Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1537-1543

  Trzoss, Micheal ^a   Bensen, Daniel C ^a   Li, Xiaoming ^a   Chen, Zhiyong ^a   Lam, Thanh ^a   Zhang, Junhu ^a   Creighton, Christopher J ^a   Cunningham, Mark L ^a   Kwan, Bryan ^a   Stidham, Mark ^a   Nelson, Kirk ^a   Brown Driver, Vickie ^a   Castellano, Amanda ^a   Shaw, Karen J ^a   Lightstone, Felice C ^b   Wong, Sergio E ^b   Nguyen, Toan B ^b   Finn, John ^a   Tari, Leslie W ^a  

^a Trius Therapeutics   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Bacterial topoisomerases; Gram negative antibacterial agents; GyrB; Inhibitor; ParE; Pyrrolopyrimidine

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING) B; DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; NOVOBIOCIN; PROTEIN PARE; PYRROLOPYRIMIDINE DERIVATIVE;

ACINETOBACTER BAUMANNII; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR ELECTRONICS; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG DESIGN; HUMANS; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84873729257     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.073     Document Type: Article

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