PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK)

Toxicology and Applied Pharmacology

Volumn 259, Issue 1, 2012, Pages 115-123

  Senthilkumar, P K ^a   Robertson, L W ^a   Ludewig, G ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Cell growth; Polychlorinated biphenyls (PCBs); Skin keratinocytes; Superoxide; Telomerase; Telomere

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TELOMERASE;

ARTICLE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL IMMORTALIZATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPOTHESIS; INCUBATION TIME; KERATINOCYTE; PREPUCE; TELOMERE;

CELL CULTURE TECHNIQUES; CELL CYCLE; CELL LINE; CELL SURVIVAL; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; ENZYME ACTIVATION; FORESKIN; HUMANS; KERATINOCYTES; MALE; OXIDATIVE STRESS; POLYCHLORINATED BIPHENYLS; SUPEROXIDES; TELOMERASE; TELOMERE SHORTENING;

EID: 84857110702     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.12.015     Document Type: Article

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