Diabetes and Obesity Research using Nonhuman Primates

Nonhuman Primates in Biomedical Research: Diseases: Second Edition

Volumn 2, Issue , 2012, Pages 699-732

  Wagner, Janice D ^a   Cann, Jennifer A ^a   Zhang, Li ^a   Harwood, H James ^a  

^a WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882514609     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-381366-4.00014-6     Document Type: Chapter

References (240)

1. Abbott D.H., Foong S.C., Barnett D.K., Dumesic D.A. Nonhuman primates contribute unique understanding to anovulatory infertility in women. Institute Lab. Anim. Res. J 2004, 45:116-131.
2. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010, 33:S62-S69. American Diabetes Association.
3. Arifin E., Shively C.A., Register T.C., Cline J.M. Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis). Vet. Pathol 2008, 45:512-515.
4. Ausman L.M., Rasmussen K.M., Gallina D.L. Spontaneous obesity in maturing squirrel monkeys fed semipurified diets. Am. J. Physiol 1981, 241:R316-R321.
5. Bagdade J.D., Wagner J.D., Rudel L.L., Clarkson T.B. Accelerated cholesteryl ester transfer and altered lipoprotein composition in diabetic cynomolgus monkeys. J. Lipid Res 1995, 36:759-766.
6. Banks W.A., Altmann J., Sapolsky R.M., Phillips-Conroy J.E., Morley J.E. Serum leptin levels as a marker for a syndrome X-like condition in wild baboons. J. Clin. Endocrinol. Metab 2003, 88:1234-1240.
7. Barrett-Connor E., Ferrara A. Dehydroepiandrosterone, dihydroepiandrosterone sulfate, obesity, waist-hip ratio, and noninsulin-dependent diabetes in postmenopausal women: The Rancho Bernardo Study. J. Clin. Endocrinol. Metab 1996, 81:59-64.
8. Bergman R.N., Ider Y.Z., Bowden C.R., Cobelli C. Quantitative estimation of insulin sensitivity. Am. J. Physiol 1979, 236:E667-E677.
9. Bierman E.L. Atherogenesis in diabetes. Arterioscler. Thromb 1992, 12:647-656.
10. Björntorp P. Neuroendocrine perturbations as a cause of insulin resistance. Diabetes Metab. Res. Rev 1999, 15:427-441.
11. Bluestone J.A., Herold K., Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010, 464:1293-1300.
12. Bodkin N.L. The rhesus monkey (Macaca mulatta): A unique and valuable model for the study of spontaneous diabetes mellitus and associated conditions. Animal Models in Diabetes: A Primer 2000, 309-325. Taylor & Francis, Inc, Singapore. A.F. Sima, E. Shafrir (Eds.).
13. Bodkin N.L., Alexander T.M., Ortmeyer H.K., Johnson E., Hansen B.C. Mortality and morbidity in laboratory-maintained rhesus monkeys and effects of long-term dietary restriction. J. Gerontol 2003, 58A:212-219.
14. Bodkin N.L., Metzger B.L., Hansen B.C. Hepatic glucose production and insulin sensitivity preceding diabetes in monkeys. Am. J. Physiol 1989, 256:E676-E681.
15. Bodkin N.L., Ortmeyer H.K., Hansen B.C. Long-term dietary restriction in older-aged rhesus monkeys: Effects on insulin resistance. J. Gerontol. A. Biol. Sci. Med. Sci 1995, 50:B142-B147.
16. Bonora E., Targher G., Alberiche M., Bonadonna R.C., Saggiani F., Zenere M.B., Monauni T., Muggeo M. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000, 23:57-63.
17. Brady A.G., Koritnik D.R. The effects of ketamine anesthesia on glucose clearance in African green monkeys. Am. J. Primatol 1985, 47:99-107.
18. Brown W.V. Microvascular complications of diabetes mellitus: Renal protection accompanies cardiovascular protection. Am. J. Cardiol 2008, 102:10L-13L.
19. Brownlee M. The pathogenesis of diabetic complications: A unifying mechanism. Diabetes 2005, 54:1615-1625.
20. Bruns C.M., Kemnitz J.W. Sex hormones, insulin sensitivity, and diabetes mellitus. Int. J. Lab. Anim. Res 2004, 45:160-169.
21. Butler A.E., Cao-Minh L., Galasso R., Rizza R.A., Corradin A., Cobelli C., Butler P.C. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia 2010, (in press).
22. Cabrera O., Berman D.M., Kenyon N.S., Ricordi C., Berggren P.-O., Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc. Nat'l. Acad. Sci. (USA) 2006, 103:2334-2339.
23. Cai G., Cole S.A., Tejero E., Proffitt J.M., Freeland-Graves J.H., Blangero J., Comuzzie A.G. Pleiotropic effects of genes for insulin resistance on adiposity in baboons. Obes. Res 2004, 12:1766-1772.
24. Cann J.A., Kavanagh K., Jorgensen M.J., Mohanan S., Howard T.D., Gray S.B., Hawkins G.A., Fairbanks L.A., Wagner J.D. Clinicopathologic characterization of naturally occurring diabetes mellitus in African green monkeys. Vet. Pathol 2010, 47:713-718.
25. Castrillo A., Tontonoz P. PPARs in atherosclerosis: The clot thickens. J. Clin. Invest 2004, 114:1538-1540.
26. Casu A., Bottino R., Balamurugan A.N., Hara H., Windt D.J., Campanile N., Smetanka C., Cooper D.K.C., Trucco M. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: Implications for translation into clinical practice. Diabetologia 2008, 51:120-129.
27. Cefalu W.T. Animal models of type 2 diabetes: Clinical presentation and pathophysiological relevance to the human condition. Institute Lab. Anim. Res. J 2006, 47:186-198.
28. Cefalu W.T., Wagner J.D. Aging and atherosclerosis in human and nonhuman primates. Age 1997, 20:15-28.
29. Cefalu W.T., Wagner J.D., Bell-Farrow A.D. Role of glycated proteins in detecting and monitoring diabetes in cynomolgus monkeys. Lab. Anim. Sci 1993, 43:73-77.
30. Cefalu W.T., Wagner J.D., Bell-Farrow A.D., Wang Z.Q., Adams M.R., Toffolo G., Cobelli C. The effects of hormonal replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys (Macaca fascicularis). Am. J. Obstet. Gynecol 1994, 171:440-445.
31. Cefalu W.T., Wang Z.Q., Bell-Farrow A.D., Collins J., Morgan T., Wagner J.D. Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): Metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial. J. Gerontol 2004, 59A:1007-1014.
32. National diabetes fact sheet: General information and national estimates on diabetes in the United States, 2007 2008, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA.
33. Chavez A.O., Lopez-Alvarenga J.C., Tejero M.E., Triplitt C., Bastarrachea R.A., Sriwijitkamol A., Tantiwong P., Voruganti V.S., Musi N., Comuzzie A.G., DeFronzo R.A., Folli F. Physiological and molecular determinants of insulin action in the baboon. Diabetes 2008, 57:899-908.
34. Chen L.D., Kushwaha R.S., McGill H.C., Rice K.S., Carey K.D. Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). Atherosclerosis 1998, 136:89-98.
35. Chrousos G.P. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuroendocrine and target tissue-related causes. Int. J. Obesity 2000, 24:S50-S55.
36. Clark A., Nilsson M.R. Islet amyloid: A complication of islet dysfunction or an aetiological factor in type 2 diabetes?. Diabetologia 2004, 47:157-169.
37. Clarkson T.B., Koritnik D.R., Weingand K.W., Miller L.C. Nonhuman primate models of atherosclerosis: Potential for the study of diabetes mellitus and hyperinsulinemia. Metabolism 1985, 34:51-59.
38. Cline J.M., Wood C.E. Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis). Am. J. Primatol 2009, 71:722-731.
39. Combs T.P., Wagner J.A., Berger J., Doebber T., Wang W.J., Zhang B.B., Tanen M., Berg A.H., O'Rahilly S., Savage D.B., Chatterjee K., Weiss S., Larson P.J., Gottesdiener K.M., Gertz B.J., Charron M.J., Scherer P.E., Moller D.E. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: A potential mechanism of insulin sensitization. Endocrinol 2002, 143:998-1007.
40. Comuzzie A.G., Cole S.A., Martin L., Carey K.D., Mahaney M.C., Blangero J., VandeBerg J.L. The baboon as a nonhuman primate model for the study of the genetics of obesity. Obes. Res 2003, 11:75-80.
41. Contreras J.L., Smyth C.A., Bilbao G., Young C.J., Thompson J.A., Eckhoff D.E. 17-Beta estradiol protects isolated human pancreatic islets against proinflammatory cytokin-induced cell death: Molecular mechanisms and islet functionality. Transplant 2002, 74:1252-1259.
42. Contreras J.L., Smyth C.A., Curiel D.T., Eckhoff D.E. Nonhuman primate models in type 1 diabetes research. Institute Lab. Anim. Res. J 2004, 45:334-342.
43. Corton J.C., Anderson S.P., Strauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu. Rev. Pharmacol. Toxicol 2000, 40:491-518.
44. Cota D., Sandoval D.A., Olivieri M., Prodi E., D'Alessio D.A., Woods S.C., Seeley R.J., Obici S. Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity 2009, 17:1641-1645.
45. Coutinho M., Gerstein H.C., Wang Y., Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95, 783 individuals followed for 12.4 years. Diabetes Care 1999, 22:233-240.
46. Cox P.J., Ryan D.A., Hollis F.J., Harris A.M., Miller A.K., Vousden M., Cowley H. Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. Drug Metab. Dispos 2000, 28:772-780.
47. Cromeens D.M., Stephens L.C. Insular amyloidosis and diabetes mellitus in a crab-eating macaque (Macaca fascicularis). Lab. Anim. Sci 1985, 35:642-645.
48. Cusumano A.M., Bodkin N.L., Hansen B.C., Lotti R., Owens J., Klotman P.E., Kopp J.B. Glomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in aging rhesus monkeys. Am. J. Kidney Dis 2002, 40:1075-1085.
49. D'Alessio D.A., Vogel R., Prigeon R., Laschansky E., Koerker D., Eng J., Ensinck J.W. Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. J. Clin. Invest 1996, 97:133-138.
50. Danaei G., Lawes C.M., Vander Hoorn S., Murray C.J., Ezzati M. Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: Comparative risk assessment. Lancet 2006, 368:1651-1659.
51. Dang Z.C., Audinot V., Papapoulos S.E., Boutin J.A., Lowik C.W. Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein. J. Biol. Chem 2003, 278:962-967.
52. Daniel P.M., Henderson J.R. The effect of atropine on insulin release caused by intravenous glucose in the rhesus monkey. Acta Endocrinologica 1975, 78:736-745.
53. de Koning E.J.P., Bodkin N.L., Hansen B.C., Clarks A. Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population. Diabetologia 1993, 36:378-384.
54. DeFronzo R.A. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988, 37:667-687.
55. DeFronzo R.A. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 1997, 5:177-269.
56. Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001, 357:905-910. Diabetes Atherosclerosis Intervention Investigators.
57. Ding S.Y., Tigno X.T., Braileanu G.T., Ito K., Hansen B.C. A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist ameliorates dyslipidemia and insulin resistance in prediabetic rhesus monkeys. Metab 2007, 56:1334-1339.
58. Dunning B.E., Foley J.E., Ahren B. Alpha cell function in health and disease: Influence of glucagon-like-peptide-1. Diabetologia 2005, 48:1700-1713.
59. Eckel R.H., Barouch W.W., Ershow A.G. Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on the pathophysiology of obesity-associated cardiovascular disease. Circulation 2002, 105:2923-2928.
60. Edwards I.J., Wagner J.D., Litwak K.N., Rudel L.L., Cefalu W.T. Glycation of plasma low density lipoproteins increases interaction with arterial proteoglycans. Diabetes Res. Clin. Pract 1999, 46:9-18.
61. Elkeles R.S., Diamond J.R., Poulter C., Dhanjil S., Nicolaides A.N., Mahmood S., Richmond W., Mather H., Sharp P., Feher M.D. Cardiovascular outcomes in type 2 diabetes. A double-blind placebo-controlled study of bezafibrate: The St. Mary's, Ealing, Northwick Park Diabetes Cardiovascular Disease Prevention (SENDCAP) Study. Diabetes Care 1998, 21:641-648.
62. Faergeman O. Hypertriglyceridemia and the fibrate trials. Curr. Opin. Lipidol 2000, 11:609-614.
63. Fajans S.S., Bell G.I., Polonsky K.S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med 2001, 345:971-980.
64. Fernández-Real J.M., Lopez-Bermejo A., Casamitjana R., Ricart W. Novel interactions of adiponectin with the endocrine system and inflammatory parameters. J. Clin. Endocrinol. Metab 2004, 88:2714-2718.
65. Franks P.W., Brage S., Luan J., Ekelund U., Rahman M., Farooqi I.S., Halsall I., O'Rahilly S., Wareham N.J. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obes. Res 2005, 13:1476-1484.
66. Gaur L.K., Nepom G.T., Lernmark A. Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina. Autoimmunity 2001, 33:103-114.
67. Gee M.K., Zhang L., Rankin S.E., Collins J.N., Kauffman R.F., Wagner J.D. Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeys. Metabolism 2004, 53:1121-1125.
68. Gilardi K.V.K., Shideler S.E., Valverde C.R., Roberts J.A., Lasley B.L. Characterization of the onset of menopause in the rhesus macaque. Biol. Reprod 1997, 57:335-340.
69. Goldstein B.J. Rosiglitazone. Intern. J. Clin. Pract 2000, 54:333-337.
70. Goto S., Takahashi R., Radak Z., Sharma R. Beneficial biochemical outcomes of late-onset dietary restriction in rodents. Ann. N.Y. Acad. Sci 2007, 1100:431-441.
71. Gould K.G., Flint M., Graham C.E. Chimpanzee reproductive senescence: A possible model for evolution of the menopause. Maturitas 1981, 3:157-166.
72. Gray S.B., Howard T.D., Langefeld C.D., Hawkins G.A., Diallo A.F., Wagner J.D. Comparative analysis of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity. Comparative Med 2009, 59:580-588.
73. Greenspan F.S., Gardner D.G. Normal hormone reference ranges. Basic and Clinical Endocrinology 2006, 920-938. McGraw-Hill Companies, New York. 7th ed. F.S. Greenspan, D.G. Gardner (Eds.).
74. Gresl T.A., Coleman R.J., Roecker E.B., Havighurst T.C., Huang Z., Allison D.B., Burgman R.N., Kemnitz J.W. Dietary restriction and glucose regulation in aging rhesus monkeys: A follow-up report at 8.5 yr. Am. J. Physiol. Endocrinol. Metab 2001, 281:E757-E765.
75. Guerre-Millo M., Gervois P., Raspé E., Madsen L., Poulain P., Derudas B., Herbert J.M., Winegar D.A., Willson T.M., Fruchart J.C., Berge R.K., Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J. Biol. Chem 2000, 275:16,638-16,642.
76. Gustafson B. Adipose tissue, inflammation and atherosclerosis. J. Atheroscler. Thromb 2010, 17:332-341.
77. Haarbo J., Marslew U., Gotfredsen A., Christiansen C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism 1991, 40:1323-1326.
78. Haffner S.M., Valdez R.A., Hazuda H.P., Mitchell B.D., Morales P.A., Stren M.P. Prospective analysis of the insulin resistance syndrome (syndrome X). Diabetes 1992, 41:715-722.
79. Hamilton C.L., Ciaccia P. The course of development of glucose intolerance in the monkey (Macaca mulatta). J. Med. Primatol 1978, 7:165-173.
80. Hansen B.C., Bodkin N.L. Beta-cell hyperresponsiveness: Earliest event in development of diabetes in monkeys. Am. J. Physiol 1990, 259:R612-R617.
81. Hansen B.C., Bodkin N.L. Heterogeneity of insulin responses: Phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey. Diabetologia 1986, 29:713-719.
82. Hansen B.C., Bodkin N.L., Ortmeyer H.K. Calorie restriction in nonhuman primates: Mechanisms of reduced morbidity and mortality. Tox. Sci 1999, 52:S56-S60.
83. Harwood H.J. Treating the metabolic syndrome: Acetyl-CoA carboxylase inhibition. Expert Opin. Ther. Targets 2005, 9:267-281.
84. Harwood H.J., Petras S.F., Hoover D.J., Mankowski D.C., Soliman V.F., Sugarman E.D., Hulin B., Kwon Y., Gibbs E.M., Mayne J.T., Treadway J.L. Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase. J. Lipid Res 2005, 46:547-563.
85. Harwood H.J., Hamanaka E.S. Modulators of dyslipidemia. Emerging Drugs 1998, 3:147-172.
86. Higgins P.B., Bastarrachea R.A., Lopez-Alvarenga J.C., Garcia-Forey M., Proffitt J.M., Voruganti V.S., Tejero M.E., Mattern V., Haack K., Shade R.E., Cole S.A., Comuzzie A.G. Eight week exposure to a high sugar high fat diet results in adiposity gain and alterations in metabolic biomarkers in baboons (Papio hamadryas sp.). Cardiovasc. Diabetol 2010, 9:71.
87. Holman R.R., Paul S.K., Bethel M.A., Matthews D.R., Neil H.A.W. 10-Year follow-up of intensive glucose control in type 2 diabetes. N. Engl. J. Med 2008, 359:1577-1589.
88. Hotta K., Funahashi T., Bodkin N.L., Ortmeyer H.K., Arita Y., Hansen B.C., Matsuzawa Y. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001, 50:1126-1133.
89. Howard C.F., Van Bueren A. Changes in islet cell composition during development of diabetes in. Macaca nigra. Diabetes 1986, 35:165-171.
90. Howard C.F., Kessler M.J., Schwartz S. Metabolic abnormalities among free-ranging Macaca mulatta on Cayo Santiago: Comparisons with Macaca mulatta at Sabana Seca. Am. J. Primatol 1990, 21:189-200.
91. Howard C.F. Diabetes in Macaca nigra: Metabolic and histologic changes. Diabetologia 1974, 10:671-677.
92. Howard C.F. Diabetes mellitus: Relationships of nonhuman primates and other animal models to human forms of diabetes. Adv. Vet. Sci. Comp. Med 1984, 28:115-149.
93. Howard C.F. Atherosclerosis and insulin in primates with diabetes mellitus. Metabolism 1985, 34(Suppl. 1). 60-69.
94. Howard C.F., Kessler M.J., Schwartz S. Carbohydrate impairment and insulin secretory abnormalities among Macaca mulatta from Cayo Santiago. Am. J. Primatol 1986, 11:147-162.
95. Howard C.F., Yasuda M. Diabetes mellitus in nonhuman primates: Recent research advances and current husbandry practices. J. Med. Primatol 1990, 19:609-625.
96. Hubbard G.B., Steele K.E., Davis K.J., Leland M.M. Spontaneous pancreatic islet amyloidosis in 40 baboons. J. Med. Primatol 2002, 31:84-90.
97. Hull R.L., Westermark G.T., Westermark P., Kahn S.E. Islet amyloid: A critical entity in the pathogenesis of type 2 diabetes. J. Clin. Endocrinol. Metab 2004, 89:3629-3643.
98. Hwang C.S., Kwak H.S., Lim H.J., Lee S.H., Kang Y.S., Choe T.B., Hur H.G., Han K.O. Isoflavone metabolites and their in vitro dual functions: They can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J. Steroid Biochem. Mol. Biol 2006, 101:246-253.
99. Jen K.-L.C., Hansen B.C. Glucose disappearance rate in rhesus monkeys: Some technical considerations. Am. J. Primatol 1988, 14:153-166.
100. Johnson M.A., Lutty G.A., McLeod D.S., Otsuji T., Flower R.W., Sandagar G., Alexander T., Steidl S.M., Hansen B.C. Ocular structure and function in an aged monkey with spontaneous diabetes mellitus. Exp. Eye Res 2005, 80:37-42.
101. Jones A.B. Peroxisome proliferator-activated receptor (PPAR) modulators: Diabetes and beyond. Med. Res. Rev 2001, 21:540-552.
102. Kaneko J.J. Carbohydrate Metabolism. The Clinical Chemistry of Laboratory Animals 1999, (Chapter 10, pp. 165-180). Philadelphia: Taylor & Francis. 2nd ed. W.F. Loeb, F.W. Quimby (Eds.).
103. Kannel W.B., McGee D.L. Diabetes and cardiovascular disease. The Framingham study. J. Am. Med. Assn 1979, 241:2035-2038.
104. Kaplan J.R. Dominance and affiliation in the Cercopithecini and Papionini: A comparative examination. Monogr. Primatol 1987, 10:127-150.
105. Kaplan J.R., Adams M.R., Clarkson T.B., Manuck S.B., Shively C.A., Williams J.K. Psychosocial factors, sex differences, and atherosclerosis: Lessons from animal models. Psychosom. Med 1996, 58:598-611.
106. Kaplan J.R., Manuck S.B. Status, stress, and atherosclerosis: The role of environment and individual behavior. Ann. N.Y. Acad. Sci 1999, 896:145-161.
107. Kaplan J.R., Wagner J.D. Type 2 diabetes-An introduction to the development and use of animal models. Institute Lab. Anim. Res. J 2006, 47:181-185.
108. Kaufman D., Smith E.L.P., Gohil B.C., Banerji M., Coplan J.D., Kral J.G., Rosenblum L.A. Early appearance of the metabolic syndrome in socially reared bonnet macaques. J. Clin. Endocrinol. Metabol 2005, 90:404-408.
109. Kaufman D., Banerji M., Shorman I., Smith E.L.P., Coplan J.D., Rosenblum L.A., Kral J.G. Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques. Diabetes 2007, 56:1382-1386.
110. Kaplan J.R., Wagner J.D. Type 2 diabetes-An introduction to the development and use of animal models. Institute Lab. Anim. Res. J 2006, 47:181-185.
111. Kavanagh K., Jones K.L., Zhang L., Flynn D.M., Shadoan M.K., Wagner J.D. High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates. Nutr. Res 2008, 28:368-376.
112. Kavanagh K., Fairbanks L.A., Bailey J.N., Jorgensen M.J., Wilson M., Zhang L., Rudel L.L., Wagner J.D. Characterization and heritability of obesity and associated risk factors in vervet monkeys. Anim. Physiol 2007, 15:1666-1674.
113. Kavanagh K., Jones K.L., Sawyer J., Kelley K., Carr J.J., Wagner J.D., Rudel L.L. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity 2007, 15:1675-1684.
114. Kavanagh K., Williams J.K., Wagner J.D. Naturally occurring menopause in cynomolgus monkeys: Changes in hormone, lipid, and carbohydrate measures with hormonal status. J. Med. Primatol 2005, 34:171-177.
115. Kavanagh K., Brown K.K., Berquist M.L., Zhang L., Wagner J.D. Fluid compartmental shifts with efficacious poiglitazone therapy in overweight monkeys: Implications for PPARγ agonist use in prediabetics. Metabolism 2010, 59:914-920.
116. Kemnitz J.W., Elson D.F., Roecker E.B., Baum S.T., Bergman R.N., Meglasson M.D. Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys. Diabetes 1994, 43:204-211.
117. Kemnitz J.W., Francken G.A. Characteristics of spontaneous obesity in male rhesus monkeys. Physiol. & Behav 1986, 38:477-483.
118. Kemnitz J.W., Gibber J.R., Lindsay K.A., Eisele S.G. Effects of ovarian hormones on eating behaviors, body weight, and glucoregulation in rhesus monkeys. Horm. Behav 1988, 23:235-250.
119. Kemnitz J.W., Holston K.A., Colman R.J. Nutrition, aging and reproduction in rhesus monkeys. Pennington Center Nutrition Series. Part IV. Evolution of Research Methods in Nutrition and Reproduction. Nutrition and Reproduction 1998, Vol. 8:180-195. Louisiana State University Press, Baton Rouge. W. Hansel, G.A. Bray, D.H. Ryan (Eds.).
120. Kemnitz J.W., Kraemer G.W. Assessment of glucoregulaton in rhesus monkeys sedated with ketamine. Am. J. Primatol 1982, 3:201-210.
121. Kemnitz J.W., Roecker E.B., Weindruch R., Elson D.F., Baum S.T., Bergman R.N. Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am. J. Physiol. Endocrinol. Metab 1994, 266:E540-E547.
122. Kern P.A., Di Gregorio G.B., Lu T., Rassouli N., Ranganathan G. Adiponectin expression from human adipose tissue: Relation to obesity, insulin resistance, and tumor necrosis factor-α expression. Diabetes 2003, 52:1779-1785.
123. Kessler M.J., Howard C.F., London W.T. Gestational diabetes mellitus and impaired glucose tolerance in an aged Macaca mulatta. J. Med. Primatol 1985, 14:237-244.
124. Kharitonenkov A., Wroblewski V.J., Koester A., Chen Y.F., Clutinger C.K., Tigno X.T., Hansen B.C., Shanafelt A.B., Etgen G.J. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 2007, 148:774-781.
125. Kim S.Y., Johnson M.A., McLeod D.S., Alexander T., Hansen B.C., Lutty G.A. Neutrophils are associated with capillary closure in spontaneously diabetic monkey retinas. Diabetes 2005, 54:1534-1542.
126. Kim C., Seidel K.W., Begier E.A., Kwok Y.S. Diabetes and depot medroxyprogesterone contraception in Navajo women. Arch. Intern. Med 2001, 161:1766-1771.
127. Kim S.K., Park S.W., Hwang I.J., Lee Y.K., Cho Y.W. High fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: An anthropometric determinant of carotid atherosclerosis and insulin resistance. Int. J. Obes 2010, 34:105-110.
128. Kinder L.S., Carnethon M.R., Palaniappan L.P., King A.C., Fortmann S.P. Depression and the metabolic syndrome in young adults: Findings from the Third National Health and Nutrition Examination Survey. Psychosom. Med 2004, 66:316-322.
129. Klein S., Burke L.E., Bray G.A., Blair S., Allison D.B., Pi-Sunyer X., Hong Y., Eckel R.H. Clinical implications of obesity with specific focus on cardiovascular disease: A statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation. Circulation 2004, 110:2952-2967.
130. Kuiper G.G., Lemmen J.G., Carlsson B., Corton J.C., Safe S.H., van der Saag P.T., van der Burg B., Gustafsson J.A. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998, 139:4252-4263.
131. Laber-Laird K.E., Jokinen M.P., Lehner N.D. Fatal fatty liver-kidney syndrome in obese monkeys. Lab. Animal Sci 1987, 37:205-209.
132. Lane M.A., Black A., Handy A., Tilmont E.M., Ingram D.K., Roth G.S. Caloric restriction in primates. Ann. N.Y. Acad. Sci 2001, 928:287-295.
133. Larsen M.O., Rolin B., Sturis J., Wilken M., Carr R.D., Pørksen N., Gotfredsen C.F. Measurements of insulin responses as predictive markers of pancreatic β-cell mass in normal and β-cell-reduced lean and obese Göttingen minipigs in vivo. Am. J. Physiol. Endocrinol. Metab 2006, 290B:E670-E677.
134. Lau D.C.W., Dhillon B., Yan H., Szmitko P.E., Verma S. Adipokines: Molecular links between obesity and atheroslcerosis. Am. J. Physiol. Heart Circ. Physiol 2005, 288:H2031-H2041.
135. Lee C., Olson P., Evans R.M. Minireview: Lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology 2003, 144:2201-2207.
136. Ley C.J., Lees B., Stevenson J.C. Sex and menopause associated changes in body-fat distribution. Am. J. Clin. Nutr 1992, 55:950-954.
137. Li A.C., Binder C.J., Gutierrez A., Brown K.K., Plotkin C.R., Pattison J.W., Valledor A.F., Davis R.A., Willson T.M., Witztum J.L., Palinski W., Glass C.K. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J. Clin. Invest 2004, 114:1564-1576.
138. Libby P., Theroux P. Pathophysiology of coronary artery disease. Circulation 2005, 111:3481-3488.
139. Lindheim S.R., Buchanan T.A., Duffy D.M., Vijod M.A., Kojima T., Stanczyk F.Z., Lobo R.A. Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J. Soc. Gynecol. Invest 1994, 1:150-154.
140. Litwak K.N., Cefalu W.T., Wagner J.D. Streptozotocin-induced diabetes mellitus in cynomolgus monkeys: Changes in carbohydrate metabolism, skin glycation, and pancreatic islets. Lab. Anim. Sci 1998, 48:172-178.
141. Litwak K.N., Cefalu W.T., Wagner J.D. Chronic hyperglycemia increases arterial low-density lipoprotein metabolism and atherosclerosis in cynomolgus monkeys. Metabolism 1998, 47:1-8.
142. Lovegrove J.A., Silva K.D., Wright J.W., Williams C.M. Adiposity, insulin and lipid metabolism in post-menopausal women. Int. J. Obes. Relat. Metab. Disord 2002, 26:475-486.
143. Ludvik B., Kautzky-Miller A., Prager R., Thomaseth K., Pacini G. Amylin: History and Overview. Diabetic Med 1997, 14:S9-S13.
144. Margolis K.L., Bonds D.E., Rodabough R.J., Tinker L., Phillips L.S., Allen C., Bassford T., Burke G., Torrens J., Howard B.V. Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: Results from the Women's Health Initiative Hormone Trial. Diabetologia 2004, 47:1175-1187.
145. Matrougui K. Diabetes and microvascular pathophysiology: Role of epidermal growth factor receptor tyrosine kinase. Diabetes Metab. Res. Rev 2010, 26:13-16.
146. Matute M.L., Kalkhoff R.K. Sex steroids influence on hepatic gluconeogenesis and glycogen formation. Endocrinology 1973, 92:762-768.
147. Mauro L., Salerno M., Panno M.L., Bellizzi D., Sisci D., Miglietta A., Surmacz E., Ando S. Estradiol increases IRS-1 gene expression and insulin signaling in breast cancer cells. Biochem. Biophys. Res. Comm 2001, 288:685-689.
148. McTighe M.S., Hansen B.C., Ely J.J., Lee D.R. Determination of hemoglobin A1c and fasting blood glucose reference intervals in captive chimpanzees (Pan troglodytes). J. Am. Assoc. Lab. Anim. Sci 2011, 50:165-170.
149. Meis P.J., Kaplan J.R., Koritnik D.R., Rose J.C. Effects of gestation on glucose tolerance and plasma insulin in cynomolgus monkeys (Macaca fascicularis). Am. J. Obstet. Gynecol 1982, 144:543-545.
150. Merimee T.J., Tyson J.E. Hypoglycemia in man. Diabetes 1977, 26:161-165.
151. Mezei O., Banz W.J., Steger R.W., Peluso M.R., Winters T.A., Shay N. Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells. J. Nutr 2003, 133:1238-1243.
152. Morito K., Aomori T., Hirose T., Kinjo J., Hasegawa J., Ogawa S., Inoue S., Muramatsu M., Masamune Y. Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Biol. Pharm. Bull 2002, 25:48-52.
153. Muldoon M.F., Mackey R.H., Korytkowski M.T., Flory J.D., Pollock B.G., Manuck S.B. The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers. J. Clin. Endocrinol. Metab 2006, 91:718-721.
154. Mullan R.J. Nonhuman primate importation and quarantine: United States 2006, Presentation at Annual Meeting of the Association of Primate Veterinarians, Park City, Utah, October 12-14.
155. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). J. Am. Med. Assn 2001, 285:2486-2497. National Cholesterol Education Program Expert Panel.
156. NHANES National Health and Nutrition Examination Survey 2007, http://www.cdc.gov/nchs/nhanes.htm.
157. Nogueiras R., Veyrat-Durebex C., Suchanek P.M., Klein M., Tschop J., Caldwell C., Woods S.C., Wittmann G., Watanabe M., Liposits Z., Fekete C., Reizes O., Rohner-Jeanrenaud F., Tschop M.H. Peripheral, but not central, CB1 antagonism provides food intake independent metabolic benefits in diet-induced obese rats. Diabetes 2008, 57:2977-2991.
158. Nogueiras R., Diaz-Arteagaa A., Lockiec S.H., Velásqueza D.A., Tschopd J., Lópeza M., Cadwell C.C., Diégueza C., Tschop M.H. The endocannabinoid system: Role in glucose and energy metabolism. Pharm. Res 2009, 60:93-98.
159. Nyirenda M.J., Carter R., Tang J.I., Vries A., Schlumbohm C., Hillier S.G., Streit F., Oellerich M., Armstrong V.W., Fuchs E., Seckl J.R. Prenatal programming of metabolic syndrome in the common marmoset is associated with increased expression of 11β-hydroxysteroid dehydrogenase type 1. Diabetes 2009, 58:2873-2879.
160. O'Brien T.D., Butler P.C., Westermark P., Johnson K.H. Islet amyloid polypeptide: A review of its biology and potential roles in the pathogenesis of diabetes mellitus. Vet. Pathol 1993, 30:317-332.
161. O'Brien T.D., Wagner J.D., Litwak K.N., Carlson C.S., Cefalu W.T., Jordan K., Johnson K.H., Butler P.C. Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): An animal model of human non-insulin dependent diabetes mellitus. Vet. Pathol 1996, 33:479-485.
162. Ohagi S., Nishi M., Bell G.I., Ensinck J.W., Steiner D.F. Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina) and the dog (Canis familiaris). Diabetologia 1991, 34:555-558.
163. Oliver E.R., Shenk J.L., Snaith M.R., Russell C.S., Plunket K.D., Bodkin N.L., Lewis M.C., Winegar D.A., Sznaidman M.L., Lambert M.H., Xu H.E., Sternbach D.D., Kliewer S.A., Hansen B.C., Wilson T.M. A selective peroxisome proliferators-activated receptor agonist promotes reverse cholesterol transport. Proc. Na'l. Acad. Sci. (USA) 2001, 98:5306-5311.
164. Ortmeyer H.K., Bodkin N.L. Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys. Am. J. Physiol 1998, 274:G1005-G1010.
165. Ortmeyer H.K., Bodkin N.L., Hansen B.C. Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic rhesus monkeys. Am. J. Physiol 1993, 265:R552-R558.
166. Ortmeyer H.K., Bodkin N.L., Yoshioka S., Horikoshi H., Hansen B.C. A thiazolidinedione improves insulin action on skeletal muscle glycogen synthase in insulin resistant monkeys. Int. J. Exp. Diabetes Res 1999, 48:195-202.
167. Osei-Hyiaman D., Liu J., Zhou L., Godlewski G., Harvey-White J., Jeong W.I., Batkai S., Marsicano G., Lutz B., Buettner C., Kunos G. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J. Clin. Invest 2008, 118:3160-3169.
168. Pacini G., Bergman R.N. MINMOD: A Computer Program to Calculate Insulin Sensitivity and Pancreatic Responsivity from the Frequently Sampled Intravenous Glucose Tolerance Test. Computer Meth. Programs Biomed 1986, 23:113-122.
169. Pagotto U., Marsicano G., Cota D., Lutz B., Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr. Rev 2006, 27:73-100.
170. Park Y.W., Zhu S., Palaniappan L., Heshka S., Carnethon M.R., Heymsfield S.B. The metabolic syndrome: Prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch. Intern. Med 2003, 163:427-436.
171. Pennathur S., Heinecke J.W. Mechanisms of oxidative stress in diabetes: Implications for the pathogenesis of vascular disease and antioxidant therapy. Frontiers Biosci 2004, 9:565-574.
172. Pennathur S., Wagner J.D., Leeuwenburgh C., Litwak K.N., Heinecke J.W. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. J. Clin. Invest 2001, 107:853-860.
173. Picard F., Auwerx J. PPAR(gamma) and glucose homeostasis. Annu. Rev. Nutr 2002, 22:167-197.
174. Pirarat N., Kesdangsakolwut S., Chotiapisitkul S., Assarasakorn S. Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: A case report. J. Med. Primatol 2008, 37:162-165.
175. 1 Signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metabol 2010, 11:273-285.
176. Ramsey J.J., Laatsch J.L., Kemnitz J.W. Age and gender differences in body composition, energy expenditure, and glucoregulation of adult rhesus monkeys. J. Med. Primatol 2000, 29:11-19.
177. Raskin P., Rappaport E.B., Cole S.T., Yan Y., Patwardhan R., Freed M.I. Rosiglitazone short-term monotherapy lowers fasting and post-prandial glucose in patients with type II diabetes. Diabetologia 2000, 43:278-284.
178. Ratner R.E., Dickey R., Fineman M., Maggs D.G., Shen L., Strobel S.A., Weyer C., Kolterman O.G. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: A 1-year, randomized controlled trial. Diabetic Med 2004, 21:1204-1212.
179. Remick A.K., Wood C.E., Cann J.A., Gee M.K., Feiste E.A., Kock N.D., Cline J.M. Histologic and immunohistochemical characterization of spontaneous pituitary adenomas in fourteen cynomolgus macaques (Macaca fascicularis). Vet. Pathol 2006, 43:484-493.
180. Rieck S., Kaestner K.H. Expansion of b-cell mass in response to pregnancy. Trends Endocrinol. Metab 2010, (in press).
181. Riley W.J., Maclaren N.K. Islet cell autoantibodies. The Endocrine Pancreas 1991, 409-419. Raven Press, Ltd, New York. E. Samols (Ed.).
182. Rosenblum I.Y., Barbolt T.A., Howard C.F. Diabetes mellitus in the chimpanzee (Pan Troglodytes). J. Med. Primatol 1981, 10:93-101.
183. Rosmond R. Stress disturbances of the HPA axis: A pathway to type 2 diabetes?. Med. Sci. Monit 2003, 9:RA35-RA39.
184. Roth J.D., Roland B.L., Cole R.L., Trevaskis J.L., Weyer C., Koda J.E., Anderson C.M., Parkes D.G., Baron A.D. Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies. Proc. Natl. Acad. Sci. USA 2008, 105:7257-7262.
185. Saisho Y., Butler A.E., Manesso E., Galasso R., Zhang L., Gurlo T., Toffolo G.M., Cobelli C., Kavanagh K., Wagner J.D., Butler P.C. Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Diabetologia 2010, 53:111-114.
186. Saisho Y., Manesso E., Butler A.E., Galasso R., Kavanagh K., Flynn M., Zhang L., Clark P., Gurlo T., Toffolo G.M., Cobelli C., Wagner J.D., Butler P.C. Ongoing β-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes 2011, 60:848-856.
187. Schwartz S.M., Kemnitz J.W. Age- and gender-related changes in body size, adiposity, and endocrine and metabolic parameters in free-ranging rhesus macaques. Am. J. Phys. Anthropol 1992, 89:109-121.
188. Seino S., Bell G.I., Li W.H. Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys. Mol. Biol. Evol 1992, 9:193-203.
189. Seino S., Steiner D.F., Bell G.I. Sequence of a New World primate insulin having low biological potency and immunoreactivity. Proc. Nat'l. Acad. Sci. (USA) 1987, 84:7423-7427.
190. Setchell K.D.R., Cassidy A. Dietary isoflavones: Biological effects and relevance to human health. J. Nutr 1999, 129:758S-767S.
191. Shadoan M.K., Anthony M.S., Rankin S.E., Clarkson T.B., Wagner J.D. Effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys. Metabolism 2003, 52:1085-1091.
192. Shadoan M.K., Kavanagh K., Zhang L., Anthony M.S., Wagner J.D. Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism 2007, 56:830-837.
193. Shadoan M.K., Zhang L., Wagner J.D. Effects of hormone replacement therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeys. Steroids 2004, 69:313-318.
194. Sharma R.C., Kramsch D.M., LEE P.L., Colletti P., Jiao Q. Quantitation and localization of regional body fat distribution-A comparison between magnetic resonance imaging and somatometry. Obesity Res 1996, 4:167-178.
195. Silverstone F.A., Solomons E., Rubricus J. The rapid intravenous tolerance test in pregnancy. J. Clin. Invest 1961, 40:2180-2189.
196. Skyler J.S., O'Sullivan M.J., Holsinger K.K. The relationship between maternal glycemia and macrosomia. Diabetes Care 1980, 3:433-434.
197. Stokes W.S. Spontaneous diabetes mellitus in a baboon (Papio cynocephalus anubis). Lab. Anim. Sci 1986, 36:529-533.
198. Stolar M. Glycemic control and complications in type 2 diabetes mellitus. Am. J. Med 2010, 123:S3-S11.
199. Stroud F.C., Appt S.E., Wilson M.E., Franke A.A., Adams M.R., Kaplan J.R. Concentrations of isoflavones in macaques consuming standard laboratory monkey diet. J. Am. Assoc. Lab. Anim. Sci 2006, 45:20-23.
200. Susa J.B., McCormick K.L., Widness J.A., Singer D.B., Adarnsons K., Schwartz R. Chronic hyperinsulinemia in the fetal rhesus monkey: Effects on fetal growth and composition. Diabetes 1979, 28:1058-1063.
201. Tan K.C.B., Xu A., Chow W.S., Lam M.C.W., Ai V.G.H., Tam S.C.F., Lam K.S.L. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J. Clin. Endocrinol. Metab 2004, 89:765-769.
202. Tanaka Y., Ohto H., Kohno M., Cho F., Honjo S. Spontaneous diabetes mellitus in cynomolgus monkeys (macaca fascicularis). Experimental Animals 1986, 35:11-19.
203. Tardif S.D., Power M.L., Ross C.N., Rutherford J.N., Layne-Colon D.G., Paulik M.A. Characterization of obese phenotypes in a small nonhuman primate, the common marmoset (Callithrix jacchus). Obesity 2009, 17:1499-1505.
204. Tardif S.D., Mansfield K.G., Ratnam R., Ross C.N., Ziegler T.E. The marmoset model of aging and age-related diseases Institute Lab. Anim. Res. J 2011, 52:54-65.
205. Tejero M.E., Voruganti V.S., Rodríguez-Sánchez I.P., Proffitt J.M., Blangero J., Cox L.A., Mahaney M.C., Rogers J., VandeBerg J.L., Cole S.A., Comuzzie A.G. Genetics of variation in adiponectin in pedigreed baboons: Evidence for pleiotropic effects on adipocyte volume and serum adiponectin. Heredity 2008, 100:382-389.
206. Thigpen J.E., Setchell K.D., Ahlmark K.B., Locklear J., Spahr T., Caviness G.F., Goelz M.F., Haseman J.K., Newbold R.R., Forsythe D.B. Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. Lab. Anim. Sci 1999, 49:530-536.
207. Tigno X.T., Gerzanich G., Hansen B.C. Age-related changes in metabolic parameters on nonhuman primates. J. Gerontol 2004, 59A:1081-1088.
208. Toffolo G., Bergman R.N., Finegood D.T., Bowden C.R., Cobelli C. Quantitative estimation of beta cell sensitivity to glucose in the intact organism-A minimal model of insulin kinetics in the dog. Diabetes 1980, 29:979-990.
209. Torra I.P., Chinetti G., Duval C., Fruchart J.C., Staels B. Peroxisome proliferator-activated receptors: From transcriptional control to clinical practice. Lipidology 2001, 12:245-254.
210. Valdes C.T., Elkind-Hirsch K.E. Intravenous glucose tolerance test-derived insulin sensitivity changes during the menstrual cycle. J. Clin. Endocrinol. Metab 1991, 72:642-646.
211. Von Herrath M., Nepom G.T. Animal models of human type 1 diabetes. Nat. Immunol 2009, 10:129-132.
212. Wachtman L.M., Kramer J.A., Miller A.D., Hachey A.M., Curran E.H., Mansfield K.G. Differential contribution of dietary fat and monosaccharide to metabolic syndrome in the common marmoset (Callithrix jacchus) 2010, Obesity. doi:10.1038/oby.2010.303.
213. Wagenknecht L.E., Langefeld C.D., Scherzinger A.L., Norris J.M., Haffner S.M., Saad M.F., Bergman R.N. Insulin sensitivity, insulin secretion, and abdominal fat: The Insulin Resistance Atherosclerosis Study. Diabetes 2003, 52:2490-2496.
214. Wagner J.D. Effects of ERT and HRT on cardiovascular risk factors and coronary artery atherosclerosis. Menopausal Med 2001, 10:12-15.
215. Wagner J.D., Bagdade J.D., Litwak K.N., Zhang L., Bell-Farrow A.D., Wang Z.Q., Cefalu W.T. Increased glycation of plasma lipoproteins in diabetic cynomolgus monkeys. Lab. Anim. Sci 1996, 46:31-35.
216. Wagner J.D., Carlson C.S., O'Brien T.D., Anthony M.S., Bullock B.C., Cefalu W.T. Diabetes mellitus and islet amyloidosis in cynomolgus monkeys. Lab. Anim. Sci 1996, 46:36-41.
217. Wagner J.D., Cefalu W.T., Anthony M.S., Litwak K.N., Zhang L., Clarkson T.B. Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynomolgus monkeys. Metab. Clin. Exp 1997, 46:698-705.
218. Wagner J.D., Cline J.M., Shadoan M.K., Bullock B.C., Rankin S.E., Cefalu W.T. Naturally occurring and experimental diabetes in cynomolgus monkeys: A comparison of carbohydrate and lipid metabolism and islet pathology. Toxicol. Pathol 2001, 29:142-148.
219. Wagner J.D., Jayo M.J., Bullock B.C., Washburn S.A. Gestational diabetes mellitus in a cynomolgus monkey with group A streptococcal metritis and hemolytic uremic syndrome. J. Med. Primatol 1992, 21:371-374.
220. Wagner J.D., Jorgensen M.J., Cline J.M., Lees C.J., Franke A.A., Zhang L., Ayers M.R., Schultz C., Kaplan J.R. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am. J. Primatol 2009, 71(9):802-811.
221. Wagner J.D., Kaplan J.R., Burkman R.T. Reproductive hormones and cardiovascular disease mechanism of action and clinical implications. Obstet. Gynecol. Clin. North. Am 2002, 29:475-493.
222. Wagner J.D., Kavanagh K., Ward G.M., Auerbach B.J., Harwood H.J., Kaplan J.R. Old world nonhuman primate models of type 2 diabetes mellitus. Institute Lab. Animal Res. J 2006, 47:259-271.
223. Wagner J.D., Martino M.A., Jayo M.J., Anthony M.S., Clarkson T.B., Cefalu W.T. The effects of hormone replacement therapy on carbohydrate metabolism and cardiovascular risk factors in surgically postmenopausal cynomolgus monkeys. Metabolism 1996, 45:1254-1262.
224. Wagner J.D., Thomas M.J., Williams J.K., Zhang L., Greaves K.A., Cefalu W.T. Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate. J. Clin. Endocrinol 1998, 83:896-901.
225. Wagner J.D., Shadoan M.K., Zhang L., Ward G.M., Royer L.J., Kavanagh K., Francone O.L., Auerbach B.J., Harwood H.J. A selective PPARα agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. J. Pharmacol. Exp. Therap 2010, 333:844-853.
226. Wagner J.D., Zhang L., Kavanagh K., Ward G.M., Chin J.E., Hadcock J.R., Auerbach B.J., Harwood H.J. A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys. J. Pharmacol. Exp. Therap 2010, 335:103-113.
227. Wallace J.M., Schwarz M., Coward P., Houze J., Sawyer J.K., Kelley K.L., Chai A., Rudel L.L. Effects of peroxisome proliferators-activated receptor α/δ agonists on HDL-cholesterol in vervet monkeys. J. Lipid. Res 2005, 46:1009-1016.
228. Wang Z.Q., Floyd E., Qin J., Liu X., Yu Y., Zhang X.H., Wagner J.D., Cefalu W.T. Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys. Diabetes 2009, 58:1488-1498.
229. Weinbauer G.F., Niehoff M., Niehaus M., Srivastav S., Fuchs A., Van Esch E., Cline J.M. Physiology and endocrinology of the ovarian cycle in macaques. Toxicol. Pathol 2008, 36:7S-23S.
230. Weindruch R. The retardation of aging by caloric restriction: Studies in rodents and primates. Toxicol. Pathol 1996, 24:742-745.
231. Weir G.C., Leahy J.L. Pathogenesis of non-insulin-dependent (type II) diabetes mellitus. Joslin's Diabetes Mellitus 1994, 240-264. Lea & Febiger, Malvern. 13th ed. C.R. Kahn, G.C. Weir (Eds.).
232. Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. J. Clin. Invest 2005, 115:1111-1119.
233. Weyer C., Bogardus C., Mott D.M., Pratley R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest 1999, 104:787-794.
234. Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
235. Willson T.M., Brown P.J., Sternbach D.D., Henke B.R. The PPARs: From orphan receptors to drug discovery. J. Med. Chem 2000, 43:527-550.
236. Willson T.M., Lambert M.H., Kliewer S.A. Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu. Rev. Biochem 2001, 70:341-367.
237. Winegar D.A., Brown P.J., Wilkison W.O., Lewis M.C., Ott R.J., Tong W.Q., Brown H.R., Lehmann J.M., Kliewer S.A., Plunket K.D., Way J.M., Bodkin N.L., Hansen B.C. Effects of fenofibrate on lipid parameters in obese rhesus monkeys. J. Lipid. Res 2001, 42:1543-1551.
238. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., Sol J., Nichols A., Ross J.A., Tartaglia L.A., Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest 2003, 112:1821-1830.
239. Yan H., Gu W., Yang J., Bi V., Shen Y., Lee E., Winters K.A., Komorowski R., Zhang C., Patel J.J., Caughey D., Elliott G.S., Lau Y.Y., Wang J., Li Y.S., Boone T., Lindberg R.A., Hu S., Véniant M.M. Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. J. Pharmacol. Exp. Therap 2009, 329:102-111.
240. Yasuda M., Takaoka M., Fujiwara T., Mori M. Occurrence of spontaneous diabetes mellitus in a cynomolgus monkey (Macaca fascicularis) and impaired glucose tolerance in its descendants. J. Med. Primatol 1988, 17:319-332.