-
1
-
-
37449007904
-
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake
-
Addy C., Wright H., Van Laere K., Gantz I., Erondu N., Musser B.J., Lu K., Yuan J., Sanabria-Bohórquez S.M., Stoch A., et al. The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab. 7 (2008) 68-78
-
(2008)
Cell Metab.
, vol.7
, pp. 68-78
-
-
Addy, C.1
Wright, H.2
Van Laere, K.3
Gantz, I.4
Erondu, N.5
Musser, B.J.6
Lu, K.7
Yuan, J.8
Sanabria-Bohórquez, S.M.9
Stoch, A.10
-
2
-
-
58149214108
-
A critical review of the cannabinoid receptor as a drug target for obesity management
-
Akbas F., Gasteyger C., Sjödin A., Astrup A., and Larsen T.M. A critical review of the cannabinoid receptor as a drug target for obesity management. Obes. Rev. 10 (2009) 58-67
-
(2009)
Obes. Rev.
, vol.10
, pp. 58-67
-
-
Akbas, F.1
Gasteyger, C.2
Sjödin, A.3
Astrup, A.4
Larsen, T.M.5
-
3
-
-
0034741267
-
A CamKIIalpha iCre BAC allows brain-specific gene inactivation
-
Casanova E., Fehsenfeld S., Mantamadiotis T., Lemberger T., Greiner E., Stewart A.F., and Schütz G. A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis 31 (2001) 37-42
-
(2001)
Genesis
, vol.31
, pp. 37-42
-
-
Casanova, E.1
Fehsenfeld, S.2
Mantamadiotis, T.3
Lemberger, T.4
Greiner, E.5
Stewart, A.F.6
Schütz, G.7
-
4
-
-
85047690626
-
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
-
Cota D., Marsicano G., Tschöp M., Grübler Y., Flachskamm C., Schubert M., Auer D., Yassouridis A., Thöne-Reineke C., Ortmann S., et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J. Clin. Invest. 112 (2003) 423-431
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 423-431
-
-
Cota, D.1
Marsicano, G.2
Tschöp, M.3
Grübler, Y.4
Flachskamm, C.5
Schubert, M.6
Auer, D.7
Yassouridis, A.8
Thöne-Reineke, C.9
Ortmann, S.10
-
5
-
-
67749101769
-
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism
-
Cota D., Sandoval D.A., Olivieri M., Prodi E., D'Alessio D.A., Woods S.C., Seeley R.J., and Obici S. Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring) 17 (2009) 1641-1645
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 1641-1645
-
-
Cota, D.1
Sandoval, D.A.2
Olivieri, M.3
Prodi, E.4
D'Alessio, D.A.5
Woods, S.C.6
Seeley, R.J.7
Obici, S.8
-
6
-
-
0035848818
-
Leptin-regulated endocannabinoids are involved in maintaining food intake
-
Di Marzo V., Goparaju S.K., Wang L., Liu J., Bátkai S., Járai Z., Fezza F., Miura G.I., Palmiter R.D., Sugiura T., and Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410 (2001) 822-825
-
(2001)
Nature
, vol.410
, pp. 822-825
-
-
Di Marzo, V.1
Goparaju, S.K.2
Wang, L.3
Liu, J.4
Bátkai, S.5
Járai, Z.6
Fezza, F.7
Miura, G.I.8
Palmiter, R.D.9
Sugiura, T.10
Kunos, G.11
-
7
-
-
2942538498
-
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling
-
Fukudome Y., Ohno-Shosaku T., Matsui M., Omori Y., Fukaya M., Tsubokawa H., Taketo M.M., Watanabe M., Manabe T., and Kano M. Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur. J. Neurosci. 19 (2004) 2682-2692
-
(2004)
Eur. J. Neurosci.
, vol.19
, pp. 2682-2692
-
-
Fukudome, Y.1
Ohno-Shosaku, T.2
Matsui, M.3
Omori, Y.4
Fukaya, M.5
Tsubokawa, H.6
Taketo, M.M.7
Watanabe, M.8
Manabe, T.9
Kano, M.10
-
8
-
-
36048988035
-
Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism
-
Galiè M., Farace P., Nanni C., Spinelli A., Nicolato E., Boschi F., Magnani P., Trespidi S., Ambrosini V., Fanti S., et al. Epithelial and mesenchymal tumor compartments exhibit in vivo complementary patterns of vascular perfusion and glucose metabolism. Neoplasia 9 (2007) 900-908
-
(2007)
Neoplasia
, vol.9
, pp. 900-908
-
-
Galiè, M.1
Farace, P.2
Nanni, C.3
Spinelli, A.4
Nicolato, E.5
Boschi, F.6
Magnani, P.7
Trespidi, S.8
Ambrosini, V.9
Fanti, S.10
-
9
-
-
64949116079
-
The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake
-
Grill H.J., and Hayes M.R. The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake. Int. J. Obes. (Lond.) 33 Suppl 1 (2009) S11-S15
-
(2009)
Int. J. Obes. (Lond.)
, vol.33
, Issue.SUPPL. 1
-
-
Grill, H.J.1
Hayes, M.R.2
-
10
-
-
0025980831
-
Improvements in automated analysis of catecholamine and related metabolites in biological samples by column-switching high-performance liquid chromatography
-
Grossi G., Bargossi A.M., Lucarelli C., Paradisi R., Sprovieri C., and Sprovieri G. Improvements in automated analysis of catecholamine and related metabolites in biological samples by column-switching high-performance liquid chromatography. J. Chromatogr. 22 (1991) 273-284
-
(1991)
J. Chromatogr.
, vol.22
, pp. 273-284
-
-
Grossi, G.1
Bargossi, A.M.2
Lucarelli, C.3
Paradisi, R.4
Sprovieri, C.5
Sprovieri, G.6
-
11
-
-
42449164329
-
Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats
-
Herling A.W., Kilp S., Elvert R., Haschke G., and Kramer W. Increased energy expenditure contributes more to the body weight-reducing effect of rimonabant than reduced food intake in candy-fed wistar rats. Endocrinology 149 (2008) 2557-2566
-
(2008)
Endocrinology
, vol.149
, pp. 2557-2566
-
-
Herling, A.W.1
Kilp, S.2
Elvert, R.3
Haschke, G.4
Kramer, W.5
-
12
-
-
24644500204
-
The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance
-
Jbilo O., Ravinet-Trillou C., Arnone M., Buisson I., Bribes E., Péleraux A., Pénarier G., Soubrié P., Le Fur G., Galiègue S., and Casellas P. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J. 19 (2005) 1567-1569
-
(2005)
FASEB J.
, vol.19
, pp. 1567-1569
-
-
Jbilo, O.1
Ravinet-Trillou, C.2
Arnone, M.3
Buisson, I.4
Bribes, E.5
Péleraux, A.6
Pénarier, G.7
Soubrié, P.8
Le Fur, G.9
Galiègue, S.10
Casellas, P.11
-
13
-
-
57749119549
-
Endocannabinoids and the control of energy homeostasis
-
Kunos G., Osei-Hyiaman D., Liu J., Godlewski G., and Bátkai S. Endocannabinoids and the control of energy homeostasis. J. Biol. Chem. 283 (2008) 33021-33025
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33021-33025
-
-
Kunos, G.1
Osei-Hyiaman, D.2
Liu, J.3
Godlewski, G.4
Bátkai, S.5
-
14
-
-
58149138840
-
Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
-
Kunos G., Osei-Hyiaman D., Bátkai S., Sharkey K.A., and Makriyannis A. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?. Trends Pharmacol. Sci. 30 (2009) 1-7
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 1-7
-
-
Kunos, G.1
Osei-Hyiaman, D.2
Bátkai, S.3
Sharkey, K.A.4
Makriyannis, A.5
-
15
-
-
58849116267
-
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice
-
LoVerme J., Duranti A., Tontini A., Spadoni G., Mor M., Rivara S., Stella N., Xu C., Tarzia G., and Piomelli D. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg. Med. Chem. Lett. 19 (2009) 639-643
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 639-643
-
-
LoVerme, J.1
Duranti, A.2
Tontini, A.3
Spadoni, G.4
Mor, M.5
Rivara, S.6
Stella, N.7
Xu, C.8
Tarzia, G.9
Piomelli, D.10
-
16
-
-
34548854232
-
Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors
-
Makara J.K., Katona I., Nyíri G., Németh B., Ledent C., Watanabe M., de Vente J., Freund T.F., and Hájos N. Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors. J. Neurosci. 27 (2007) 10211-10222
-
(2007)
J. Neurosci.
, vol.27
, pp. 10211-10222
-
-
Makara, J.K.1
Katona, I.2
Nyíri, G.3
Németh, B.4
Ledent, C.5
Watanabe, M.6
de Vente, J.7
Freund, T.F.8
Hájos, N.9
-
17
-
-
0033452718
-
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
-
Marsicano G., and Lutz B. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur. J. Neurosci. 11 (1999) 4213-4225
-
(1999)
Eur. J. Neurosci.
, vol.11
, pp. 4213-4225
-
-
Marsicano, G.1
Lutz, B.2
-
18
-
-
0036682222
-
The endogenous cannabinoid system controls extinction of aversive memories
-
Marsicano G., Wotjak C.T., Azad S.C., Bisogno T., Rammes G., Cascio M.G., Hermann H., Tang J., Hofmann C., Zieglgänsberger W., et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature 418 (2002) 530-534
-
(2002)
Nature
, vol.418
, pp. 530-534
-
-
Marsicano, G.1
Wotjak, C.T.2
Azad, S.C.3
Bisogno, T.4
Rammes, G.5
Cascio, M.G.6
Hermann, H.7
Tang, J.8
Hofmann, C.9
Zieglgänsberger, W.10
-
19
-
-
0141865717
-
CB1 cannabinoid receptors and on-demand defense against excitotoxicity
-
Marsicano G., Goodenough S., Monory K., Hermann H., Eder M., Cannich A., Azad S.C., Cascio M.G., Gutiérrez S.O., van der Stelt M., et al. CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302 (2003) 84-88
-
(2003)
Science
, vol.302
, pp. 84-88
-
-
Marsicano, G.1
Goodenough, S.2
Monory, K.3
Hermann, H.4
Eder, M.5
Cannich, A.6
Azad, S.C.7
Cascio, M.G.8
Gutiérrez, S.O.9
van der Stelt, M.10
-
20
-
-
77950214934
-
Non-brain penetrant CB1 receptor antagonists as novel treatment of obesity and related metabolic disorders
-
McElroy J., Sieracki C., and Chorvat R. Non-brain penetrant CB1 receptor antagonists as novel treatment of obesity and related metabolic disorders. Obesity (Silver Spring) 16 Suppl. 1 (2008) S47
-
(2008)
Obesity (Silver Spring)
, vol.16
, Issue.SUPPL. 1
-
-
McElroy, J.1
Sieracki, C.2
Chorvat, R.3
-
21
-
-
33746913292
-
The endocannabinoid system controls key epileptogenic circuits in the hippocampus
-
Monory K., Massa F., Egertová M., Eder M., Blaudzun H., Westenbroek R., Kelsch W., Jacob W., Marsch R., Ekker M., et al. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51 (2006) 455-466
-
(2006)
Neuron
, vol.51
, pp. 455-466
-
-
Monory, K.1
Massa, F.2
Egertová, M.3
Eder, M.4
Blaudzun, H.5
Westenbroek, R.6
Kelsch, W.7
Jacob, W.8
Marsch, R.9
Ekker, M.10
-
22
-
-
58149128824
-
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
-
Nogueiras R., Veyrat-Durebex C., Suchanek P.M., Klein M., Tschöp J., Caldwell C., Woods S.C., Wittmann G., Watanabe M., Liposits Z., et al. Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes 57 (2008) 2977-2991
-
(2008)
Diabetes
, vol.57
, pp. 2977-2991
-
-
Nogueiras, R.1
Veyrat-Durebex, C.2
Suchanek, P.M.3
Klein, M.4
Tschöp, J.5
Caldwell, C.6
Woods, S.C.7
Wittmann, G.8
Watanabe, M.9
Liposits, Z.10
-
23
-
-
51349153318
-
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
-
Osei-Hyiaman D., Liu J., Zhou L., Godlewski G., Harvey-White J., Jeong W.I., Bátkai S., Marsicano G., Lutz B., Buettner C., and Kunos G. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J. Clin. Invest. 118 (2008) 3160-3169
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3160-3169
-
-
Osei-Hyiaman, D.1
Liu, J.2
Zhou, L.3
Godlewski, G.4
Harvey-White, J.5
Jeong, W.I.6
Bátkai, S.7
Marsicano, G.8
Lutz, B.9
Buettner, C.10
Kunos, G.11
-
24
-
-
32444440208
-
The emerging role of the endocannabinoid system in endocrine regulation and energy balance
-
Pagotto U., Marsicano G., Cota D., Lutz B., and Pasquali R. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr. Rev. 27 (2006) 73-100
-
(2006)
Endocr. Rev.
, vol.27
, pp. 73-100
-
-
Pagotto, U.1
Marsicano, G.2
Cota, D.3
Lutz, B.4
Pasquali, R.5
-
25
-
-
1842866963
-
CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
-
Ravinet Trillou C., Delgorge C., Menet C., Arnone M., and Soubrié P. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int. J. Obes. Relat. Metab. Disord. 28 (2004) 640-648
-
(2004)
Int. J. Obes. Relat. Metab. Disord.
, vol.28
, pp. 640-648
-
-
Ravinet Trillou, C.1
Delgorge, C.2
Menet, C.3
Arnone, M.4
Soubrié, P.5
-
26
-
-
42449151676
-
CB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant
-
Scheen A.J. CB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant. J. Neuroendocrinol. 20 Suppl 1 (2008) 139-146
-
(2008)
J. Neuroendocrinol.
, vol.20
, Issue.SUPPL. 1
, pp. 139-146
-
-
Scheen, A.J.1
-
27
-
-
50949092455
-
Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
-
Tedesco L., Valerio A., Cervino C., Cardile A., Pagano C., Vettor R., Pasquali R., Carruba M.O., Marsicano G., Lutz B., et al. Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes 57 (2008) 2028-2036
-
(2008)
Diabetes
, vol.57
, pp. 2028-2036
-
-
Tedesco, L.1
Valerio, A.2
Cervino, C.3
Cardile, A.4
Pagano, C.5
Vettor, R.6
Pasquali, R.7
Carruba, M.O.8
Marsicano, G.9
Lutz, B.10
-
28
-
-
35348918857
-
Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue
-
Thackeray J.T., Beanlands R.S., and Dasilva J.N. Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue. J. Nucl. Med. 48 (2007) 1733-1740
-
(2007)
J. Nucl. Med.
, vol.48
, pp. 1733-1740
-
-
Thackeray, J.T.1
Beanlands, R.S.2
Dasilva, J.N.3
-
29
-
-
0031929438
-
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
-
Tsou K., Brown S., Sañudo-Peña M.C., Mackie K., and Walker J.M. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83 (1998) 393-411
-
(1998)
Neuroscience
, vol.83
, pp. 393-411
-
-
Tsou, K.1
Brown, S.2
Sañudo-Peña, M.C.3
Mackie, K.4
Walker, J.M.5
-
30
-
-
58849117501
-
The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure
-
Verty A.N., Allen A.M., and Oldfield B.J. The effects of rimonabant on brown adipose tissue in rat: implications for energy expenditure. Obesity (Silver Spring) 17 (2009) 254-261
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 254-261
-
-
Verty, A.N.1
Allen, A.M.2
Oldfield, B.J.3
-
31
-
-
0037207071
-
Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example
-
Wager-Miller J., Westenbroek R., and Mackie K. Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example. Chem. Phys. Lipids 121 (2002) 83-89
-
(2002)
Chem. Phys. Lipids
, vol.121
, pp. 83-89
-
-
Wager-Miller, J.1
Westenbroek, R.2
Mackie, K.3
-
32
-
-
34447635408
-
Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus
-
Wittmann G., Deli L., Kalló I., Hrabovszky E., Watanabe M., Liposits Z., and Fekete C. Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J. Comp. Neurol. 503 (2007) 270-279
-
(2007)
J. Comp. Neurol.
, vol.503
, pp. 270-279
-
-
Wittmann, G.1
Deli, L.2
Kalló, I.3
Hrabovszky, E.4
Watanabe, M.5
Liposits, Z.6
Fekete, C.7
|