Structural function of C-terminal amidation of endomorphin: Conformational comparison of μ-selective endomorphin-2 with its C-terminal free acid, studied by1H-NMR spectroscopy, molecular calculation, and X-ray crystallography

FEBS Journal

Volumn 272, Issue 19, 2005, Pages 5079-5097

  In, Yasuko ^a   Minoura, Katsuhiko ^a   Tomoo, Koji ^a   Sasaki, Yusuke ^b   Lazarus, Lawrence H ^c   Okada, Yoshio ^d   Ishida, Toshimasa ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

C terminal deaminated endomorphin 2; Endomorphin 2; Molecular calculation; NMR; X ray crystal analysis

Indexed keywords

AMIDE; AMPHOLYTE; CARBOXYL GROUP; DIMETHYL SULFOXIDE; DODECYLPHOSPHORYLCHOLINE; ENDOMORPHIN 2; MU OPIATE RECEPTOR; RHODOPSIN; TRIFLUOROETHANOL; WATER;

AMIDATION; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CRYSTAL STRUCTURE; HYDROGEN BOND; MICELLE; MOLECULAR MODEL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY;

AMIDES; CRYSTALLOGRAPHY, X-RAY; HYDROXIDES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NARCOTICS; OLIGOPEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTONS; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 26244446907     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04919.x     Document Type: Conference Paper

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