Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

European Journal of Pharmacology

Volumn 340, Issue 1, 1997, Pages 1-15

  Meunier, Jean Claude ^a  

^a U de Neuropharmacologie Molec   (France)

Author keywords

Analgesia; G protein coupled receptor; Neuropeptide; Pain

Indexed keywords

DYNORPHIN A; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; NEUROPEPTIDE; NOCICEPTIN; OPIATE PEPTIDE; OPIATE RECEPTOR; OPIOID RECEPTOR LIKE ORPHAN RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIA; CYTOCHEMISTRY; ELECTROPHYSIOLOGY; HISTOCHEMISTRY; HUMAN; IMMUNITY; LEARNING; LOCOMOTION; MOLECULAR CLONING; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; RECEPTOR BINDING; REVIEW; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE RELAXATION;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; BRAIN; CLONING, MOLECULAR; HUMANS; MOLECULAR SEQUENCE DATA; OPIOID PEPTIDES; PAIN; RECEPTORS, OPIOID; SEQUENCE ALIGNMENT; SPINAL CORD;

EID: 0031553387     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01411-8     Document Type: Review

References (108)

1. Anton B., Fein J., To T., Li X., Silberstein L., Evans C.J. Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J. Comp. Neurol. 368:1996;229-251.
2. Berzetei-Gurske I., Schwartz R.W., Toll L. Determination of activity for nociceptin in the mouse vas deferens. Eur. J. Pharmacol. 302:1996;R1-R2.
3. ème Colloque de la Société des Neurosciences (Bordeaux, France), No. E-18, p. 122.
4. Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. FEBS Lett. 347:1994;284-288.
5. Butour J.-L., Moisand C., Mazarguil H., Mollereau C., Meunier J.-C. Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids. Eur. J. Pharmacol. 321:1997;97-103.
6. Calo G., Rizzi A., Bogoni G., Neugebauer V., Salvadori S., Guerrini R., Bianchi C., Regoli D. The mouse vas deferens: a pharmacological preparation sensitive to nociceptin. Eur. J. Pharmacol. 311:1996;R3-R5.
7. Champion H.C., Kadowitz P.J. Nociceptin, an endogenous ligand for the ORL(1) receptor, has novel hypotensive activity in the rat. Life Sci. 60:1997;PL241-245.
8. Chavkin C., Goldstein A. Specific receptor for the opioid peptide dynorphin: structure-activity relationships. Proc. Natl. Acad. Sci. USA. 78:1981;6543-6547.
9. Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., Yu L. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. FEBS Lett. 347:1994;279-283.
10. 3-opioid receptors in the SH-SY5Y human neuroblastoma cell line. J. Neurochem. 65:1995;170-175.
11. 2+ in the SH-SY5Y human neuroblastoma cell line. Brit. J. Pharmacol. 118:1996;205-207.
12. Connor M., Vaughan C.W., Chieng B., Christie M.J. Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurons in vitro. Brit. J. Pharmacol. 119:1996;1614-1618.
13. Dawson-Basoa M., Gintzler A.R. Nociceptin (Orphanin FQ) abolishes gestational and ovarian sex steroid-induced antinociception and induces hyperalgesia. Brain Res. 750:1997;48-52.
14. Devine D.P., Taylor L., Reinscheid R., Monsma F.J. Jr., Civelli O., Akil H. Rats rapidly develop tolerance to the locomotor-inhibitory effects of the novel neuropeptide orphanin FQ. Neurochem. Res. 21:1996;1387-1396.
15. Devine D.P., Reinscheid R., Monsma F.J. Jr., Civelli O., Akil H. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Res. 727:1996;225-229.
16. Dhawan B.N., Cesselin F., Raghubir R., Reisine T., Bradley P.B., Portoghese P.S., Hamon M. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 48:1997;567-592.
17. Di Chiara G., North R.A. Neurobiology of opiate abuse. TiPS. 13:1992;185-193.
18. Dooley C., Hougthen R.A. Orphanin FQ: receptor binding and analog structure activity relationships in rat brain. Life Sci. 59:1996;23-29.
19. th International Narcotics Research Conference, Long Beach, CA, USA, No. TU13, p. 78.
20. Faber E.S.L., Chambers J.P., Evans R.H., Henderson G. Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro. Brit. J. Pharmacol. 119:1996;189-190.
21. Florin S., Suaudeau C., Meunier J.-C., Costentin J. Nociceptin stimulates locomotion and exploratory behaviour in mice. Eur. J. Pharmacol. 317:1996;9-13.
22. + ions and GppNHp selectively inhibit agonist interactions at μ- and κ-opioid receptor sites in rabbit and guinea pig cerebellum membranes. Eur. J. Pharmacol. 117:1985;223-232.
23. Fukuda K., Kato S., Mori K., Nishi M., Takeshima H., Iwabe N., Miyata T., Houtani T., Sugimoto T. cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett. 343:1994;42-46.
24. Gintzler A.R., Adapa I.D., Toll L., Medina V.M., Wang L. Modulation of enkephalin release by nociceptin (orphanin FQ). Eur. J. Pharmacol. 325:1997;29-34.
25. Giuliani S., Maggi C.A. Inhibition of tachykinin release from peripheral nerve endings of sensory nerves by nociceptin, a novel opioid peptide. Brit. J. Pharmacol. 118:1996;1567-1569.
26. Grisel J.E., Mogil J.S., Belknap J.K., Grandy D.K. Orphanin FQ acts as asupraspinal, but not as a spinal, anti-opioid peptide. NeuroReport. 7:1996;2125-2129.
27. 1) receptors possesses systemic vasorelaxant properties. Life Sci. 60:1997;141-145.
28. Halford W.P., Gebhardt B.M., Carr D.J.J. Functional role and sequence analysis of a lymphocyte orphan opioid receptor. J. Neuroimmunol. 59:1995;91-101.
29. Hao J.-X., Wiesenfeld-Hallin Z., Xu X.-J. Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat. Neurosci. Lett. 223:1997;49-52.
30. Houtani T., Nishi M., Takeshima H., Nukada T., Sugimoto T. Structure and regional distribution of nociceptin/orphanin FQ precursor. Biochem. Biophys. Res. Commun. 219:1996;714-719.
31. + (GIRK) channel. Mol. Brain Res. 45:1997;117-126.
32. Julius D. Home for an orphan endorphin. Nature. 377:1995;476.
33. Kapusta D.R., Sezen S.F., Chang J.-K., Lippton H., Kenigs V.A. Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ). Life Sci. 60:1997;15-21.
34. Kavaliers M., Perrot-Sinal T.S. Pronociceptive effects of the neuropeptide, nociceptin, in the land snail Cepaea nemoralis. Peptides. 17:1996;763-768.
35. Kieffer B.L. Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cell. Mol. Neurobiol. 15:1995;615-635.
36. Kieffer, B.L., 1997. Molecular aspects of opioid receptors. In: Dickenson, A.H., Besson, J.-M. (Eds.), Pain, Handbook of Experimental Pharmacology, Springer, Berlin, Heidelberg, Vol. 130, pp. 281-303.
37. King M.A., Rossi G.C., Chang A.H., Williams L., Pasternak G.W. Spinal analgesic activity of orphanin FQ/nociceptin and its fragments. Neurosci. Lett. 223:1997;113-116.
38. Knoflach F., Reinscheid R., Civelli O., Kemp J.A. Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. J. Neurosci. 16:1996;6657-6664.
39. + channel in Xenopus oocytes. Brit. J. Pharmacol. 120:1997;986-987.
40. Koob G.F. Drugs of abuse: anatomy, pharmacology and function of reward pathways. TiPS. 13:1992;177-184.
41. Lachowicz J.E., Shen Y., Monsma Jr F.J., Sibley D.R. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J. Neurochem. 64:1995;34-40.
42. Le Moal M., Simon H. Mesocorticolimbic dopaminergic network: functional and regulatory roles. Pharmacol. Rev. 71:1991;155-234.
43. Libert F., Parmentier M., Lefort A., Dinsart C., Van Sande J., Maenhaut C., Simons M.-J., Dumont J.-E., Vassart G. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science. 244:1989;569-572.
44. Ma L., Cheng Z.-J., Fan G.-H., Cai Y.-C., Jiang L.-Z., Pei G. Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma×glioma NG 108-15 hybrid cells. FEBS Lett. 403:1997;91-94.
45. Mathis J.P., Ryan-Moro J., Chang A., Hom J.S.H., Scheinberg D.A., Pasternak G.W. Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochem. Biophys. Res. Commun. 230:1997;462-465.
46. Matthes H., Seward E.P., Kieffer B., North R.A. Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunit in Xenopus laevis oocytes. Mol. Pharmacol. 50:1996;447-450.
47. Meng F., Taylor L.P., Hoversten M.T., Ueda Y., Ardati A., Reinscheid R.K., Monsma Jr F.J., Watson S.J., Civelli O., Akil H. Moving from the orphanin FQ receptor to an opioid receptor using four point mutations. J. Biol. Chem. 271:1996;32016-32020.
48. Meunier J.-C. Récepteurs des opioïdes, tolérance et dépendance. Thérapie. 47:1992;495-502.
49. 1 receptor. Nature. 377:1995;532-535.
50. Mills A., Duggan M.J. Orphan seven transmembrane domain receptors: reversing pharmacology. TiPS. 14:1993;394-396.
51. Mogil J.S., Grisel J.E., Zhangs G., Belknap J.K., Grandy D.K. Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ. Neurosci. Lett. 214:1996;131-134.
52. Mogil J.S., Grisel J.E., Reinscheid R., Civelli O., Belknap J.K., Grandy D.K. Orphanin FQ is a functional anti-opioid peptide. Neuroscience. 75:1996;333-337.
53. Mollereau C., Parmentier M., Mailleux P., Butour J.-L., Moisand C., Chalon P., Caput D., Vassart G., Meunier J.-C. ORL1, a novel member of the opioid receptor family: cloning, functional expression and localization. FEBS Lett. 341:1994;33-38.
54. Mollereau C., Moisand C., Butour J.-L., Parmentier M., Meunier J.-C. Replacement of Gln280 by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids. FEBS Lett. 395:1996;17-21.
55. Mollereau C., Simons M.-J., Soularue P., Liners F., Vassart G., Meunier J.-C., Parmentier M. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Proc. Natl. Acad. Sci. USA. 93:1996;8666-8670.
56. th International Narcotics Research Conference, Long Beach, CA, USA, No. TU4, p. 75.
57. Montiel J.-L., Cornille F., Roques B.P., Noble F. Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J. Neurochem. 68:1997;354-361.
58. Morley J.E., Levine A.S., Grace M., Kniep J. Opioid modulation of appetite. Neurosci. Biobehav. Rev. 7:1983;281-305.
59. Murphy N.P., Ly H.T., Maidment N.T. Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats. Neuroscience. 75:1996;1-4.
60. Neal M.J., Cunningham J.R., Paterson S.J., McKnight A.T. Inhibition by nociceptin of the light-evoked release of Ach from retinal cholinergic neurones. Brit. J. Pharmacol. 120:1997;1399-1400.
61. + evoked glutamate release from rat cerebrocortical slices. Brit. J. Pharmacol. 119:1996;1081-1083.
62. Nishi M., Takeshima H., Mori M., Nakagawara K.-I., Takeuchi T. Structure and chromosomal mapping for the mouse κ-opioid receptor and an opioid receptor homologue (MOR-C). Biochem. Biophys. Res. Commun. 205:1994;1353-1357.
63. Nishi M., Houtani T., Noda Y., Mamiya T., Sato K., Doi T., Kuno J., Takeshima H., Nukada T., Nabeshima T., Yamashita T., Noda T., Sugimoto T. Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor. EMBO J. 16:1997;1858-1864.
64. Noble F., Roques B.P. Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice. FEBS Lett. 401:1997;227-229.
65. Nothacker H.P., Reinscheid R., Mansour A., Henningsen R.A., Ardati A., Monsma Jr F.J., Watson S.J., Civelli O. Primary structure and tissue distribution of the orphanin FQ precursor. Proc. Natl. Acad. Sci. USA. 93:1996;8677-8682.
66. Okuda-Ashitaka E., Tachibana S., Houtani T., Minami T., Masu Y., Takeshima H., Sugimoto T., Ito S. Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus. Mol. Brain Res. 43:1996;96-104.
67. Pan Y.-X., Xu J., Pasternak G.W. Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor. Biochem. J. 315:1996;11-13.
68. Panula P., Aarnisalo A.A., Wasowicz K. Neuropeptide FF, a mammalian neuropeptide with multiple functions. Prog. Neurobiol. 48:1996;461-487.
69. Parmentier M., Libert F., Vassart G. La famille des récepteurs couplés aux protéines G et ses orphelins. Médecine Sci. 11:1995;222-231.
70. Petsko G.A. For medical purposes, in Intelligent drug design. Nature. 384 (Suppl.):1996;7-9.
71. 1, stimulates feeding in rats. NeuroReport. 8:1996;369-371.
72. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma Jr F.J., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid like G protein-coupled receptor. Science. 270:1995;792-794.
73. Reinscheid R., Ardati A., Monsma F.J. Jr., Civelli O. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J. Biol. Chem. 271:1996;14163-14168.
74. Reisine T., Bell G.I. Molecular biology of opioid receptors. TiNS. 16:1993;506-510.
75. Riedl M., Shuster S., Vulchanova L., Wang J., Loh H.H., Elde R. Orphanin FQ/nociceptin immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord. NeuroReport. 7:1996;1369-1372.
76. Rossi G.C., Leventhal L., Pasternak G.W. Naloxone sensitive orphanin FQ-induced analgesia in mice. Eur. J. Pharmacol. 311:1996;R7-R8.
77. Rowe P.M. Excitement over orphanin FQ/nociceptin. Lancet. 347:1996;606.
78. Saito Y., Maruyama K., Saido T.C., Kawashima S. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochem. Biophys. Res. Commun. 217:1995;539-545.
79. Saito Y., Maruyama K., Kawano H., Hagino-Yamagishi K., Kawamura K., Saido T.C., Kawashima S. Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule. J. Biol. Chem. 271:1996;15615-15622.
80. Salvadori S., Picone D., Tancredi T., Guerrini R., Spadaccini R., Lazarus L.H., Regoli D., Temussi P.A. Solution conformation of nociceptin. Biochem. Biophys. Res. Commun. 233:1997;640-643.
81. Sandin J., Georgieva J., Schött P.A., Ögren S.O., Terenius L. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. Eur. J. Neurosci. 9:1997;194-197.
82. Satoh M., Minami M. Molecular pharmacology of the opioid receptors. Pharmac. Ther. 68:1995;343-364.
83. Schuligoi R., Amann R., Angelberger P., Peskar B.A. Determination of nociceptin-like immunoreactivity in the rat dorsal spinal cord. Neurosci. Lett. 224:1997;136-138.
84. Schulz S., Schreff M., Nüß D., Gramsch C., Höllt V. Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions. NeuroReport. 7:1996;3021-3025.
85. Schwartz J.-C. La biologie moléculaire des récepteurs et l'essor d'une nouvelle pharmacologie. Médecine Sci. 9:1993;9-11.
86. Schwyzer R. ACTH: a short introductory review. Ann. N.Y. Acad. Sci. 297:1977;3-26.
87. Shimohigashi Y., Hatano R., Fujita T., Nakashima R., Nose T., Sujaku T., Saigo A., Shinjo K., Nagahisa A. Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide. J. Biol. Chem. 271:1996;23642-23645.
88. 35S )thio]-triphosphate binding Proc. Natl. Acad. Sci. USA. 92:1995;7242-7246.
89. 35S ]GTPγS binding in rat brain NeuroReport. 7:1996;729-733.
90. Simonds W.F. The molecular basis of opioid receptor function. Endocrine Rev. 9:1988;200-212.
91. Spanagel R., Herz A., Schippenberg T.S. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc. Natl. Acad. Sci. USA. 89:1992;2046-2050.
92. Stanfa L.C., Chapman V., Kerr N., Dickenson A.H. Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo. Brit. J. Pharmacol. 118:1996;1875-1877.
93. Stratford T.R., Holahan M.R., Kelley A.E. Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake. NeuroReport. 8:1997;423-426.
94. Tian J.-H., Xu W., Mogil J.S., Grisel J.E., Grandy D.K., Han J.-S. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Brit. J. Pharmacol. 120:1997;676-680.
95. Tian J.-H., Xu W., Zhang W., Fang Y., Grisel J.E., Mogil J.S., Grandy D.K., Han J.-S. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. NeuroReport. 8:1997;497-500.
96. Vaughan C.W., Christie M.J. Increase by the ORL1 receptor (opioid receptor-like 1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurons. Brit. J. Pharmacol. 117:1996;1609-1611.
97. Vaughan C.W., Ingram S.L., Christie M.J. Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro. J. Neurosci. 17:1997;996-1003.
98. Walker J.M. Nonopiate effects of dynorphin and des-Tyr-dynorphin. Science. 218:1982;1136-1138.
99. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., Uhl G.R. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett. 348:1994;75-79.
100. Wang X.-M., Zhang K.M., Mokha S.S. Nociceptin (orphanin FQ), an endogenous ligand for the ORL1 (opioid receptor-like 1) receptor, modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. J. Neurophysiol. 76:1996;3568-3572.
101. Wick M.J., Minnerath S.R., Lin X., Elde R., Law P.-Y., Loh H.H. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ and κ opioid receptors. Mol. Brain Res. 27:1994;37-44.
102. Wick M.J., Minnerath S.R., Roy S., Ramakrishnan S., Loh H.H. Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated peripheral blood lymphocytes and lymphocytic cell lines. Mol. Brain Res. 32:1995;342-347.
103. Xu X.-J., Hao J.-X., Wiesenfeld-Hallin Z. Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. NeuroReport. 7:1996;2092-2094.
104. 1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat. Neurosci. Lett. 224:1997;107-110.
105. 1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw. Brain Res. 754:1997;329-332.
106. Yu J., Chait B.T., Toll L., Kreek M.J. Nociceptin in vitro biotransformation in human blood. Peptides. 17:1996;873-876.
107. Yu T.P., Fein J., Phan T., Evans C.J., Xie C.-W. Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus. Hippocampus. 7:1997;88-94.
108. Zhang S., Yu L. Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor. J. Biol. Chem. 270:1995;22772-22776.