Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1529-1536

  Tari, Leslie W ^a   Trzoss, Michael ^a   Bensen, Daniel C ^a   Li, Xiaoming ^a   Chen, Zhiyong ^a   Lam, Thanh ^a   Zhang, Junhu ^a   Creighton, Christopher J ^a   Cunningham, Mark L ^a   Kwan, Bryan ^a   Stidham, Mark ^a   Shaw, Karen J ^a   Lightstone, Felice C ^b   Wong, Sergio E ^b   Nguyen, Toan B ^b   Nix, Jay ^c   Finn, John ^a  

^a Trius Therapeutics   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Bacterial topoisomerases; GyrB; Inhibitor; ParE; Pyrrolopyrimidine

Indexed keywords

ABC TRANSPORTER; ANTIINFECTIVE AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING) B; DNA TOPOISOMERASE IV; PYRROLOPYRIMIDINE DERIVATIVE; PYRROLOPYRIMIDINE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; NONHUMAN; PHARMACOPHORE;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG DESIGN; MODELS, MOLECULAR; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

BACTERIA (MICROORGANISMS);

EID: 84873734502     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.032     Document Type: Article

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