Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity

Genome Research

Volumn 15, Issue 7, 2005, Pages 978-986

  Stone, Eric A ^a,b   Sidow, Arend ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; AMINO ACID SEQUENCE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EVOLUTION; HUMAN; MISSENSE MUTATION; ORTHOLOGY; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS;

ALGORITHMS; AMINO ACID SUBSTITUTION; ANEMIA; EVOLUTION, MOLECULAR; GENETIC TECHNIQUES; HEMOGLOBINS; HIV INFECTIONS; HIV PROTEASE; HUMANS; MULTIVARIATE ANALYSIS; MUTATION, MISSENSE; NEOPLASMS; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 22244437614     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.3804205     Document Type: Article

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