Conformational analysis of the endogenous μ-opioid agonist endomorphin-1 using NMR spectroscopy and molecular modeling

FEBS Letters

Volumn 439, Issue 1-2, 1998, Pages 13-20

  Podlogar, Brent L ^a   Paterlini, M Germana ^b   Ferguson, David M ^b   Leo, Gregory C ^a   Demeter, David A ^a   Brown, Frank K ^a   Reitz, Allen B ^a  

^a The RW Johnson Pharmaceutical R ^*  (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Conformational analysis; Molecular dynamics; Multidimensional nuclear magnetic resonance spectroscopy; Opioid; Peptide structure; Structure activity relationship

Indexed keywords

DIMETHYL SULFOXIDE; ENDOMORPHIN 1; OPIATE RECEPTOR; WATER;

AGONIST; ARTICLE; HYPOTHESIS; ISOMER; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION;

COMPUTER SIMULATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN CONFORMATION; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 17144452429     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01202-2     Document Type: Article

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