Structural studies of [2′,6′-dimethyl-L-tyrosine1]endomorphin-2 analogues: Enhanced activity and cis orientation of the Dmt-Pro amide bond

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 9, 2003, Pages 1983-1994

  Okada, Yoshio ^a   Fujita, Yoshio ^a   Motoyama, Takashi ^a   Tsuda, Yuko ^a   Yokoi, Toshio ^a   Li, Tingyou ^a   Sasaki, Yusuke ^b   Ambo, Akihiro ^b   Jinsmaa, Yunden ^c   Bryant, Sharon D ^c   Lazarus, Lawrence H ^c  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',6' DIMETHYLTYROSINE; 2',6' DIMETHYLTYROSYLPROLINAMIDE; 2',6' DIMETHYLTYROSYLPROLYLPHENYLALANINAMIDE; 2',6' DIMETHYLTYROSYLPROLYLPHENYLALANYLPHENETHYLAMINE; ALANYLPROLYLPHENYLALANYLPHENYLALANINAMIDE; AMIDE; ENDOMORPHIN 2 [2',6' DIMETHYL 1 TYROSINE]; ENDORPHIN DERIVATIVE; FUNCTIONAL GROUP; MU OPIATE RECEPTOR; TYROSINE; TYROSINE DERIVATIVE; TYROSYLALANYLPHENYLALANYLPHENYLALANINAMIDE; TYROSYLPROLINAMIDE; TYROSYLPROLYLALANYLPHENYLALANINAMIDE; TYROSYLPROLYLPHENYLALANYLALANINAMIDE; TYROSYLPROLYLPHENYLALANYLPHENETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CIS ISOMER; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; TRANS ISOMER;

EID: 0037401355     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00068-3     Document Type: Article

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