Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 7046-7052

  Zhou, Juhua ^a   Shen, Xinglei ^a   Huang, Jianping ^a   Hodes, Richard J ^a   Rosenberg, Steven A ^a   Robbins, Paul F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CANCER INFILTRATION; CANCER REGRESSION; CELL TRANSFER; CLONE; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; LYMPHOCYTIC INFILTRATION; MELANOMA; METASTASIS; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; TELOMERE; TREATMENT OUTCOME;

EID: 27744450650     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.7046     Document Type: Article

References (33)

1. Dudley, M. E., J. R. Wunderlich, P. F. Robbins, J. C. Yang, P. Hwu, D. J. Schwartzentruber, S. L. Topalian, R. Sherry, N. P. Restifo, A. M. Hubicki, et al. 2002. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298: 850-854.
2. Dudley, M. E., J. R. Wunderlich, J. C. Yang, R. M. Sherry, S. L. Topalian, N. P. Restifo, R. E. Royal, U. Kammula, D. E. White, S. A. Mavroukakis, et al. 2005. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J. Clin. Oncol. 23: 2346-2357.
3. Zhou, J., M. E. Dudley, S. A. Rosenberg, and P. F. Robbins. 2004. Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma. J. Immunol. 173: 7622-7629.
4. Zhou, J., M. E. Dudley, S. A. Rosenberg, and P. F. Robbins. 2005. Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy. J. Immunother. 28: 53-62.
5. Robbins, P. F., M. E. Dudley, J. Wunderlich, M. El-Gamil, Y. F. Li, J. Zhou, J. Huang, D. J. Powell, Jr., and S. A. Rosenberg. 2004. Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J. Immunol. 173: 7125-7130.
6. Blackburn, E. H. 1991. Structure and function of telomeres. Nature 350: 569-573.
7. Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
8. Rufer, N., W. Dragowska, G. Thornbury, E. Roosnek, and P. M. Lansdorp. 1998. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16: 743-747.
9. Modes, R. J., K. S. Hathcock, and N. P. Weng. 2002. Telomeres in T and B cells. Nat. Rev. Immunol. 2: 699-706.
10. Reed, J. R., M. Vukmanovic-Stejic, J. M. Fletcher, M. V. Soares, J. E. Cook, C. H. Orteu, S. E. Jackson, K. E. Birch, G. R. Foster, M. Salmon, et al. 2004. Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J. Exp. Med. 199: 1433-1443.
11. Wagner, U. G., K. Koetz, C. M. Weyand, and J. J. Goronzy. 1998. Perturbation of the T cell repertoire in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 95: 14447-14452.
12. Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106: 661-673.
13. de Lange, T. 2002. Protection of mammalian telomeres. Oncogene 21: 532-540.
14. Greider, C. W., and E. H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413.
15. Weng, N. P., B. L. Levine, C. H. June, and R. J. Hodes. 1996. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183: 2471-2479.
16. Weng, N. P., L. D. Palmer, B. L. Levine, H. C. Lane, C. H. June, and R. J. Hodes. 1997. Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol. Rev. 160: 43-54.
17. Weng, N. P., B. L. Levine, C. H. June, and R. J. Hodes. 1995. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. USA 92: 11091-11094.
18. Roth, A., H. Yssel, J. Pene, E. A. Chavez, M. Schertzer, P. M. Lansdorp, H. Spits, and R. M. Luiten. 2003. Telomerase levels control the lifespan of human T lymphocytes. Blood 102: 849-857.
19. + T cell clones by ectopic expression of telomerase reverse transcriptase. J. Immunol. 165: 4239-4245.
20. + counterparts. J. Immunol. 156: 3587-3590.
21. + T cells. Blood 101: 2711-2720.
22. Beyersdorf, N. B., X. Ding, K. Karp, and T. Hanke. 2001. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. Eur. J. Immunol. 31: 3443-3452.
23. - cells are induced by antigen and evolve through extensive rounds of division. Int. Immunol. 11: 1027-1033.
24. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8: 379-385.
25. + T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp. Gerontol 29: 601-609.
26. Dudley, M. E., J. R. Wunderlich, T. E. Shelton, J. Even, and S. A. Rosenberg. 2003. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J. Immunother. 26: 332-342.
27. van Baarle, D., A. Tsegaye, F. Miedema, and A. Akbar. 2005. Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune system. Immunol. Lett. 97: 19-29.
28. Slagboom, P. E., S. Droog, and D. I. Boomsma. 1994. Genetic determination of telomere size in humans: a twin study of three age groups. Am. J. Hum. Genet. 55: 876-882.
29. Rufer, N., T. H. Brummendorf, S. Kolvraa, C. Bischoff, K. Christensen, L. Wadsworth, M. Schulzer, and P. M. Lansdorp. 1999. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med. 190: 157-167.
30. Cristofalo, V. J., A. Lorenzini, R. G. Allen, C. Torres, and M. Tresini. 2004. Replicative senescence: a critical review. Mech. Ageing Dev. 125: 827-848.
31. Rufer, N., M. Migliaccio, J. Antonchuk, R. K. Humphries, E. Roosnek, and P. M. Lansdorp. 2001. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98: 597-603 .
32. + T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J. Immunol. 173: 6303-6311.
33. Valenzuela, H. F., and R. B. Effros. 2002. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin. Immunol. 105: 117-125.