-
1
-
-
0029947902
-
A 3D model of the δ opioid receptor and ligand-receptor complexes
-
Alkorta, I., and G. Loew. 1996. A 3D model of the δ opioid receptor and ligand-receptor complexes. Protein Eng. 9:573-583.
-
(1996)
Protein Eng.
, vol.9
, pp. 573-583
-
-
Alkorta, I.1
Loew, G.2
-
2
-
-
0027716138
-
The role of backbone flexibility in the accomodation of variants that repack the core of T4 lysozyme
-
Baldwin, E. P., O. Hajiseyedjavadi, W. A. Baase, and B. W. Matthews. 1993. The role of backbone flexibility in the accomodation of variants that repack the core of T4 lysozyme. Science. 262:1715-1718.
-
(1993)
Science
, vol.262
, pp. 1715-1718
-
-
Baldwin, E.P.1
Hajiseyedjavadi, O.2
Baase, W.A.3
Matthews, B.W.4
-
3
-
-
0029892667
-
Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme
-
Baldwin, E., J. Xu, O. Hajiseyedjavadi, W. A. Baase, and B. W. Matthews. 1996. Thermodynamic and structural compensation in "size-switch" core repacking variants of bacteriophage T4 lysozyme. J. Mol. Biol. 121:542-559.
-
(1996)
J. Mol. Biol.
, vol.121
, pp. 542-559
-
-
Baldwin, E.1
Xu, J.2
Hajiseyedjavadi, O.3
Baase, W.A.4
Matthews, B.W.5
-
4
-
-
0027506471
-
The probable arrangement of the helices in G protein-coupled receptors
-
Baldwin, J. M. 1993. The probable arrangement of the helices in G protein-coupled receptors. EMBO J. 12:1693-1703.
-
(1993)
EMBO J.
, vol.12
, pp. 1693-1703
-
-
Baldwin, J.M.1
-
5
-
-
0031565726
-
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptos
-
Baldwin, J. M. 1997. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptos. J. Mol. Biol. 272:144-164.
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 144-164
-
-
Baldwin, J.M.1
-
6
-
-
77957055780
-
Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G protein-coupled receptors
-
Ballesteros, J. A., and H. Weinstein. 1995. Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods Neurosci. 25:366-427.
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-427
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
7
-
-
0024278714
-
Helix geometry in proteins
-
Barlow, D. J., and J. M. Thornton. 1988. Helix geometry in proteins. J. Mol. Biol. 201:601-619.
-
(1988)
J. Mol. Biol.
, vol.201
, pp. 601-619
-
-
Barlow, D.J.1
Thornton, J.M.2
-
8
-
-
0030040907
-
The conserved aspartate residue in the third putative transmembrane domain of the δ-opioid receptor is not the anionic counterpart for cationic opiate binding but is a constituent of the receptor binding site
-
Befort, K., L. P. Tabbara, S. Bausch, C. Chavkin, C. Evans, and B. L Kieffer. 1996a. The conserved aspartate residue in the third putative transmembrane domain of the δ-opioid receptor is not the anionic counterpart for cationic opiate binding but is a constituent of the receptor binding site. Mol. Pharmacol. 49:216-223.
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 216-223
-
-
Befort, K.1
Tabbara, L.P.2
Bausch, S.3
Chavkin, C.4
Evans, C.5
Kieffer, B.L.6
-
9
-
-
0029937609
-
Role of aromatic transmembrane residues of the δ-opioid receptor in ligand recognition
-
Befort, K., L. P. Tabbara, D. Kling, B. Maigret, and B. L. Kieffer. 1996b. Role of aromatic transmembrane residues of the δ-opioid receptor in ligand recognition. J. Biol. Chem. 271:10161-10168.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10161-10168
-
-
Befort, K.1
Tabbara, L.P.2
Kling, D.3
Maigret, B.4
Kieffer, B.L.5
-
10
-
-
0017411710
-
The Protein Data Bank: A computer-based archival file for macromolecular structures
-
Bernstein, F. C., T. F. Koetzle, G. J. Williams, E. E. Meyer, M. D. Brice, J. R. Rodgers, O. Kennard, T. Shimanouchi, and M. Tasumi. 1977. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 112:535-542.
-
(1977)
J. Mol. Biol.
, vol.112
, pp. 535-542
-
-
Bernstein, F.C.1
Koetzle, T.F.2
Williams, G.J.3
Meyer, E.E.4
Brice, M.D.5
Rodgers, J.R.6
Kennard, O.7
Shimanouchi, T.8
Tasumi, M.9
-
11
-
-
0024328781
-
14-β-(Bromoacetamido)morphine irreversible labels μ-opioid receptor in rat brain membranes
-
Bidlack, J. M., D. K. Frey, A. Seyed-Mozaffari, and S. Archer. 1989. 14-β-(Bromoacetamido)morphine irreversible labels μ-opioid receptor in rat brain membranes. Biochemistry. 28:4333-4339.
-
(1989)
Biochemistry
, vol.28
, pp. 4333-4339
-
-
Bidlack, J.M.1
Frey, D.K.2
Seyed-Mozaffari, A.3
Archer, S.4
-
12
-
-
84986512474
-
CHARMM: A program for macromolecular energy, minimization and dynamics calculations
-
Brooks, B. R., E. R. Bruccoleri, E. R. Olafson, D. J. States, S. Swaminathan, and M. Karplus. 1983. CHARMM: a program for macromolecular energy, minimization and dynamics calculations. J. Comput. Chem. 4:187-217.
-
(1983)
J. Comput. Chem.
, vol.4
, pp. 187-217
-
-
Brooks, B.R.1
Bruccoleri, E.R.2
Olafson, E.R.3
States, D.J.4
Swaminathan, S.5
Karplus, M.6
-
13
-
-
0017065454
-
The crystal structure of morphine hydrate
-
Bye, E. 1976. The crystal structure of morphine hydrate. Acta Chem. Scand. 630:549-554.
-
(1976)
Acta Chem. Scand.
, vol.630
, pp. 549-554
-
-
Bye, E.1
-
14
-
-
14444274551
-
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective 5 agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide δ opioid receptor ligands
-
Calderon, S. N., K. C. Rice, R. B. Rothman, F. Porreca, J. L. Flippen-Anderson, H. Kayakiri, H. Xu, K. Beckets, L. E. Smith, E. J. Bilsky, P. Davis, and R. Horvath. 1997. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective 5 agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80) and related novel nonpeptide δ opioid receptor ligands. J. Med. Chem. 40:695-704.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 695-704
-
-
Calderon, S.N.1
Rice, K.C.2
Rothman, R.B.3
Porreca, F.4
Flippen-Anderson, J.L.5
Kayakiri, H.6
Xu, H.7
Beckets, K.8
Smith, L.E.9
Bilsky, E.J.10
Davis, P.11
Horvath, R.12
-
15
-
-
0030028469
-
Synthesis, biological evaluation, and quantitive receptor docking simulation of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for κ-opioid receptors
-
Cappelli, A., M. Anzini, S. Vomero, C. M. Menziani, P. G. De-Benedetti, M. Sbacchi, G. D. Clarke, and L. Mennuni. 1996. Synthesis, biological evaluation, and quantitive receptor docking simulation of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for κ-opioid receptors. J. Med. Chem. 39: 860-872.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 860-872
-
-
Cappelli, A.1
Anzini, M.2
Vomero, S.3
Menziani, C.M.4
De-Benedetti, P.G.5
Sbacchi, M.6
Clarke, G.D.7
Mennuni, L.8
-
17
-
-
0030742024
-
The mu-opioid receptor down-regulates differently from the delta-opioid receptor: Requirement of a high affinity receptor/G protein complex formation
-
Chakrabarti, S., W. Yang, P. Y. Law, and H. H. Loh. 1997. The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Mol. Pharmacol. 52:105-113.
-
(1997)
Mol. Pharmacol.
, vol.52
, pp. 105-113
-
-
Chakrabarti, S.1
Yang, W.2
Law, P.Y.3
Loh, H.H.4
-
18
-
-
0028590201
-
κ-Opioid receptor selective affinity labels, electrophilic benzeneacetamides as κ-selective opioid antagonists
-
Chang, A.-C., A. E. Takemori, W. H. Ojala, W. B. Gleanson, and P. S. Portoghese. 1994. κ-Opioid receptor selective affinity labels, electrophilic benzeneacetamides as κ-selective opioid antagonists. J. Med. Chem. 3:4490-4498.
-
(1994)
J. Med. Chem.
, vol.3
, pp. 4490-4498
-
-
Chang, A.-C.1
Takemori, A.E.2
Ojala, W.H.3
Gleanson, W.B.4
Portoghese, P.S.5
-
19
-
-
0029047521
-
Characterization of irreversible binding of β-funaltrexamine to the cloned rat μ-opioid receptor
-
Chen, C., J.-C. Xue, J. Zhu, Y.-W. Chen, S. P. Kunapuli, J. K. de Riel, L. Yu, and L.-Y. Liu-Chen. 1995. Characterization of irreversible binding of β-funaltrexamine to the cloned rat μ-opioid receptor. J. Biol. Chem. 270:17866-17870.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17866-17870
-
-
Chen, C.1
Xue, J.-C.2
Zhu, J.3
Chen, Y.-W.4
Kunapuli, S.P.5
De Riel, J.K.6
Yu, L.7
Liu-Chen, L.-Y.8
-
21
-
-
0022399830
-
Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family
-
Chothia, C., and A. M. Lesk. 1985a. Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family. J. Mol. Biol. 182:151-158.
-
(1985)
J. Mol. Biol.
, vol.182
, pp. 151-158
-
-
Chothia, C.1
Lesk, A.M.2
-
23
-
-
0029942187
-
Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists
-
Claude, P. A., D. R. Wotta, X. H. Zhang, P. L. Prather, T. M. McGinn, L. J. Erickson, H. H. Lon, and P. Y. Law. 1996. Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists. Proc. Natl. Acad. Sci. USA. 93:5715-5719.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5715-5719
-
-
Claude, P.A.1
Wotta, D.R.2
Zhang, X.H.3
Prather, P.L.4
McGinn, T.M.5
Erickson, L.J.6
Lon, H.H.7
Law, P.Y.8
-
25
-
-
0025822990
-
Structural and thermodynamic analysis of the packing of two α-helices in bacteriophage T4 lysozyme
-
Daopin, S., T. Alber, W. A. Baase, J. A. Wozniak, and B. W. Matthews. 1991. Structural and thermodynamic analysis of the packing of two α-helices in bacteriophage T4 lysozyme. J. Mol. Biol. 221:647-667.
-
(1991)
J. Mol. Biol.
, vol.221
, pp. 647-667
-
-
Daopin, S.1
Alber, T.2
Baase, W.A.3
Wozniak, J.A.4
Matthews, B.W.5
-
26
-
-
0030198591
-
Projection structure of an invertebrate rhodopsin
-
Davies, A., G. F. X. Schertler, B. E. Gowen, and H. R. Saibil. 1996. Projection structure of an invertebrate rhodopsin. J. Struct. Biol. 117: 36-44.
-
(1996)
J. Struct. Biol.
, vol.117
, pp. 36-44
-
-
Davies, A.1
Schertler, G.F.X.2
Gowen, B.E.3
Saibil, H.R.4
-
27
-
-
0030334822
-
Conformational investigation of designed short linear peptides able to fold into β-hairpin structures in aqueous solution
-
deAlba, E., M. A. Jiménez, M. Rico, and J. Nieto. 1996. Conformational investigation of designed short linear peptides able to fold into β-hairpin structures in aqueous solution. Folding Design. 1:133-144.
-
(1996)
Folding Design
, vol.1
, pp. 133-144
-
-
DeAlba, E.1
Jiménez, M.A.2
Rico, M.3
Nieto, J.4
-
28
-
-
0025790423
-
Structures of bacterial photosynthetic reaction centers
-
Deisenhofer, J., and H. Michel. 1991. Structures of bacterial photosynthetic reaction centers. Annu. Rev. Cell Biol. 7:1-23.
-
(1991)
Annu. Rev. Cell Biol.
, vol.7
, pp. 1-23
-
-
Deisenhofer, J.1
Michel, H.2
-
29
-
-
0029671001
-
Structural studies of opioid peptides: A review of recent progress in x-ray diffraction studies
-
Deschamps, J. R., C. George, and J. L. Flippen-Anderson. 1996. Structural studies of opioid peptides: a review of recent progress in x-ray diffraction studies. Biopolymers. 40:121-139.
-
(1996)
Biopolymers
, vol.40
, pp. 121-139
-
-
Deschamps, J.R.1
George, C.2
Flippen-Anderson, J.L.3
-
30
-
-
0030472350
-
International Union of Pharmacology. XII. Classification of opioid receptors
-
Dhawan, B. N., F. Cesselin, R. Raghubir, T. Reisine, P. B. Bradley, P. S. Portoghese, and M. Hamon. 1996. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 48:567-592.
-
(1996)
Pharmacol. Rev.
, vol.48
, pp. 567-592
-
-
Dhawan, B.N.1
Cesselin, F.2
Raghubir, R.3
Reisine, T.4
Bradley, P.B.5
Portoghese, P.S.6
Hamon, M.7
-
31
-
-
0025168615
-
Conformational characteristics of opioid κ-receptor agonist: Crystal structure of (5S,7S,8S)-(-)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] benzeneacetamide (U69, 593), and conformational comparison with some κ-agonists
-
Doi, M., T. Ishida, and M. Inoue. 1990. Conformational characteristics of opioid κ-receptor agonist: crystal structure of (5S,7S,8S)-(-)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl] benzeneacetamide (U69, 593), and conformational comparison with some κ-agonists. Chem. Pharm. Bull. 38:1815-1818.
-
(1990)
Chem. Pharm. Bull.
, vol.38
, pp. 1815-1818
-
-
Doi, M.1
Ishida, T.2
Inoue, M.3
-
32
-
-
0028235604
-
The evolution and structure of aminergic G protein-coupled receptors
-
Donnelly, D., J. B. C. Findlay, and T. L. Blundell. 1994. The evolution and structure of aminergic G protein-coupled receptors. Receptors Channels. 2:61-78.
-
(1994)
Receptors Channels
, vol.2
, pp. 61-78
-
-
Donnelly, D.1
Findlay, J.B.C.2
Blundell, T.L.3
-
33
-
-
0028800729
-
Conversion of antagonist-binding site to metal-ion site in the tachikinin NK-1 receptor
-
Elling, C. E., S. M. Nielsen, and T. W. Schwartz. 1995. Conversion of antagonist-binding site to metal-ion site in the tachikinin NK-1 receptor. Nature. 374:74-77.
-
(1995)
Nature
, vol.374
, pp. 74-77
-
-
Elling, C.E.1
Nielsen, S.M.2
Schwartz, T.W.3
-
34
-
-
0026567907
-
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effects
-
Eriksson, A. E., W. A. Baase, X.-J. Zhang, D. W. Heinz, M. Blaber, E. P. Baldwin, and B. W. Matthews. 1992. Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effects. Science. 255:178-183.
-
(1992)
Science
, vol.255
, pp. 178-183
-
-
Eriksson, A.E.1
Baase, W.A.2
Zhang, X.-J.3
Heinz, D.W.4
Blaber, M.5
Baldwin, E.P.6
Matthews, B.W.7
-
35
-
-
0029085550
-
Photoactivated state of rhodopsin and how it can form
-
Fahmy, K., F. Siebert, and T. P. Sakmar. 1995. Photoactivated state of rhodopsin and how it can form. Biophys. Chem. 56:171-181.
-
(1995)
Biophys. Chem.
, vol.56
, pp. 171-181
-
-
Fahmy, K.1
Siebert, F.2
Sakmar, T.P.3
-
36
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens, D. L., C. Altenbach, K. Yang, W. L. Hubbell, and H. G. Khorana. 1996. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science. 274:768-770.
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
37
-
-
0029670790
-
583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling
-
583 in the third extracellular loop of the lutropin/choriogonadotropin receptor is critical for signaling. J. Biol. Chem. 271:925-930.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 925-930
-
-
Fernandez, L.M.1
Puett, D.2
-
38
-
-
0001436328
-
X-ray structure of potent opioid receptor ligands: Etonitazene, cis-(+)-3-methylfentanyl, etorphine, diprenorphine, and buprenorphine
-
Flippen-Anderson, J. L., and C. George. 1994. X-ray structure of potent opioid receptor ligands: etonitazene, cis-(+)-3-methylfentanyl, etorphine, diprenorphine, and buprenorphine. Heterocycles. 39:751-766.
-
(1994)
Heterocycles
, vol.39
, pp. 751-766
-
-
Flippen-Anderson, J.L.1
George, C.2
-
39
-
-
0028100316
-
5]enkephalin, a highly potent, δ opioid receptor-selective compound: Comparisons with proposed solution conformations
-
5]enkephalin, a highly potent, δ opioid receptor-selective compound: comparisons with proposed solution conformations. J. Am. Chem. Soc. 116:7523-7531.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 7523-7531
-
-
Flippen-Anderson, J.L.1
Hruby, V.J.2
Collins, N.3
George, C.4
Cudney, B.5
-
40
-
-
0024847889
-
Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: Conserved aspartic acids play important roles in receptor function
-
Fraser, C. M., C.-D. Wang, D. A. Robinson, J. D. Gocayne, and J. C. Venter. 1989. Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function. Mol. Pharmacol. 36:840-847.
-
(1989)
Mol. Pharmacol.
, vol.36
, pp. 840-847
-
-
Fraser, C.M.1
Wang, C.-D.2
Robinson, D.A.3
Gocayne, J.D.4
Venter, J.C.5
-
41
-
-
0025637152
-
Conformational search in enkephalin analogues containing a disulfide bond
-
Froimowitz, M. 1990. Conformational search in enkephalin analogues containing a disulfide bond. Biopolymers. 30:1011-1025.
-
(1990)
Biopolymers
, vol.30
, pp. 1011-1025
-
-
Froimowitz, M.1
-
42
-
-
0029757635
-
Residues I the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice
-
Fu, D., J. A. Ballesteros, H. Weinstein, J. Chen, and J. A. Javitch. 1996. Residues I the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice. Biochemistry. 35: 11278-11285.
-
(1996)
Biochemistry
, vol.35
, pp. 11278-11285
-
-
Fu, D.1
Ballesteros, J.A.2
Weinstein, H.3
Chen, J.4
Javitch, J.A.5
-
43
-
-
0029131679
-
Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ- and μ-opioid receptors
-
Fukuda, K., K. Terasako, S. Kato, and K. Mori. 1995. Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ- and μ-opioid receptors. FEBS Lett. 373: 177-181.
-
(1995)
FEBS Lett.
, vol.373
, pp. 177-181
-
-
Fukuda, K.1
Terasako, K.2
Kato, S.3
Mori, K.4
-
44
-
-
0022472932
-
Crystal structure of α- and β-funaltrexamine: Conformational requirements of the fumaramate moiety in the irreversible blockage of μ opioid receptors
-
Griffin, J. F., D. L. Larson, and P. S. Portoghese. 1986. Crystal structure of α- and β-funaltrexamine: conformational requirements of the fumaramate moiety in the irreversible blockage of μ opioid receptors. J. Med. Chem. 29:778-783.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 778-783
-
-
Griffin, J.F.1
Larson, D.L.2
Portoghese, P.S.3
-
45
-
-
0029903197
-
Electron-crystallographic refinement of the structure of bacteriorhodopsin
-
Grigorieff, N., T. A. Ceska, K. H. Downing, J. M. Baldwin, and R. Henderson. 1996. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J. Mol. Biol. 259:393-421.
-
(1996)
J. Mol. Biol.
, vol.259
, pp. 393-421
-
-
Grigorieff, N.1
Ceska, T.A.2
Downing, K.H.3
Baldwin, J.M.4
Henderson, R.5
-
46
-
-
0026089657
-
Efficient computation of three-dimensional protein structure in solution from NMR data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA
-
Güntert, P., W. Brawn, and K. Wüthrich. 1991. Efficient computation of three-dimensional protein structure in solution from NMR data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA. J. Mol. Biol. 217:517-530.
-
(1991)
J. Mol. Biol.
, vol.217
, pp. 517-530
-
-
Güntert, P.1
Brawn, W.2
Wüthrich, K.3
-
47
-
-
0026259488
-
Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints
-
Güntert, P., and K. Wüthrich. 1991. Improved efficiency of protein structure calculations from NMR data using the program DIANA with redundant dihedral angle constraints. J. Biomol. NMR. 1:447-456.
-
(1991)
J. Biomol. NMR
, vol.1
, pp. 447-456
-
-
Güntert, P.1
Wüthrich, K.2
-
48
-
-
0028182223
-
3]DPDPE: A new enkephalin analog with unique receptor activity profile. Further evidence of δ-opioid receptor multiplicity
-
3]DPDPE: a new enkephalin analog with unique receptor activity profile. Further evidence of δ-opioid receptor multiplicity. J. Med. Chem. 37:1572-1577.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1572-1577
-
-
Haaseth, R.C.1
Horan, P.J.2
Bilsky, E.J.3
Davis, P.4
Zalewska, T.5
Slaninova, J.6
Yamamura, H.I.7
Weber, S.J.8
Davis, T.P.9
Porreca, F.10
Hruby, V.J.11
-
49
-
-
0000111543
-
Computer-aided receptor modeling of human opioid receptors (mu, kappa and delta)
-
Habibi-Nezhad, B., M. Hanifian, and M. Mahmoudian. 1996. Computer-aided receptor modeling of human opioid receptors (mu, kappa and delta). J. Mol. Model. 2:362-369.
-
(1996)
J. Mol. Model.
, vol.2
, pp. 362-369
-
-
Habibi-Nezhad, B.1
Hanifian, M.2
Mahmoudian, M.3
-
50
-
-
0029730779
-
Functional interaction if transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant
-
Han, M., S. W. Lin, M. Minkova, S. O. Smith, and T. P. Sakmar. 1996a. Functional interaction if transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant. J. Biol. Chem. 271: 32337-32342.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32337-32342
-
-
Han, M.1
Lin, S.W.2
Minkova, M.3
Smith, S.O.4
Sakmar, T.P.5
-
51
-
-
0029753237
-
The effects of amono acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin
-
Han, M., S. W. Lin, S. O. Smith, and T. P. Sakmar. 1996b. The effects of amono acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin. J. Biol. Chem. 271:32330-32336.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32330-32336
-
-
Han, M.1
Lin, S.W.2
Smith, S.O.3
Sakmar, T.P.4
-
52
-
-
0025292355
-
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
-
Henderson, R., J. M. Baldwin, T. A. Ceska, F. Zemlin, E. Beckmann, and K. H. Downing. 1990. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. Biol. 213:899-929.
-
(1990)
J. Mol. Biol.
, vol.213
, pp. 899-929
-
-
Henderson, R.1
Baldwin, J.M.2
Ceska, T.A.3
Zemlin, F.4
Beckmann, E.5
Downing, K.H.6
-
53
-
-
0028829235
-
Automated method for modeling seven-helix transmembrane receptors from experimental data
-
Herzyk, P., and R. E. Hubbard. 1995. Automated method for modeling seven-helix transmembrane receptors from experimental data. Biophys. J. 69:2419-2442.
-
(1995)
Biophys. J.
, vol.69
, pp. 2419-2442
-
-
Herzyk, P.1
Hubbard, R.E.2
-
55
-
-
0026613033
-
3 aromatic moiety in a series of delta receptor-selective dermorphin/ deltorphin-related tetrapeptides: Effects on opioid receptor binding
-
3 aromatic moiety in a series of delta receptor-selective dermorphin/ deltorphin-related tetrapeptides: effects on opioid receptor binding. Int. J. Pept. Protein Res. 39:450-457.
-
(1992)
Int. J. Pept. Protein Res.
, vol.39
, pp. 450-457
-
-
Heyl, D.L.1
Mosberg, H.I.2
-
56
-
-
0026612763
-
3 aromatic ring in cyclic delta receptor-selective dermorphin/deltorphin tetrapeptide analogs: Electronic and lipophilic requirements for receptor affinity
-
3 aromatic ring in cyclic delta receptor-selective dermorphin/deltorphin tetrapeptide analogs: electronic and lipophilic requirements for receptor affinity. J. Med. Chem. 35:1535-1541.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 1535-1541
-
-
Heyl, D.L.1
Mosberg, H.I.2
-
57
-
-
0029013360
-
Analysis of selective binding epitope for the κ-opioid receptor antagonist norbinaltorphimine
-
Hjorth, S. A., K. Thirstrup, D. K. Grandy, and T. W. Schwartz. 1995. Analysis of selective binding epitope for the κ-opioid receptor antagonist norbinaltorphimine. Mol. Pharmacol. 47:1089-1094.
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 1089-1094
-
-
Hjorth, S.A.1
Thirstrup, K.2
Grandy, D.K.3
Schwartz, T.W.4
-
60
-
-
0025899958
-
Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor
-
Housset, D., K.-S Kim,. J. Fuchs, C. Woodward, and A. Wlodawer. 1991. Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor. J. Mol. Biol. 220:757-770.
-
(1991)
J. Mol. Biol.
, vol.220
, pp. 757-770
-
-
Housset, D.1
Kim, K.-S.2
Fuchs, J.3
Woodward, C.4
Wlodawer, A.5
-
61
-
-
0031033944
-
Synergism of constitutive activity in alpha-1-adrenergic receptor
-
Hwa, S., R. Gaivin, J. E. Porter, and D. M. Perez. 1997. Synergism of constitutive activity in alpha-1-adrenergic receptor. Biochemistry. 36: 633-639.
-
(1997)
Biochemistry
, vol.36
, pp. 633-639
-
-
Hwa, S.1
Gaivin, R.2
Porter, J.E.3
Perez, D.M.4
-
62
-
-
0028920298
-
Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method
-
Javitch, J. A., D. Fu, J. Chen, and A. Karlin. 1995. Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method. Neuron. 14:825-831.
-
(1995)
Neuron
, vol.14
, pp. 825-831
-
-
Javitch, J.A.1
Fu, D.2
Chen, J.3
Karlin, A.4
-
64
-
-
0023571499
-
Experimental electron density distribution of naloxone hydrochloride dihydrate, a potent opiate antagonist
-
Klein, C. L., R. J. Majeste, and E. D. Stevens. 1987. Experimental electron density distribution of naloxone hydrochloride dihydrate, a potent opiate antagonist. J. Am. Chem. Soc. 109:6675-6681.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 6675-6681
-
-
Klein, C.L.1
Majeste, R.J.2
Stevens, E.D.3
-
65
-
-
0029041510
-
Molecular biology and pharmacology of cloned opioid receptors
-
Knapp, R. J., E. Malatynska, N. Collins, L. Fang, J. Y. Wang, V. J. Hruby, W. R. Roeske, and H. I. Yamamura. 1995. Molecular biology and pharmacology of cloned opioid receptors. FASEB J. 9:516-525.
-
(1995)
FASEB J.
, vol.9
, pp. 516-525
-
-
Knapp, R.J.1
Malatynska, E.2
Collins, N.3
Fang, L.4
Wang, J.Y.5
Hruby, V.J.6
Roeske, W.R.7
Yamamura, H.I.8
-
66
-
-
7044239742
-
Free energy calculations: Applications to chemical and biochemical phenomena
-
Kollman, P. A. 1993. Free energy calculations: applications to chemical and biochemical phenomena. Chem. Rev. 93:2395-2417.
-
(1993)
Chem. Rev.
, vol.93
, pp. 2395-2417
-
-
Kollman, P.A.1
-
67
-
-
0027932239
-
Agonists and antagonists bind to different domains of the cloned κ-opioid receptor
-
Kong, H., K. Raynor, H. Yano, J. Takeda, G. I. Bell, and T. Reisine. 1994. Agonists and antagonists bind to different domains of the cloned κ-opioid receptor. Proc. Natl. Acad. Sci. USA. 91:8042-8046.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8042-8046
-
-
Kong, H.1
Raynor, K.2
Yano, H.3
Takeda, J.4
Bell, G.I.5
Reisine, T.6
-
68
-
-
0027444691
-
A single residue, aspartic acid 95, in the δ-opioid receptor specifies selective high affinity agonist binding
-
Kong, H., K. Raynor, H. Yano, K. Yasuda, S. T. Moe, P. S. Portoghese, G. I. Bell, and T. Reisine. 1993. A single residue, aspartic acid 95, in the δ-opioid receptor specifies selective high affinity agonist binding. J. Biol. Chem. 268:23055-23058.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 23055-23058
-
-
Kong, H.1
Raynor, K.2
Yano, H.3
Yasuda, K.4
Moe, S.T.5
Portoghese, P.S.6
Bell, G.I.7
Reisine, T.8
-
69
-
-
0021895054
-
3H]-U69,593, a highly selective ligand for the opioid κ-receptor
-
3H]-U69,593, a highly selective ligand for the opioid κ-receptor. Eur. J. Pharmacol. 109:281-284.
-
(1985)
Eur. J. Pharmacol.
, vol.109
, pp. 281-284
-
-
Lahti, R.A.1
Mickelson, M.M.2
McCall, J.M.3
Von Voigtlander, P.F.4
-
70
-
-
0019332167
-
How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of globins
-
Lesk, A. M., and C. Chothia. 1980. How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of globins. J. Mol. Biol. 136:225-270.
-
(1980)
J. Mol. Biol.
, vol.136
, pp. 225-270
-
-
Lesk, A.M.1
Chothia, C.2
-
72
-
-
0030070839
-
Development of a model for the opioid receptor pharmacophore. 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Phe]OH with other conformation-ally constrained δ-receptor selective ligands
-
Lomize, A. L., I. D. Pogozheva, and H. I. Mosberg. 1996. Development of a model for the opioid receptor pharmacophore. 3. Comparison of the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Phe]OH with other conformation-ally constrained δ-receptor selective ligands. Biopolymers. 38:221-234.
-
(1996)
Biopolymers
, vol.38
, pp. 221-234
-
-
Lomize, A.L.1
Pogozheva, I.D.2
Mosberg, H.I.3
-
74
-
-
0024842566
-
A polypeptide chain-refolding event occurs in the Gly82 variant of yeast iso-1-cytochrome c
-
Louie, G. V., and G. D. Brayer. 1989. A polypeptide chain-refolding event occurs in the Gly82 variant of yeast iso-1-cytochrome c. J. Mol. Biol. 209:313-322.
-
(1989)
J. Mol. Biol.
, vol.209
, pp. 313-322
-
-
Louie, G.V.1
Brayer, G.D.2
-
75
-
-
0026940770
-
Site-directed mutagenesis of the human dopamine D2 receptor
-
Mansour, A., F. Meng, J. H. Meador-Woodruff, L. P. Taylor, O. Civelli, and H. Akil. 1992. Site-directed mutagenesis of the human dopamine D2 receptor. Eur. J. Pharmacol. 227:205-214.
-
(1992)
Eur. J. Pharmacol.
, vol.227
, pp. 205-214
-
-
Mansour, A.1
Meng, F.2
Meador-Woodruff, J.H.3
Taylor, L.P.4
Civelli, O.5
Akil, H.6
-
76
-
-
0031018775
-
Key residues defining the μ opioid receptor binding pocket: A site-directed mutagenesis study
-
Mansour, A., L. P. Taylor, J. L. Fine, R. C. Thompson, M. T. Hoversten, H. I. Mosberg, S. J. Watson, and H. Akil. 1997. Key residues defining the μ opioid receptor binding pocket: a site-directed mutagenesis study. J. Neurochem. 68:344-353.
-
(1997)
J. Neurochem.
, vol.68
, pp. 344-353
-
-
Mansour, A.1
Taylor, L.P.2
Fine, J.L.3
Thompson, R.C.4
Hoversten, M.T.5
Mosberg, H.I.6
Watson, S.J.7
Akil, H.8
-
77
-
-
0028304962
-
Satisfying hydrogen bonding potential in proteins
-
McDonald, I. K., and J. M. Thornton. 1994. Satisfying hydrogen bonding potential in proteins. J. Mol. Biol. 238:777-793.
-
(1994)
J. Mol. Biol.
, vol.238
, pp. 777-793
-
-
McDonald, I.K.1
Thornton, J.M.2
-
78
-
-
0029017044
-
A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ-opioid receptors
-
Meng, F., M. T. Hoversten, R. C. Thompson, L. Taylor, S. J. Watson, and H. Akil. 1995. A chimeric study of the molecular basis of affinity and selectivity of the κ and the δ-opioid receptors. J. Biol. Chem. 270: 12730-12736.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12730-12736
-
-
Meng, F.1
Hoversten, M.T.2
Thompson, R.C.3
Taylor, L.4
Watson, S.J.5
Akil, H.6
-
79
-
-
0030581509
-
Mapping the receptor domains critical for the binding selectivity of δ-opioid receptor ligands
-
Meng, F., Y. Ueda, M. T. Hoversten, R. C. Thompson, L. Taylor, S. J. Watson, and H. Akil. 1996. Mapping the receptor domains critical for the binding selectivity of δ-opioid receptor ligands. Eur. J. Pharmacol. 311:285-292.
-
(1996)
Eur. J. Pharmacol.
, vol.311
, pp. 285-292
-
-
Meng, F.1
Ueda, Y.2
Hoversten, M.T.3
Thompson, R.C.4
Taylor, L.5
Watson, S.J.6
Akil, H.7
-
80
-
-
0028866118
-
On the role of extracellular loops of opioid receptors in conferring ligand selectivity
-
Metzger, T. G., and D. M. Ferguson. 1995. On the role of extracellular loops of opioid receptors in conferring ligand selectivity. FEBS Lett. 375:1-4.
-
(1995)
FEBS Lett.
, vol.375
, pp. 1-4
-
-
Metzger, T.G.1
Ferguson, D.M.2
-
81
-
-
0029994263
-
Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models
-
Metzger, T. G., M. G. Paterline, P. S. Portoghese, and D. M. Ferguson. 1996. Application of the message-address concept to the docking of naltrexone and selective naltrexone-derived opioid antagonists into opioid receptor models. Neurochem. Res. 21:1287-1294.
-
(1996)
Neurochem. Res.
, vol.21
, pp. 1287-1294
-
-
Metzger, T.G.1
Paterline, M.G.2
Portoghese, P.S.3
Ferguson, D.M.4
-
82
-
-
0029844422
-
A single residue, Lys108 of the δ-opioid receptor prevents the μ-opioid selective ligand [D-Ala2,N-MePhe4,Glyol5]enkephalin from binding to the δ-opioid receptor
-
Minami, M., T. Nakagawa, T. Seki, T. Onogi, Y. Aoki, Y. Katao, S. Katsumata, and M. Satoh. 1996. A single residue, Lys108 of the δ-opioid receptor prevents the μ-opioid selective ligand [D-Ala2,N-MePhe4,Glyol5]enkephalin from binding to the δ-opioid receptor. Mol. Pharmacol. 50:1413-1422.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1413-1422
-
-
Minami, M.1
Nakagawa, T.2
Seki, T.3
Onogi, T.4
Aoki, Y.5
Katao, Y.6
Katsumata, S.7
Satoh, M.8
-
83
-
-
84986505827
-
Validation of the general purpose QUANTA3.2/CHARMm force field
-
Momany, F. A., and R. Rone. 1992. Validation of the general purpose QUANTA3.2/CHARMm force field. J. Comput. Chem. 13:888-900.
-
(1992)
J. Comput. Chem.
, vol.13
, pp. 888-900
-
-
Momany, F.A.1
Rone, R.2
-
84
-
-
0030248962
-
Development of a model for the δ opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-cyclo-[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain
-
Mosberg, H. I., R. K. Dua, I. D. Pogozheva, and A. L. Lomize. 1996. Development of a model for the δ opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-cyclo-[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain. Biopolymers. 39:287-296.
-
(1996)
Biopolymers
, vol.39
, pp. 287-296
-
-
Mosberg, H.I.1
Dua, R.K.2
Pogozheva, I.D.3
Lomize, A.L.4
-
85
-
-
0000440578
-
Bis-penicillinamine enkephalins possess highly improved apecificity toward δ-opioid receptors
-
Mosberg, H. I., R. Hurst, V. J. Hruby, K. Gee, H. I. Yamamura, J. J. Galligan, and T. F. Burks. 1983. Bis-penicillinamine enkephalins possess highly improved apecificity toward δ-opioid receptors. Proc. Natl. Acad. Sci. USA. 80:5871-5874.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 5871-5874
-
-
Mosberg, H.I.1
Hurst, R.2
Hruby, V.J.3
Gee, K.4
Yamamura, H.I.5
Galligan, J.J.6
Burks, T.F.7
-
86
-
-
0028587577
-
1 replacements in the cyclic δ-receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)
-
1 replacements in the cyclic δ-receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). J. Med. Chem. 37: 4371-4383.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4371-4383
-
-
Mosberg, H.I.1
Lomize, A.L.2
Wang, C.3
Kroona, H.4
Heyl, D.L.5
Sobczyk-Kojiro, K.6
Ma, W.7
Mousigan, C.8
Porreca, F.9
-
87
-
-
0028576426
-
3 replacements in the cyclic δ-receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)
-
3 replacements in the cyclic δ-receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). J. Med. Chem. 37:4384-4391.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4384-4391
-
-
Mosberg, H.I.1
Omnaas, J.R.2
Lomize, A.L.3
Heyl, D.L.4
Nordan, I.5
Mousigan, C.6
Davis, P.7
Porreca, F.8
-
88
-
-
0023810741
-
Cyclic disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligand with enhanced delta opioid receptor selectivity and potency
-
Mosberg, H. I., J. R. Omnaas, C. B. Smith, and F. Medzihradsky. 1988. Cyclic disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with enhanced delta opioid receptor selectivity and potency Life Sci. 43:1013-1020.
-
(1988)
Life Sci.
, vol.43
, pp. 1013-1020
-
-
Mosberg, H.I.1
Omnaas, J.R.2
Smith, C.B.3
Medzihradsky, F.4
-
89
-
-
0344852777
-
1H NMR study of HTyr-D-Cys-Phe-D-PenOH (JOM-13), a highly selective ligand for the delta opioid receptor
-
V. Renugopalakrishnan, editor. ESCOM, Leiden, the Netherlands
-
1H NMR study of HTyr-D-Cys-Phe-D-PenOH (JOM-13), a highly selective ligand for the delta opioid receptor. In Proteins. V. Renugopalakrishnan, editor. ESCOM, Leiden, the Netherlands. 105-109.
-
(1991)
Proteins
, pp. 105-109
-
-
Mosberg, H.I.1
Sobczyk-Kojiro, K.2
-
91
-
-
0001228323
-
A common motif in G-protein-coupled seven transmembrane helix receptors
-
Oliveira, L., A. C. M. Paiva, and G. Vriend. 1993. A common motif in G-protein-coupled seven transmembrane helix receptors. J. Computer-Aided Mol. Design. 7:649-658.
-
(1993)
J. Computer-Aided Mol. Design.
, vol.7
, pp. 649-658
-
-
Oliveira, L.1
Paiva, A.C.M.2
Vriend, G.3
-
92
-
-
0028978424
-
DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops
-
Onogi, T., M. Minami, Y. Katao, T. Nakagawa, Y. Aoki, T. Toya, S. Katsumata, and M. Satoh. 1995. DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. FEBS Lett. 357:93-97.
-
(1995)
FEBS Lett.
, vol.357
, pp. 93-97
-
-
Onogi, T.1
Minami, M.2
Katao, Y.3
Nakagawa, T.4
Aoki, Y.5
Toya, T.6
Katsumata, S.7
Satoh, M.8
-
93
-
-
1842335688
-
Novel "restoration of function" mutagenesis strategy to identify amino acids of the δ-opioid receptor involved in ligand binding
-
Pepin, M.-C., S. Y. Yue, E. Roberts, C. Wahlestedt, and P. Walker. 1997. Novel "restoration of function" mutagenesis strategy to identify amino acids of the δ-opioid receptor involved in ligand binding. J. Biol. Chem. 272:9260-9267.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 9260-9267
-
-
Pepin, M.-C.1
Yue, S.Y.2
Roberts, E.3
Wahlestedt, C.4
Walker, P.5
-
94
-
-
0030998038
-
The transmembrane 7-α-bundle of rhodopsin: Distance geometry calculation with hydrogen bonding constraints
-
Pogozheva, I. D., A. L. Lomize, and H. I. Mosberg. 1997. The transmembrane 7-α-bundle of rhodopsin: distance geometry calculation with hydrogen bonding constraints. Biophys. J. 70:1963-1985.
-
(1997)
Biophys. J.
, vol.70
, pp. 1963-1985
-
-
Pogozheva, I.D.1
Lomize, A.L.2
Mosberg, H.I.3
-
95
-
-
0029661256
-
Activation of the alpha-1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint
-
Porter, J. E., J. Hwa, and D. M. Perez. 1996. Activation of the alpha-1b-adrenergic receptor is initiated by disruption of an interhelical salt bridge constraint. J. Biol. Chem. 45:28318-28323.
-
(1996)
J. Biol. Chem.
, vol.45
, pp. 28318-28323
-
-
Porter, J.E.1
Hwa, J.2
Perez, D.M.3
-
96
-
-
0028275934
-
Structure-activity relationship of N17′-substituted norbinaltorphimine congeners. Role of the N17′ basic group in the interaction with a putative address subsite on the κ opioid receptor
-
Portoghese, P. S., C.-E. Lin, F. Farour-Grant, and A. E. Takemori. 1994. Structure-activity relationship of N17′-substituted norbinaltorphimine congeners. Role of the N17′ basic group in the interaction with a putative address subsite on the κ opioid receptor. J. Med. Chem. 37: 1495-1500.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1495-1500
-
-
Portoghese, P.S.1
Lin, C.-E.2
Farour-Grant, F.3
Takemori, A.E.4
-
97
-
-
0023130929
-
Bimorphinans as highly selective, potent kappa receptor antagonists
-
Portoghese, P. S., A. W. Lipkowski, and A. E. Takemori. 1987. Bimorphinans as highly selective, potent kappa receptor antagonists. J. Med. Chem. 30:238-239.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 238-239
-
-
Portoghese, P.S.1
Lipkowski, A.W.2
Takemori, A.E.3
-
98
-
-
0025314942
-
Design of peptidomimetic δ-opioid receptor antagonists using the message-address concept
-
Portoghese, P. S., M. Sultana, and A. E. Takemori. 1990. Design of peptidomimetic δ-opioid receptor antagonists using the message-address concept. J. Med. Chem. 33:1714-1720.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 1714-1720
-
-
Portoghese, P.S.1
Sultana, M.2
Takemori, A.E.3
-
99
-
-
0029054001
-
Opiate receptors
-
Reisine, T. 1995. Opiate receptors. Neuropharmacology. 34:463-472.
-
(1995)
Neuropharmacology
, vol.34
, pp. 463-472
-
-
Reisine, T.1
-
101
-
-
0026661978
-
Constitutively active mutants of rhodopsin
-
Rohinson, P. R., G. B. Cohen, E. A. Zhukovsky, and D. D. Oprian. 1992. Constitutively active mutants of rhodopsin. Neuron. 9:719-725.
-
(1992)
Neuron
, vol.9
, pp. 719-725
-
-
Rohinson, P.R.1
Cohen, G.B.2
Zhukovsky, E.A.3
Oprian, D.D.4
-
102
-
-
0019187196
-
Bremazocine: A potent, long-acting opiate kappa-agonist
-
Römer, D., H. Buscher, R. C. Hill, R. Maurer, T. J. Petcher, H. B. Welle, H. C. Bakel, A. M. Akkerman. 1980. Bremazocine: a potent, long-acting opiate kappa-agonist. Life Sci. 27:971-978.
-
(1980)
Life Sci.
, vol.27
, pp. 971-978
-
-
Römer, D.1
Buscher, H.2
Hill, R.C.3
Maurer, R.4
Petcher, T.J.5
Welle, H.B.6
Bakel, H.C.7
Akkerman, A.M.8
-
103
-
-
85005586843
-
Properties and photoactivity of rhodopsin mutants
-
Sakmar, T. P., and K. Fahmy. 1995. Properties and photoactivity of rhodopsin mutants. Isr. J. Chem. 35:325-337.
-
(1995)
Isr. J. Chem.
, vol.35
, pp. 325-337
-
-
Sakmar, T.P.1
Fahmy, K.2
-
104
-
-
0026548156
-
In vitro mutagenesis and the search for structure-function relationships among G-protein-coupled receptors
-
Savarese, T. M., and C. M. Fraser. 1992. In vitro mutagenesis and the search for structure-function relationships among G-protein-coupled receptors. Biochem. J. 283:1-19.
-
(1992)
Biochem. J.
, vol.283
, pp. 1-19
-
-
Savarese, T.M.1
Fraser, C.M.2
-
105
-
-
0026806846
-
Tolerance of T4 lysozyme to proline substitutions within the long interdomain α-helix illustrates the adaptability of protein to potentially destabilizing lesions
-
Sauer, U. H., S. Dao-pin, and B. W. Matthews. 1992. Tolerance of T4 lysozyme to proline substitutions within the long interdomain α-helix illustrates the adaptability of protein to potentially destabilizing lesions. J. Biol. Chem. 267:2393-2399.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 2393-2399
-
-
Sauer, U.H.1
Dao-pin, S.2
Matthews, B.W.3
-
107
-
-
0001761402
-
Structure-function relationships in the membrane channel porin as based on 1.8 Å resolution crystal structure
-
A. Pullman, J. Jortner, and B. Pullman, editors. KJuwer Academic Publishers, Dordrecht, the Netherlands
-
Schultz, G. E. 1992. Structure-function relationships in the membrane channel porin as based on 1.8 Å resolution crystal structure. In Membrane Proteins: Structure, Interactions and Models. A. Pullman, J. Jortner, and B. Pullman, editors. KJuwer Academic Publishers, Dordrecht, the Netherlands. 403-412.
-
(1992)
Membrane Proteins: Structure, Interactions and Models
, pp. 403-412
-
-
Schultz, G.E.1
-
110
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices c and F
-
Sheikh, S., T. A. Zviaga, O. Lichtarge, T. P. Sakmar, and H. R. Bourne. 1996. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices c and F. Nature. 383:347-350.
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.1
Zviaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
111
-
-
0031566429
-
The steric trigger in rhodopsin activation
-
Shieh, T., M. Han, T. P. Sakmar, and S. O. Smith. 1997. The steric trigger in rhodopsin activation. J. Mol. Biol. 269:373-384.
-
(1997)
J. Mol. Biol.
, vol.269
, pp. 373-384
-
-
Shieh, T.1
Han, M.2
Sakmar, T.P.3
Smith, S.O.4
-
112
-
-
0026351935
-
Conformation of β-hairpins in protein structures: Classification and diversity in homologous structures
-
Sibanda, B. L., and J. M. Thornton. 1991. Conformation of β-hairpins in protein structures: classification and diversity in homologous structures. Methods Enzymol. 202:59-83.
-
(1991)
Methods Enzymol.
, vol.202
, pp. 59-83
-
-
Sibanda, B.L.1
Thornton, J.M.2
-
113
-
-
0024344941
-
Identification of two serine residues involved in agonist activation of the β-adrenergic receptor
-
Strader, C. D., M. R. Candelore, W. S. Hill, I. S. Sigal, and R. A. F. Dixon. 1989. Identification of two serine residues involved in agonist activation of the β-adrenergic receptor. J. Biol. Chem. 264:13572-13578.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 13572-13578
-
-
Strader, C.D.1
Candelore, M.R.2
Hill, W.S.3
Sigal, I.S.4
Dixon, R.A.F.5
-
114
-
-
0023740863
-
Conserved aspartic acid residues 79 and 113 of the β-adrenergic receptor have different roles in receptor function
-
Strader, C. D., I. S. Sigal, M. R. Candelore, E. Rands, W. S. Hill, and R. A. F. Dixon. 1988. Conserved aspartic acid residues 79 and 113 of the β-adrenergic receptor have different roles in receptor function. J. Biol. Chem. 263:10267-10271.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 10267-10271
-
-
Strader, C.D.1
Sigal, I.S.2
Candelore, M.R.3
Rands, E.4
Hill, W.S.5
Dixon, R.A.F.6
-
115
-
-
0023263617
-
Identification of residues required for ligand binding to the β-adrenergic receptor
-
Strader, C. D., I. S. Sigal, R. B. Register, M. R. Candelore, E. Rands, and R. A. F. Dixon. 1987. Identification of residues required for ligand binding to the β-adrenergic receptor. Proc. Natl Acad. Sci. USA. 84: 4384-4388.
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, pp. 4384-4388
-
-
Strader, C.D.1
Sigal, I.S.2
Register, R.B.3
Candelore, M.R.4
Rands, E.5
Dixon, R.A.F.6
-
116
-
-
0028170438
-
Opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity
-
Surratt, C. K., P. S. Johnson, A. Moriwaki, B. K. Seidleck, C. J. Blaschak, J. B. Wang, and G. R. Uhl. 1994. Opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. J. Biol. Chem. 269:20548-20553.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 20548-20553
-
-
Surratt, C.K.1
Johnson, P.S.2
Moriwaki, A.3
Seidleck, B.K.4
Blaschak, C.J.5
Wang, J.B.6
Uhl, G.R.7
-
117
-
-
0020450977
-
Benzeneacetamide amines: Structurally novel non-μ,-opioids
-
Szmuszkovicz, J., and P. F. Von Voightlander. 1982. Benzeneacetamide amines: structurally novel non-μ,-opioids. J. Med. Chem. 25:1125-1126.
-
(1982)
J. Med. Chem.
, vol.25
, pp. 1125-1126
-
-
Szmuszkovicz, J.1
Von Voightlander, P.F.2
-
119
-
-
0029873472
-
Construction of a high affinity zinc switch in the κ-opioid receptor
-
Thirstrup, K., C. E. Elling, S. A. Hjorth, and T. W. Schwartz. 1996. Construction of a high affinity zinc switch in the κ-opioid receptor. J. Biol. Chem. 271:7875-7878.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7875-7878
-
-
Thirstrup, K.1
Elling, C.E.2
Hjorth, S.A.3
Schwartz, T.W.4
-
120
-
-
0030775615
-
Arrangement of rhodopsin transmembrane α-helices
-
Unger, V. M., P. A. Hargrave, J. M. Baldwin, and G. F. X. Schertler. 1997. Arrangement of rhodopsin transmembrane α-helices. Nature. 389: 203-206.
-
(1997)
Nature
, vol.389
, pp. 203-206
-
-
Unger, V.M.1
Hargrave, P.A.2
Baldwin, J.M.3
Schertler, G.F.X.4
-
121
-
-
0028962270
-
Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy
-
Unger, V. M., and G. F. X. Schertler. 1995. Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. Biophys. J. 68:1776-1786.
-
(1995)
Biophys. J.
, vol.68
, pp. 1776-1786
-
-
Unger, V.M.1
Schertler, G.F.X.2
-
122
-
-
38249033893
-
The crystal structure of a bimorphinan with highly selective kappa opioid receptor antagonist activity
-
Urbanczyk-Lipkowska, Z., and M. C. Etter. 1987. The crystal structure of a bimorphinan with highly selective kappa opioid receptor antagonist activity. J. Mol. Struct. 159:287-295.
-
(1987)
J. Mol. Struct.
, vol.159
, pp. 287-295
-
-
Urbanczyk-Lipkowska, Z.1
Etter, M.C.2
-
124
-
-
8044237103
-
The third extracellular loop of the human δ-opioid receptor determines the selectivity of δ-opioid agonists
-
Varga, E. V., X. Li, D. Stropova, T. Zalewska, R. S. Landsman, R. J. Knapp, V. J. Hruby, W. R. Roeske, and H. I. Yamamura. 1996. The third extracellular loop of the human δ-opioid receptor determines the selectivity of δ-opioid agonists. Mol. Pharmacol. 50:1619-1624.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 1619-1624
-
-
Varga, E.V.1
Li, X.2
Stropova, D.3
Zalewska, T.4
Landsman, R.S.5
Knapp, R.J.6
Hruby, V.J.7
Roeske, W.R.8
Yamamura, H.I.9
-
125
-
-
0007112475
-
5-Ethyl-2′-hydroxy-2-[(1-hydroxycyclopropyl)methyl]-9,9-dimethyl-6, 7-benzomorphan hydrochloride (bremazocine)
-
Verlinde, C. L., N. M. Blaton, C. J. De Ranter, and O. M. Peeters. 1984. 5-Ethyl-2′-hydroxy-2-[(1-hydroxycyclopropyl)methyl]-9,9-dimethyl-6,7- benzomorphan hydrochloride (bremazocine). Acta Crystallogr. C. 40:1759-1761.
-
(1984)
Acta Crystallogr. C.
, vol.40
, pp. 1759-1761
-
-
Verlinde, C.L.1
Blaton, N.M.2
De Ranter, C.J.3
Peeters, O.M.4
-
126
-
-
0026006986
-
2A-adrenergicreceptors: Identification of amino acids involved in ligand binding and receptor activation by agonists
-
2A-adrenergicreceptors: identification of amino acids involved in ligand binding and receptor activation by agonists. Mol. Pharmacol. 40:168-179.
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 168-179
-
-
Wang, C.-D.1
Buck, M.A.2
Fraser, C.M.3
-
127
-
-
0027175853
-
2 receptor: Identification of amino acid necessary for ligand binding and receptor activation
-
2 receptor: identification of amino acid necessary for ligand binding and receptor activation. Mol. Pharmacol. 43:931-940.
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 931-940
-
-
Wang, C.-D.1
Gallaher, T.K.2
Shih, J.C.3
-
128
-
-
0028143479
-
Human κ-opiate receptor second extracellular loop elevates dynorphin's affinity for human μ/κ-chimeras
-
Wang, J. B., P. S. Johnson, J. M. Wu, W. F. Wang, and G. R. Uhl. 1994. Human κ-opiate receptor second extracellular loop elevates dynorphin's affinity for human μ/κ-chimeras. J. Biol. Chem. 269:25966-25969.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25966-25969
-
-
Wang, J.B.1
Johnson, P.S.2
Wu, J.M.3
Wang, W.F.4
Uhl, G.R.5
-
129
-
-
0029586680
-
Studies on the μ and δ opioid receptor selectivity utilizing chimeric and site-mutagenized receptors
-
Wang, W. W., M. Shahrestanifar, J. Jin, and R. D. Howells. 1995. Studies on the μ and δ opioid receptor selectivity utilizing chimeric and site-mutagenized receptors. Proc. Natl. Acad. Sci. USA. 92:12436-12440.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 12436-12440
-
-
Wang, W.W.1
Shahrestanifar, M.2
Jin, J.3
Howells, R.D.4
-
131
-
-
0026040728
-
Site-directed mutagenesis of the m3 muscarinic receptor: Identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding
-
Wess, J., D. Gdula, and M. R. Brann. 1991. Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding. EMBO. J. 10:3729-3734.
-
(1991)
EMBO. J.
, vol.10
, pp. 3729-3734
-
-
Wess, J.1
Gdula, D.2
Brann, M.R.3
-
133
-
-
0023941859
-
The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains
-
Wong, S. K.-F., C. Slaughter, A. Ruoho, and E. M. Ross. 1988. The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains. J. Biol. Chem. 263: 7925-7928.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 7925-7928
-
-
Wong, S.K.-F.1
Slaughter, C.2
Ruoho, A.3
Ross, E.M.4
-
134
-
-
0028822684
-
General method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins
-
Yu, H., M. Kono, T. D. McKee, and D. D. Oprian. 1995. General method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry. 34:14963-14969.
-
(1995)
Biochemistry
, vol.34
, pp. 14963-14969
-
-
Yu, H.1
Kono, M.2
McKee, T.D.3
Oprian, D.D.4
-
135
-
-
0028104682
-
Differential binding domains of peptide and non-peptide ligands in the cloned rat κ-opioid receptor
-
Xue, J.-C., C. Chen, J. Zhu, S. P. Kunapuli, J. K. de Riel, L. Yu, and L.-Y. Liu-Chen. 1994. Differential binding domains of peptide and non-peptide ligands in the cloned rat κ-opioid receptor. J. Biol. Chem. 269:30195-30199.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 30195-30199
-
-
Xue, J.-C.1
Chen, C.2
Zhu, J.3
Kunapuli, S.P.4
De Riel, J.K.5
Yu, L.6
Liu-Chen, L.-Y.7
-
136
-
-
0029045917
-
The third extracellular loop of the μ-opioid receptor is important for agonist selectivity
-
Xue, J.-C., C. Chen, J. Zhu, S. P. Kunapuli, J. K. de Riel, L. Yu, and L.-Y. Liu-Chen. 1995. The third extracellular loop of the μ-opioid receptor is important for agonist selectivity. J. Biol. Chem. 270:12977-12979.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12977-12979
-
-
Xue, J.-C.1
Chen, C.2
Zhu, J.3
Kunapuli, S.P.4
De Riel, J.K.5
Yu, L.6
Liu-Chen, L.-Y.7
-
137
-
-
0029949928
-
Opioid receptor types and subtypes: The δ-receptor as a model
-
Zaki, P. A., E. J. Bilsky, T. W. Vanderah, J. Lai, C. J. Evans, F. Porreca. 1996. Opioid receptor types and subtypes: the δ-receptor as a model. Annu. Rev. Pharmacol. Toxicol. 36:379-401.
-
(1996)
Annu. Rev. Pharmacol. Toxicol.
, vol.36
, pp. 379-401
-
-
Zaki, P.A.1
Bilsky, E.J.2
Vanderah, T.W.3
Lai, J.4
Evans, C.J.5
Porreca, F.6
-
138
-
-
0028031727
-
A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor
-
Zhou, W., C. Flanagan, J. A. Ballesteros, K. Konvicka, J. S. Davidson, H. Weinstein, R. P. Millar, and S. C. Sealfon. 1994. A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol. Pharmacol. 45:165-170.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 165-170
-
-
Zhou, W.1
Flanagan, C.2
Ballesteros, J.A.3
Konvicka, K.4
Davidson, J.S.5
Weinstein, H.6
Millar, R.P.7
Sealfon, S.C.8
-
139
-
-
0030067780
-
Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the δ-opioid receptor and determination of its binding domain
-
Zhu, J., J. Yin, P.-Y. Law, P. A. Claude, K. C. Rice, C. J. Evans, C. Chen, L. Yu, and L.-Y. Liu-Chen. 1996a. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the δ-opioid receptor and determination of its binding domain. J. Biol. Chem. 271:1430-1434.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 1430-1434
-
-
Zhu, J.1
Yin, J.2
Law, P.-Y.3
Claude, P.A.4
Rice, K.C.5
Evans, C.J.6
Chen, C.7
Yu, L.8
Liu-Chen, L.-Y.9
-
140
-
-
0029919552
-
The region in the μ opioid receptor conferring selectivity for sufentanil over the δ receptor is different from over the K receptor
-
Zhu, J., J.-C. Xue, P.-Y. Law, P. A. Claude, L.-Y. Luo, J. Yin, C. Chen, and L.-Y. Liu-Chen. 1996b. The region in the μ opioid receptor conferring selectivity for sufentanil over the δ receptor is different from over the K receptor. FEBS Lett. 384:198-202.
-
(1996)
FEBS Lett.
, vol.384
, pp. 198-202
-
-
Zhu, J.1
Xue, J.-C.2
Law, P.-Y.3
Claude, P.A.4
Luo, L.-Y.5
Yin, J.6
Chen, C.7
Liu-Chen, L.-Y.8
-
141
-
-
0026475571
-
Changing the location of the Schiff base counterion in rhodopsin
-
Zhukovsky, E. A., P. R. Robinson, and D. D. Oprian. 1992. Changing the location of the Schiff base counterion in rhodopsin. Biochemistry. 31: 10400-10405.
-
(1992)
Biochemistry
, vol.31
, pp. 10400-10405
-
-
Zhukovsky, E.A.1
Robinson, P.R.2
Oprian, D.D.3
|