Endomorphin-1 analogues containing β-proline are μ-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2571-2578

  Cardillo, Giuliana ^a   Gentilucci, Luca ^a   Qasem, Ahmed R ^a   Sgarzi, Fabio ^a   Spampinato, Santi ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMINO ACID; BETA TYROSYLPROLYLTRYPTOPHYLPHENYLALANINE; CYCLIC AMP; ENDORPHIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FORSKOLIN; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; PROLINE; TETRAPEPTIDE; TYROSYL BETA PROLYLTRYPTOPHYLPHENYLALANINE; TYROSYL DEXTRO BETA PROLYLTRYPTOPHYLPHENYLALANINE; TYROSYLPROLYL BETA TRYPTOPHYLPHENYLALANINE; TYROSYLPROLYLTRYPTOPHYL BETA PHENYLALANINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY;

ANIMALS; ANTIGENS, CD13; BINDING, COMPETITIVE; BRAIN; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; CHYMOTRYPSIN; CYCLIC AMP; HYDROLYSIS; OLIGOPEPTIDES; PROLINE; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, MU; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 0037030643     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011059z     Document Type: Article

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