Telomere shortening in smokers with and without COPD

European Respiratory Journal

Volumn 27, Issue 3, 2006, Pages 525-528

  Morla M ^a   Busquets, X ^a   Pons, J ^a   Sauleda, J ^a   MacNee, W ^b   Agusti A G N ^a  

^a HOSPITAL UNIVERSITARIO SON ESPASES   (Spain)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Ageing; Chronic bronchitis; Emphysema; Inflammation; Repair; Tobacco

Indexed keywords

ADULT; AIRWAY OBSTRUCTION; ARTICLE; CHROMOSOME SIZE; CHRONIC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FORCED EXPIRATORY FLOW; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; LUNG FUNCTION; LYMPHOCYTE; MALE; PRIORITY JOURNAL; SPIROMETRY; TELOMERE; TOBACCO;

ADULT; AGE FACTORS; AGED; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; TELOMERE;

EID: 33644861968     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.06.00087005     Document Type: Article

References (13)

1. Celli BR, MacNee W, Agusti AG, et al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23: 932-946.
2. Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005; 366: 662-664.
3. Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci USA 1998; 95: 5607-5610.
4. Rufer N, Brummendorf TH, Kolvraa S, et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Fxp Med 1999; 190: 157-167.
5. Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 2004; 101: 17312-17315.
6. American Thoracic Society Official Statement. Standardization of spirometry. 1994 update. Am J Respir Crit Care Med 1995; 152: 1107-1136.
7. Roca J, Sanchis J, Agustí-Vidal A, et al. Spirometric reference values for a mediterranean population. Bull Eur Physiopathol Respir 1986; 22: 217-224.
8. van Eeden SF, Yeung AC, Quinlam K, Hogg JC. Systemic response to ambient particulate matter. Relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005; 2: 61-67.
9. Agusti AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 2003; 21: 347-360.
10. van der Vaart H, Postma DS, Timens W, ten Hacken NH. Acute effects of cigarette smoke on inflammation and oxidative stress: a review. Thorax 2004; 59: 713-721.
11. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
12. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 2000; 35: 927-945.
13. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet 2001; 358: 472-473.