Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity

Obesity Research

Volumn 13, Issue 8, 2005, Pages 1476-1484

  Franks, Paul W ^a,b   Brage, Soren ^b   Luan, JiaN'An ^b   Ekelund, Ulf ^b   Rahman, Mushtaquar ^c   Sadaf Farooqi, I ^d   Halsall, Ian ^d   O'Rahilly, Stephen ^d   Wareham, Nicholas J ^b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Glucose intolerance; Hyperleptinemia; Insulin resistance; Metabolic syndrome; Prospective cohort study

Indexed keywords

LEPTIN;

ADULT; ARTICLE; BLOOD; COHORT ANALYSIS; FEMALE; HUMAN; MALE; METABOLIC SYNDROME X; OBESITY; PROSPECTIVE STUDY; RISK FACTOR;

ADULT; COHORT STUDIES; FEMALE; HUMANS; LEPTIN; MALE; METABOLIC SYNDROME X; OBESITY; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 32944463503     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2005.178     Document Type: Article

References (59)

1. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med. 2002;162:1867-72.
2. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.
3. Huang KC, Lin RC, Kormas N, et al. Plasma leptin is associated with insulin resistance independent of age, body mass index, fat mass, lipids, and pubertal development in nondiabetic adolescents. Int J Obes Relat Metab Disord. 2004;28:470-5.
4. Moreno LA, Pineda I, Rodriguez G, et al. Leptin and metabolic syndrome in obese and non-obese children. Horm Metab Res. 2002;34:394-9.
5. Hodge AM, Boyko EJ, de Courten M, et al. Leptin and other components of the metabolic syndrome in Mauritius - a factor analysis. Int J Obes Relat Metab Disord. 2001;25:126-31.
6. Haffner SM, Mykkanen LA, Gonzalez CC, Stern MP. Leptin concentrations do not predict weight gain: the Mexico City Diabetes Study. Int J Obes Relat Metab Disord. 1998;22:695-9.
7. Hodge AM, de Courten MP, Dowse GK, et al. Do leptin levels predict weight gain? A 5-year follow-up study in Mauritius. Mauritius Non-communicable Disease Study Group. Obes Res. 1998;6:319-25.
8. Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 1997;3:238-40.
9. Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS, Rimm EB. Plasma leptin concentrations and four-year weight gain among US men. Int J Obes Relat Metab Disord. 2001;25:346-53.
10. Lindroos AK, Lissner L, Carlsson B, et al. Familial predisposition for obesity may modify the predictive value of serum leptin concentrations for long-term weight change in obese women. Am J Clin Nutr. 1998;67:1119-23.
11. Chessler SD, Fujimoto WY, Shofer JB, Boyko EJ, Weigle DS. Increased plasma leptin levels are associated with fat accumulation in Japanese Americans. Diabetes. 1998;47:239-43.
12. Folsom AR, Jensen MD, Jacobs DR Jr, Hilner JE, Tsai AW, Schreiner PJ. Serum leptin and weight gain over 8 years in African American and Caucasian young adults. Obes Res. 1999;7:1-8.
13. Mavri A, Stegnar M, Sabovic M. Do baseline serum leptin levels predict weight regain after dieting in obese women? Diabet Obes Metab. 2001;3:293-6.
14. Lissner L, Karlsson C, Lindroos AK, et al. Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin levels in Swedish women. Obes Res. 1999;7:150-4.
15. Nagy TR, Davies SL, Hunter GR, Darnell B, Weinsier RL. Serum leptin concentrations and weight gain in postobese, postmenopausal women. Obes Res. 1998;6:257-61.
16. van Rossum CTM, Hoebee B, van Baak MA, Mars M, Saris WHM, Siedell JC. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res. 2003;11:377-86.
17. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. 1997;389:374-7.
18. Minokoshi Y, Haque MS, Shimazu T. Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats. Diabetes. 1999;48:287-91.
19. Aizawa-Abe M, Ogawa Y, Masuzaki H, et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest. 2000;105:1243-52.
20. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension. 1998;31:409-14.
21. Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes. 1997;46:2040-3.
22. Nakata M, Yada T, Soejima N, Maruyama I. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes. 1999;48:426-9.
23. Corsonello A, Perticone F, Malara A, et al. Leptin-dependent platelet aggregation in healthy, overweight and obese subjects. Int J Obes Relat Metab Disord. 2003;27:566-73.
24. Maruyama I, Nakata M, Yamaji K. Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis. Ann N Y Acad Sci. 2000;902:315-9.
25. Suzuki R, Tobe K, Aoyama M, et al. Expression of DGAT2 in white adipose tissue is regulated by central leptin action. J Biol Chem 2005;280:3331-7.
26. Satoh N, Ogawa Y, Katsuura G, et al. Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes. 1999;48:1787-93.
27. Minokoshi Y, Kim YB, Peroni OD, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Natur. 2002;415:339-43.
28. Muoio DM, Dohm GL, Fiedorek FT Jr, Tapscott EB, Coleman RA, Dohm GL. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes. 1997;46:1360-3.
29. Ajuwon KM, Kuske JL, Anderson DB, et al. Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue. J Nutr Biochem. 2003;14:576-83.
30. Shibuya I, Utsunomiya K, Toyohira Y, et al. Regulation of catecholamine synthesis by leptin. Ann N Y Acad Sci. 2002;971:522-7.
31. Wareham NJ, Wong M-Y, Day NE. Glucose intolerance and physical inactivity: the relative importance of low habitual energy expenditure and cardiorespiratory fitness. Am J Epidemiol. 2000;152:132-9.
32. Wareham NJ, Wong MY, Hennings S, et al. Quantifying the association between habitual energy expenditure and blood pressure. Int J Epidemiol. 2000;29:655-60.
33. Franks PW, Ekelund U, Brage S, Wong M-Y, Wareham NJ. Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness? Diabetes Care. 2004;27:1187-93.
34. Wareham NJ, Ness EM, Byrne CD, Cox BD, Day NE, Hales CN. Cigarette smoking is not associated with hyperinsulinemia: evidence against a causal relationship between smoking and insulin resistance. Metabolism. 1996;45:1551-6.
35. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-53.
36. Brage S, Wedderkopp N, Ekelund U, et al. Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children. The European Youth Heart Study (EYHS). Diabetes Care. 2004;27:2141-48.
37. Ragland DR. Dichotomizing continuous outcome variables: dependence of the magnitude of association and statistical power on the cutpoint. Epidemiology. 1992;3:434-40.
38. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-5.
39. Ruhl CE, Everhart JE. Leptin concentrations in the United States: relations with demographic and anthropometric measures. Am J Clin Nutr. 2001;74:295-301.
40. Ruhl CE, Everhart JE, Ding J, et al. Health, Aging, and Body Composition Study. Serum leptin concentrations and body adipose measures in older black and white adults. Am J Clin Nutr. 2004;80:576-83.
41. Morabia A, Ross A, Curtin F, Pichard C, Slosman DO. Relation of BMI to a dual-energy X-ray absorptiometry measure of fatness. Br J Nutr. 1999;82:49-55.
42. Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104:3052-6.
43. Söderberg S, Stegmayr B, Stenlund H, et al. Leptin, but not adiponectin, predicts stroke in males. J Intern Med. 2004;256:128-36.
44. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000;141:2328-39.
45. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in Ob/ob mice. Science. 1995;269:540-3.
46. Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. J Am Med Assoc. 1999;282:1568-75.
47. Welt CK, Chan JL, Bullen J, et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004;351:987-97.
48. Ren J. Leptin and hyperleptinemia - from friend to foe for cardiovascular function. J Endocrinol. 2004;181:1-10.
49. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996;379:632-5.
50. Darnell JE Jr. STATs and gene regulation. Science. 1997;277:1630-5.
51. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998;1:619-25.
52. Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol. 1999;277:E1-10.
53. Clement K, Vega N, Laville M, et al. Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor. Int J Obes Relat Metab Disord. 2002;26:1533-8.
54. Donahoo WT, Jensen DR, Yost TJ, Eckel RH. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab. 1997;82:4139-43.
55. Hardie LJ, Guilhot N, Trayhurn P. Regulation of leptin production in cultured mature white adipocytes. Horm Metab Res. 1996;28:685-9.
56. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci. 1998;1:445-50.
57. Jin X, Fukuda N, Su J, et al. Effects of leptin on endothelial function with OB-Rb gene transfer in Zucker fatty rats. Atherosclerosis. 2003;169:225-33.
58. Goetze S, Bungenstock A, Czupalla C, et al. Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands. Hypertension. 2002;40:748-54.
59. Oral EA, Simha V, Ruiz E, et al. Leptin-replacement therapy for lipodystrophy. N Engl J Med. 2002;21:346:570-8.