Design, synthesis, and evaluation of opioid analogues with non-peptidic β-turn scaffold: Enkephalin and endomorphin mimetics

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1395-1398

  Eguchi, Masakatsu ^a,b   Shen, Richard Y W ^c   Shea, J Paul ^c   Lee, Min S ^c   Kahn, Michael ^a,b  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Molecumetics Ltd   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDORPHIN DERIVATIVE; ENKEPHALIN DERIVATIVE; MORPHINE SULFATE; MU OPIATE RECEPTOR AGONIST; OPIATE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BETA SHEET; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ENKEPHALINS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; NALOXONE; NARCOTICS; OLIGOPEPTIDES; PEPTIDE BIOSYNTHESIS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, OPIOID; TIME FACTORS;

EID: 0037187386     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0155897     Document Type: Article

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