Curr. Med. Chem. 9: 1567-89.
    • (2002) Curr. Med. Chem. , vol.9 , pp. 1567-1589
    • Kaczor, A.1    Matosiuk, D.2
  • 52
    • 33646271609 scopus 로고    scopus 로고
    • A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist
    • Kane, B. E., Nieto, M. J., McCurdy, C. R., Ferguson, D. M. 2006. A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. FEBS J. 273: 1966-74.
    • (2006) FEBS J. , vol.273 , pp. 1966-1974
    • Kane, B.E.1    Nieto, M.J.2    McCurdy, C.R.3    Ferguson, D.M.4
  • 53
    • 41149143712 scopus 로고    scopus 로고
    • Toward a structure based model of salvinorin A recognition of the κ-opioid receptor
    • Kane, B. E., McCurdy, C. R., Ferguson, D. M. 2008. Toward a structure based model of salvinorin A recognition of the κ-opioid receptor. J. Med. Chem. 51: 1824-30.
    • (2008) J. Med. Chem. , vol.51 , pp. 1824-1830
    • Kane, B.E.1    McCurdy, C.R.2    Ferguson, D.M.3
  • 54
    • 0035829437 scopus 로고    scopus 로고
    • Pseudoproline-containing analogues of morphiceptin and endomorphin-2: Evidence for a cis Tyr-Pro amide bond in the bioactive conformation
    • Keller, M., Boissard, C., Patiny, L., et al. 2001. Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation. J. Med. Chem. 44: 3896-903.
    • (2001) J. Med. Chem. , vol.44 , pp. 3896-3903
    • Keller, M.1    Boissard, C.2    Patiny, L.3
  • 55
    • 77955104823 scopus 로고    scopus 로고
    • Recent advances in endomorphin engineering
    • Keresztes, A., Borics, A., Tóth, G. 2010. Recent advances in endomorphin engineering. Chem. Med. Chem. 5: 1176-96.
    • (2010) Chem. Med. Chem. , vol.5 , pp. 1176-1196
    • Keresztes, A.1    Borics, A.2    Tóth, G.3
  • 56
    • 0020163940 scopus 로고
    • Conformation and biological activity of cyclic peptide
    • Kessler, H. 1982. Conformation and biological activity of cyclic peptide. Angew. Chem. Int. Ed. Engl. 21: 512-23.
    • (1982) Angew. Chem. Int. Ed. Engl. , vol.21 , pp. 512-523
    • Kessler, H.1
  • 57
    • 0036462451 scopus 로고    scopus 로고
    • Oligomerization of opioid receptors: Generation of novel signaling units
    • Levac, B. A., O’Dowd, B. F., George, S. R. 2002. Oligomerization of opioid receptors: generation of novel signaling units. Curr. Opin. Pharmacol. 2: 76-81.
    • (2002) Curr. Opin. Pharmacol. , vol.2 , pp. 76-81
    • Levac, B.A.1    O’Dowd, B.F.2    George, S.R.3
  • 58
    • 0020414774 scopus 로고
    • Double enkephalins-synthesis, activity on guinea pig ileum and analgesic effect
    • Lipkowski, A. W., Konecka, A. M., Sroczynska, I. 1982. Double enkephalins-synthesis, activity on guinea pig ileum and analgesic effect. Peptides. 3: 697-700.
    • (1982) Peptides. , vol.3 , pp. 697-700
    • Lipkowski, A.W.1    Konecka, A.M.2    Sroczynska, I.3
  • 60
    • 68949116093 scopus 로고    scopus 로고
    • Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor
    • Liu, X., Kai, M., Jin, L., Wang, R. 2009. Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg. Med. Chem. Lett. 19: 5387-91.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5387-5391
    • Liu, X.1    Kai, M.2    Jin, L.3    Wang, R.4
  • 61
    • 13244298667 scopus 로고    scopus 로고
    • Are mu-opioid receptor polymorphisms important for clinical opioid therapy?
    • Loetsch, J., Geisslinger, G. 2005. Are mu-opioid receptor polymorphisms important for clinical opioid therapy?. Trends Mol. Med. 11: 82-9.
    • (2005) Trends Mol. Med. , vol.11 , pp. 82-89
    • Loetsch, J.1    Geisslinger, G.2
  • 62
    • 0035855594 scopus 로고    scopus 로고
    • [2,6-Dimethyltyrosine1]-dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: Potent and selective κ opioid antagonists
    • Lu, Y., Nguyen, T. M., Weltrowska, G., Berezowska, I., Lemieux, C., Chung, N. N., Schiller, P. W. 2001. [2,6-Dimethyltyrosine1]-dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective κ opioid antagonists. J. Med. Chem. 44: 3048-53.
    • (2001) J. Med. Chem. , vol.44 , pp. 3048-3053
    • Lu, Y.1    Nguyen, T.M.2    Weltrowska, G.3    Berezowska, I.4    Lemieux, C.5    Chung, N.N.6    Schiller, P.W.7
  • 63
    • 0035847691 scopus 로고    scopus 로고
    • Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide
    • Lu, Y., Weltrowska, G., Lemieux, C., Chung, N. N., Schiller, P. W. 2001. Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide. Bioorg. Med. Chem. Lett. 11: 323-5.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 323-325
    • Lu, Y.1    Weltrowska, G.2    Lemieux, C.3    Chung, N.N.4    Schiller, P.W.5
  • 64
    • 77951451674 scopus 로고    scopus 로고
    • Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: A systematic review
    • McDaid, C., Maund, E., Rice, S., Wright, K., Jenkins, B., Woolacott N. 2010. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review. Health Technol. Assess. 14: 1-153.
    • (2010) Health Technol. Assess. , vol.14 , pp. 1-153
    • McDaid, C.1    Maund, E.2    Rice, S.3    Wright, K.4    Jenkins, B.5    Woolacott, N.6
  • 65
    • 0033680378 scopus 로고    scopus 로고
    • Tetrapeptide derivatives of [D-Pen(2), D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor
    • McFadyen, I. J., Sobczyk-Kojiro, K., Schaefer, M. J., et al. 2000. Tetrapeptide derivatives of [D-Pen(2), D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor. J. Pharmacol. Exp. Ther. 295: 960-6.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 960-966
    • McFadyen, I.J.1    Sobczyk-Kojiro, K.2    Schaefer, M.J.3
  • 67
    • 0031553387 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
    • Meunier, J. C. 1997. Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor. Eur. J. Pharmacol. 340: 1-15.
    • (1997) Eur. J. Pharmacol. , vol.340 , pp. 1-15
    • Meunier, J.C.1
  • 68
    • 3042663287 scopus 로고    scopus 로고
    • G protein-coupled receptor dimerization: Function and ligand pharmacology
    • Milligan, G. 2004. G protein-coupled receptor dimerization: function and ligand pharmacology. Mol. Pharmacol. 66: 1-7.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1-7
    • Milligan, G.1
  • 69
    • 69049108756 scopus 로고    scopus 로고
    • Modern homology modeling of G-protein coupled receptors: Which structural template to use?
    • Mobarec, J. C., Sanchez, R., Filizola, M. 2009. Modern homology modeling of G-protein coupled receptors: which structural template to use?. J. Med. Chem. 52: 5207-16.
    • (2009) J. Med. Chem. , vol.52 , pp. 5207-5216
    • Mobarec, J.C.1    Sanchez, R.2    Filizola, M.3
  • 70
    • 65749105197 scopus 로고    scopus 로고
    • Pharmacological management of cancer pain
    • Montagnini, M. L., Zaleon, C. R. 2009. Pharmacological management of cancer pain. J. Opioid Manag. 5: 89-96.
    • (2009) J. Opioid Manag. , vol.5 , pp. 89-96
    • Montagnini, M.L.1    Zaleon, C.R.2
  • 71
    • 0036945574 scopus 로고    scopus 로고
    • Development and validation of opioid ligand-receptor interaction models: The structural basis of mu vs. delta selectivity
    • Mosberg, H. I., Fowler, C. B. 2002. Development and validation of opioid ligand-receptor interaction models: the structural basis of mu vs. delta selectivity. J. Pept. Res. 60: 329-35.
    • (2002) J. Pept. Res. , vol.60 , pp. 329-335
    • Mosberg, H.I.1    Fowler, C.B.2
  • 72
    • 0032491267 scopus 로고    scopus 로고
    • A high affinity, mu-opioid receptorselective enkephalin analogue lacking an N-terminal tyrosine
    • Mosberg, H. I., Ho, J. C., Sobczyk-Kojiro, K. 1998. A high affinity, mu-opioid receptorselective enkephalin analogue lacking an N-terminal tyrosine. Bioorg. Med. Chem. Lett. 8: 2681-4.
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 2681-2684
    • Mosberg, H.I.1    Ho, J.C.2    Sobczyk-Kojiro, K.3
  • 73
    • 0023810741 scopus 로고
    • Cyclic disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligand with enhanced delta opioid receptor selectivity and potency
    • Mosberg, H. I., Omnaas, J. R., Medzihradsky, F., Smith, C. B. 1988. Cyclic disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with enhanced delta opioid receptor selectivity and potency. Life Sci. 43: 1013-20.
    • (1988) Life Sci. , vol.43 , pp. 1013-1020
    • Mosberg, H.I.1    Omnaas, J.R.2    Medzihradsky, F.3    Smith, C.B.4
  • 74
    • 12344326698 scopus 로고    scopus 로고
    • Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist
    • Munro, T. A., Rizzacasa, M. A., Roth, B. L., Toth, B. A., Yan, F. 2005. Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. J. Med. Chem. 48: 345-8.
    • (2005) J. Med. Chem. , vol.48 , pp. 345-348
    • Munro, T.A.1    Rizzacasa, M.A.2    Roth, B.L.3    Toth, B.A.4    Yan, F.5
  • 75
    • 0033697451 scopus 로고    scopus 로고
    • Pharmacology of amphibian opiate peptides
    • Negri, L., Melchiorri, P., Lattanzi, R. 2000. Pharmacology of amphibian opiate peptides. Peptides. 21: 1639-47.
    • (2000) Peptides. , vol.21 , pp. 1639-1647
    • Negri, L.1    Melchiorri, P.2    Lattanzi, R.3
  • 76
    • 0028077209 scopus 로고
    • Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists
    • Noble, F., Smadja, C., Roques, B. P. 1994. Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists. J. Pharmacol. Exp. Ther. 271: 1127-34.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1127-1134
    • Noble, F.1    Smadja, C.2    Roques, B.P.3
  • 77
    • 0037401355 scopus 로고    scopus 로고
    • 1] endomorphin-2 analogues: Enhanced activity and cis orientation of the Dmt-Pro amide bond
    • 1] endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond. Bioorg. Med. Chem. Lett. 11: 1983-94.
    • (2003) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1983-1994
    • Okada, Y.1    Fujita, Y.2    Motoyama, T.3
  • 78
    • 0034675285 scopus 로고    scopus 로고
    • 2, and Examination of their opioid receptor binding activities and solution conformation
    • 2, and Examination of their opioid receptor binding activities and solution conformation. Biochem. Biophys. Res. Commun. 276: 7-11.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 7-11
    • Okada, Y.1    Fukumizu, A.2    Takahashi, M.3
  • 79
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G proteincoupled receptor
    • Palczewski, K., Kumasaka, T., Hori, T., et al. 2000. Crystal structure of rhodopsin: a G proteincoupled receptor. Science. 289: 739-45.
    • (2000) Science. , vol.289 , pp. 739-745
    • Palczewski, K.1    Kumasaka, T.2    Hori, T.3
  • 80
    • 0034037247 scopus 로고    scopus 로고
    • Stereochemical requirements for receptor recognition of the µ-opioid peptide endomorphin-1
    • Paterlini, M. G., Avitabile, F., Ostrowski, B. G., Ferguson, D. M., Portoghese, P. S. 2000. Stereochemical requirements for receptor recognition of the µ-opioid peptide endomorphin-1. Biophys. J. 78: 590-9.
    • (2000) Biophys. J. , vol.78 , pp. 590-599
    • Paterlini, M.G.1    Avitabile, F.2    Ostrowski, B.G.3    Ferguson, D.M.4    Portoghese, P.S.5
  • 81
    • 74249113409 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of cyclic endomorphin-2 analogs
    • Perlikowska, R., do-Rego, J. C., Cravezic, A. 2010. Synthesis and biological evaluation of cyclic endomorphin-2 analogs. Peptides. 31: 339-45.
    • (2010) Peptides. , vol.31 , pp. 339-345
    • Perlikowska, R.1    do-Rego, J.C.2    Cravezic, A.3
  • 82
    • 17144452429 scopus 로고    scopus 로고
    • Conformational analysis of the endogenous mu-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modelling
    • Podlogar, B. L., Paterlini, M. G., Ferguson, D. M., et al. 1998. Conformational analysis of the endogenous mu-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modelling. FEBS Lett. 439: 13-20.
    • (1998) FEBS Lett. , vol.439 , pp. 13-20
    • Podlogar, B.L.1    Paterlini, M.G.2    Ferguson, D.M.3
  • 83
    • 0031848224 scopus 로고    scopus 로고
    • Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints
    • Pogozheva, I. D., Lomize, A. L., Mosberg, H. I. 1998. Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints. Biophys. J. 75: 612-34.
    • (1998) Biophys. J. , vol.75 , pp. 612-634
    • Pogozheva, I.D.1    Lomize, A.L.2    Mosberg, H.I.3
  • 84
    • 8744302247 scopus 로고    scopus 로고
    • G-protein-coupled receptor accessory proteins: Their potential role in future drug discovery
    • Presland, J. 2004. G-protein-coupled receptor accessory proteins: their potential role in future drug discovery. Biochem. Soc. Trans. 32: 888-91.
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 888-891
    • Presland, J.1
  • 87
    • 0037015067 scopus 로고    scopus 로고
    • Salvinorin A: A potent naturally occurring nonnitrogenous κ-opioid selective agonist
    • Roth, B. L., Baner, K., Westkaemper, R., et al. 2002. Salvinorin A: a potent naturally occurring nonnitrogenous κ-opioid selective agonist. Proc. Natl. Acad. Sci. USA. 99: 11934-9.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 11934-11939
    • Roth, B.L.1    Baner, K.2    Westkaemper, R.3
  • 88
    • 0032852719 scopus 로고    scopus 로고
    • Europeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus
    • Roumy, M., Zajac, J. 1999. Europeptide FF selectively attenuates the effects of nociceptin on acutely dissociated neurons of the rat dorsal raphe nucleus. Brain Res. 845: 208-14.
    • (1999) Brain Res. , vol.845 , pp. 208-214
    • Roumy, M.1    Zajac, J.2
  • 89
    • 0033672679 scopus 로고    scopus 로고
    • Non-opioid antinociceptive effects of supraspinal histogranin and related peptides: Possible involvement of central dopamine D(2) receptor
    • Ruan, H., Prasad, J. A., Lemaire, S. 2000. Non-opioid antinociceptive effects of supraspinal histogranin and related peptides: possible involvement of central dopamine D(2) receptor. Pharmacol. Biochem. Behav. 67: 83-91.
    • (2000) Pharmacol. Biochem. Behav. , vol.67 , pp. 83-91
    • Ruan, H.1    Prasad, J.A.2    Lemaire, S.3
  • 90
    • 0030468202 scopus 로고    scopus 로고
    • Ligand recognition in µ opioid receptor: Experimentally based modeling of µ opioid receptor binding sites and their testing by ligand docking
    • Sagara, T., Egashira, H., Okamura, M., Fujii, I., Shimohigashi, Y., Kanematsu, K. 1996. Ligand recognition in µ opioid receptor: experimentally based modeling of µ opioid receptor binding sites and their testing by ligand docking. Bioorg. Med. Chem. 4: 2151-66.
    • (1996) Bioorg. Med. Chem. , vol.4 , pp. 2151-2166
    • Sagara, T.1    Egashira, H.2    Okamura, M.3    Fujii, I.4    Shimohigashi, Y.5    Kanematsu, K.6
  • 92
    • 0034000876 scopus 로고    scopus 로고
    • Novel ligands lacking a positive charge for the delta-and mu-opioid receptors
    • Schiller, P. W., Berezowska, I., Nguyen, T. M.-D., et al. 2000. Novel ligands lacking a positive charge for the delta-and mu-opioid receptors. J. Med. Chem. 43: 551-9.
    • (2000) J. Med. Chem. , vol.43 , pp. 551-559
    • Schiller, P.W.1    Berezowska, I.2    Nguyen, T.M.-D.3
  • 93
    • 0037835959 scopus 로고    scopus 로고
    • Conversion of δ-, κ-, and µ-receptor selective opioid peptide agonists into δ-, κ- and µ-selective antagonists
    • Schiller, P. W., Weltrowska, G., Nguyen, T. M.-D., Lemieux, C., Chung, N. N., Lu, Y. 2003. Conversion of δ-, κ-, and µ-receptor selective opioid peptide agonists into δ-, κ- and µ-selective antagonists. Life Sci. 73: 691-8.
    • (2003) Life Sci. , vol.73 , pp. 691-698
    • Schiller, P.W.1    Weltrowska, G.2    Nguyen, T.M.-D.3    Lemieux, C.4    Chung, N.N.5    Lu, Y.6
  • 94
    • 34047174129 scopus 로고    scopus 로고
    • Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling
    • Shao, X., Gao, Y., Zhu, C., et al. 2007. Conformational analysis of endomorphin-2 analogs with phenylalanine mimics by NMR and molecular modeling. Bioorg. Med. Chem. 15: 3539-47.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 3539-3547
    • Shao, X.1    Gao, Y.2    Zhu, C.3
  • 95
    • 0034628575 scopus 로고    scopus 로고
    • Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor
    • Subramanian, G., Paterlini, M. G., Portoghese, P. S., Ferguson, D. M. 2000. Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. J. Med. Chem. 43: 381-91.
    • (2000) J. Med. Chem. , vol.43 , pp. 381-391
    • Subramanian, G.1    Paterlini, M.G.2    Portoghese, P.S.3    Ferguson, D.M.4
  • 97
    • 0038396397 scopus 로고    scopus 로고
    • Receptor ligands derived from food proteins
    • Teschemacher, H. 2003. Receptor ligands derived from food proteins. Curr. Pharm. Design. 9: 1331-44.
    • (2003) Curr. Pharm. Design. , vol.9 , pp. 1331-1344
    • Teschemacher, H.1
  • 98
    • 37849005357 scopus 로고    scopus 로고
    • Endomorphin-2 with a beta-turn backbone constraint retains the potent mu-opioid receptor agonist properties
    • Tömböly, C., Ballet, S., Feytens, D., et al. 2008. Endomorphin-2 with a beta-turn backbone constraint retains the potent mu-opioid receptor agonist properties. J. Med. Chem. 51: 173-7.
    • (2008) J. Med. Chem. , vol.51 , pp. 173-177
    • Tömböly, C.1    Ballet, S.2    Feytens, D.3
  • 99
    • 0035751792 scopus 로고    scopus 로고
    • Endogenous opiates: 2000
    • Vaccarino, A. L., Kastin, A. J. 2001. Endogenous opiates: 2000. Peptides. 22: 2257-328.
    • (2001) Peptides. , vol.22 , pp. 2257-2328
    • Vaccarino, A.L.1    Kastin, A.J.2
  • 100
    • 26244432567 scopus 로고    scopus 로고
    • Recent advances in elucidating pain mechanisms
    • Vadivelu, N., Sinatra, R. 2005. Recent advances in elucidating pain mechanisms. Curr. Opin. Anaesthesiol. 18: 540-7.
    • (2005) Curr. Opin. Anaesthesiol. , vol.18 , pp. 540-547
    • Vadivelu, N.1    Sinatra, R.2
  • 102
    • 0037431419 scopus 로고    scopus 로고
    • Novel N-terminal cyclic dynorphin A analogue cycloN,5 [Trp3, Trp4, Glu5] dynorphin A-(1-11)NH2 that lacks the basic N-terminus
    • Vig, B. S., Murray, T. F., Aldrich, J. V. A. 2003. Novel N-terminal cyclic dynorphin A analogue cycloN,5 [Trp3, Trp4, Glu5] dynorphin A-(1-11)NH2 that lacks the basic N-terminus. J. Med. Chem. 46: 1279-82.
    • (2003) J. Med. Chem. , vol.46 , pp. 1279-1282
    • Vig, B.S.1    Murray, T.F.2    Aldrich, J.V.A.3
  • 104
    • 77950584650 scopus 로고    scopus 로고
    • “Carba”-analogues of fentanyl are opioid receptor agonists
    • Weltrowska, G., Chung, N. N., Lemieux, C., et al. 2010. “Carba”-analogues of fentanyl are opioid receptor agonists. J. Med. Chem. 53: 2875-81.
    • (2010) J. Med. Chem. , vol.53 , pp. 2875-2881
    • Weltrowska, G.1    Chung, N.N.2    Lemieux, C.3
  • 106
    • 0034528235 scopus 로고    scopus 로고
    • Dissociation of analgesic and rewarding effects of endomorphin-1 in rats
    • Wilson, A. M., Soignier, R. D., Zadina, J. E., et al. 2000. Dissociation of analgesic and rewarding effects of endomorphin-1 in rats. Peptides. 21: 1871-4.
    • (2000) Peptides. , vol.21 , pp. 1871-1874
    • Wilson, A.M.1    Soignier, R.D.2    Zadina, J.E.3
  • 107
    • 0035748363 scopus 로고    scopus 로고
    • Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability
    • Witt, K. A., Gillespie, T. J., Huber, J. D., Egleton, R. D., Davis, T. P. 2001. Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. Peptides. 22: 2329-43.
    • (2001) Peptides. , vol.22 , pp. 2329-2343
    • Witt, K.A.1    Gillespie, T.J.2    Huber, J.D.3    Egleton, R.D.4    Davis, T.P.5
  • 108
    • 2342523931 scopus 로고    scopus 로고
    • Non-opioid actions of opioid peptides
    • Wollemann, M., Benyhe, S. 2004. Non-opioid actions of opioid peptides. Life Sci. 75: 257-70.
    • (2004) Life Sci. , vol.75 , pp. 257-270
    • Wollemann, M.1    Benyhe, S.2
  • 109
    • 20544441511 scopus 로고    scopus 로고
    • Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to κ-opioid receptors
    • Yan, F., Mosier, P. D., Westkaemper, R. B., et al. 2005. Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to κ-opioid receptors. Biochemistry. 44: 8643-51.
    • (2005) Biochemistry. , vol.44 , pp. 8643-8651
    • Yan, F.1    Mosier, P.D.2    Westkaemper, R.B.3
  • 110
    • 0035824792 scopus 로고    scopus 로고
    • Rubiscolin, a δ-selective opioid peptide derived from plant Rubisco
    • Yang, S., Yunden, J., Sonoda, S., et al. 2001. Rubiscolin, a δ-selective opioid peptide derived from plant Rubisco. FEBS Lett. 509: 213-17.
    • (2001) FEBS Lett. , vol.509 , pp. 213-217
    • Yang, S.1    Yunden, J.2    Sonoda, S.3
  • 111
    • 0030933655 scopus 로고    scopus 로고
    • A potent and selective endogenous agonist for the mu-opiate receptor
    • Zadina, J. E., Hackler, L., Ge, L.-J., Kastin, A. J. 1997. A potent and selective endogenous agonist for the mu-opiate receptor. Nature. 386: 499-502.
    • (1997) Nature. , vol.386 , pp. 499-502
    • Zadina, J.E.1    Hackler, L.2    Ge, L.-J.3    Kastin, A.J.4
  • 112
    • 21044437346 scopus 로고    scopus 로고
    • Homology Modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system
    • Zhang, Y., Sham, Y. Y., Rajamani, R., Gao, J., Portoghese, P. S. 2005. Homology Modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system. Chem. Bio. Chem. 6: 853-9.
    • (2005) Chem. Bio. Chem. , vol.6 , pp. 853-859
    • Zhang, Y.1    Sham, Y.Y.2    Rajamani, R.3    Gao, J.4    Portoghese, P.S.5
  • 113
    • 20644453964 scopus 로고    scopus 로고
    • 2, display partial agonist potency but significant antinociception
    • 2, display partial agonist potency but significant antinociception. Life Sci. 77: 1155-65.
    • (2005) Life Sci. , vol.77 , pp. 1155-1165
    • Zhao, Q.-Y.1    Chen, Q.2    Yang, D.-J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.