Critically short telomeres are associated with sperm DNA fragmentation

Fertility and Sterility

Volumn 84, Issue 4, 2005, Pages 843-845

  Rodríguez, Silvia ^a   Goyanes, Vicente ^a,b   Segrelles, Enrique ^b   Blasco, María ^c   Gosálvez, Jaime ^d   Fernández, José Luis ^a,b  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b ARGGORA Unidad de la Mujer   (Spain)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

DNA fragmentation; Sperm; Telomeres

Indexed keywords

DNA FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CHROMOSOME; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; DNA REPLICATION; DNA STRAND BREAKAGE; KNOCKOUT MOUSE; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERTOLI CELL; SPERM; SPERMATOCYTE; SPERMATOGENESIS; TELOMERE; TESTIS ATROPHY;

ANIMALS; DNA FRAGMENTATION; GENETIC TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPERMATOZOA; TELOMERE;

EID: 26244461612     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.05.014     Document Type: Article

References (14)

1. A. Agarwal, T.M. Said Role of sperm chromatin abnormalities and DNA damage in male infertility Hum Reprod Update 9 2003 331 345
2. D.P. Evenson, K.J. Larson, L.K. Jost Sperm chromatin structure assay its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques J Androl 23 2002 25 43
3. D. Sakkas, G.C. Manicardi, D. Bizzaro Sperm nuclear damage in the human B. Robaire B.F. Hales Advances in male mediated developmental toxicity 2003 Kluwer Academic/Plenum Publishers New York 73 84
4. S.E. Artandi, R.A. DePinho A critical role for telomeres in suppressing and facilitating carcinogenesis Curr Opin Genet Dev 10 2000 39 46
5. M.A. Blasco Mammalian telomeres and telomerase why they matter for cancer and ageing Eur J Cell Biol 82 2003 441 446
6. E. Herrera, E. Samper, J. Martín-Caballero, J.M. Flores, H. Lee, M.A. Blasco Disease states associated with telomerase deficiency appear earlier in mice with short telomeres EMBO J 18 1999 2950 2960
7. M.T. Hemann, K.L. Rudolph, M.A. Strong, R.A. DePinho, L. Chin, C.W. Greider Telomere dysfunction triggers developmentally regulated germ cell apoptosis Mol Cell Biol 12 2001 2023 2030
8. J.L. Fernández, M. Lourdes, V.J. Goyanes, E. Segrelles, J. Gosálvez, M. Enciso Simple determination of sperm DNA fragmentation with an improved sperm chromatin dispersion test [abstract] Fertil Steril 84 2005 833 842
9. M. Vasquez, R.R. Tice Comparative analysis of apoptosis versus necrosis using the single cell gel (SCG) assay [abstract] Environ Mol Mutagen 29 suppl 28 1997 53
10. L. Liu, M. Blasco, J. Trimarchi, D. Keefe An essential role for functional telomeres in mouse germ cells during fertilization and early development Dev Biol 249 2002 74 84
11. A.J. Ross, K.G. Waymire, J.E. Moss, A.F. Parlow, M.K. Skinner, L.D. Russel Testicular degeneration in Bclw-deficient mice Nature Genet 18 1998 251 256
12. L. Marcon, G. Boissonneault Transient DNA strand breaks during mouse and human spermiogenesis new insights in stage specificity and link to chromatin remodeling Biol Reprod 70 2004 910 918
13. S.R. Lai, S.M. Phipps, L. Liu, L.G. Andrews, T.O. Tollefsboll Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems Front Biosci 10 2005 1779 1796
14. M.V. Achi, N. Ravindranath, N. Dym Telomere length in male germ cells is inversely correlated with telomerase activity Biol Reprod 63 2000 591 598