-
1
-
-
0037257321
-
The importance of efflux pumps in antibiotic resistance
-
Webber MA, Piddock LVJ. The importance of efflux pumps in antibiotic resistance. J Antimicrob Chemother 2003; 51: 9-11.
-
(2003)
J Antimicrob Chemother
, vol.51
, pp. 9-11
-
-
Webber, M.A.1
Piddock, L.V.J.2
-
2
-
-
0442307441
-
Efflux-mediated drug resistance in bacteria
-
Li HZ, Nikaido H. Efflux-mediated drug resistance in bacteria. Drugs 2004; 64: 159-204.
-
(2004)
Drugs
, vol.64
, pp. 159-204
-
-
Li, H.Z.1
Nikaido, H.2
-
3
-
-
33646251815
-
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
-
Piddock LV. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 2006; 19: 382-402.
-
(2006)
Clin Microbiol Rev
, vol.19
, pp. 382-402
-
-
Piddock, L.V.1
-
5
-
-
0036050858
-
Active efflux, a common mechanism for biocide and antibiotic resistance
-
Levy SB. Active efflux, a common mechanism for biocide and antibiotic resistance. J Appl Microbiol 2002; 92 (Suppl): 65S-71S.
-
(2002)
J Appl Microbiol
, vol.92
, Issue.SUPPL.
-
-
Levy, S.B.1
-
6
-
-
24044514016
-
Efflux-mediated antimicrobial resistance
-
Poole K. Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 2005; 56: 20-51.
-
(2005)
J Antimicrob Chemother
, vol.56
, pp. 20-51
-
-
Poole, K.1
-
8
-
-
27644575196
-
Bacterial efflux system and efflux pump inhibitors
-
Marquez B. Bacterial efflux system and efflux pump inhibitors. Biochimie 2005; 87: 1137-1147.
-
(2005)
Biochimie
, vol.87
, pp. 1137-1147
-
-
Marquez, B.1
-
9
-
-
33644552115
-
Efflux systems in bacterial pathogens: An opportunity for therapeutic intervention? An industry view
-
Lynch AS. Efflux systems in bacterial pathogens: An opportunity for therapeutic intervention? An industry view. Biochem Pharmacol 2006; 71: 949-956.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 949-956
-
-
Lynch, A.S.1
-
10
-
-
23144431968
-
Inhibitors of efflux pumps in Gram-negative bacteria
-
Pagès JM, Masi M, Barbe J. Inhibitors of efflux pumps in Gram-negative bacteria. Trends Mol Med 2005; 11: 382-389.
-
(2005)
Trends Mol Med
, vol.11
, pp. 382-389
-
-
Pagès, J.M.1
Masi, M.2
Barbe, J.3
-
11
-
-
0242573103
-
Multidrug resistance ABC transporters
-
Chang G. Multidrug resistance ABC transporters. FEBS Lett 2003; 555: 102-105.
-
(2003)
FEBS Lett
, vol.555
, pp. 102-105
-
-
Chang, G.1
-
12
-
-
0041833334
-
ABC-transporters: Implications on drug resistance from microorganisms to human cancer
-
Lage H. ABC-transporters: Implications on drug resistance from microorganisms to human cancer. Int J Antimicrob Agents 2003; 22: 188-199.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 188-199
-
-
Lage, H.1
-
13
-
-
0035019469
-
ABC transporters: Physiology, structure, and mechanism- an overview
-
Higgins CF. ABC transporters: Physiology, structure, and mechanism- an overview. Res Microbiol 2001; 152: 205-210.
-
(2001)
Res Microbiol
, vol.152
, pp. 205-210
-
-
Higgins, C.F.1
-
14
-
-
0343831467
-
The role of ABC transporters in antibiotic-producing organisms: Drug secretion and resistance mechanism
-
Mèndez C, Salas JA. The role of ABC transporters in antibiotic-producing organisms: Drug secretion and resistance mechanism. Res Microbiol 2001; 152: 341-352.
-
(2001)
Res Microbiol
, vol.152
, pp. 341-352
-
-
Mèndez, C.1
Salas, J.A.2
-
15
-
-
0025456967
-
Inducible erythromycin resistance in Staphylococci is encoded by a member of ATP-binding transporter super-gene family
-
Ross JI, Eady EA, Cove JH, Cunliffe WJ, Baumberg S, Wooton JC. Inducible erythromycin resistance in Staphylococci is encoded by a member of ATP-binding transporter super-gene family. Mol Microbiol 1990; 4: 1207-1214.
-
(1990)
Mol Microbiol
, vol.4
, pp. 1207-1214
-
-
Ross, J.I.1
Eady, E.A.2
Cove, J.H.3
Cunliffe, W.J.4
Baumberg, S.5
Wooton, J.C.6
-
16
-
-
4644309833
-
Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR
-
Mansom JM, Keis S, Smith JMB, Cook GM. Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR. Antimicrob Agents Chemother 2004; 48: 3743-3748.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3743-3748
-
-
Mansom, J.M.1
Keis, S.2
Smith, J.M.B.3
Cook, G.M.4
-
18
-
-
0344012053
-
EfrAB, an ABC multidrug efflux in pump in Enterococcus faecalis
-
Lee RW, Huda MN, Kuroda T, Mizushima T, Tsuchiya T. EfrAB, an ABC multidrug efflux in pump in Enterococcus faecalis. Antimicrob Agents Chemother 2003; 47: 3733-3738.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 3733-3738
-
-
Lee, R.W.1
Huda, M.N.2
Kuroda, T.3
Mizushima, T.4
Tsuchiya, T.5
-
19
-
-
0041767580
-
Molecular cloning and characterisation of an ABC multidrug efflux pump, VcaM, in non-O1 Vibrio cholerae
-
Nuda N, Lee EW, Chen J, et al. Molecular cloning and characterisation of an ABC multidrug efflux pump, VcaM, in non-O1 Vibrio cholerae. Antimicrob Agents Chemother 2003; 47: 2413-2417.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 2413-2417
-
-
Nuda, N.1
Lee, E.W.2
Chen, J.3
-
20
-
-
0036167744
-
Evidence of active efflux pump in resistance to ciprofloxacin and to ethidium bromide by Mycoplasma hominis
-
Raherison S, Gonzales P, Renaudin H, Charron A, Bebear C, Bebear CM. Evidence of active efflux pump in resistance to ciprofloxacin and to ethidium bromide by Mycoplasma hominis. Antimicrob Agents Chemother 2002; 46: 672-679.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 672-679
-
-
Raherison, S.1
Gonzales, P.2
Renaudin, H.3
Charron, A.4
Bebear, C.5
Bebear, C.M.6
-
22
-
-
0033170990
-
The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins
-
Tseng TT, Gratwick KS, Kollman J, et al. The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins. Mol Microbiol Biotechnol 1999; 1: 107-125.
-
(1999)
Mol Microbiol Biotechnol
, vol.1
, pp. 107-125
-
-
Tseng, T.T.1
Gratwick, K.S.2
Kollman, J.3
-
23
-
-
0025688065
-
Nucleotide sequence and characterization of the Staphyloccus aureus NorA gene, which confers resistance to quinolones
-
Yoshida H, Bogaki M, Nakamura S, Ubukata K, Konno M. Nucleotide sequence and characterization of the Staphyloccus aureus NorA gene, which confers resistance to quinolones. J Bacteriol 1990; 172: 6942-6949.
-
(1990)
J Bacteriol
, vol.172
, pp. 6942-6949
-
-
Yoshida, H.1
Bogaki, M.2
Nakamura, S.3
Ubukata, K.4
Konno, M.5
-
24
-
-
0032907704
-
Identification of an efflux pump gene, pmrA, associated with fluoroquinolones resistance in Streptococcus pneumoniae
-
Gill MJ, Brenwald NP, Wise R. Identification of an efflux pump gene, pmrA, associated with fluoroquinolones resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 1999; 43: 187-189.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 187-189
-
-
Gill, M.J.1
Brenwald, N.P.2
Wise, R.3
-
25
-
-
0043269351
-
Functional cloning and expression of EmeA and characterization of EmeA, a multidrug efflux pump from Enterococcus faecalis
-
Lee EW, Chen J, Huda MN, Kuroda T, Mizushima T, Tsuchiya T. Functional cloning and expression of EmeA and characterization of EmeA, a multidrug efflux pump from Enterococcus faecalis. Biol Pharm Bull 2003; 26: 266-270.
-
(2003)
Biol Pharm Bull
, vol.26
, pp. 266-270
-
-
Lee, E.W.1
Chen, J.2
Huda, M.N.3
Kuroda, T.4
Mizushima, T.5
Tsuchiya, T.6
-
26
-
-
49549088341
-
Multidrug efflux transporter, AcrB-the pumping mechanism
-
Murakami S. Multidrug efflux transporter, AcrB-the pumping mechanism. Curr Opin Struct Biol 2008; 18: 459-465.
-
(2008)
Curr Opin Struct Biol
, vol.18
, pp. 459-465
-
-
Murakami, S.1
-
28
-
-
0032949426
-
The multidrug efflux protein NorM is a prototype of a new family of transporters
-
Brown MH, Paulsen IT, Skurray RA. The multidrug efflux protein NorM is a prototype of a new family of transporters. Mol Microbiol 1999; 31: 393-395.
-
(1999)
Mol Microbiol
, vol.31
, pp. 393-395
-
-
Brown, M.H.1
Paulsen, I.T.2
Skurray, R.A.3
-
29
-
-
4344612328
-
The AcrAB-TolC pump is involved in macrolide resistance but not in thelitromycin efflux in Enterobacter aerogenes and Escherichia coli
-
Chollet R, Chevalier J, Bryskier A, Pages JM. The AcrAB-TolC pump is involved in macrolide resistance but not in thelitromycin efflux in Enterobacter aerogenes and Escherichia coli. Antimicrob Agents Chemother 2004; 48:3621-3624.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3621-3624
-
-
Chollet, R.1
Chevalier, J.2
Bryskier, A.3
Pages, J.M.4
-
30
-
-
0037417016
-
Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates
-
Peric M, Bozdogan B, Jacobs MR, Appelbaum PC. Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates. Antimicrob Agents Chemother 2003; 47: 1017-1022.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 1017-1022
-
-
Peric, M.1
Bozdogan, B.2
Jacobs, M.R.3
Appelbaum, P.C.4
-
31
-
-
0037417013
-
Efflux-mediated resistance to tigegycline (GAR-936) in Pseudomonas aeruginosa PAO1
-
Dean CR, Visalli MA, Projan SJ, Sum PE, Bradford PA. Efflux-mediated resistance to tigegycline (GAR-936) in Pseudomonas aeruginosa PAO1. Antimicrob Agents Chemother 2003; 47: 972-978.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 972-978
-
-
Dean, C.R.1
Visalli, M.A.2
Projan, S.J.3
Sum, P.E.4
Bradford, P.A.5
-
32
-
-
0037309748
-
AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis
-
Visalli MA, Murphy E, Projan SJ, Bradford PA. AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis. Antimicrob Agents Chemother 2003; 47: 665-669.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 665-669
-
-
Visalli, M.A.1
Murphy, E.2
Projan, S.J.3
Bradford, P.A.4
-
33
-
-
0027494050
-
Multiple antibiotic resistance in Pseudomonas aeruginosa: Evidence for involvement of an efflux operon
-
Pole K. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol 1993; 175: 7363-7372.
-
(1993)
J Bacteriol
, vol.175
, pp. 7363-7372
-
-
Pole, K.1
-
34
-
-
0035353081
-
Multidrug efflux in Pseudomonas aeruginosa: Components, mechanisms and significance
-
Pole K, Srikumar R. Multidrug efflux in Pseudomonas aeruginosa: Components, mechanisms and significance. Curr Top Med Chem 2001; 1: 59-71.
-
(2001)
Curr Top Med Chem
, vol.1
, pp. 59-71
-
-
Pole, K.1
Srikumar, R.2
-
35
-
-
0346991732
-
+-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa
-
+-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. J Bacteriol 2004; 186: 262-265.
-
(2004)
J Bacteriol
, vol.186
, pp. 262-265
-
-
He, G.X.1
Kuroda, T.2
Mima, T.3
Morita, Y.4
Mizushima, T.5
Tsuchiya, T.6
-
36
-
-
0141615783
-
AcrB multidrug efflux pump of Escherichia coli: Composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity
-
Yu EW, Aires JR, Nikaido H. AcrB multidrug efflux pump of Escherichia coli: Composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J Bacteriol 2003; 185: 5657-5664.
-
(2003)
J Bacteriol
, vol.185
, pp. 5657-5664
-
-
Yu, E.W.1
Aires, J.R.2
Nikaido, H.3
-
37
-
-
0035178557
-
Resistance-nodulation-cell-division-type efflux pump involved in aminoglycoside resistance in A cinetobacter baumannii strain BM4454
-
Magnet S, Courvalin P, Lambert T. Resistance-nodulation-cell-division-type efflux pump involved in aminoglycoside resistance in A cinetobacter baumannii strain BM4454. Antimicrob Agents Chemother 2001; 45: 3375-3380.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 3375-3380
-
-
Magnet, S.1
Courvalin, P.2
Lambert, T.3
-
38
-
-
1642461445
-
Expression of AcrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: Role in multiple antibiotic resistance
-
Eaves DJ, Ricci V, Piddock LJ. Expression of AcrB, acrF, acrD, marA, and soxS in Salmonella enterica serovar Typhimurium: Role in multiple antibiotic resistance. Antimicrob Agents Chemother 2004; 48: 1145-1150.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1145-1150
-
-
Eaves, D.J.1
Ricci, V.2
Piddock, L.J.3
-
39
-
-
0037050288
-
Identification and molecular characterisation of CmeB, a Campylobacter jejuni multidrug efflux pump
-
Pumbwe L, Piddock JV. Identification and molecular characterisation of CmeB, a Campylobacter jejuni multidrug efflux pump. FEMS Microbiol Lett 2002; 206: 185-189.
-
(2002)
FEMS Microbiol Lett
, vol.206
, pp. 185-189
-
-
Pumbwe, L.1
Piddock, J.V.2
-
40
-
-
0036785342
-
Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae
-
Veal WL, Nicholas RA, Shafer WM. Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. J Bacteriol 2002; 184: 5619-5624.
-
(2002)
J Bacteriol
, vol.184
, pp. 5619-5624
-
-
Veal, W.L.1
Nicholas, R.A.2
Shafer, W.M.3
-
41
-
-
33747878184
-
Clinical significance of overexpression of multiple RND-family efflux pumps in Bacterioides fragilis isolates
-
Pumbwe L, Chang A, Smith RL, Wexler HM. Clinical significance of overexpression of multiple RND-family efflux pumps in Bacterioides fragilis isolates. J Antimicrob Chemother 2006; 58: 543-548.
-
(2006)
J Antimicrob Chemother
, vol.58
, pp. 543-548
-
-
Pumbwe, L.1
Chang, A.2
Smith, R.L.3
Wexler, H.M.4
-
42
-
-
0035991982
-
The AcrB-TolC efflux pump contributes to multidrug resistance in nosocomial pathogen Enterobacter aerogenes
-
Pradel E, Pages JM. The AcrB-TolC efflux pump contributes to multidrug resistance in nosocomial pathogen Enterobacter aerogenes. Antimicrob Agents Chemother 2002; 46: 2640-2643.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 2640-2643
-
-
Pradel, E.1
Pages, J.M.2
-
43
-
-
0036895630
-
AcrAB efflux system: Expression and contribution to fluoroquinolone resistance in Klebsiella spp
-
Mazzariol A, Zuliani J, Cornaglia G, Rossolini GM, Fontana R. AcrAB efflux system: Expression and contribution to fluoroquinolone resistance in Klebsiella spp. Antimicrob Agents Chemother 2002; 46: 3984-3986.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3984-3986
-
-
Mazzariol, A.1
Zuliani, J.2
Cornaglia, G.3
Rossolini, G.M.4
Fontana, R.5
-
44
-
-
16244421361
-
Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens
-
Kumar A, Worobec EA. Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens. Antimicrob Agents Chemother 2005; 49: 1495-1501.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1495-1501
-
-
Kumar, A.1
Worobec, E.A.2
-
45
-
-
0030663047
-
The AcrB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump
-
Sanchez L, Pan W, Vinas M, Niakaido H. The AcrB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. J Bacteriol 1997; 179: 6855-6857.
-
(1997)
J Bacteriol
, vol.179
, pp. 6855-6857
-
-
Sanchez, L.1
Pan, W.2
Vinas, M.3
Niakaido, H.4
-
46
-
-
16244385589
-
A Helicobacter pylori TolC efflux pump confers resistance to metronidazole
-
van Amsterdam K, Bart A, van der Ende A. A Helicobacter pylori TolC efflux pump confers resistance to metronidazole. Antimicrob Agents Chemother 2005, 49: 1477-1482.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1477-1482
-
-
van Amsterdam, K.1
Bart, A.2
van der Ende, A.3
-
47
-
-
0027270540
-
Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus
-
Kaatz GW, Seo SM, Ruble CA. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob Agents Chemother 1993; 37: 1086-1094.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 1086-1094
-
-
Kaatz, G.W.1
Seo, S.M.2
Ruble, C.A.3
-
48
-
-
15244342379
-
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus
-
Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC. MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J Bacteriol 2005; 187: 2395-2405.
-
(2005)
J Bacteriol
, vol.187
, pp. 2395-2405
-
-
Truong-Bolduc, Q.C.1
Dunman, P.M.2
Strahilevitz, J.3
Projan, S.J.4
Hooper, D.C.5
-
49
-
-
35948985469
-
Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus
-
De Marco CE, Cushing LA, Frempong-Manso E, Seo SM, Jaravaza GA, Kaatz GW. Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. Antimicrob Agents Chemother 2007; 51: 3235-3239.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 3235-3239
-
-
De Marco, C.E.1
Cushing, L.A.2
Frempong-Manso, E.3
Seo, S.M.4
Jaravaza, G.A.5
Kaatz, G.W.6
-
50
-
-
18244388696
-
Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein
-
Kaatz GW, McAleese F, Seo SM. Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein. Antimicrob Agents Chemother 2005; 49: 1857-1864.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1857-1864
-
-
Kaatz, G.W.1
McAleese, F.2
Seo, S.M.3
-
51
-
-
27644571508
-
Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multiple transporters involved in intrinsic resistance to antimicrobial agents
-
Robertson GT, Doyle TB, Lynch AS. Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multiple transporters involved in intrinsic resistance to antimicrobial agents. Antimicrob Agents Chemother 2005; 49: 4781-4783.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4781-4783
-
-
Robertson, G.T.1
Doyle, T.B.2
Lynch, A.S.3
-
52
-
-
33750459868
-
Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis
-
Oyamada Y, Ito H, Inoue M, Yamagishi J. Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis. J Med Microbiol 2006; 55: 1395-1401.
-
(2006)
J Med Microbiol
, vol.55
, pp. 1395-1401
-
-
Oyamada, Y.1
Ito, H.2
Inoue, M.3
Yamagishi, J.4
-
53
-
-
3042585064
-
Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis
-
Ly XZ, Zhang L, Nikaido H. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother 2004; 48: 2415-2423.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 2415-2423
-
-
Ly, X.Z.1
Zhang, L.2
Nikaido, H.3
-
54
-
-
27644475760
-
mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis
-
Pasca MR, Guglierame P, De Rossi E, Zara F, Riccardi G. mmpL7 gene of Mycobacterium tuberculosis is responsible for isoniazid efflux in Mycobacterium smegmatis. Antimicrob Agents Chemother 2005; 49: 4775-4777.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4775-4777
-
-
Pasca, M.R.1
Guglierame, P.2
De Rossi, E.3
Zara, F.4
Riccardi, G.5
-
55
-
-
20144387448
-
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol
-
Colangeli R, Helb D, Sridharan S, et al. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Mol Microbiol 2005; 55:1829-1840.
-
(2005)
Mol Microbiol
, vol.55
, pp. 1829-1840
-
-
Colangeli, R.1
Helb, D.2
Sridharan, S.3
-
56
-
-
33644900505
-
Role of mycobacterial efflux transporters in drug resistance: An unresolved question
-
De Rossi E, Ainsa JA, Riccardi G. Role of mycobacterial efflux transporters in drug resistance: an unresolved question. FEMS Microbiol Rev 2006; 30: 36-52.
-
(2006)
FEMS Microbiol Rev
, vol.30
, pp. 36-52
-
-
De Rossi, E.1
Ainsa, J.A.2
Riccardi, G.3
-
57
-
-
34248189172
-
Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG
-
Ramón-García S, Martín C, De Rossi E, Aínsa JA. Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG. J Antimicrob Chemother 2007; 59: 544-547.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 544-547
-
-
Ramón-García, S.1
Martín, C.2
De Rossi, E.3
Aínsa, J.A.4
-
59
-
-
46249116233
-
Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump
-
Jeannot K, Elsen S, Köhler T, Attree I, van Delden C, Plésiat P. Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Antimicrob Agents Chemother 2008; 52: 2455-2462.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2455-2462
-
-
Jeannot, K.1
Elsen, S.2
Köhler, T.3
Attree, I.4
van Delden, C.5
Plésiat, P.6
-
60
-
-
34447547677
-
Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria
-
Hansen LH, Jensen LB, Sorensen HI, Sørensen SJ. Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria. J Antimicrob Chemother 2007; 60: 145-147.
-
(2007)
J Antimicrob Chemother
, vol.60
, pp. 145-147
-
-
Hansen, L.H.1
Jensen, L.B.2
Sorensen, H.I.3
Sørensen, S.J.4
-
61
-
-
23044512221
-
Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli
-
Ge B, McDermott PF, White DG, Meng J. Role of efflux pumps and topoisomerase mutations in fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Antimicrob Agents Chemother 2005; 49: 3347-3354.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 3347-3354
-
-
Ge, B.1
McDermott, P.F.2
White, D.G.3
Meng, J.4
-
62
-
-
0942301295
-
-
Kehrenberg C, Schwarz S. fex A, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. Antimicrob Agents Chemother 2004; 48: 615-618.
-
Kehrenberg C, Schwarz S. fex A, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. Antimicrob Agents Chemother 2004; 48: 615-618.
-
-
-
-
63
-
-
4544384074
-
Genetic elements carrying macrolide efflux genes in streptococci
-
Pozzi G, Iannelli F, Oggioni MR, Santagatti M, Stefani S. Genetic elements carrying macrolide efflux genes in streptococci. Curr Drug Targets Infect Disord 2004; 4: 203-206.
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 203-206
-
-
Pozzi, G.1
Iannelli, F.2
Oggioni, M.R.3
Santagatti, M.4
Stefani, S.5
-
64
-
-
0034806355
-
Novel macrolide-specific ABC-type efflux transporter in Escherichia coli
-
Kobayashi N, Nishino K, Yamaguchi A. Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J Bacteriol 2001; 183: 5639-5644.
-
(2001)
J Bacteriol
, vol.183
, pp. 5639-5644
-
-
Kobayashi, N.1
Nishino, K.2
Yamaguchi, A.3
-
65
-
-
35948957361
-
Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni
-
Gibreel A, Wetsch NM, Taylor DE. Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. Antimicrob Agents Chemother 2007; 51: 3212-3216.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 3212-3216
-
-
Gibreel, A.1
Wetsch, N.M.2
Taylor, D.E.3
-
66
-
-
10744225004
-
Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus
-
Huang J, O'Toole PW, Shen W, et al. Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus. Antimicrob Agents Chemother 2004; 48: 909-917.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 909-917
-
-
Huang, J.1
O'Toole, P.W.2
Shen, W.3
-
67
-
-
0042835378
-
Msr(A) and related macrolide/streptogramin resistance determinants: Incomplete transporters?
-
Reynolds E, Ross JI, CoveJH. Msr(A) and related macrolide/streptogramin resistance determinants: Incomplete transporters? Int J Antimicrob Agents 2003; 22: 228-236.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 228-236
-
-
Reynolds, E.1
Ross, J.I.2
CoveJH3
-
68
-
-
0034060888
-
Macrolide resistance genes in Enterococcus spp
-
Portillo A, Ruiz-Larrea F, Zarazaga M, Alonso A, Martinez JL, Torres C. Macrolide resistance genes in Enterococcus spp. Antimicrob Agents Chemother 2000; 44: 967-971.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 967-971
-
-
Portillo, A.1
Ruiz-Larrea, F.2
Zarazaga, M.3
Alonso, A.4
Martinez, J.L.5
Torres, C.6
-
69
-
-
0036896893
-
A novel efflux system in inducibly erythromycin-resistant strains of Streptococcus pyogenes
-
Giovanetti E, Brenciani A, Burioni R, Varaldo PE. A novel efflux system in inducibly erythromycin-resistant strains of Streptococcus pyogenes. Antimicrob Agents Chemother 2002; 46: 3750-3755.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3750-3755
-
-
Giovanetti, E.1
Brenciani, A.2
Burioni, R.3
Varaldo, P.E.4
-
70
-
-
0037636475
-
Nonsense mutations in the lsa-like gene in Enterococcus faecalis isolates susceptible to lincosamides and streptogramins A
-
Dina J, Malbruny B, Leclercq R. Nonsense mutations in the lsa-like gene in Enterococcus faecalis isolates susceptible to lincosamides and streptogramins A. Antimicrob Agents Chemother 2003; 47: 2307-2309.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 2307-2309
-
-
Dina, J.1
Malbruny, B.2
Leclercq, R.3
-
71
-
-
0041833332
-
Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria
-
Butaye P, Cloeckaert A, Schwarz S. Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria. Int J Antimicrob Agents 2003; 22: 205-210.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 205-210
-
-
Butaye, P.1
Cloeckaert, A.2
Schwarz, S.3
-
72
-
-
38749151369
-
-
J Bacteriol
-
Matsuo T, Chen J, Minato Y, et al. SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens. J Bacteriol 2008; 190: 648-654.
-
(2008)
SmdAB, a heterodimeric ABC-Type multidrug efflux pump, in Serratia marcescens
, vol.190
, pp. 648-654
-
-
Matsuo, T.1
Chen, J.2
Minato, Y.3
-
73
-
-
18244403495
-
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Stophylococcus aureus mutants to tigecycline
-
McAleese F, Peterson P, Ruzin A, et al. A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Stophylococcus aureus mutants to tigecycline. Antimicrob Agents Chemother 2005; 49: 1865-1871.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1865-1871
-
-
McAleese, F.1
Peterson, P.2
Ruzin, A.3
-
75
-
-
33747410819
-
Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome
-
Guglierame P, Pasca MR, De Rossi E, et al. Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome. BMC Microbiol 2006; 6: 66.
-
(2006)
BMC Microbiol
, vol.6
, pp. 66
-
-
Guglierame, P.1
Pasca, M.R.2
De Rossi, E.3
-
76
-
-
0036619713
-
New development in tetracycline antibiotics: Glycylcyclines and tetracycline efflux pump inhibitors
-
Chopra I. New development in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors. Drug Resist Update 2002; 5: 119-125.
-
(2002)
Drug Resist Update
, vol.5
, pp. 119-125
-
-
Chopra, I.1
-
77
-
-
1242291834
-
Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B) and mef(A) mediated macrolide resistance
-
Farrell DJ, Morrissey I, Bakker S, Morris L, Buckridge S, Felmingham D. Molecular epidemiology of multiresistant Streptococcus pneumoniae with both erm(B) and mef(A) mediated macrolide resistance. J Clin Microbiol 2004; 42: 764-768.
-
(2004)
J Clin Microbiol
, vol.42
, pp. 764-768
-
-
Farrell, D.J.1
Morrissey, I.2
Bakker, S.3
Morris, L.4
Buckridge, S.5
Felmingham, D.6
-
78
-
-
65449168913
-
-
US20080076741
-
Glinka, T., Bostian, K., Lomvskaya, O., Surber, M., Sun, D.: US20080076741 (2008).
-
(2008)
-
-
Glinka, T.1
Bostian, K.2
Lomvskaya, O.3
Surber, M.4
Sun, D.5
-
79
-
-
0034454247
-
Mechanisms of action and resistance of older and newer fluoroquinolones
-
Hooper DC. Mechanisms of action and resistance of older and newer fluoroquinolones. Clin Inf Dis 2000; 31: S24-28.
-
(2000)
Clin Inf Dis
, vol.31
-
-
Hooper, D.C.1
-
80
-
-
65449173705
-
-
Comita-Prevoir, J., Cronin, M., Geng, B., Godfrey, A.A., Reck, F.: WO2008071961 (2008).
-
Comita-Prevoir, J., Cronin, M., Geng, B., Godfrey, A.A., Reck, F.: WO2008071961 (2008).
-
-
-
-
81
-
-
65449115842
-
-
US20070004712A1 2007
-
Selvakumar, N., Das, J., Trehan, S., Iqbal, J., Kumar, M.S., Rajagopalan, R., Rao, M.N.V.S.: US20070004712A1 (2007).
-
-
-
Selvakumar, N.1
Das, J.2
Trehan, S.3
Iqbal, J.4
Kumar, M.S.5
Rajagopalan, R.6
Rao, M.N.V.S.7
-
82
-
-
34447562686
-
Antibiotic efflux pumps in Gram negative bacteria: The inhibitory response strategy
-
Mahamoud A, Chevalier J, Libert-Franco S, Kern WV, Pages JM. Antibiotic efflux pumps in Gram negative bacteria: the inhibitory response strategy. J Antimicrob Chemother 2007; 59: 1223-1229.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 1223-1229
-
-
Mahamoud, A.1
Chevalier, J.2
Libert-Franco, S.3
Kern, W.V.4
Pages, J.M.5
-
83
-
-
33644499476
-
Practical applications and feasibility of efflux pump inhibitors in the clinic - A vision for applied use
-
Lomovskaya O, Bostian KA. Practical applications and feasibility of efflux pump inhibitors in the clinic - A vision for applied use. Biochem Pharmacol 2006; 71: 910-918.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 910-918
-
-
Lomovskaya, O.1
Bostian, K.A.2
-
84
-
-
33747154459
-
Multidrug-resistance efflux pumps - not just for resistance
-
Piddock LVJ. Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol 2006; 4: 629-636.
-
(2006)
Nat Rev Microbiol
, vol.4
, pp. 629-636
-
-
Piddock, L.V.J.1
-
85
-
-
0031764440
-
Porin alteration and active efflux: Two in vivo drug resistance strategies used by Enterobacter aerogenes
-
Mallea M, Chevalier J, Bornet C, et al. Porin alteration and active efflux: Two in vivo drug resistance strategies used by Enterobacter aerogenes. Microbiology 1998; 144: 3003-3009.
-
(1998)
Microbiology
, vol.144
, pp. 3003-3009
-
-
Mallea, M.1
Chevalier, J.2
Bornet, C.3
-
86
-
-
0030770318
-
The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in vitro susceptibilities of fluorquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin
-
Brenwald N, Gill M, Wise R. The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in vitro susceptibilities of fluorquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin. J Antimicrob Chemother 1997; 40: 458-460.
-
(1997)
J Antimicrob Chemother
, vol.40
, pp. 458-460
-
-
Brenwald, N.1
Gill, M.2
Wise, R.3
-
87
-
-
0033040998
-
Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus
-
Aeschlimann JR, Dresser LD, Kaatz GW, Rybak MJ. Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus. Antimicrob Agents Chemother 1999; 43: 335-340.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 335-340
-
-
Aeschlimann, J.R.1
Dresser, L.D.2
Kaatz, G.W.3
Rybak, M.J.4
-
88
-
-
0032445682
-
The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Sthapylococcus aureus
-
Schmitz F, Fluit A, Luckefahr M, et al. The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Sthapylococcus aureus. J Antimicrob Chemother 1998; 42: 807-810.
-
(1998)
J Antimicrob Chemother
, vol.42
, pp. 807-810
-
-
Schmitz, F.1
Fluit, A.2
Luckefahr, M.3
-
89
-
-
0034024754
-
The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant
-
Gibbons S, Udo EE. The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant. Phytother Res 2000; 14: 139-140.
-
(2000)
Phytother Res
, vol.14
, pp. 139-140
-
-
Gibbons, S.1
Udo, E.E.2
-
90
-
-
33847652171
-
Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of multidrug efflux pump NorA of Staphylococcus aureus
-
Vidaillac C, Guillon J, Arpin C, et al. Synthesis of omeprazole analogues and evaluation of these as potential inhibitors of multidrug efflux pump NorA of Staphylococcus aureus. Antimicrob Agents Chemother 2007; 51: 831-838.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 831-838
-
-
Vidaillac, C.1
Guillon, J.2
Arpin, C.3
-
91
-
-
0031057694
-
Inhibition of the transport function of membrane proteins by some substituted phenothiazines in Escherichia coli and multidrug resistant tumor cells
-
Molnar J, Hever A, Fakla I, Fisher J, Ocsovski I, Aszalos A. Inhibition of the transport function of membrane proteins by some substituted phenothiazines in Escherichia coli and multidrug resistant tumor cells. Anticancer Res 1997; 17: 481-486.
-
(1997)
Anticancer Res
, vol.17
, pp. 481-486
-
-
Molnar, J.1
Hever, A.2
Fakla, I.3
Fisher, J.4
Ocsovski, I.5
Aszalos, A.6
-
92
-
-
33748479692
-
Interaction of phenothiazines with lipid bilayer and their role in multidrug resistance reversal
-
Michalak K, Wesolowska O, Motohashi N, Molnar J, Hendrich AB. Interaction of phenothiazines with lipid bilayer and their role in multidrug resistance reversal. Curr Drug Targets 2006; 7: 1095-1105.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 1095-1105
-
-
Michalak, K.1
Wesolowska, O.2
Motohashi, N.3
Molnar, J.4
Hendrich, A.B.5
-
93
-
-
39149121434
-
Potential role of non-antibiotics (helper compounds) in treatment of multidrug-resistant gram-negative infections: Mechanisms for their direct and indirect activities
-
Martins M, Dastidar SG, Fanning S, et al. Potential role of non-antibiotics (helper compounds) in treatment of multidrug-resistant gram-negative infections: mechanisms for their direct and indirect activities. Int J Antimicrob Agents 2008; 31: 198-208.
-
(2008)
Int J Antimicrob Agents
, vol.31
, pp. 198-208
-
-
Martins, M.1
Dastidar, S.G.2
Fanning, S.3
-
94
-
-
33846572768
-
Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei
-
Chan YY, Ong YM, Chua KL. Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei. Antimicrob Agents Chemother 2007; 51: 623-630.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 623-630
-
-
Chan, Y.Y.1
Ong, Y.M.2
Chua, K.L.3
-
95
-
-
34249865621
-
Promethazine renders Escherichia coli susceptible to Penicillin G: Real-time measurement of bacterial susceptibility by fluoro-luminometry
-
Lehtinen J, Lilius EM. Promethazine renders Escherichia coli susceptible to Penicillin G: Real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents 2007; 30: 44-51.
-
(2007)
Int J Antimicrob Agents
, vol.30
, pp. 44-51
-
-
Lehtinen, J.1
Lilius, E.M.2
-
96
-
-
0035098674
-
Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines
-
Viveiros M, Amaral L. Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines. Int J Antimicrob Agents 2001; 17: 225-228.
-
(2001)
Int J Antimicrob Agents
, vol.17
, pp. 225-228
-
-
Viveiros, M.1
Amaral, L.2
-
98
-
-
0031863674
-
in vitro and in vivo Reversal of chloroquine resistance in Plasmodium falciparum with promethazine
-
Oduola A, Sowunmi A, Milhous W, et al. in vitro and in vivo Reversal of chloroquine resistance in Plasmodium falciparum with promethazine. Am J Trop Med Hyg 1998; 58: 625-629.
-
(1998)
Am J Trop Med Hyg
, vol.58
, pp. 625-629
-
-
Oduola, A.1
Sowunmi, A.2
Milhous, W.3
-
99
-
-
0034652383
-
Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor
-
Stermitz FR, Lorenz P, Tawara-Matsuda JN, Lorenz P, Muller P, Zenewicz LA. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. J Natl Acad Sci USA 2000; 97: 1433-1437.
-
(2000)
J Natl Acad Sci USA
, vol.97
, pp. 1433-1437
-
-
Stermitz, F.R.1
Lorenz, P.2
Tawara-Matsuda, J.N.3
Lorenz, P.4
Muller, P.5
Zenewicz, L.A.6
-
100
-
-
33847222712
-
N-Caffeoylphenalkylamide derivates as bacterial efflux pump inhibitors
-
Michalet S, Cartier G, David B, et al. N-Caffeoylphenalkylamide derivates as bacterial efflux pump inhibitors. Bioorg Med Chem Lett 2007; 17: 1755-1758.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1755-1758
-
-
Michalet, S.1
Cartier, G.2
David, B.3
-
101
-
-
2942615162
-
Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey
-
Hasdemir UO, Chevalier J, Nordmann P, Pages JM. Detection and prevalence of active drug efflux mechanism in various multidrug-resistant Klebsiella pneumoniae strains from Turkey. J Clin Microbiol 2004; 42: 2701-2706.
-
(2004)
J Clin Microbiol
, vol.42
, pp. 2701-2706
-
-
Hasdemir, U.O.1
Chevalier, J.2
Nordmann, P.3
Pages, J.M.4
-
102
-
-
0344717988
-
Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluorquinolone antibacterial levofloxacin
-
Renau TE, Leger R, Flamme EM, et al. Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluorquinolone antibacterial levofloxacin. J Med Chem 1999; 42: 4928-4931.
-
(1999)
J Med Chem
, vol.42
, pp. 4928-4931
-
-
Renau, T.E.1
Leger, R.2
Flamme, E.M.3
-
103
-
-
0034425544
-
High level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA
-
Mazzariol A, Tokue Y, Kanegawa TM, Cornaglia G, Nikaido H. High level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA. Antimicrob Agents Chemother 2000; 44: 3441:3443.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 3441-3443
-
-
Mazzariol, A.1
Tokue, Y.2
Kanegawa, T.M.3
Cornaglia, G.4
Nikaido, H.5
-
104
-
-
12244312498
-
The AcrB multidrug transporters plasy a major role in high-level fluorquinolone resistance in Salmonella enterica serovar thyphimurium phage typer DT 204
-
Baucheron S, Imberechts H, Chaslus-Dancla E, Cloeckaert A. The AcrB multidrug transporters plasy a major role in high-level fluorquinolone resistance in Salmonella enterica serovar thyphimurium phage typer DT 204. Microb Drug Resist 2002; 8: 281-289.
-
(2002)
Microb Drug Resist
, vol.8
, pp. 281-289
-
-
Baucheron, S.1
Imberechts, H.2
Chaslus-Dancla, E.3
Cloeckaert, A.4
-
105
-
-
0036078788
-
Inhibitors of antibiotic efflux pumps in resistant Enterobacter aerogenes strains
-
Mallèa M, Chevalier J, Eyraud A, Pagès JM. Inhibitors of antibiotic efflux pumps in resistant Enterobacter aerogenes strains. Biochem Biophys Res Commun 2002; 293: 1370-1373.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 1370-1373
-
-
Mallèa, M.1
Chevalier, J.2
Eyraud, A.3
Pagès, J.M.4
-
106
-
-
0035162640
-
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: Novel agents for combination therapy
-
Lomovskaya O, Warren MS, Lee A, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother 2001; 45: 105-116.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 105-116
-
-
Lomovskaya, O.1
Warren, M.S.2
Lee, A.3
-
107
-
-
1842830032
-
A multidrug efflux inhibitor reduces fluorquinolone resistance in Pseudomonas aeruginosa isolates
-
Coban AY, Ekinci AB, Durupinar B. A multidrug efflux inhibitor reduces fluorquinolone resistance in Pseudomonas aeruginosa isolates. Chemotherapy 2004; 50: 22-26.
-
(2004)
Chemotherapy
, vol.50
, pp. 22-26
-
-
Coban, A.Y.1
Ekinci, A.B.2
Durupinar, B.3
-
108
-
-
0041833328
-
A phenylalaninearginine beta-napthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides
-
Mamelli L, Amoros JP, Pajès JM, Bolla JM. A phenylalaninearginine beta-napthylamide sensitive multidrug efflux pump involved in intrinsic and acquired resistance of Campylobacter to macrolides. Int J Antimicrob Agents 2003; 22: 237-241.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 237-241
-
-
Mamelli, L.1
Amoros, J.P.2
Pajès, J.M.3
Bolla, J.M.4
-
109
-
-
0037060903
-
Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa
-
Renau TE, Leger R, Yen R, et al. Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa. Bioorg Med Chem Lett 2002; 12: 763-766.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 763-766
-
-
Renau, T.E.1
Leger, R.2
Yen, R.3
-
110
-
-
10744228144
-
The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors
-
Watkins WJ, Landaverry Y, Leger R, et al. The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors. Bioorg Med Chem Lett 2003; 13: 4241-4244.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4241-4244
-
-
Watkins, W.J.1
Landaverry, Y.2
Leger, R.3
-
111
-
-
34548828818
-
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate
-
Yoshida K, Nakayama K, Ohtsuka M, et al. MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate. Bioorg Med Chem 2007; 15: 7087-7097.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 7087-7097
-
-
Yoshida, K.1
Nakayama, K.2
Ohtsuka, M.3
-
112
-
-
44849104070
-
Citral derived amides as potent bacterial NorA efflux pump inhibitors
-
in press doi:10.1016/j.bmc.2008.05.030
-
Thota N, Koul S, Reddy MV, et al. Citral derived amides as potent bacterial NorA efflux pump inhibitors. Bioorg Med Chem 2008; (in press) doi:10.1016/j.bmc.2008.05.030.
-
(2008)
Bioorg Med Chem
-
-
Thota, N.1
Koul, S.2
Reddy, M.V.3
-
113
-
-
0347986616
-
Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates
-
Mallea M, Mahamoud A, Chevalier J, et al. Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates. Biochem J 2003; 376: 801-805.
-
(2003)
Biochem J
, vol.376
, pp. 801-805
-
-
Mallea, M.1
Mahamoud, A.2
Chevalier, J.3
-
114
-
-
1442300064
-
Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains
-
Chevalier J, Bredin J, Mahamaud A, Mallea M, Barbe J, Pages JM. Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains. Antimicrob Agents Chemother 2004; 48: 1043-1046.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1043-1046
-
-
Chevalier, J.1
Bredin, J.2
Mahamaud, A.3
Mallea, M.4
Barbe, J.5
Pages, J.M.6
-
115
-
-
33745737489
-
Quinolone derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes
-
Mahamoud A, Chevalier J, Davin-Regli A, Barbe J, Pagès JM. Quinolone derivatives as promising inhibitors of antibiotic efflux pump in multidrug resistant Enterobacter aerogenes. Curr Drugs Targets 2006; 7: 843-847.
-
(2006)
Curr Drugs Targets
, vol.7
, pp. 843-847
-
-
Mahamoud, A.1
Chevalier, J.2
Davin-Regli, A.3
Barbe, J.4
Pagès, J.M.5
-
116
-
-
4544265254
-
Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro Structure-activity relationships of (N-methyl-piperazynil)-containing derivatives
-
Watkins WJ, Lemoine RC, Chong L, et al. Quinazolinone fungal efflux pump inhibitors. Part 2: in vitro Structure-activity relationships of (N-methyl-piperazynil)-containing derivatives. Bioorg Med Chem Lett 2004; 14: 5133-5137.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 5133-5137
-
-
Watkins, W.J.1
Lemoine, R.C.2
Chong, L.3
-
117
-
-
54149101312
-
Synthesis and evaluation of fluoroquinolones derivatives as substrate-based inhibitors of bacterial efflux pumps
-
in press doi: 10.1016/ j.ejmc.2008.01.042
-
German N, Wei P, Kaatz GW, Kerns RJ. Synthesis and evaluation of fluoroquinolones derivatives as substrate-based inhibitors of bacterial efflux pumps. Eur J Med Chem 2008 (in press) doi: 10.1016/ j.ejmc.2008.01.042.
-
(2008)
Eur J Med Chem
-
-
German, N.1
Wei, P.2
Kaatz, G.W.3
Kerns, R.J.4
-
119
-
-
0042835371
-
Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus
-
Kaatz GW, Moudgal VV, Seo SM, Hansen JB, Kristiansen JE. Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus. Int J Antimicrob Agents 2003; 22: 254-261.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 254-261
-
-
Kaatz, G.W.1
Moudgal, V.V.2
Seo, S.M.3
Hansen, J.B.4
Kristiansen, J.E.5
-
120
-
-
39049137510
-
Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps
-
German N, Kaatz GW, Kerns RJ. Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps. Bioorg Med Chem Lett 2008; 18: 1368-1373.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 1368-1373
-
-
German, N.1
Kaatz, G.W.2
Kerns, R.J.3
-
121
-
-
31544441414
-
Effect of 1-(1-naphtylmethyl)-piperazine, a novel putative efflux pumps inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
-
Kern WV, Steinke P, Schumacher A, Schuster S, von Baum H, Bohnert JA. Effect of 1-(1-naphtylmethyl)-piperazine, a novel putative efflux pumps inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J Antimicrob Chem 2006; 57: 339-343.
-
(2006)
J Antimicrob Chem
, vol.57
, pp. 339-343
-
-
Kern, W.V.1
Steinke, P.2
Schumacher, A.3
Schuster, S.4
von Baum, H.5
Bohnert, J.A.6
-
123
-
-
33645828405
-
Multidrug efflux inhibition in Acinetobacter baumannii: Comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-β-naphtylamide
-
Pannek S, Higgins PG, Steinke P, et al. Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-β-naphtylamide. J Antimicrob Chemother 2006, 57: 970-974.
-
(2006)
J Antimicrob Chemother
, vol.57
, pp. 970-974
-
-
Pannek, S.1
Higgins, P.G.2
Steinke, P.3
-
126
-
-
34249022092
-
Synthesis and evalutation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of S. aureus
-
Fournier dit Chabert J, Marquez B, Neville L, et al. Synthesis and evalutation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transporter of S. aureus. J Biorg Med Chem 2007; 18: 4482-4497.
-
(2007)
J Biorg Med Chem
, vol.18
, pp. 4482-4497
-
-
Fournier dit Chabert, J.1
Marquez, B.2
Neville, L.3
-
127
-
-
0032871136
-
Multiple novel inhibitors of the NorA multidrug trasnporter of Staphylococcus aureus
-
Markham PN, Westhaus E, Klyachko K, Johnson ME, Neyfakh AA. Multiple novel inhibitors of the NorA multidrug trasnporter of Staphylococcus aureus. Antimicrob Agents Chemother 1999; 43: 2404-2408.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 2404-2408
-
-
Markham, P.N.1
Westhaus, E.2
Klyachko, K.3
Johnson, M.E.4
Neyfakh, A.A.5
-
128
-
-
47849111266
-
Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pumps in S. aureus
-
Ambrus JI, Kelso MJ, Bremner JB, Ball AR, Casadei G, Lewis K. Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pumps in S. aureus. Bioorg Med Chem Lett 2008; 18: 4294-4297.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 4294-4297
-
-
Ambrus, J.I.1
Kelso, M.J.2
Bremner, J.B.3
Ball, A.R.4
Casadei, G.5
Lewis, K.6
-
129
-
-
2542458523
-
Epigallocaechin-gallate enhances the activity of tetracyclines in staphylococci by inhibiting its efflux from bacterial cells
-
Sudeno Roccaro A, Blanco AR, Giuliano F, Rusciano D, Enea V. Epigallocaechin-gallate enhances the activity of tetracyclines in staphylococci by inhibiting its efflux from bacterial cells. Antimicrob Agents Chemother 2004; 48: 1968-1973.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 1968-1973
-
-
Sudeno Roccaro, A.1
Blanco, A.R.2
Giuliano, F.3
Rusciano, D.4
Enea, V.5
-
130
-
-
11944261504
-
Catechingallates inhibit multidrug resistance (MDR) in Staphylococcus aureus
-
Gibbons S, Moser E, Kaatz GW. Catechingallates inhibit multidrug resistance (MDR) in Staphylococcus aureus. Plante Med 2004; 70: 1240-1242.
-
(2004)
Plante Med
, vol.70
, pp. 1240-1242
-
-
Gibbons, S.1
Moser, E.2
Kaatz, G.W.3
-
131
-
-
0037259896
-
A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus
-
Gibbons S, Oluwatuyi M, Kaatz GW. A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus. J Antimicrob Chemother 2003; 51: 13-17.
-
(2003)
J Antimicrob Chemother
, vol.51
, pp. 13-17
-
-
Gibbons, S.1
Oluwatuyi, M.2
Kaatz, G.W.3
-
132
-
-
7244260438
-
Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853)
-
Mullin S, Mani N, Grossman TH. Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853). Antimicrob Agents Chemother 2004; 48: 4171-4176.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 4171-4176
-
-
Mullin, S.1
Mani, N.2
Grossman, T.H.3
-
134
-
-
33748670458
-
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
-
Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 2006; 443: 173-179.
-
(2006)
Nature
, vol.443
, pp. 173-179
-
-
Murakami, S.1
Nakashima, R.2
Yamashita, E.3
Matsumoto, T.4
Yamaguchi, A.5
-
135
-
-
52449109122
-
The AcrB efflux pump: Conformational cycling and peristalsis lead to multidrug resistance
-
Seeger MA, Diederichs K, Eicher T, et al. The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance. Curr Drug Targets 2008; 9: 729-749.
-
(2008)
Curr Drug Targets
, vol.9
, pp. 729-749
-
-
Seeger, M.A.1
Diederichs, K.2
Eicher, T.3
-
136
-
-
57949095949
-
Quantitative-structure-activity relationship (QSAR) of aryl alkenyl amides/imines for bacterial efflux pump inhibitors
-
in press doi: 10.1016/ejmche.2008.02.015
-
Nargotra A, Koul S, Sharma S, et al. Quantitative-structure-activity relationship (QSAR) of aryl alkenyl amides/imines for bacterial efflux pump inhibitors. Eur J Med Chem 2008 (in press) doi: 10.1016/ejmche.2008.02.015.
-
(2008)
Eur J Med Chem
-
-
Nargotra, A.1
Koul, S.2
Sharma, S.3
-
137
-
-
0027160409
-
Mutants of Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine
-
Ahmed M, Borsch C, Neyfakh A, Schuldner S. Mutants of Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine. J Biol Chem 1993; 268: 11086-11089.
-
(1993)
J Biol Chem
, vol.268
, pp. 11086-11089
-
-
Ahmed, M.1
Borsch, C.2
Neyfakh, A.3
Schuldner, S.4
-
138
-
-
0030949566
-
Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter BMR
-
Klyachko KA, Schuldiner S, Neyfakh AA. Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter BMR J Bacteriol 1997; 179: 2189-2193.
-
(1997)
J Bacteriol
, vol.179
, pp. 2189-2193
-
-
Klyachko, K.A.1
Schuldiner, S.2
Neyfakh, A.A.3
-
139
-
-
42949152261
-
The efflux pump inhibitor reserpine selects multidrug resistant S. pneumoniae strains that overexpress the ABC transporters PatA and PatB
-
Garvey MI, Piddock LSV. The efflux pump inhibitor reserpine selects multidrug resistant S. pneumoniae strains that overexpress the ABC transporters PatA and PatB. Antimicrob Agents Chemother 2008; 52: 1677-1685.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 1677-1685
-
-
Garvey, M.I.1
Piddock, L.S.V.2
|