Use of comparative genomics approaches to characterize interspecies differences in response to environmental chemicals: Challenges, opportunities, and research needs

Toxicology and Applied Pharmacology

Volumn 271, Issue 3, 2013, Pages 372-385

  Burgess Herbert, Sarah L ^a   Euling, Susan Y ^b  

^a AAAS   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

omics; Biological pathway; Cross species; Human health risk assessment; Molecular network; Selective constraints; Systems biology

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; COUMARIN; ENVIRONMENTAL CHEMICAL; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; XENOBIOTIC AGENT;

BIOINFORMATICS; BIOLOGICAL MODEL; COMPUTER MODEL; ENVIRONMENTAL EXPOSURE; GENOMICS; HEALTH HAZARD; HUMAN; MATHEMATICAL MODEL; NONHUMAN; REVIEW; RISK ASSESSMENT; SPECIES DIFFERENCE; SYSTEMS BIOLOGY; TOXICOGENETICS;

-OMICS; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE 2 (MITOCHONDRIAL); ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION; ADME; AHR; APAP; ARYL HYDROCARBON RECEPTOR; BIOLOGICAL PATHWAY; CROSS-SPECIES; DBP; DEOXYRIBONUCLEIC ACID; DIBUTYL PHTHALATE; DIOXIN RESPONSE ELEMENT; DNA; DRE; EGBE; ENVIRONMENTAL PROTECTION AGENCY; EPA; ETHYLENE GLYCOL MONOBUTYL ETHER; HMGCS2; HUMAN HEALTH RISK ASSESSMENT; INTEGRATED RISK INFORMATION SYSTEM; IRIS; JUN; JUN PROTO-ONCOGENE; LOAEL; LOWEST-OBSERVED-ADVERSE-EFFECT-LEVEL; MOA; MODE OF ACTION; MOLECULAR NETWORK; MYC; MYELOCYTOMATOSIS ONCOGENE; N-ACETYL-P-AMINOPHENOL; NATIONAL RESEARCH COUNCIL; NO-OBSERVED-ADVERSE-EFFECT-LEVEL; NOAEL; NRC; PERCENT IDENTITY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PID; PPARΑ; PREGNANE X RECEPTOR; PXR; REFERENCE CONCENTRATION; REFERENCE DOSE; RFC; RFD; RIBONUCLEIC ACID; RNA; SELECTIVE CONSTRAINTS; SYSTEMS BIOLOGY; TCDD; TD; TK; TOXICODYNAMIC; TOXICOKINETIC;

ANIMALS; ENVIRONMENTAL POLLUTANTS; GENOMICS; HUMANS; RISK ASSESSMENT;

EID: 84883743254     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.11.011     Document Type: Review

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