Telomeres and aging-related meiotic dysfunction in women

Cellular and Molecular Life Sciences

Volumn 64, Issue 2, 2007, Pages 139-143

  Keefe, D L ^a   Liu, L ^a   Marquard, K ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Aging; Aneuploidy; Infertility; Meiosis; Reproduction; Telomeres

Indexed keywords

ACETYLCYSTEINE; FREE RADICAL; GLUTATHIONE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SCAVENGER; TELOMERASE;

AGE DISTRIBUTION; AGING; ANEUPLOIDY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL CYCLE ARREST; CHROMOSOME SIZE; DNA REPAIR; DNA REPLICATION; EGG; EMBRYO DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETIC RECOMBINATION; GENETIC RISK; GENOMIC INSTABILITY; HUMAN; MALE GENITAL SYSTEM; MAMMAL; MEIOSIS; MITOSIS; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; OVULATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHENOTYPE; PROTEIN FUNCTION; REPRODUCTION; REVIEW; TELOMERE;

ANIMALS; CELL AGING; FEMALE; HUMANS; MEIOSIS; MICE; MITOTIC SPINDLE APPARATUS; NONDISJUNCTION, GENETIC; REPRODUCTION; TELOMERE;

MAMMALIA; MUS;

EID: 33846558987     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6466-z     Document Type: Review

References (42)

1. Hassold, T. and Hunt, P. (2001) To err (meiotically) is human: the genesis of human aneuploidy. Nat. Rev. Genet. 2, 280-291.
2. Verlinsky, Y., Cohen, J., Munne, S., Gianaroli, L., Simpson, J. L., Ferraretti, A. P. and Kuliev, A. (2004) Over a decade of experience with preimplantation genetic diagnosis: a multicenter report. Fertil. Steril. 82, 292-294.
3. Munne, S., Chen, S., Fischer, J., Colls, P., Zheng, X., Stevens, J., Escudero, T., Oter, M., Schoolcraft, B., Simpson, J. T. and Cohen, J. (2005) Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 and older with a history of recurrent miscarriages. Fertil. Steril. 84, 331-335.
4. Navot, D., Bergh, P.A., Williams, M. A., Garrisi, G. J., Guzman, I., Sandler, B. and Grunfeld, L. (1991) Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet 337, 1375-1377.
5. Liu, L., Trimarchi, J., and Keefe, D. L. (2002) Haploidy but not parthenogenetic activation leads to increased incidence of apoptosis in mouse embryos. Biol. Reprod. 66, 204-210.
6. Abruzzo, M. A. and Hassold, T. J. (1995) Etiology of nondisjunction in humans. Environ. Mol. Mutagen. 28, 167-175.
7. Battaglia, D. E., Goodwin, P., Klein, N. A. and Soules, M. R. (1996) Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling women. Hum. Reprod. 11, 2217-2222.
8. Keefe, D. L., Niven-Fairchild, T., Powell, S. and Buradagunta, S. (1995) MtDNA deletions in oocytes and reproductive aging in women. Fertil. Steril. 64, 577-583.
9. Barritt, J. A., Brenner, C. A., Cohen, J. and Matt, D. W. (1999) Mitochondrial DNA rearrangements in human oocytes and embryos. Mol. Hum. Reprod. 5, 927-933.
10. Barrit, J. A., Cohen, J., and Brenner, C. A. (2000) Mitochondrial DNA point mutation in human oocytes is associated with maternal age. Reprod. Biomed. Online 1, 96-100.
11. Edwards, R. G. (1970) Are oocytes formed and used sequentially in the mammalian ovary? Philos. Trans. R. Soc. Lond. B. Biol. Sci. 259, 103-105.
12. Henderson, S.A. and Edwards, R. G. (1968) Chiasma frequency and maternal age in mammals. Nature 218, 22-28.
13. Polani, P. E. and Crolla, J. A. (1991) A test of the production line hyothesis of mammalian cogenesis. Hum. Genet. 88, 64-70.
14. Liu, L., Franco, S., Spyropoulos, B., Moens, P. B., Blasco, M. A. and Keefe, D. L. (2004) Irregular telomeres impair meiotic synapsis and recombination in mice. Proc. Natl. Acad. Sci. USA 101, 6496-6501.
15. Liu, L., Blasco, M. A. and Keefe, D. L.(2002) Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles. EMBO Rep. 3, 230-234.
16. Liu, L., Trimarchi, J. R., Navarro, P., Blasco, M. A. and Keefe, D. L. (2003) Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis. J. Biol. Chem. 278, 31998-32004.
17. Keefe, D. L., Franco, S., Liu, L., Trimarchi, J., Cao, B., Weitzen, S., Agarwal, S. and Blasco, M. A. (2005) Telomere length predicts embryo fragmentation after in vitro fertilization in women - toward a telomere theory of reproductive aging in women. Am. J. Obstet. Gynecol. 192, 1256-1260.
18. Liu, L., Trimarchi, J. R., Smith, P. J. and Keefe, D. L.(2002). Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1, 40-46.
19. Keefe, D. L., Marquard, K., and Liu, L. (2006) The telomere theory of reproductive senescence in women. Curr. Opin. Obstet. Gynecol. 18, 280-285.
20. Blasco, M. A., Gasser, S. M., and Lingner, J. (1999) Telomeres and telomerase. Genes Dev. 13, 2353-2359.
21. Blackburn, E. H. (2005) Telomerase and cancer: Kirk, A. Landon-AACR prize for basic cancer research lecture. Mol. Cancer Res. 3, 477-482.
22. Blackburn, E. H. (2005) Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett. 579, 859-862.
23. Passos, J. F. and von Zglinicki, T. (2005) Mitochondria, telomeres and cell senescence. Exp. Gerontol. 40, 466-472.
24. Kurz, D. J., Decary, S., Hong, Y., Trivier, E., Akhmedoc, A. and Erusalimsky, J. D. (2004) Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J. Cell Sci. 117, 2417-2426.
25. Liu, L., Trimarchi, J. R., Smith, P. J. and Keefe, D. L. (2002) Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell 1, 40-46.
26. Scherthan, H., Weich, S., Schwegler, H., Heyting, C., Harle, M. and Cremer, T. (1996) Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J. Cell Biol. 134, 1109-1125.
27. Scherthan, H. (2006). Factors directing telomere dynamics in synaptic meiosis. Biochem. Soc. Trans. 34, 550-553.
28. Roig, I., Liebe, B., Egozcue, J., Cabero, L., Garcia, M. and Scherthan, H. (2004) Female-specific features of recombinatorial double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Chromosoma 113, 22-23.
29. Bass, H. W., Marshall, W. F., Sedat, J. W., Agard, D. A. and Cande, W. Z. (1997) Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J. Cell Biol. 137, 5-18.
30. Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W. and Shay, J. W. (1996) Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18, 173-179.
31. Petronis, A. (1999) Alzheimer's disease and Down syndrome: from meiosis to dementia. Exp. Neurol. 158, 403-413.
32. Lamb, N. E., Feingold, E., Savage, A., Avramopoulos, D., Freeman, S., Gu, Y., Hallberg, A., Hersey, J., Karadima, G., Pettay, D. et al. (1997) Characterization of susceptible chiasma configurations that increase the risk for maternal nondisjunction of chromosome 21. Hum. Mol. Genet. 6, 1391-1399.
33. LeMaire-Adkins, R., Radke, K., and Hunt, P. A. (1997) Lack of checkpoint control at the metaphase/anaphase transition: a mechanism of meiotic nondisjunction in mammalian females. J. Cell Biol., 139, 1611-1619.
34. Woods, L. M., Hodges, C. A., Baart, E., Baker, S. M., Liskay, M. and Hunt, P. A. (1999) Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh 1 mutant mice. J. Cell Biol. 145, 1395-1406.
35. Sastre, J., Borras, C., Garcia-Sala, D., Lloret, A., Pallardo, F. V. and Nina, J. (2002) Mitochondrial damage in aging and apoptosis. Ann. N. Y. Acad. Sci. 959, 448-451.
36. Tarin, J. J., Perez-Albala, S. and Cano, A.(2002). Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouse. Mol. Reprod. Dev. 61, 385-397.
37. Zijlmans, J. M., Martens, U. M., Poon, S. S., Raap, A. K., Tanke, H. J. Ward, R. K. and Lansdorp, P. M. (1997) Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc. Natl. Acad. Sci. USA 94, 7423-7428.
38. Lansdorp, P. M. (1996) Close encounters of the PNA kind. Nat. Biotech. 14, 1653.
39. Navarro, P. A., Liu, L., Ferriani, R. A. and Keefe, D. L. (2006). Arsenite induces aberrations in meiosis that can be prevented by coadministration of N-acetylcysteine in mice. Fertil. Steril. 85:S1, 1187-1194.
40. Chen, X., Prosser, R., Simonetti, S., Sadlock, J., Jagiella, G. and Schon, E. A. (1995) Rearranged mitochondrial genomes are present in human oocytes. Am. J. Hum. Genet. 57, 29-47.
41. Nicolaides, K. H., Spencer, K., Avquidou, K., Faiola, S. and Falcon, O. (2005) Multicenter study of first-trimester screening for trisomy 21 in 75, 821 pregnancies: results and estimation of the potential impact of individual risk-oriented two-stage first-trimester screening. Ultrasound Obstet. Gynecol. 25221-25226.
42. Keefe, D. L., Franco, S., Liu, L., Cho B., Weitzen, S. and Blasco, M. A., (2004) Telomere length and reproductive outcome in women. Abstract, Presented at the Annual Meeting of the American Society for Reproductive Medicine, October, 2004.