Pyrazolo[4,3-c ][1,2]benzothiazines 5,5-dioxide: A promising new class of staphylococcus aureus NorA efflux pump inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3568-3572

  Sabatini, Stefano ^a   Gosetto, Francesca ^a   Serritella, Serena ^a   Manfroni, Giuseppe ^a   Tabarrini, Oriana ^a   Iraci, Nunzio ^a   Brincat, Jean Pierre ^a   Carosati, Emanuele ^a   Villarini, Milena ^a   Kaatz, Glenn W ^b   Cecchetti, Violetta ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 CHLOROPHENYL) 1 (4 NITROPHENYL) 1,4 DIHYDROPYRAZOLO[4,3 C][1,2]BENZOTHIAZINE 5,5 DIOXIDE; ANTIBIOTIC AGENT; CELECOXIB; MULTIDRUG RESISTANCE PROTEIN; NORA PROTEIN; PAROXETINE; PYRAZOLO[4,3 C][1,2]BENZOTHIAZINE 5,5 DIOXIDE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RESERPINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYCLOOXYGENASE 2 INHIBITORS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG SYNERGISM; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PYRAZOLES; SMALL MOLECULE LIBRARIES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZINES;

EID: 84859790955     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201446h     Document Type: Article

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