A thiazolidinedione improves in vivo insulin action on skeletal muscle glycogen synthase in insulin-resistant monkeys

Experimental Diabesity Research

Volumn 1, Issue 3, 2000, Pages 195-202

  Ortmeyer, Heidi K ^a   Bodkin, Noni L ^a   Haney, Joseph ^a   Yoshioka, Shinji ^b   Horikoshi, Hiroyoshi ^b   Hansen, Barbara C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Glycogen synthase; Insulin action; Rhesus monkey; Skeletal muscle; Thiazolidinedione

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE 6 PHOSPHATE; GLYCOGEN SYNTHASE; INSULIN; R 102380; THIAZOLE DERIVATIVE;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HISTOLOGY; INSULIN RESISTANCE; INTRAVENOUS DRUG ADMINISTRATION; MACACA; MALE; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; GLUCOSE CLAMP TECHNIQUE; GLUCOSE-6-PHOSPHATE; GLYCOGEN SYNTHASE; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INSULIN; INSULIN RESISTANCE; MACACA MULATTA; MALE; MUSCLE, SKELETAL; OBESITY; THIAZOLES;

EID: 0034574399     PISSN: 15438600     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/edr.2000.195     Document Type: Article

References (23)

1. Berger, J., Biswas, C., Hayes, N., Ventre, J., Wu, M. and Doebber, T. W. (1996). An antidiabetic thiazolidinedione potentiates insulin stimulation of glycogen synthase in rat adipose tissue. Endocrinology, 137, 1984-1990.
2. Blackmore, P. F., McPherson, R. K. and Stevenson, R. W. (1993). Actions of the novel antidiabetic agent englitazone in rat hepatocytes. Metabolism, 42, 1583-1587.
3. Bogardus, C., Lillioja, S., Stone, K. and Mott, D. (1984). Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J. Clin. Invest., 73, 1185-1190.
4. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
5. Ciaraldi, T. P., Gilmore, A., Olefsky, J. M., Goldberg, M. and Heidenreich, K. A. (1990). In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism, 39, 1056-1062.
6. Fujiwara, T., Okuno, A., Yoshioka, S. and Horikoshi, H. (1995). Suppression of hepatic gluconeogenesis in long-term Troglitazone treated diabetic KK and C57BL/KsJ-db/db mice. Metabolism, 44, 486-490.
7. Hallakou, S., Doaré, L., Foufelle, F., Kergoat, M., Guerre-Millo, M., Berthault, M. -F., Dugail, I., Morin, J., Auwerx, J. and Ferré, P. (1997). Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes, 46, 1393-1399.
8. Hansen, B. C. and Bodkin, N. L. (1986). Heterogeneity of insulin responses: phases in the continuum leading to non-insulin-dependent diabetes mellitus. Diabetologia, 29, 713-719.
9. Henderson, P., Statistical analysis of enzyme kinetic data. In: Enzyme Assays: A Practical Approach, edited by Eisenthal, R. and Danson, M. Oxford: IRL press, 1993, pp. 277-316.
10. Kemnitz, J., Elson, D., Roecker, E., Baum, S., Bergman, R. and Meglasson, M. (1994). Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure in obese, insulin-resistant rhesus monkeys. Diabetes, 43, 204-211.
11. Lee, M. K. and Olefsky, J. M. (1995). Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism, 44, 1166-1169.
12. Mandarino, L. J., Printz, R. L., Cusi, K. A., Kinchington, P., O'Doherty, R. M., Osawa, H., Sewell, C., Consoli, A., Granner, D. K. and DeFronzo, R. A. (1995). Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle. Am. J. Physiol., 269, E701-E708.
13. Mimura, K., Umeda, F., Hiramatsu, S., Taniguchi, S., Ono, Y., Nakashima, N., Kobayashi, K., Masakado, M., Sako, Y. and Nawata, H. (1994). Effects of a new oral hypoglycemic agent (CS-045) on metabolic abnormalaties and insulin resistance in type 2 diabetes. Diabetic Medicine, 11, 685-691.
14. Ortmeyer, H. K. and Bodkin, N. L. (1998). Lack of defect in insulin action on hepatic glycogen synthase and Phosphorylase in insulin-resistant monkeys. Am. J. Physiol, 274, G1005-G1010.
15. Ortmeyer, H. K., Bodkin, N. L. and Hansen, B. C. (1994). Chronic caloric restriction alters glycogen metabolism in rhesus monkeys. Obes. Res., 2, 549-555.
16. Ortmeyer, H. K., Bodkin, N. L. and Hansen, B. C. (1993). Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic rhesus monkeys. Am. J. Physiol., 265, R552-R558.
17. Ortmeyer, H. K., Bodkin, N. L. and Hansen, B. C. (1999). Paradoxical phosphorylation of skeletal muscle glycogen synthase by in vivo insulin in very lean young adult rhesus monkeys. Annals New York Academy of Sciences, 892, 247-260.
18. Ortmeyer, H. K., Bodkin, N. L. and Hansen, B. C. (1994). Relationship of skeletal muscle glucose-6-phosphate to glucose disposal rate and glycogen synthase activity in insulin-resistant and non-insulin-dependent diabetic rhesus monkeys. Diabetologia, 37, 127-133.
19. Ortmeyer, H. K., Huang, L., Lamer, J. and Hansen, B. C. (1998). Insulin unexpectedly increases the glucose 6-phosphate Ka of skeletal muscle glycogen synthase in calorie-restricted monkeys. J. Basic Clin. Physiol. Pharmacol., 9, 309-323.
20. Park, K. S., Ciaraldi, T. P., Abrams-Carter, L., Mudaliar, S., Nikoulina, S. E. and Henry, R. R. (1998). Troglitazone regulation of glucose metabolism in human skeletal muscle cultures from obese type II diabetic subjects. J. Clin. Endocrinol. Metab., 83, 1636-1643.
21. Park, K. S., Ciaraldi, T. P., Lindgren, K., Abrams-Carter, L., Mudaliar, S., Nikoulina, S. E., Tufari, S. R., Veerkamp, J. H., Vidal-Puig, A. and Henry, R. R. (1998). Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma. J. Clin. Endocrinol. Metab., 83, 2830-2835.
22. Schalin-Jäntti, C., Laurila, E., Löfman, M. and Groop, L. C. (1995). Determinants of insulin-stimulated skeletal muscle glycogen metabolism in man. European Journal of Clinical Investigation, 25, 693-698.
23. Vestergaard, H., Bjorbaek, C., Andersen, P. H., Bak, J. F. and Pedersen, O. (1991). Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. Diabetes, 40, 1740-1745.