-
1
-
-
69549111337
-
Antibiotics for emerging pathogens
-
Fischbach, M.A. & C.T. Walsh 2009. Antibiotics for emerging pathogens. Science 325: 1089-1093.
-
(2009)
Science
, vol.325
, pp. 1089-1093
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
2
-
-
78650351703
-
-
Infectious Diseases Society of America. Bad bugs, no drugs: as antibiotic R&D stagnates, a public health crisis brews, accessed October 23, 2010).
-
Infectious Diseases Society of America. 2004. Bad bugs, no drugs: as antibiotic R&D stagnates, a public health crisis brews, (accessed October 23, 2010).
-
(2004)
-
-
-
3
-
-
33144473431
-
Bad bugs need drugs: an update on the development pipeline from the antimicrobial availability task force of the Infectious Diseases Society of America
-
Talbot, G.H., J. Bradley Jr., J.E. Edwards et al. 2006. Bad bugs need drugs: an update on the development pipeline from the antimicrobial availability task force of the Infectious Diseases Society of America. Clin. Infect. Dis. 42: 657-668.
-
(2006)
Clin. Infect. Dis.
, vol.42
, pp. 657-668
-
-
Talbot, G.H.1
Bradley Jr, J.2
Edwards, J.E.3
-
4
-
-
33845719937
-
Antibacterial discovery and development-the failure of success?
-
Fernandes, P. 2006. Antibacterial discovery and development-the failure of success? Nat. Biotechnol. 24: 1497-1503.
-
(2006)
Nat. Biotechnol.
, vol.24
, pp. 1497-1503
-
-
Fernandes, P.1
-
5
-
-
36248994803
-
The targets of currently used antibacterial agents: lessons for drug discovery
-
Lange, R.P., H.H. Locher, C.P. Wyss et al. 2007. The targets of currently used antibacterial agents: lessons for drug discovery. Curr. Pharm. Design 13: 3140-3154.
-
(2007)
Curr. Pharm. Design
, vol.13
, pp. 3140-3154
-
-
Lange, R.P.1
Locher, H.H.2
Wyss, C.P.3
-
6
-
-
78650357154
-
-
Royal Society Policy Document. Innovative mechanisms for tackling antibacterial resistance, accessed October 23, 2010).
-
Royal Society Policy Document. 2008. Innovative mechanisms for tackling antibacterial resistance, (accessed October 23, 2010).
-
(2008)
-
-
-
7
-
-
2342595765
-
Trends in antimicrobial drug development: implications for the future
-
Spellberg, B., J.H. Powers, E.P. Brass et al. 2004. Trends in antimicrobial drug development: implications for the future. Clin. Infect. Dis. 38: 1279-1286.
-
(2004)
Clin. Infect. Dis.
, vol.38
, pp. 1279-1286
-
-
Spellberg, B.1
Powers, J.H.2
Brass, E.P.3
-
8
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Payne, D.J., M.N. Gwynn, D.J. Holmes et al. 2007. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6: 29-40.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
-
9
-
-
78650352608
-
-
IDSA. Challenges in the pathway to antibiotic approvals. (accessed October 23, 2010).
-
IDSA. 2008. Challenges in the pathway to antibiotic approvals. (accessed October 23, 2010).
-
(2008)
-
-
-
10
-
-
0037374498
-
The price of innovation: new estimates of drug development costs
-
DiMasi, J.A., R.W. Hansen & H.G. Grabowski 2003. The price of innovation: new estimates of drug development costs. J. Health Econ. 22: 151-185.
-
(2003)
J. Health Econ.
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
12
-
-
67349272763
-
Future antibiotics scenarios: is the tide starting to turn?
-
Theuretzbacher, U. 2009. Future antibiotics scenarios: is the tide starting to turn? Int. J. Antimicrob. Agents 34: 15-20.
-
(2009)
Int. J. Antimicrob. Agents
, vol.34
, pp. 15-20
-
-
Theuretzbacher, U.1
-
13
-
-
14844347928
-
Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents
-
Mitscher, L.A. 2005. Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. Chem. Rev. 105: 559-592.
-
(2005)
Chem. Rev.
, vol.105
, pp. 559-592
-
-
Mitscher, L.A.1
-
14
-
-
50949110901
-
Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases
-
Black, M.T., T. Stachyra, D. Platel et al. 2008. Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases. Antimicrob. Agents Chemother. 52: 3339-3349.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 3339-3349
-
-
Black, M.T.1
Stachyra, T.2
Platel, D.3
-
15
-
-
77955917935
-
Type IIA topoisomerase inhibition by a new class of antibacterial agents
-
Bax, B.D., P.F. Chan, D.S. Eggleston et al. 2010. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature 466: 935-940.
-
(2010)
Nature
, vol.466
, pp. 935-940
-
-
Bax, B.D.1
Chan, P.F.2
Eggleston, D.S.3
-
16
-
-
48749117988
-
Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors
-
Miller A.A., G.L. Bundy, J.E. Mott et al. 2008. Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors. Antimicrob. Agents Chemother. 8: 2806-2812.
-
(2008)
Antimicrob. Agents Chemother.
, vol.8
, pp. 2806-2812
-
-
Miller, A.A.1
Bundy, G.L.2
Mott, J.E.3
-
17
-
-
77649153351
-
The pleuromutilin antibiotics: a new class for human use
-
Novak R. & D.M. Shlaes 2010. The pleuromutilin antibiotics: a new class for human use. Curr. Opin. Invest. Drugs 11: 182-191.
-
(2010)
Curr. Opin. Invest. Drugs
, vol.11
, pp. 182-191
-
-
Novak, R.1
Shlaes, D.M.2
-
18
-
-
34248339238
-
Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents
-
Ochsner, U.A., X. Sun, T. Jarvis et al. 2007. Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents. Expert Opin. Inv. Drug. 16: 573-593.
-
(2007)
Expert Opin. Inv. Drug.
, vol.16
, pp. 573-593
-
-
Ochsner, U.A.1
Sun, X.2
Jarvis, T.3
-
19
-
-
4444342056
-
Rebuilding big pharma's business model
-
&, accessed October 23, 2010).
-
Gilbert, J., P. Henske & A. Singh 2003. Rebuilding big pharma's business model. Business Med. Rep. (accessed October 23, 2010).
-
(2003)
Business Med. Rep
-
-
Gilbert, J.1
Henske, P.2
Singh, A.3
-
20
-
-
0038441346
-
Exploiting genomics, genetics and chemistry to combat antibiotic resistance
-
Hughes, D. 2003. Exploiting genomics, genetics and chemistry to combat antibiotic resistance. Nat. Rev. Genet. 4: 432-441.
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 432-441
-
-
Hughes, D.1
-
21
-
-
78650341174
-
-
NCBI Genome Project., accessed October 23, 2010).
-
NCBI Genome Project. (accessed October 23, 2010).
-
-
-
-
22
-
-
42149131579
-
Cell-division inhibitors: new insights for future antibiotics
-
Lock, R.L., & E.J. Harry 2008. Cell-division inhibitors: new insights for future antibiotics. Nat. Rev. Drug Discov. 7: 324-338.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 324-338
-
-
Lock, R.L.1
Harry, E.J.2
-
23
-
-
0038779250
-
Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes
-
Gentry, D.R., K.A. Ingraham, M.J. Stanhope et al. 2003. Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes. Antimicrob. Agents Chemother. 47: 1784-1789.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 1784-1789
-
-
Gentry, D.R.1
Ingraham, K.A.2
Stanhope, M.J.3
-
24
-
-
0036783668
-
Discovery of a novel and potent class of FabI-directed antibacterial agents
-
Payne, D.J., W.H. Miller, V. Berry et al. 2002. Discovery of a novel and potent class of FabI-directed antibacterial agents. Antimicrob. Agents.Chemother. 46: 3118-3124.
-
(2002)
Antimicrob. Agents.Chemother.
, vol.46
, pp. 3118-3124
-
-
Payne, D.J.1
Miller, W.H.2
Berry, V.3
-
25
-
-
0033939999
-
Two active forms of UDP-N-Acetylglucosamine enolpyruvyl transferase in Gram-positive bacteria
-
Du, W., J.R. Brown, D.R. Sylvester et al. 2000. Two active forms of UDP-N-Acetylglucosamine enolpyruvyl transferase in Gram-positive bacteria. J. Bacteriol. 182: 4146-4152.
-
(2000)
J. Bacteriol.
, vol.182
, pp. 4146-4152
-
-
Du, W.1
Brown, J.R.2
Sylvester, D.R.3
-
26
-
-
75649084906
-
Evolution of MRSA during hospital transmission and intercontinental spread
-
Harris, S.R., E.J. Feil, M.T.G. Holden et al. 2010. Evolution of MRSA during hospital transmission and intercontinental spread. Science 327: 469-474.
-
(2010)
Science
, vol.327
, pp. 469-474
-
-
Harris, S.R.1
Feil, E.J.2
Holden, M.T.G.3
-
27
-
-
61949263942
-
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
-
Brinster, S., G. Lamberet, B. Staels et al. 2009. Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens. Nature 458: 83-86.
-
(2009)
Nature
, vol.458
, pp. 83-86
-
-
Brinster, S.1
Lamberet, G.2
Staels, B.3
-
28
-
-
75149139456
-
Essentiality of FASII pathway for Staphylococcus aureus
-
[arising from Nature, 2009, 458: 83-86].
-
Balemans, W., N. Lounis, R. Gilissen et al. 2010. Essentiality of FASII pathway for Staphylococcus aureus [arising from Nature, 2009, 458: 83-86]. Nature 463: E3.
-
(2010)
Nature
, vol.463
-
-
Balemans, W.1
Lounis, N.2
Gilissen, R.3
-
29
-
-
85056016503
-
Replying to W. Balemans 2009, Nature 463: E3
-
Brinster, S., G. Lamberet, B. Staels et al. 2010. Replying to W. Balemans et al. 2009, Nature 463: E3. Nature 463: E4.
-
(2010)
Nature
, vol.463
-
-
Brinster, S.1
Lamberet, G.2
Staels, B.3
-
30
-
-
0036051992
-
High-throughput crystallography for lead discovery in drug design
-
Blundell, T.L., H. Jhoti & C. Abell 2002. High-throughput crystallography for lead discovery in drug design. Nat. Rev. Drug Discov. 1: 45-54.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 45-54
-
-
Blundell, T.L.1
Jhoti, H.2
Abell, C.3
-
31
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
-
Arkin, M.R. & J.A. Wells 2004. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3: 301-317.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
32
-
-
52249120794
-
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity
-
Haydon, D.J., N.R. Stokes, R. Ure et al. 2008. An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science 321: 1673-1675.
-
(2008)
Science
, vol.321
, pp. 1673-1675
-
-
Haydon, D.J.1
Stokes, N.R.2
Ure, R.3
-
33
-
-
33644558385
-
Does the cell wall of bacteria remain a viable source of targets for novel antibiotics
-
Silver, L.L. 2008. Does the cell wall of bacteria remain a viable source of targets for novel antibiotics. Biochem. Pharmacol. 71: 996-1005.
-
(2008)
Biochem. Pharmacol.
, vol.71
, pp. 996-1005
-
-
Silver, L.L.1
-
34
-
-
67650718178
-
In vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
-
Stachyra, T., P. Levasseur, M.-C. Péchereau et al. 2009. In vitro activity of the β-lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases. J. Antimicrob. Chemoth. 64: 326-329.
-
(2009)
J. Antimicrob. Chemoth.
, vol.64
, pp. 326-329
-
-
Stachyra, T.1
Levasseur, P.2
Péchereau, M.3
-
35
-
-
23444456920
-
Prevention of drug access to bacterial targets: permeability barriers and active efflux
-
Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264: 382-388.
-
(1994)
Science
, vol.264
, pp. 382-388
-
-
Nikaido, H.1
-
36
-
-
70349420962
-
Prospects for the next anti-Pseudomonas drug
-
Page, M.G.P. & J. Heim 2009. Prospects for the next anti-Pseudomonas drug. Curr. Opin Pharmacol. 9: 558-565.
-
(2009)
Curr. Opin Pharmacol
, vol.9
, pp. 558-565
-
-
Page, M.G.P.1
Heim, J.2
-
37
-
-
0027535455
-
Discovery and development of new antibiotics: the problem of antibiotic resistance
-
Silver, L.L. & K.A. Bostian 1993. Discovery and development of new antibiotics: the problem of antibiotic resistance. Antimicrob. Agents Chemother. 37: 377-383.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 377-383
-
-
Silver, L.L.1
Bostian, K.A.2
-
39
-
-
77952583878
-
Enhancements of screening collections to address areas of unmet medical need: an industry perspective
-
Drewry, D.H. & R. Macarron 2010. Enhancements of screening collections to address areas of unmet medical need: an industry perspective. Curr. Opin. Chem. Biol. 14: 289-298.
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 289-298
-
-
Drewry, D.H.1
Macarron, R.2
-
40
-
-
0035324944
-
Molecular complexity and its impact on the probability of finding leads for drug discovery
-
Hann, M.M., A.R. Leach & G. Harper 2001. Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem. Inf. Model. 41: 856-864.
-
(2001)
J. Chem. Inf. Model.
, vol.41
, pp. 856-864
-
-
Hann, M.M.1
Leach, A.R.2
Harper, G.3
-
41
-
-
46749105500
-
The impact of diversity-based, high-throughput screening on drug discovery: "chance favours the prepared mind."
-
Snowden, M.A. & D.V.S. Green 2008. The impact of diversity-based, high-throughput screening on drug discovery: "chance favours the prepared mind." Curr. Opin. Drug Dis. Dev. 11: 553-558.
-
(2008)
Curr. Opin. Drug Dis. Dev.
, vol.11
, pp. 553-558
-
-
Snowden, M.A.1
Green, D.V.S.2
-
42
-
-
33644839988
-
Diversity oriented synthesis: exploring the intersections between chemistry and biology
-
Tan, D.S. 2005. Diversity oriented synthesis: exploring the intersections between chemistry and biology. Nat. Chem. Biol. 1: 74-84.
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 74-84
-
-
Tan, D.S.1
-
43
-
-
65349177763
-
The discovery of antibacterial agents using diversity-oriented synthesis
-
Galloway, W.R.J.D., A. Bender, M. Welch & D.R. Spring 2009. The discovery of antibacterial agents using diversity-oriented synthesis. Chem. Commun. 18: 2446-2462.
-
(2009)
Chem. Commun.
, vol.18
, pp. 2446-2462
-
-
Galloway, W.R.J.D.1
Bender, A.2
Welch, M.3
Spring, D.R.4
-
44
-
-
70450199467
-
Chemogenomic strategies to expand the bioactive chemical space
-
Jacoby, E. & A. Mozzarelli 2009. Chemogenomic strategies to expand the bioactive chemical space. Curr. Med. Chem. 16: 4374-4381.
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 4374-4381
-
-
Jacoby, E.1
Mozzarelli, A.2
-
45
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman, D.J. & G.M. Cragg 2007. Natural products as sources of new drugs over the last 25 years. J. Nat. Products 70: 461-477.
-
(2007)
J. Nat. Products
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
46
-
-
33644535147
-
Natural products-the future scaffolds for novel antibiotics?
-
Butler, M.S. & A.D. Buss 2006. Natural products-the future scaffolds for novel antibiotics? Biochem. Pharmacol. 71: 919-929.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 919-929
-
-
Butler, M.S.1
Buss, A.D.2
-
47
-
-
33644549679
-
The historical delivery of antibiotics from microbial natural products-can history repeat?
-
Pelaez, F. 2006. The historical delivery of antibiotics from microbial natural products-can history repeat? Biochem. Pharmacol. 71: 981-990.
-
(2006)
Biochem. Pharmacol
, vol.71
, pp. 981-990
-
-
Pelaez, F.1
-
48
-
-
67650436176
-
Drug discovery and natural products: end of an era or an endless frontier?
-
Li, J.W.H. & J. C. Vederas 2009. Drug discovery and natural products: end of an era or an endless frontier? Science 325: 161-165.
-
(2009)
Science
, vol.325
, pp. 161-165
-
-
Li, J.W.H.1
Vederas, J.C.2
-
49
-
-
0037208308
-
Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
-
Feher, M. & J.M. Schmidt 2003. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J. Chem. Inf. Model. 43: 218-227.
-
(2003)
J. Chem. Inf. Model
, vol.43
, pp. 218-227
-
-
Feher, M.1
Schmidt, J.M.2
-
50
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn, F.E. & G.T. Carter 2005. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 4: 206-220.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
51
-
-
54849405130
-
Renaissance in antibacterial discovery from actinomycetes
-
Baltz, R.H. 2008. Renaissance in antibacterial discovery from actinomycetes. Curr. Opin. Pharmacol. 8: 557-563.
-
(2008)
Curr. Opin. Pharmacol.
, vol.8
, pp. 557-563
-
-
Baltz, R.H.1
-
52
-
-
67651033682
-
Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity
-
Chetan S.C.K., J.L. Jenkins, R.E.J. Beckwith et al. 2009. Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity. J. Biomol. Screen. 14: 690-699.
-
(2009)
J. Biomol. Screen.
, vol.14
, pp. 690-699
-
-
Chetan, S.C.K.1
Jenkins, J.L.2
Beckwith, R.E.J.3
-
53
-
-
71149103036
-
Micronutrients in parenteral nutrition: boron, silicon, and fluoride
-
Nielsen, F.H. 2009. Micronutrients in parenteral nutrition: boron, silicon, and fluoride. Gastroenterology 137: S55-S60.
-
(2009)
Gastroenterology
, vol.137
-
-
Nielsen, F.H.1
-
54
-
-
77951815067
-
Therapeutic potential of boron-containing compounds
-
Baker, S.J., C.Z. Ding, T. Akama et al. 2009. Therapeutic potential of boron-containing compounds. Future Med. Chem. 1: 1275-1288.
-
(2009)
Future Med. Chem.
, vol.1
, pp. 1275-1288
-
-
Baker, S.J.1
Ding, C.Z.2
Akama, T.3
-
55
-
-
78650393680
-
-
Systemic Anti-Infectives Pipeline. Anacor Pharmaceuticals. (accessed October 23, 2010).
-
Systemic Anti-Infectives Pipeline. Anacor Pharmaceuticals. 2009. (accessed October 23, 2010).
-
(2009)
-
-
-
56
-
-
34250799619
-
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
-
Rock, F.L., W. Mao, A. Yaremchuk et al. 2007. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science 316: 1759-1761.
-
(2007)
Science
, vol.316
, pp. 1759-1761
-
-
Rock, F.L.1
Mao, W.2
Yaremchuk, A.3
-
57
-
-
67349127495
-
Crystal structures of the human and fungal cytosolic leucyl-tRNA synthetase editing domains: a structural basis for the rational design of antifungal benzoxaboroles
-
Seiradake, E., W. Mao, V. Hernandez et al. 2009. Crystal structures of the human and fungal cytosolic leucyl-tRNA synthetase editing domains: a structural basis for the rational design of antifungal benzoxaboroles. J. Mol. Biol. 390: 196-207.
-
(2009)
J. Mol. Biol.
, vol.390
, pp. 196-207
-
-
Seiradake, E.1
Mao, W.2
Hernandez, V.3
-
58
-
-
69249218864
-
Design, synthesis and selection of DNA-encoded small-molecule libraries
-
Clark, M.A., R.A. Acharya, C.C. Arico-Muendel et al. 2009. Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat. Chem. Biol. 5: 647-654.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 647-654
-
-
Clark, M.A.1
Acharya, R.A.2
Arico-Muendel, C.C.3
-
59
-
-
67649341990
-
From fragment to clinical candidate-a historical perspective
-
Chessari, G. & A.J. Woodhead 2009. From fragment to clinical candidate-a historical perspective. Drug Discov. Today 14: 668-675.
-
(2009)
Drug Discov. Today
, vol.14
, pp. 668-675
-
-
Chessari, G.1
Woodhead, A.J.2
-
60
-
-
67649295267
-
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches
-
Mochalkin, I., J.R. Miller, L. Narasimhan et al. 2009. Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. ACS Chem. Biol. 4: 473-483.
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 473-483
-
-
Mochalkin, I.1
Miller, J.R.2
Narasimhan, L.3
-
61
-
-
27144460621
-
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
-
Brotz-Oesterhelt, H., D. Beyer, H.-P. Kroll et al. 2005. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 11: 1082-1087.
-
(2005)
Nat. Med.
, vol.11
, pp. 1082-1087
-
-
Brotz-Oesterhelt, H.1
Beyer, D.2
Kroll, H.3
-
62
-
-
77957870442
-
A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential
-
Gentry, D.R., I. Wilding, J.M. Johnson et al. 2010.A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential. J. Microbiol. Methods. 83: 254-256.
-
(2010)
J. Microbiol. Methods.
, vol.83
, pp. 254-256
-
-
Gentry, D.R.1
Wilding, I.2
Johnson, J.M.3
-
63
-
-
28844488672
-
Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay
-
Stokes, N.R., J. Sievers, S. Barker et al. 2005. Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay. J. Biol. Chem. 280: 39709-39715.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39709-39715
-
-
Stokes, N.R.1
Sievers, J.2
Barker, S.3
-
64
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang, J., S.M. Soisson, K. Young et al. 2006. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441: 358-361.
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
Soisson, S.M.2
Young, K.3
-
65
-
-
0038779197
-
Genetic strategies for antibacterial drug discovery
-
Miesel, L., J. Greene & T.A. Black 2003. Genetic strategies for antibacterial drug discovery. Nat. Rev. Genet. 4: 442-456.
-
(2003)
Nat. Rev. Genet.
, vol.4
, pp. 442-456
-
-
Miesel, L.1
Greene, J.2
Black, T.A.3
-
66
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries, K., V. Peter, J. Guillemont et al. 2005. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307: 223-227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
Peter, V.2
Guillemont, J.3
-
67
-
-
70350342020
-
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting
-
Pathania, R., S. Zlitni, C. Barker et al. 2009. Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat. Chem. Biol. 5: 849-856.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 849-856
-
-
Pathania, R.1
Zlitni, S.2
Barker, C.3
-
68
-
-
60549115249
-
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
-
Miller, J.R., S. Dunhama, I. Mochalkin et al. 2009. A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. Proc. Natl. Acad. Sci. USA 106: 1737-1742.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1737-1742
-
-
Miller, J.R.1
Dunhama, S.2
Mochalkin, I.3
-
69
-
-
34247568394
-
Efflux pumps as antimicrobial resistance mechanisms
-
Poole, K. 2007. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med. 39: 162-176.
-
(2007)
Ann. Med.
, vol.39
, pp. 162-176
-
-
Poole, K.1
-
71
-
-
33644499476
-
Practical applications and feasibility of efflux pump inhibitors in the clinic-a vision for applied use
-
Lomovskaya, O. & K.A. Bostian 2006. Practical applications and feasibility of efflux pump inhibitors in the clinic-a vision for applied use. Biochem. Pharmacol. 71: 910-918.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 910-918
-
-
Lomovskaya, O.1
Bostian, K.A.2
-
72
-
-
18644384233
-
Antibiotic-associated diarrhea and pseudomembranous colitis: are they less common with poorly absorbed antimicrobials?
-
Surawicz, C.M. 2005. Antibiotic-associated diarrhea and pseudomembranous colitis: are they less common with poorly absorbed antimicrobials? Chemotherapy 51(Suppl. 1): 81-89.
-
(2005)
Chemotherapy
, vol.51
, Issue.SUPPL. 1
, pp. 81-89
-
-
Surawicz, C.M.1
-
74
-
-
0026746192
-
Antibiotic-associated diarrhea
-
Bartlett, J.G. 1992. Antibiotic-associated diarrhea. Clin. Infect. Dis. 15: 573-579.
-
(1992)
Clin. Infect. Dis.
, vol.15
, pp. 573-579
-
-
Bartlett, J.G.1
-
75
-
-
33750974153
-
Antimicrobial therapy of Clostridium difficile-associated diarrhea
-
Bouza, E., A. Burillo & P. Munoz 2006. Antimicrobial therapy of Clostridium difficile-associated diarrhea. Med. Clin. North Am. 90: 1141-1163.
-
(2006)
Med. Clin. North Am.
, vol.90
, pp. 1141-1163
-
-
Bouza, E.1
Burillo, A.2
Munoz, P.3
-
76
-
-
7244250115
-
Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species
-
Credito, K.L. & P.C. Appelbaum 2004. Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species. Antimicrob. Agents Chemother. 48: 4430-4434.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4430-4434
-
-
Credito, K.L.1
Appelbaum, P.C.2
-
77
-
-
9644257232
-
In vitro activities of OPT-80 and comparator drugs against intestinal bacteria
-
Finegold, S.M., D. Molitoris, M.-L. Vaisanenet et al. 2004. In vitro activities of OPT-80 and comparator drugs against intestinal bacteria. Antimicrob. Agents Chemother. 48: 4898-4902.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4898-4902
-
-
Finegold, S.M.1
Molitoris, D.2
Vaisanenet, M.3
-
78
-
-
0025310084
-
Quantitative study of antibiotic-induced susceptibility to Clostridium difficile enterocecitis in hamsters
-
Larson, H.E. & S.P. Borriello 1990. Quantitative study of antibiotic-induced susceptibility to Clostridium difficile enterocecitis in hamsters. Antimicrob. Agents Chemother. 34: 1348-1353.
-
(1990)
Antimicrob. Agents Chemother.
, vol.34
, pp. 1348-1353
-
-
Larson, H.E.1
Borriello, S.P.2
-
79
-
-
42049099454
-
Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses
-
Shue, Y.K., P.S. Sears, S. Shangle et al. 2008. Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses. Antimicrob. Agents Chemother. 52: 1391-1395.
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 1391-1395
-
-
Shue, Y.K.1
Sears, P.S.2
Shangle, S.3
-
80
-
-
74849098405
-
Treatment with monoclonal antibodies against Clostridium difficile toxins
-
Lowry, I., D.C. Molrine, B.A. Leav et al. 2010. Treatment with monoclonal antibodies against Clostridium difficile toxins. N. Engl. J. Med. 362: 197-205.
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 197-205
-
-
Lowry, I.1
Molrine, D.C.2
Leav, B.A.3
-
81
-
-
57049154860
-
Antibodies for the treatment of bacterial infections: current experience and future prospects
-
Bebbington, C. & G. Yarranton 2008. Antibodies for the treatment of bacterial infections: current experience and future prospects. Curr. Opin. Biotech. 19: 613-619.
-
(2008)
Curr. Opin. Biotech.
, vol.19
, pp. 613-619
-
-
Bebbington, C.1
Yarranton, G.2
-
82
-
-
61949116417
-
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics
-
Obrecht, D., J.A. Robinson, F. Bernardini et al. 2009. Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics. Curr. Med. Chem. 16: 42-65.
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 42-65
-
-
Obrecht, D.1
Robinson, J.A.2
Bernardini, F.3
-
83
-
-
77149159117
-
Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa
-
Srinivas, N., P. Jetter, B.J. Ueberbacher et al. 2010. Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. Science 327: 1010-1013.
-
(2010)
Science
, vol.327
, pp. 1010-1013
-
-
Srinivas, N.1
Jetter, P.2
Ueberbacher, B.J.3
-
84
-
-
68649102987
-
The use of ribosomal crystal structures in antibiotic drug design
-
Wimberly, B.T. 2009. The use of ribosomal crystal structures in antibiotic drug design. Curr. Opin. Invest. Drugs 10: 750-765.
-
(2009)
Curr. Opin. Invest. Drugs
, vol.10
, pp. 750-765
-
-
Wimberly, B.T.1
-
85
-
-
78650374058
-
-
Augmentin label approved 12/04/2008. 2008. FDA.gov, accessed October 23, 2010).
-
Augmentin label approved 12/04/2008. 2008. FDA.gov (accessed October 23, 2010).
-
-
-
-
86
-
-
78650392590
-
-
Avandia label approved 10/20/2008. 2008. FDA.gov, accessed October 23, 2010).
-
Avandia label approved 10/20/2008. 2008. FDA.gov (accessed October 23, 2010).
-
-
-
-
87
-
-
0034861516
-
A review of rosiglitazone in type 2 diabetes mellitus
-
Werner, A.L. & M.T. Travaglini 2001. A review of rosiglitazone in type 2 diabetes mellitus. Pharmacotherapy 21: 1082-1099.
-
(2001)
Pharmacotherapy
, vol.21
, pp. 1082-1099
-
-
Werner, A.L.1
Travaglini, M.T.2
-
88
-
-
78650329985
-
-
Imitrex label approved 10/13/2004. 2004. FDA.gov, accessed October 23, 2010).
-
Imitrex label approved 10/13/2004. 2004. FDA.gov (accessed October 23, 2010).
-
-
-
-
89
-
-
0031803892
-
Sumatriptan. An updated review of its use in migraine
-
Perry, C.M. & M. Anthony 1998. Sumatriptan. An updated review of its use in migraine. Drugs 55: 889-922.
-
(1998)
Drugs
, vol.55
, pp. 889-922
-
-
Perry, C.M.1
Anthony, M.2
-
90
-
-
0036570099
-
Timing of new black box warnings and withdrawals for prescription medications
-
Lasser, K.E., P.D. Allen, S.J. Woolhandler et al. 2002. Timing of new black box warnings and withdrawals for prescription medications. J. Am. Med. Assoc. 287: 2215-2220.
-
(2002)
J. Am. Med. Assoc.
, vol.287
, pp. 2215-2220
-
-
Lasser, K.E.1
Allen, P.D.2
Woolhandler, S.J.3
-
92
-
-
84886012175
-
Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
-
&, In, Vol. C. Han, B.D. Charles &, B. Wang, Eds.: - John Wiley & Sons, Inc., Hoboken
-
Chaudhary, K.W. & B.S. Brown 2010. Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes. In Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology, Vol. 10. C. Han, B.D. Charles & B. Wang, Eds.: 253-278. John Wiley & Sons, Inc. Hoboken
-
(2010)
Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes
, vol.10
, pp. 253-278
-
-
Chaudhary, K.W.1
Brown, B.S.2
-
93
-
-
9744232909
-
Time-related differences in the physical property profiles of oral drugs
-
Leeson, P.D. & A.M. Davis 2004. Time-related differences in the physical property profiles of oral drugs. J. Med. Chem. 47: 6338-6348.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6338-6348
-
-
Leeson, P.D.1
Davis, A.M.2
-
94
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medician chemistry
-
Leeson, P.D. & B. Springthorpe 2007. The influence of drug-like concepts on decision-making in medician chemistry. Nat. Rev. Drug Discov. 6: 881-890.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
96
-
-
0036226940
-
Animal model pharmacokinetics and pharmacodynamics: a critical review
-
Andes, D. & W.A. Craig 2002. Animal model pharmacokinetics and pharmacodynamics: a critical review. Int. J. Antimicrob. Agents 19: 261-288.
-
(2002)
Int. J. Antimicrob. Agents
, vol.19
, pp. 261-288
-
-
Andes, D.1
Craig, W.A.2
-
97
-
-
56849110070
-
Can pharmacokinetic-pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance?
-
Courvalin, P. 2008. Can pharmacokinetic-pharmacodynamic parameters provide dosing regimens that are less vulnerable to resistance? Clin. Microbiol. Infect. 14: 989-994.
-
(2008)
Clin. Microbiol. Infect.
, vol.14
, pp. 989-994
-
-
Courvalin, P.1
-
98
-
-
0035173688
-
Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint
-
Drusano, G.L., S.L. Preston, C. Hardalo et al. 2001. Use of preclinical data for selection of a phase II/III dose for evernimicin and identification of a preclinical MIC breakpoint. Antimicrob. Agents Chemother. 45: 13-22.
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 13-22
-
-
Drusano, G.L.1
Preston, S.L.2
Hardalo, C.3
-
99
-
-
24144496190
-
Use of pharmacokinetic-pharmacodynamic target attainment analyses to support phase 2 and 3 dosing strategies for doripenem
-
Bhavnani, S.M., J.P. Hammel, B.B. Cirincione et al. 2005. Use of pharmacokinetic-pharmacodynamic target attainment analyses to support phase 2 and 3 dosing strategies for doripenem. Antimicrob. Agents Chemother. 49: 3944-3947.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 3944-3947
-
-
Bhavnani, S.M.1
Hammel, J.P.2
Cirincione, B.B.3
-
100
-
-
0036839738
-
In vivo pharmacodynamics of a new oxazolidinone (linezolid)
-
Andes, D., M.L. van Ogtrop, J. Peng et al. 2002. In vivo pharmacodynamics of a new oxazolidinone (linezolid). Antimicrob. Agents Chemother. 46: 3483-3489.
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 3483-3489
-
-
Andes, D.1
van Ogtrop, M.L.2
Peng, J.3
-
101
-
-
42549140820
-
Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumonia
-
Pertel, P.E., P. Bernardo, C. Fogarty et al. 2008. Effects of prior effective therapy on the efficacy of daptomycin and ceftriaxone for the treatment of community-acquired pneumonia. Clin. Infect. Dis. 46: 1142-1151.
-
(2008)
Clin. Infect. Dis.
, vol.46
, pp. 1142-1151
-
-
Pertel, P.E.1
Bernardo, P.2
Fogarty, C.3
-
102
-
-
20444384347
-
Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact
-
Silverman, J.A., L.I. Mortin, A.D.G. VanPraagh et al. 2005. Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact. J. Infect. Dis. 191: 2149-2152.
-
(2005)
J. Infect. Dis.
, vol.191
, pp. 2149-2152
-
-
Silverman, J.A.1
Mortin, L.I.2
VanPraagh, A.D.G.3
-
103
-
-
78650363156
-
-
New Transatlantic Task Force on Antimicrobial Resistance: A Path Forward, accessed October 23, 2010).
-
Guidos, R.J. 2009. New Transatlantic Task Force on Antimicrobial Resistance: A Path Forward (accessed October 23, 2010).
-
(2009)
-
-
Guidos, R.J.1
-
104
-
-
78650326081
-
-
Infectious Diseases Society of America. Bad Bugs, No Drugs ... 10 New Antibiotics by 2020, accessed October 23, 2010).
-
Infectious Diseases Society of America. Bad Bugs, No Drugs ... 10 New Antibiotics by 2020, (accessed October 23, 2010).
-
-
-
|