Telomere length in reproduction

Andrologia

Volumn 45, Issue 5, 2013, Pages 289-304

  Thilagavathi, J ^a   Venkatesh, S ^a   Dada, R ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Oxidative stress and infertility; Reproduction; Telomere length; Telomere binding proteins

Indexed keywords

ATM PROTEIN; MISMATCH REPAIR PROTEIN; PROTECTION OF TELOMERE 1; PROTEIN; REPRESSOR ACTIVATOR PROTEIN; TANKYRASE; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; TATA BINDING PROTEIN RELATED FACTOR; TBPL1 PROTEIN, HUMAN;

AGING; ANEUPLOIDY; CELL ELONGATION; DIET; ENVIRONMENTAL FACTOR; EXERCISE; HEREDITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIFESTYLE MODIFICATION; MATERNAL STRESS; MENTAL STRESS; NONHUMAN; OBESITY; PACHYTENE; REPRESSOR GENE; REPRODUCTION; REVIEW; SENESCENCE; SMOKING; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; FEMALE; GENETICS; MALE; PHYSIOLOGY; TELOMERE; ULTRASTRUCTURE;

FEMALE; HUMANS; MALE; REPRODUCTION; SPERMATOGENESIS; SPERMATOZOA; TATA BOX BINDING PROTEIN-LIKE PROTEINS; TELOMERE;

EID: 84883427237     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12008     Document Type: Review

References (153)

1. Achi MV, Ravindranath N, Dym M (2000) Telomere length in male germ cells is inversely correlated with telomerase activity. Biol Reprod 63:591-598.
2. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114-10118.
3. Ancelin K, Brunori M, Bauwens S, Koering CE, Brun C, Ricoul M, Pommier JP, Sabatier L, Gilson E (2002) Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol 22:3474-3487.
4. Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y (2010) Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci USA 107(Suppl 1):1710-1717.
5. Autexier C, Greider CW (1996) Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem Sci 21:387-391.
6. Aviv A (2004) Telomeres and human aging: facts and fibs. Sci Aging Knowledge Environ 2004:pe43.
7. Aydos SE, Elhan AH, Tukun A (2005) Is telomere length one of the determinants of reproductive life span? Arch Gynecol Obstet 272:113-116.
8. Baird DM, Britt-Compton B, Rowson J, Amso NN, Gregory L, Kipling D (2006) Telomere instability in the male germline. Hum Mol Genet 15:45-51.
9. Barlow AL, Hulten MA (1996) Combined immunocytogenetic and molecular cytogenetic analysis of meiosis I human spermatocytes. Chromosome Res 4:562-573.
10. Benard C, McCright B, Zhang Y, Felkai S, Lakowski B, Hekimi S (2001) The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 128:4045-4055.
11. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A (2001) Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37:381-385.
12. Benetti R, Schoeftner S, Munoz P, Blasco MA (2008) Role of TRF2 in the assembly of telomeric chromatin. Cell Cycle 7:3461-3468.
13. Bianchi A, Smith S, Chong L, Elias P, de Lange T (1997) TRF1 is a dimer and bends telomeric DNA. EMBO J 16:1785-1794.
14. Bianchi A, Stansel RM, Fairall L, Griffith JD, Rhodes D, de Lange T (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J 18:5735-5744.
15. Bilaud T, Brun C, Ancelin K, Koering CE, Laroche T, Gilson E (1997) Telomeric localization of TRF2, a novel human telobox protein. Nat Genet 17:236-239.
16. Biron-Shental T, Sukenik Halevy R, Goldberg-Bittman L, Kidron D, Fejgin MD, Amiel A (2010) Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR). Early Hum Dev 86:451-456.
17. Blasco MA (2005) Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J 24:1095-1103.
18. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
19. Borras M, Panizo S, Sarro F, Valdivielso JM, Fernandez E (2012) Assessment of the potential role of active vitamin D treatment in telomere length: a case-control study in hemodialysis patients. Clin Ther 34:849-856.
20. Broccoli D, Smogorzewska A, Chong L, de Lange T (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 17:231-235.
21. Butts S, Riethman H, Ratcliffe S, Shaunik A, Coutifaris C, Barnhart K (2009) Correlation of telomere length and telomerase activity with occult ovarian insufficiency. J Clin Endocrinol Metab 94:4835-4843.
22. Calado RT, Regal JA, Hills M, Yewdell WT, Dalmazzo LF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EH, Falcao RP, Young NS (2009) Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci USA 106:1187-1192.
23. Campbell PJ (2012) Telomeres and cancer: from crisis to stability to crisis to stability. Cell 148:633-635.
24. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res 30:e47.
25. Chan R, Woo J, Suen E, Leung J, Tang N (2010) Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br J Nutr 103:107-113.
26. Cherif H, Tarry JL, Ozanne SE, Hales CN (2003) Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res 31:1576-1583.
27. Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, Surdulescu GL, Kimura M, Lu X, Spector TD, Aviv A (2008) The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med 168:154-158.
28. Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ (2004) Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Mol Cell Biol 24:7024-7031.
29. Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ (2008) Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS ONE 3:e2639.
30. Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Mateo Leach I, de Boer RA, Kimura M, Aviv A; Wellcome Trust Case Control Consortium, Goodall AH, Ouwehand W, van Veldhuisen DJ, van Gilst WH, Navis G, Burton PR, Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ (2010) Common variants near TERC are associated with mean telomere length. Nat Genet 42:197-199.
31. Cook BD, Dynek JN, Chang W, Shostak G, Smith S (2002) Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol 22:332-342.
32. Cooke HJ, Smith BA (1986) Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb Symp Quant Biol 51(Pt 1):213-219.
33. Cross JA, Temple RC, Hughes JC, Dozio NC, Brennan C, Stanley K, Murphy HR, Fowler D, Hughes DA, Sampson MJ (2010) Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes. Diabet Med 27:1264-1270.
34. Dandona P, Aljada A, Bandyopadhyay A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25:4-7.
35. Deluca HF, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15:2579-2585.
36. Demerath EW, Cameron N, Gillman MW, Towne B, Siervogel RM (2004) Telomeres and telomerase in the fetal origins of cardiovascular disease: a review. Hum Biol 76:127-146.
37. Dorland M, van Montfrans JM, van Kooij RJ, Lambalk CB, te Velde ER (1998) Normal telomere lengths in young mothers of children with Down's syndrome. Lancet 352:961-962.
38. Du M, Prescott J, Kraft P, Han J, Giovannucci E, Hankinson SE, De Vivo I (2012) Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol 175:414-422.
39. Eisenberg DT (2011) An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Hum Biol 23:149-167.
40. Eisenhauer KM, Gerstein RM, Chiu CP, Conti M, Hsueh AJ (1997) Telomerase activity in female and male rat germ cells undergoing meiosis and in early embryos. Biol Reprod 56:1120-1125.
41. Entringer S, Epel ES, Kumsta R, Lin J, Hellhammer DH, Blackburn EH, Wust S, Wadhwa PD (2011) Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci USA 108:E513-E518.
42. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 101:17312-17315.
43. Friedrich U, Griese E, Schwab M, Fritz P, Thon K, Klotz U (2000) Telomere length in different tissues of elderly patients. Mech Ageing Dev 119:89-99.
44. Fujisawa M, Tanaka H, Tatsumi N, Okada H, Arakawa S, Kamidono S (1998) Telomerase activity in the testis of infertile patients with selected causes. Hum Reprod 13:1476-1479.
45. Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N (1998) Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63:935-948.
46. Gasser SM (2000) A sense of the end. Science 288:1377-1379.
47. Hanna CW, Bretherick KL, Gair JL, Fluker MR, Stephenson MD, Robinson WP (2009) Telomere length and reproductive aging. Hum Reprod 24:1206-1211.
48. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
49. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866-868.
50. Haussmann MF, Winkler DW, Huntington CE, Nisbet IC, Vleck CM (2007) Telomerase activity is maintained throughout the lifespan of long-lived birds. Exp Gerontol 42:610-618.
51. Haussmann MF, Winkler DW, O'Reilly KM, Huntington CE, Nisbet IC, Vleck CM (2003) Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones. Proc Biol Sci 270:1387-1392.
52. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P (2012) Telomere length in early life predicts lifespan. Proc Natl Acad Sci USA 109:1743-1748.
53. Henle ES, Han Z, Tang N, Rai P, Luo Y, Linn S (1999) Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications. J Biol Chem 274:962-971.
54. Hockemeyer D, Daniels JP, Takai H, de Lange T (2006) Recent expansion of the telomeric complex in rodents: two distinct POT1 proteins protect mouse telomeres. Cell 126:63-77.
55. Holt SE, Shay JW (1999) Role of telomerase in cellular proliferation and cancer. J Cell Physiol 180:10-18.
56. Hou L, Zhang X, Gawron AJ, Liu J (2012) Surrogate tissue telomere length and cancer risk: shorter or longer? Cancer Lett 319:130-135.
57. Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ (2008) Telomere length assessment: biomarker of chronic oxidative stress? Free Radic Biol Med 44:235-246.
58. Hsiao SJ, Poitras MF, Cook BD, Liu Y, Smith S (2006) Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol 26:2044-2054.
59. Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, Li GC, Campisi J, Kohwi-Shigematsu T, Chen DJ (2000) Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 14:2807-2812.
60. Huang J, Okuka M, McLean M, Keefe DL, Liu L (2010) Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro. Free Radic Biol Med 48:1663-1676.
61. Hunt SC, Chen W, Gardner JP, Kimura M, Srinivasan SR, Eckfeldt JH, Berenson GS, Aviv A (2008) Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study. Aging Cell 7:451-458.
62. Jeon HS, Choi JE, Jung DK, Choi YY, Kang HG, Lee WK, Yoo SS, Lim JO, Park JY (2012) Telomerase activity and the risk of lung cancer. J Korean Med Sci 27:141-145.
63. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (2003) Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation. J Biol Chem 278:21678-21684.
64. Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P, Campisi J (2001) TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem 276:35891-35899.
65. Kark JD, Goldberger N, Kimura M, Sinnreich R, Aviv A (2012) Energy intake and leukocyte telomere length in young adults. Am J Clin Nutr 95:479-487.
66. Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999) p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325.
67. Karlseder J, Kachatrian L, Takai H, Mercer K, Hingorani S, Jacks T, de Lange T (2003) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol 23:6533-6541.
68. Kawanishi S, Oikawa S (2004) Mechanism of telomere shortening by oxidative stress. Ann N Y Acad Sci 1019:278-284.
69. Keefe DL, Franco S, Liu L, Trimarchi J, Cao B, Weitzen S, Agarwal S, Blasco MA (2005) Telomere length predicts embryo fragmentation after in vitro fertilization in women-toward a telomere theory of reproductive aging in women. Am J Obstet Gynecol 192:1256-1260.
70. Keefe DL, Marquard K, Liu L (2006) The telomere theory of reproductive senescence in women. Curr Opin Obstet Gynecol 18:280-285.
71. Keefe DL, Liu L, Marquard K (2007) Telomeres and aging-related meiotic dysfunction in women. Cell Mol Life Sci 64:139-143.
72. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
73. Kim S, Parks CG, DeRoo LA, Chen H, Taylor JA, Cawthon RM, Sandler DP (2009) Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomarkers Prev 18:816-820.
74. Kipling D, Cooke HJ (1990) Hypervariable ultra-long telomeres in mice. Nature 347:400-402.
75. Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276:29282-29291.
76. Kotrschal A, Ilmonen P, Penn DJ (2007) Stress impacts telomere dynamics. Biol Lett 3:128-130.
77. Kozik A, Bradbury EM, Zalensky A (1998) Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays. Mol Reprod Dev 51:98-104.
78. Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW (2008) Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol 73:513-522.
79. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M (1999) Estrogen activates telomerase. Cancer Res 59:5917-5921.
80. Liu L, Blasco M, Trimarchi J, Keefe D (2002) An essential role for functional telomeres in mouse germ cells during fertilization and early development. Dev Biol 249:74-84.
81. Liu L, Franco S, Spyropoulos B, Moens PB, Blasco MA, Keefe DL (2004) Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci USA 101:6496-6501.
82. Liu L, Bailey SM, Okuka M, Munoz P, Li C, Zhou L, Wu C, Czerwiec E, Sandler L, Seyfang A, Blasco MA, Keefe DL (2007) Telomere lengthening early in development. Nat Cell Biol 9:1436-1441.
83. Longhese MP, Anbalagan S, Martina M, Bonetti D (2012) The role of shelterin in maintaining telomere integrity. Front Biosci 17:1715-1728.
84. Ludlow AT, Zimmerman JB, Witkowski S, Hearn JW, Hatfield BD, Roth SM (2008) Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc 40:1764-1771.
85. Maser RS, DePinho RA (2002) Connecting chromosomes, crisis, and cancer. Science 297:565-569.
86. Mathieu C, Decallonne B, van Etten E (2002) 1, 25-dihydroxyvitamin D3: the endocrine system meets the immune system. Verh K Acad Geneeskd Belg 64:71-80.
87. McGrath M, Wong JY, Michaud D, Hunter DJ, De Vivo I (2007) Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev 16:815-819.
88. Meyer-Ficca ML, Lonchar J, Credidio C, Ihara M, Li Y, Wang ZQ, Meyer RG (2009) Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod 81:46-55.
89. Meyerson M (2000) Role of telomerase in normal and cancer cells. J Clin Oncol 18:2626-2634.
90. Mirabello L, Yu K, Kraft P, De Vivo I, Hunter DJ, Prescott J, Wong JY, Chatterjee N, Hayes RB, Savage SA (2010) The association of telomere length and genetic variation in telomere biology genes. Hum Mutat 31:1050-1058.
91. Mitchell JR, Wood E, Collins K (1999) A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402:551-555.
92. Moreno-Navarrete JM, Ortega F, Sabater M, Ricart W, Fernandez-Real JM (2010) Telomere length of subcutaneous adipose tissue cells is shorter in obese and formerly obese subjects. Int J Obes (Lond) 34:1345-1348.
93. Morla M, Busquets X, Pons J, Sauleda J, MacNee W, Agusti AG (2006) Telomere shortening in smokers with and without COPD. Eur Respir J 27:525-528.
94. Moskovtsev SI, Willis J, White J, Mullen JB (2010) Disruption of telomere-telomere interactions associated with DNA damage in human spermatozoa. Syst Biol Reprod Med 56:407-412.
95. Muller HJ (1938) The remaking of chromosomes. Collecting Net 13:181-198.
96. Munoz P, Blanco R, Blasco MA (2006) Role of the TRF2 telomeric protein in cancer and ageing. Cell Cycle 5:718-721.
97. Nagpal S, Na S, Rathnachalam R (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26:662-687.
98. Nasir L, Devlin P, McKevitt T, Rutteman G, Argyle DJ (2001) Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. Neoplasia 3:351-359.
99. Nawrot TS, Staessen JA, Gardner JP, Aviv A (2004) Telomere length and possible link to X chromosome. Lancet 363:507-510.
100. Njajou OT, Cawthon RM, Blackburn EH, Harris TB, Li R, Sanders JL, Newman AB, Nalls M, Cummings SR, Hsueh WC (2012) Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes (Lond). 36:1176-1179.
101. Oikawa S, Kawanishi S (1999) Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 453:365-368.
102. Oikawa S, Tada-Oikawa S, Kawanishi S (2001) Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening. Biochemistry 40:4763-4768.
103. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, Skurnick J, Awad G, Aviv A (2002) Telomere length in the newborn. Pediatr Res 52:377-381.
104. Ongradi J, Kovesdi V (2010) Factors that may impact on immunosenescence: an appraisal. Immun Ageing 7:7.
105. Pardo B, Marcand S (2005) Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J 24:3117-3127.
106. Parks CG, Miller DB, McCanlies EC, Cawthon RM, Andrew ME, DeRoo LA, Sandler DP (2009) Telomere length, current perceived stress, and urinary stress hormones in women. Cancer Epidemiol Biomarkers Prev 18:551-560.
107. Petersen S, Saretzki G, von Zglinicki T (1998) Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239:152-160.
108. Pickett HA, Reddel RR (2012) The role of telomere trimming in normal telomere length dynamics. Cell Cycle 11:1309-1315.
109. Poulet A, Pisano S, Faivre-Moskalenko C, Pei B, Tauran Y, Haftek-Terreau Z, Brunet F, Le Bihan YV, Ledu MH, Montel F, Hugo N, Amiard S, Argoul F, Chaboud A, Gilson E, Giraud-Panis MJ (2011) The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA. Nucleic Acids Res 40:2566-2576.
110. Powell D, Cran DG, Jennings C, Jones R (1990) Spatial organization of repetitive DNA sequences in the bovine sperm nucleus. J Cell Sci 97(Pt 1):185-191.
111. Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, Epel E (2010) The power of exercise: buffering the effect of chronic stress on telomere length. PLoS ONE 5:e10837.
112. Rhee DB, Ghosh A, Lu J, Bohr VA, Liu Y (2011) Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) 10:34-44.
113. Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A (2007) Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr 86:1420-1425.
114. Rodriguez S, Goyanes V, Segrelles E, Blasco M, Gosalvez J, Fernandez JL (2005) Critically short telomeres are associated with sperm DNA fragmentation. Fertil Steril 84:843-845.
115. Rodriguez-Brenes IA, Peskin CS (2010) Quantitative theory of telomere length regulation and cellular senescence. Proc Natl Acad Sci USA 107:5387-5392.
116. Ruiz-Larrea MB, Leal AM, Martin C, Martinez R, Lacort M (1997) Antioxidant action of estrogens in rat hepatocytes. Rev Esp Fisiol 53:225-229.
117. Samassekou O, Gadji M, Drouin R, Yan J (2010) Sizing the ends: normal length of human telomeres. Ann Anat 192:284-291.
118. Santiso R, Tamayo M, Gosalvez J, Meseguer M, Garrido N, Fernandez JL (2010) Swim-up procedure selects spermatozoa with longer telomere length. Mutat Res 688:88-90.
119. Sato D, Kaneda K, Wakabayashi H, Nomura T (2007) The water exercise improves health-related quality of life of frail elderly people at day service facility. Qual Life Res 16:1577-1585.
120. Savela S, Saijonmaa O, Strandberg TE, Koistinen P, Strandberg AY, Tilvis RS, Pitkala KH, Miettinen TA, Fyhrquist F (2013) Physical activity in midlife and telomere length measured in old age. Exp Gerontol 48:81-84
121. Schaetzlein S, Lucas-Hahn A, Lemme E, Kues WA, Dorsch M, Manns MP, Niemann H, Rudolph KL (2004) Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci USA 101:8034-8038.
122. Scherthan H, Weich S, Schwegler H, Heyting C, Harle M, Cremer T (1996) Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J Cell Biol 134:1109-1125.
123. Senthilkumar PK, Robertson LW, Ludewig G (2012) PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol 259:115-123.
124. Shay JW, Bacchetti S (1997) A survey of telomerase activity in human cancer. Eur J Cancer 33:787-791.
125. Shen Q, Zhang Z, Yu L, Cao L, Zhou D, Kan M, Li B, Zhang D, He L, Liu Y (2011) Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population. Eur J Hum Genet 19:721-723.
126. Siderakis M, Tarsounas M (2007) Telomere regulation and function during meiosis. Chromosome Res 15:667-679.
127. Sitte N, Saretzki G, von Zglinicki T (1998) Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic Biol Med 24:885-893.
128. Slagboom PE, Droog S, Boomsma DI (1994) Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet 55:876-882.
129. Smith S, Giriat I, Schmitt A, de Lange T (1998) Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484-1487.
130. Smogorzewska A, de Lange T (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J 21:4338-4348.
131. Smogorzewska A, de Lange T (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208.
132. Starling JA, Maule J, Hastie ND, Allshire RC (1990) Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res 18:6881-6888.
133. Tarry-Adkins JL, Chen JH, Smith NS, Jones RH, Cherif H, Ozanne SE (2009) Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets. FASEB J 23:1521-1528.
134. Treff NR, Su J, Taylor D, Scott RT Jr (2011) Telomere DNA deficiency is associated with development of human embryonic aneuploidy. PLoS Genet 7:e1002161.
135. Tremellen K (2008) Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update 14:243-258.
136. Tsang AR, Wyatt HD, Ting NS, Beattie TL (2012) hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms. Aging Cell 11:482-490.
137. Turner S, Wong HP, Rai J, Hartshorne GM (2010) Telomere lengths in human oocytes, cleavage stage embryos and blastocysts. Mol Hum Reprod 16:685-694.
138. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD (2005) Obesity, cigarette smoking, and telomere length in women. Lancet 366:662-664.
139. van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92:401-413.
140. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM (1994) Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 91:9857-9860.
141. Venkatesh S, Kumar M, Sharma A, Kriplani A, Ammini AC, Talwar P, Agarwal A, Dada R (2010) Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency. Arch Gynecol Obstet 282:313-318.
142. Vina J, Borras C, Gambini J, Sastre J, Pallardo FV (2005) Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. FEBS Lett 579:2541-2545.
143. Vincent HK, Morgan JW, Vincent KR (2004) Obesity exacerbates oxidative stress levels after acute exercise. Med Sci Sports Exerc 36:772-779.
144. Wahl GM, Carr AM (2001) The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol 3:E277-E286.
145. Walmsley RM, Petes TD (1985) Genetic control of chromosome length in yeast. Proc Natl Acad Sci USA 82:506-510.
146. Wang Z, Rhee DB, Lu J, Bohr CT, Zhou F, Vallabhaneni H, de Souza-Pinto NC, Liu Y (2010) Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet 6:e1000951.
147. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW (1996) Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 18:173-179.
148. Wright DL, Jones EL, Mayer JF, Oehninger S, Gibbons WE, Lanzendorf SE (2001) Characterization of telomerase activity in the human oocyte and preimplantation embryo. Mol Hum Reprod 7:947-955.
149. Zalenskaya IA, Bradbury EM, Zalensky AO (2000) Chromatin structure of telomere domain in human sperm. Biochem Biophys Res Commun 279:213-218.
150. Zalensky AO, Allen MJ, Kobayashi A, Zalenskaya IA, Balhorn R, Bradbury EM (1995) Well-defined genome architecture in the human sperm nucleus. Chromosoma 103:577-590.
151. Zalensky AO, Tomilin NV, Zalenskaya IA, Teplitz RL, Bradbury EM (1997) Telomere-telomere interactions and candidate telomere binding protein(s) in mammalian sperm cells. Exp Cell Res 232:29-41.
152. von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27:339-344.
153. Zhou J, Shen X, Huang J, Hodes RJ, Rosenberg SA, Robbins PF (2005) Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J Immunol 175:7046-7052.