Evaluation and target validation of indole derivatives as inhibitors of the AcrAB-TolC efflux pump

Bioscience, Biotechnology and Biochemistry

Volumn 74, Issue 11, 2010, Pages 2237-2241

  Zeng, Bo ^a   Wang, Hongning ^a   Zou, Likou ^a   Zhang, Anyun ^a   Yang, Xin ^a   Guan, Zhongbin ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Antibacterial activity; Efflux pump inhibitor; Indole derivatives; TolC

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTI-MICROBIAL ACTIVITY; ANTIBACTERIAL EFFECTS; CIPROFLOXACIN; EFFLUX PUMP INHIBITOR; EFFLUX PUMPS; FUNCTIONAL SITES; HOMOLOGOUS RECOMBINATION; INDOLE DERIVATIVES; MINIMAL INHIBITORY CONCENTRATION; SITE DIRECTED MUTAGENESIS; TOLC;

ESCHERICHIA COLI;

ANTIBIOTICS;

ACRAB TOLC PROTEIN, SALMONELLA ENTERICA; ACRAB-TOLC PROTEIN, SALMONELLA ENTERICA; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; INDOLE DERIVATIVE; MUTANT PROTEIN; OUTER MEMBRANE PROTEIN; TOLC PROTEIN, E COLI;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG POTENTIATION; GENETICS; MICROBIOLOGICAL EXAMINATION; SITE DIRECTED MUTAGENESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; CARRIER PROTEINS; DRUG DESIGN; DRUG SYNERGISM; ESCHERICHIA COLI PROTEINS; INDOLES; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS;

ESCHERICHIA COLI;

EID: 78649770073     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.100433     Document Type: Article

References (14)

1. Pagès JM, Masi M, and Barbe J, Trends Mol. Med., 11, 382-388 (2005).
2. Forunierdit Chabert J, Marquez B, Neville L, Jouchla L, Broussous S, and Bouhours P, Bioorg. Med. Chem., 15, 4482-4497 (2007).
3. Zhao ZJ, Wolkenberg SE, Lu MQ, Munshi V, Moyer G, and Feng MZ, Bioorg. Med. Chem. Lett., 18, 554-559 (2008).
4. Weng JR, Tsai CH, Kulp SK, and Chen CS, Cancer Lett., 262, 153-163 (2008).
5. Samosorn S, Bremner JB, Ball A, and Lewis K, Bioorg. Med. Chem., 14, 857-865 (2006).
6. Koronakis V, Eswaran J, and Hughes C, Annu. Rev. Biochem., 73, 467-489 (2004).
7. Freiberg C and Brötz-Oesterhelt H, Drug Discov. Today, 10, 927-935 (2005).
8. Kana BD and Mizrahi V, Tuberculosis, 84, 63-75 (2004).
9. Andersen C, Koronakis E, Bokma E, Eswaran J, Humphreys D, and Koronakis V, Proc. Natl. Acad. Sci., 99, 11103-11108 (2002).
10. Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, and Cheeseman JR, "V. G. Gaussian 98" Revision A.11, Gaussian Inc., Pittsburgh (2001).
11. Li QH and Zhao ZG, Chem. Res. Appl., 20, 348-351 (2008).
12. Datsenko KA and Wanner BL, Proc. Natl. Acad. Sci., 97, 6640-6645 (2000).
13. Yamanaka H, Nomura T, Morisada N, Shinoda S, and Okamoto K, Microb. Pathog., 33, 81-89 (2002).
14. Yamanaka H, Tadokoro S, Miyana M, Takahashi E, Kobayashi H, and Okamoto K, Microb. Pathog., 42, 184-192 (2007).