Endomorphin 1[ψ] and endomorphin 2[ψ], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception

Life Sciences

Volumn 77, Issue 10, 2005, Pages 1155-1165

  Zhao, Qian Yu ^a   Chen, Qiang ^a   Yang, Ding Jian ^a   Feng, Yun ^a   Long, Yuan ^a   Wang, Peng ^a   Wang, Rui ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Analogues; Antinociception; Endomorphins; Formalin model; Intracebroventricular; Reduced amide bond; Tail flick

Indexed keywords

AMIDE; ENDOMORPHIN 1; ENDOMORPHIN 2; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; PROLINE; TYROSINE;

ANTINOCICEPTION; ARTICLE; CHEMICAL BOND; CONFORMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PAIN; REDUCTION;

AMIDES; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; GUINEA PIGS; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; OLIGOPEPTIDES; OXIDATION-REDUCTION; PAIN; PAIN MEASUREMENT; PROTEIN CONFORMATION; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20644453964     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.03.005     Document Type: Article

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