Genetics of variation in adiponectin in pedigreed baboons: Evidence for pleiotropic effects on adipocyte volume and serum adiponectin

Heredity

Volumn 100, Issue 4, 2008, Pages 382-389

  Tejero, M E ^a   Voruganti, V S ^a   Rodriguez Sanchez I P ^b   Proffitt, J M ^a   Blangero, J ^a   Cox, L A ^a,c   Mahaney, M C ^a,c   Rogers, J ^a,c   VandeBerg, J L ^a,c   Cole, S A ^a   Comuzzie, A G ^a,c  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^c SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

Author keywords

Adiponectin; Adipose tissue; Animal model; Baboon; Pleiotropy; QTL

Indexed keywords

ADIPONECTIN; MESSENGER RNA;

BODY MASS; DIABETES; FAT; GENETIC ANALYSIS; GENETIC VARIATION; GLUCOSE; HORMONE; MAXIMUM LIKELIHOOD ANALYSIS; PLEIOTROPY; POLYMERASE CHAIN REACTION; PRIMATE; PROTEIN; RNA; SERUM; STATISTICAL ANALYSIS;

ADIPOCYTE; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BLOOD; CHEMISTRY; CHROMOSOME; FEMALE; GENETIC VARIABILITY; GENETICS; GENOME; HUMAN; MALE; METABOLIC DISORDER; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PAPIO; QUANTITATIVE TRAIT LOCUS; SEQUENCE ALIGNMENT;

ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHROMOSOMES, MAMMALIAN; FEMALE; GENOME; HUMANS; MALE; METABOLIC DISEASES; MOLECULAR SEQUENCE DATA; PAPIO; QUANTITATIVE TRAIT LOCI; RNA, MESSENGER; SEQUENCE ALIGNMENT; VARIATION (GENETICS);

ANIMALIA; PAPIO; PAPIO ANUBIS;

EID: 41149097091     PISSN: 0018067X     EISSN: 13652540     Source Type: Journal    
DOI: 10.1038/sj.hdy.6801089     Document Type: Article

References (40)

1. Almasy L, Blangero J (1998). Multipoint quantitative-trait genetic analysis in general pedigrees. Am J Hum Genet 62: 1198-1211.
2. An P, Teran-Garcia M, Rice T, Rankinen T, Weisnagel SJ, Bergman RN et al. (2005). Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE family study. Diabetologia 48: 1142-1149.
3. Banks WA, Altmann J, Sapolsky RM, Phillips-Conroy JE, Morley JE (2003). Serum leptin levels as a marker for a syndrome X-like condition in wild baboons. J Clin Endocrinol Metab 88: 1234-1240.
4. Blangero J, Williams JT, Almasy L (2000). Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 29: S8-S14.
5. Bruun J, Lihn AS, Verdich C, Pedersen SB, Toubo S, Astrup A et al. (2003). Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285: E527-E533.
6. Butte NF, Comuzzie AG, Cai G, Cole SA, Mehta NR, Bacino CA (2005). Genetic and environmental factors influencing fasting serum adiponectin in Hispanic children. J Clin Endocrinol Metab 90: 4170-4176.
7. Cai G, Cole SA, Tejero ME, Proffitt JM, Freeland-Graves JH, Blangero J et al. (2004). Pleiotropic effects of genes for insulin resistance on adiposity in baboons. Obes Res 12: 1766-1772.
8. Chen J, Tan B, Karteris E, Zervous S, Digby J, Hillhouse EW et al. (2006). Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Diabetologia 49: 1292-1302.
9. Chuang LM, Chiu YF, Sheu WH, Hung YJ, Ho LT, Grove J et al. (2005). Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. J Clin Endocrinol Metab 89: 5772-5778.
10. Comuzzie AG, Cole SA, Martin L, Dee Carey K, Mahaney MC, Blangero J et al. (2003). The baboon as a nonhuman model for the study of the genetics of obesity. Obes Res 11: 75-80.
11. Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE et al. (2001). The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 86: 4321-4325.
12. Comuzzie AG, Tejero ME, Funahasi T, Martin LJ, Kissebah A, Takahashi M et al. (2007). The genes influencing adiponectin levels also influence risk factors for the metabolic syndrome and the development of type 2 diabetes. Am J Hum Biol 79: 191-200.
13. Cox LA, Mahaney MC, VandeBerg JL, Rogers J (2006). A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. Genomics 88: 274-281.
14. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R et al. (2003). Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289: 1799-1804.
15. Feingold E, Brown PO, Siegmund D (1993). Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. Am J Hum Genet 53: 234-251.
16. Fernández Real JM, López Bermejo A, Casamitjana R, Ricart W (2003). Novel interactions of adiponectin with the endocrine system and inflammatory parameters. J Clin Endocrinol Metab 88: 2714-2718.
17. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT et al. (2001). Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98: 2005-2010.
18. Garaulet M, Perez-Llamas F, Fuente T, Zamora S, Tebar FJ (2000). Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. Eur J Endocrinol 143: 657-666.
19. Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D et al. (1998). An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 63: 1130-1138.
20. Heilbronn L, Smith SR, Ravussin E (2004). Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes 28: S12-S21.
21. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC et al. (2001). Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50: 1126-1133.
22. Kershaw E, Flier J (2004). Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
23. Lewis DS, Bertrand HA, McMahan CA, McGill Jr HC, Carey KD, Masoro EJ (1986). Preweaning food intake influences the adiposity of young adult baboons. J Clin Invest 78: 899-905.
24. Lihn AS, Bruun JM, Gengsheng H, Pedersen SB, Jensen PF, Richelsen B (2004). Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects. Mol Cell Endocrinol 219: 9-15.
25. Lindsay RS, Funahashi T, Krakoff J, Matsuzawa Y, Tanaka S, Kobes S et al. (2003). Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 52: 2419-2425.
26. Luo TH, Zhao Y, Li G, Yuan WT, Zhao JJ, Chang JL et al. (2001). A genome-wide search for type II diabetes susceptibility genes in Chinese Hans. Diabetologia 44: 501-506.
27. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996). cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1). Biochem Biophys Res Commun 221: 286-289.
28. Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N et al. (2002). Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 277: 37487-37491.
29. Nakamura Y, Shimada K, Fukuda D, Shimada Y, Ehara S, Hirose M et al. (2004). Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 90: 528-533.
30. Norman RA, Bogardus C, Ravussin E (1995). Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. J Clin Invest 96: 158-162.
31. Pausova Z (2006). From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 15: 173-178.
32. Pollin TI, Tanner K, O'connell JR, Ott SH, Damcott CM, Shuldiner AR et al. (2005). Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 54: 268-274.
33. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B et al. (2006). The human obesity gene map: the 2005 update. Obes Res 13: 381-490.
34. Rotter Sopasakis V, Sandqvist M, Gustafson B, Hammarstedt A, Schmelz M, Yang X et al. (2004). High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator. Obes Res 12: 454-460.
35. Shimada K, Miyazaki T, Daida H (2004). Adiponectin and atherosclerotic disease. Clin Chem Acta 344: 1-12.
36. Silha J, Krsek M, Skrha J, Sucharda P, Nyomba B, Murphy L (2003). Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol 149: 331-335.
37. Tejero ME, Cai G, Goring HHH, Diego V, Cole SA, Butte NA et al. (2007). Linkage analysis of circulating levels of adiponectin in Hispanic children. Int J Obes 31: 535-542.
38. Tejero ME, Freeland-Graves JH, Proffitt JM, Peebles KW, Cole SA, Comuzzie AG (2004). Adiponectin, but not resistin expression in monocytes is associated with insulin resistance in baboons. Obes Res 12: 871-877.
39. Weyer C, Folwy JE, Bogardus C, Tataranni PA, Pratley RT (2000). Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43: 1498-1506.
40. Weyer C, Funahashi T, Tanaka S, Tataranni PA (2001). Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86: 1930-1935.