Dietary isoflavones: Biological effects and relevance to human health

Journal of Nutrition

Volumn 129, Issue 3 SUPPL., 1999, Pages

  Setchell, Kenneth D R ^a   Cassidy, Aedin ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Bone; Cancer; Cardiovascular disease; Genistein; Hormones; Isoflavones; Phytoestrogens

Indexed keywords

GENISTEIN; ISOFLAVONE; PHYTOESTROGEN;

CANCER PREVENTION; CARDIOVASCULAR DISEASE; CHEMOPROPHYLAXIS; CONFERENCE PAPER; DIET SUPPLEMENTATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; PHYTOCHEMISTRY; POSTMENOPAUSE; PREMENOPAUSE; STRUCTURE ACTIVITY RELATION;

CARDIOVASCULAR DISEASES; DIET; ESTROGENS, NON-STEROIDAL; HEALTH PROMOTION; HUMANS; ISOFLAVONES; MALE; MENOPAUSE; NUTRITION PHYSIOLOGY; OSTEOPOROSIS; PHYTOESTROGENS; PLANT PREPARATIONS; PLANTS, EDIBLE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; GLYCINE MAX;

EID: 0033011895     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.3.758s     Document Type: Conference Paper

References (149)

1. Adlercreutz, H. (1995) Phytoestrogens: epidemiology and a possible role in cancer protection. Environ. Health Perspect. 103: 103-111.
2. Adlercreutz, H., Fotsis, T., Heikkiinen, R., Dwyer, J. T., Woods, M., Goldin, B. R. & Gorbach, S. L. (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian women with breast cancer. Lancet ii: 1295-1299.
3. Adlercreutz, H., Fotsis, T., Lampe, J., Wahala, K., Makela, T., Brunow, G. & Hase, T. (1993a) Quantitative determination of lignans and isoflavones in plasma of omnivorous and vegetarian women by isotope-dilution gas chromatography-mass spectrometry. Scand. J. Clin. Lab. Investig. 53: 5-18.
4. Adlercreutz, H., Hamalainen, E., Gorbach, S. & Goldin, B. (1992) Dietary phyto-oestrogens and the menopause in Japan (letter). Lancet 339: 1233.
5. Adlercreutz, H., Honjo, H., Higashi, A., Fotsis, T., Hamalainen, E., Hasegawa, T. & Okada, H. (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 54: 1093-1100.
6. Adlercreutz, H., Markkanen, H. & Watanabe, S. (1993b) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342: 1209-1210.
7. Akiyama, T., Ishida, J., Nakagava, S., Ogawara, S., Watanabe, S., Itoh, N., Shiyba, M. & Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262: 5592-5595.
8. Albertazzi, P., Pansini, F., Bonaccorsi, G., Zanotti, L., Forini, E. & DeAloysio, D. (1998) The effects of dietary soy supplementation on hot flushes. Obstet. Gynecol. 91: 6-11.
9. Anderson, J. J., Ambrose, W. W. & Garner, S. C. (1995b) Orally dosed genistein from soy and prevention of cancellous bone loss in two ovariectomized rat models. J. Nutr. 125: 799S (abs.).
10. Anderson, J.J.B. & Garner, S. C. (1997) Phytoestrogens and human function. Nutr. Today 32: 232-239.
11. Anderson, J. W. (1995) Dietary fibre, complex carbohydrate and coronary artery disease. Can. J. Cardiol. 11 (suppl.): 55G-62G.
12. Anderson, J. W., Johnstone, B. M. & Cook-Newell, M. E. (1995a) Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 333: 276-282.
13. Anthony, M. S. & Clarkson, T. B. (1998) Comparison of soy phytoestrogens and conjugated equine estrogens on atherosclerosis progression in postmenopausal monkeys. Circulation 97: 829 (abs.).
14. Anthony, M. S., Clarkson, T. B., Bullock, B. C. & Wagner, J. (1997) Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male Cynomolgous monkeys. Arterioscler. Thromb. Vasc. Biol. 17: 2524-2531.
15. Anthony, M. S., Clarkson, T. B., Hughes, C. L., Jr., Morgan, T. M. & Burke, G. L. (1996) Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J. Nutr. 126: 43-50.
16. Arjmandi, B. H., Alekel, L., Hollis, B. W., Amin, D., Stacewiczsapuntzakis, M., Guo, P. & Kukreja, S. C. (1996) Dietary soybean protein prevents bone loss in an ovarectomised rat model of osteoporosis. J. Nutr. 126: 161-167.
17. Arjmandi, B. H., Khan, D. A., Juma, S. S. & Svanborg, A. (1997) The ovarian hormone deficiency induced hypercholesterolemia is reversed by soy protein and the synthetic isoflavone, ipriflavone. Nutr. Res. 17: 885-894.
18. Axelson, M. & Setchell, K.D.R. (1981) The excretion of lignans in rats - evidence for an intestinal bacterial source for this new group of compounds. FEBS Lett., 123: 337-342.
19. Axelson, M., Sjovall, J., Gustafsson, B. & Setchell, K.D.R. (1984) Soya - a dietary source of the non-steroidal oestrogen equol in humans and animals. J. Endocrinol. 102: 49-56.
20. Baird, D. D., Umbach, D. M., Lansdell, L., Hughes, C. L., Setchell, K.D.R., Weinberg, C. R., Haney, A. F., Wilcox, A. J. & McLachlan, J. A. (1995) Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J. Clin. Endocrinol. Metab. 80: 1685-1690.
21. Bannwart, C., Adlercreutz, H., Fotsis, T., Wahala, K., Hase, T. & Brunow, G. (1984) Identification of O-desmethylangolensin, a metabolite of daidzein and of matairesinol, one likely plant precursor of the animal lignan enterolactone in human urine. Finn. Chem. Lett. 4-5: 120-125.
22. Bannwart, C., Adlercreutz, H., Wahala, K., Kotiaho, T., Hesso, A., Brunow, G. & Hase, T. (1988) Identification of the phyto-oestrogen 3′,7-dihydroxyisoflavan, an isomer of equol, in human urine and cow's milk. Biomed. Environ. Mass Spectrom. 16: 1-6.
23. Barnes, S. (1995) Effect of genistein on in vitro and in vivo models of cancer. J. Nutr. 125: 777S-783S.
24. Barnes, S., Grubbs, C., Carlson, J. & Setchell, K.D.R. (1990) Soybeans inhibit mammary tumors in rat models of breast cancer. In: Proceedings of Meeting on Mutagens and Carcinogens in the Diet, pp. 239-253. Wiley-Liss, New York, NY.
25. Barnes, S. & Peterson, T. G. (1995) Biochemical targets of the isoflavone genistein in tumor cell lines. Proc. Soc. Exp. Biol. Med. 208: 103-108.
26. Bennetts, H. W., Underwood, E. J. & Shier, F. L. (1946) A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust. Vet. J. 22: 2-12.
27. Bernstein, L., Yuan, J. M., Ross, R. K., Pike, M. C., Hanisch, R., Lobo, R., Stanczyk, F., Gao, Y. T. & Henderson B. E. (1990) Serum hormone levels in premenopausal chinese women in Shanghai and white women in Los-Angeles - results from 2 breast-cancer case-control studies. Cancer Causes Control 1: 51-58.
28. Blair, H. C., Jordan, S. E., Peterson, T. G. & Barnes, S. (1996) Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction in bone loss in ovariectomized rats. J. Cell. Biochem. 61: 630-637.
29. Borriello, S. P., Setchell, K.D.R., Axelson, M. & Lawson, A. M. (1985) Production and metabolism of lignans by the human faecal flora. J. Appl. Bacteriol. 58: 37-43.
30. Brandi, M. L. (1993) New treatment strategies: Ipriflavone, strontium, vitamin D metabolites and analogs. Am. J. Med. 95 : 69S-74S.
31. Brann, D. W., Hendry, L. B. & Mahesh, V. B. (1995) Emerging diversities in the mechanism of action of steroid hormones. J. Steroid Biochem. Mol. Biol. 52: 113-133.
32. Breckwoldt, M., Keck, C. & Karck, U. (1995) Benefits and risks of hormone replacement therapy. J. Steroid Biochem. Mol. Biol. 53: 205-208.
33. Brzezinski, A., Adlercreutz, H., Shaoul, R., Rosler, A., Shmueli, A., Tanos, V. & Schenker, J. G. (1997) Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 4: 89-94.
34. Brzozowski, A. M., Pike, A.C.W., Dauter, Z., Hubbard, R. E., Bonn, T., Engstrom, O., Ohman, L., Greene, G. L., Gustafsson, J.-A. & Carlquist, M. (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature (Lond.) 389: 753-758.
35. Carroll, K. K. (1982) Hypercholesterolemia and atherosclerosis: effects of dietary protein. Fed. Proc. 41: 2792-2796.
36. Cassidy, A. (1991) Plant Oestrogens and Their Relation to Hormonal Status in Women. Doctoral thesis, Cambridge University, Cambridge, UK.
37. Cassidy, A. (1996) Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proc. Nutr. Soc. 55: 399-417.
38. Cassidy, A., Bingham, S. & Setchell, K.D.R. (1994) Biological effects of isoflavones present in soy in premenopausal women: implications for the prevention of breast cancer. Am. J. Clin. Nutr. 60: 333-340.
39. Cassidy, A., Bingham, S. & Setchell, K. (1995) Biological effects of isoflavones in young women - importance of the chemical compostion of soya products. Br. J. Nutr. 74: 587-560.
40. Cassidy, A., Faughnan, M., Hughes, R., Fraser, C., Cathcart, A., Taylor, N., Setchell, K.D.R. & Bingham, S. (1998) Hormonal effects of phytoestrogens in postmenopausal women and middle-aged men. Am. J. Clin. Nutr. 68: 1531S (abs.).
41. Cheng, S. L., Zhang, S. F., Nelson, T. L., Warlow, P. M. & Civitelli, R. (1994) Stimulation of human osteoblast differentiation and function by Ipriflavone and its metabolites. Calcif. Tissue Int. 55: 356-362.
42. Col, N., Eckman, M. H., Karas, R. H., Pauker, S. G., Goldberg, R. J., Ross, E. M., Orr, R. K. & Wong, J. B. (1997) Patient-specific decisions about hormone replacemant therapy in postmenopausal women. J. Am. Med. Assoc. 277: 1140-1147.
43. Colditz, G. A. & Frazier A. L. (1995) Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol. Biomark. Prev. 4: 567-571.
44. Coward, L., Barnes, N. C., Setchell, K. D.R. & Barnes, S. (1993) Genistein and daidzein, and their β-glycoside conjugates: anti-tumor isoflavones in soybean foods from American and Asian diets. J. Agric. Food Chem. 41: 1961-1967.
45. Crouse, J. R., Terry, J. G., Morgan, T. M., McGill, B. L., Davis, D. H., King, T., Ellis, J. E. & Burke, G. L. (1998) Soy protein containing isoflavones reduces plasma concentrations of lipids and lipoproteins. Circulation 97: 816 (abs).
46. Cruz, M.L.A., Wong, W. W., Mimouni, F., Hachey, D. L., Setchell, K.D.R., Klein, P. D. & Tsang, R. C. (1994) Effects of infant nutrition on cholesterol synthesis rates. Pediatr. Res. 35: 135-140.
47. Cunningham, A. R., Klopman, G. & Rosenkranz, H. S. (1997) A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens. Environ. Health Perspect. 105: 665-668.
48. Dodge, J. A., Lugar, C. W., Cho, S., Short, L. L., Sato, M., Yang, N. N., Spangle, L. A., Martin, M. J., Phillips, D. L., Glasebrook, A. L., Osborne, J. J., Frolik, C. A. & Bryant, H. U. (1997) Evaluation of the major metabolites of Raloxifene as modulators of tissue selectivity. J. Steroid Biochem. Mol. Biol. 61: 97-106.
49. Draper, C. R., Edel, M. J., Dick, I. M., Randall, A. G., Martin, G. B. & Prince, R. L. (1997) Phytoestrogens reduce bone loss and bone resorption in oophorectomized rats. J. Nutr. 127: 1795-1799.
50. Duane, W. (1997) Effects of legume consumption on serum cholesterol, biliary lipids and sterol metabolism in humans. J. Lipid Res. 38: 1120-1128.
51. Essex, C. (1996) Phytoestrogens and soy based infant formula. Br. Med. J. 333: 507.
52. Evans, B.A.J., Griffiths, K. & Morton, M.S. (1995) Inhibition of 5α-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J. Endocrinol. 147: 295-302.
53. Ferrin, M. (1993) The Menstrual Cycle. Physiology, Reproductive Disorders, and Infertility. Oxford University Press, New York, NY.
54. Fotsis, T., Peper, M., Adlercreutz, H., Fleischmann, G., Hase, T., Montesano, R. & Schweigerer, L. (1993) Genistein, a dietary derived inhibitor of angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 90: 2690-2694.
55. Franke, A. A. & Custer, L. J. (1996) Daidzein and genistein concentrations in human milk after soy consumption. Clin. Chem. 42: 955-964.
56. Gavaler, J. S., Van Thiel, D. H. & Galvao-Teles, A. (1991) Oestrogenic responses in normal postmenopausal women to administration of the phytoestrogens in bourbon whiskey. Hepatology 14 (Part 2): 87a (abs.).
57. Gooderham, M. J., Adlercreutz, H. A., Ojala, S. T., Wahala, K. & Holub, B. J. (1996) A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation blood lipids and fatty acid composition of plasma phospholipids in normal men. J. Nutr. 126: 2000-2006.
58. Henderson, B. E., Ross, R. K., Judd, H. L., Krailo, M. D. & Pike, M. C. (1985) Do regular ovulatory cycles increase breast cancer risk? Cancer 56: 1206-1208.
59. Hirayama, T. (1986) A large scale cohort study on cancer risks by diet - with special reference to the risk reducing effects of green-yellow vegetable consumption. In: Diet, Nutrition and Cancer (Hayashi, Y., Nagao, M., Sugimura, T., Takayama, S., Tomatis, L., Wattenberg L.-W. & Wogan, G. N., eds.), pp. 41-53. Tokyo/VNU Sci. Press, Utrecht, Netherlands.
60. Hirohata, T., Shigematsu, T., Nomura, A.M.Y. & Horie, A. (1985) Occurrence of breast cancer in relation to diet and reproductive history: a case-control study in Fukuoka, Japan. Natl. Cancer Inst Monogr. 69: 187-190.
61. Ho, S. C. (1996) Body measurements, bone mass and fractures - does the East differ from the West? Clin. Orthop. Relat. Res .323: 75-80.
62. Honore, E. K., Williams, J. K., Anthony, M. S. & Clarkson, T. B. (1997) Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil. Steril. 67: 148-154.
63. Huggett, A. C., Pridmore, S., Malnoe, A., Haschke, F. & Offord, E. A. (1997) Phytoestrogens in soy-based infant formula. Lancet 350: 815-816.
64. Ingram, D., Sanders, K., Kolybaba, M. & Lopez, D. (1997) Case-control study of phyto-oestrogens and breast cancer. Lancet 350: 990-994.
65. Irvine, C., Fitzpatrick, M., Robertson, I. & Woodhams, D. (1995) The potential adverse effects of soybean isoflavones in infant feeding. N. Z. Med. J. 108: 208-209.
66. Jaggers, D. C., Collins, W. P. & Milligan, S. R. (1996) Potent inhibitory effects of steroids in an in vitro model of angiogenesis. J. Endocrinol. 150: 457-464.
67. Janas, L. & Ostrom K. M. (1998) Tolerance of soy formulas with reduced phytate/phytoestrogens fed to healthy term infants. Am. J. Clin. Nutr. 68, 1534S (abs.).
68. Joannou, G. E., Kelly, G. E., Reeder, A. Y., Waring, M. A. & Nelson, C. (1995) A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids. J. Steroid Biochem. Mol. Biol. 54: 167-184.
69. Jordan, V. G. (1990) The only true antioestrogen is a no oestrogen. Mol. Cell. Endocrinol. 74: C91-C96.
70. Jordan, V. C. (1997) Tamoxifen: the herald of a new era of preventive therapeutics. J. Natl. Cancer Inst. 89: 747-749.
71. Jordan, V. C., Fritz, N. F. & Tormey, D. C. (1987) Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node-positive patients with breast cancer. Cancer Res. 47: 624-630.
72. Kapiotis, S., Hermann, M., Held, I., Seelos, C., Erhinger, H. & Gmeiner, B.M.K. (1997) Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL Arterioscler. Thromb. Vasc. Biol. 17: 2868-2874.
73. Kelly, G. E., Nelson, C., Waring, M. A., Joannou, G. E. & Reeder, A. Y. (1993) Metabolites of dietary (soya) isoflavones in human urine. Clin. Chim. Acta 223: 9-22.
74. Key, T.J.A., Chen J., Wang D. Y., Pike, M. C. & Boreham, J. (1990) Sex-hormones in women in rural China and in Britain. Br. J. Cancer 62: 631-636.
75. Key, T.J.A. & Pike, M. C. (1988) The role of estrogens and progesterones in the epidemiology and prevention of breast-cancer. Eur. J. Cancer Clin. Oncol. 24: 29-43.
76. Kim, H., Peterson, T. G. & Barnes, S. (1998) Mechanisms of action of the soy isoflavone genistein: emerging role of its effects through transforming growth factor beta signalling. Am. J. Clin. Nutr. 68: 1418S-1425S.
77. Kirk, E. A., Sutherland, P., Wang, S. A., Chait, A. & LeBoeuf, R. C. (1998) Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. J. Nutr. 128: 954-959.
78. Knight, D. C. & Eden, J. A. (1996) A review of the clinical effects of phytoestrogen. Obstet. Gynecol. 87: 897-904.
79. Kuiper, G.G.J.M., Carlsson, B., Grandien, K., Enmark, E., Haggblad, J., Nilsson, S. & Gustafsson, J. A. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138: 863-870.
80. Kuiper, G.G.J.M., Enmark, E., Peltohuikki, M., Nilssori, S. & Gustaffson, J.-A. (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. U.S.A. 93: 5925-5930.
81. Kuiper, G.G.J.M., Nilsson, S. & Gustaffson, J.-A. (1998) Characteristics and function of the novel estrogen receptorβ. In: Hormones and Signaling, Vol. 1 (O'Malley, B. W., ed.), pp. 89-112. Academic Press, New York, NY.
82. Lamartiniere, C. A., Moore, J. B., Brown, N. M., Thompson, R., Hardin, M. J. & Barnes, S. (1995) Genistein suppresses mammary cancer in rats. Carcinogenesis 16: 2833-2840.
83. Leclerq, G. & Heuson, J. C. (1979) Physiological and pharmacological effects of estrogens in breast cancer. Biochim. Biophys. Acta 560: 427-455.
84. Lee, H. P., Gourley, L., Duffy, S. W., Esteve, J., Lee, J. & Day, N. E. (1991) Dietary effects on breast cancer risk in Singapore. Lancet 337: 1197-1200.
85. Makela, S., Poutanen, M., Lehtimaki, J., Kostian, M. L., Santti, R. & Vihko, R. (1995a) Estrogen-specific 17β-hydroxysteroid oxidoreductase type 1 (E. C. 1.1.1.62) as a possible target for the action of phytoestrogens. Proc. Soc. Exp. Biol. Med. 208: 51-59.
86. Makela, S. I., Pylkkanen, L. H., Santti, R.S.S. & Adlercreutz, H. (1995b) Dietary soybean may be antiestrogenic in male mice. J. Nutr. 125: 437-445.
87. Makela, S. I., Santti, R., Salo, L. & McLachlan, J. A. (1995c) Phytoestrogens are partial estrogen agonists in the adult male mouse. Environ. Health Perspect. 103: 123-127.
88. Manolagas, S. C. & Jilka, R. (1995) Bone marrow, cytokines and bone remodeling. N. Engl. J. Med. 332: 305-311.
89. Mendelson, C. R. (1996) Mechanism of steroid hormone action. In: Textbook of Endocrine Physiology, 3rd ed. (Griffin, J. E. & Ojeda, S. R., eds.), pp. 29-65. Oxford University Press, New York, NY.
90. Messina, M., Barnes, S. & Setchell, K.D.R. (1997) (editorial) Phyto-oestrogens and breast cancer. Lancet 350: 971-972.
91. Messina, M. J., Persky, V., Setchell, K.D.R. & Barnes, S. (1994) Soy intake and cancer risk: a review of the in vivo and in vitro data. Nutr. Cancer 21: 113-131.
92. Morton, M. S., Chan, P.S.F., Cheng, C., Blacklock, N., MatosFerreira, A., AbranchesMonteiro, L., Correia, R., Lloyd, S. & Griffiths, K. (1997) Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the UK. Prostate 32: 122-128.
93. Murkies, A. L., Lombard, C., Strauss, B.J.G., Wilcox, G., Burger, H. G. & Morton, M. S. (1995) Dietary flour supplementation decreases postmenopasual hot flushes - effect of soy and wheat. Maturitas 21: 189-195.
94. Murkies, A. L., Wilcox, G. & Davis, S. (1998) Phytoestrogens. J. Clin. Endocrinol. Metab. 83: 297-303.
95. Murphy, P. A. (1982) Phytoestrogen content of processed soybean products. Food Technol. 34: 60-64.
96. Murrill, W. B., Brown, N., Zhang, J.-X., Manzolillo P. A., Barnes, S. & Lamartiniere, C. A. (1996) Prepubertal genistein exposure suppresses mammary cancer enhances gland differentiation in rats. Carcinogenesis 17: 1451-1457.
97. Mykkanen, H., Tikka, J., Pitkanen, T. & Hanninen, O. (1997) Fecal bacterial enzyme activities in infants increase with age and adoption of adult-type diet. J. Pediatr. Gastroenterol. Nutr. 25: 312-316.
98. Nagata, C., Takatsuka, N., Kurisu, Y. & Shimizu, H. (1998) Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J. Nutr. 128: 209-213.
99. Nomura, A., Henderson, B. E. & Lee, J. (1978) Breast cancer and diet among the Japanese in Hawaii. Am. J. Clin. Nutr. 31: 2020-2025.
100. O'Brien, T. & Nguyen, T. T. (1997) Lipids and lipoproteins in women. Mayo Clin. Proc. 72: 235-244.
101. Paech, K., Webb, P., Kuiper, G.G.J. ., Nilsson, S., Gustafsson, J.-A., Kushner, P. J. & Scanlan, T. S. (1997) Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science (Washington, DC) 277: 1508-1510.
102. Pansini, F., Bonaccorsi, G., Albertazzi, P., Costantino, D., Valerio, A., Negri, C., Ferrazzini, S., Bonocuore, I., De Aloysio, D., Fontana, A., Pansini, N. & Mollica, G. (1997) Soy phytoestrogens and bone. In: Proceedings of North American Menopause Society, p. 44 (abs.).
103. Peterson, G. & Barnes, S. (1991) Genistein inhibition of the growth of human breast cancer cells - independence from estrogen receptors and multidrug resistance gene. Biochem. Biophys. Res. Commun. 179: 661-667.
104. Peterson, G. & Barnes, S. (1993) Isoflavones inhibit the growth of human prostate cancer cell lines without inhibiting epidermal growth factor receptor phosphorylation. Prostate 22: 335-345.
105. Phipps, W. R., Martini, M. C., Lampe, J. W., Slavin, J. L. & Kurzer, M. S. (1993) Effect of flaxseed ingestion on the menstrual cycle. J. Clin. Endocrinol. Metab. 77: 1215-1219.
106. Pollard, M. & Luckert, P. H. (1997) Influence of isoflavones in soy protein isolates on development of induced prostate-related cancers in L-W rats. Nutr. Cancer 28: 41-45.
107. Potter, S. M., Bakhit, R. M., Essex-Sorlie, D. L., Weingartner, K. E., Chapman, K. M., Nelson, R. A., Pradhudesai, M., Savage, W. D., Nelson, A. I., Winter, L. W. & Erdman, J. W., Jr. (1993) Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am. J. Clin. Nutr. 58: 501-506.
108. Potter, S. M., Baum, J. A., Teng, H., Stillman, R. J., Shay, N. F. & Erdman, J. W. (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68: 1375S-1379S.
109. Powles, T. J. (1997) Chemoprevention of breast cancer using tamoxifen. Endocrinol. Relat. Cancer 4: 255-260.
110. Reinli, K. & Block, G. (1996) Phytoestrogen content of foods - compendium of literature values. Nutr. Cancer 26: 123-148.
111. Robertson, I.G.C. (1995) Phytoestrogens: toxicology and regulatory recommendations. Proc. Nutr. Soc. N. Z. 20: 35-42.
112. Ruiz-Larrea, M. B., Mohan, A. R., Paganga, G., Miller, N. J., Bolwell, G. P. & RiceEvans, C. A. (1997) Antioxidant activity of phytoestrogenic isoflavones. Free Radic. Res. 26: 63-70.
113. Safe, S. H. (1995) Environmental and dietary estrogens and human health: is there a problem? Environ. Health Perspect. 103: 346-351.
114. 2+ entry in human platelets. FEBS Lett. 315: 242-246.
115. Sarrel, P. M. (1990) Ovarian hormones and the circulation. Maturitas 12: 287-298.
116. Setchell, K.D.R. (1985) Naturally occurring non-steroidal estrogens of dietary origin. In: Estrogens in the Environment II: Influences on Development (McLachlan, J. A., ed.), pp. 69-85. Elsevier, New York, NY.
117. Setchell, K.D.R. (1995) Non-steroidal estrogens of dietary origin: possible roles in health and disease, metabolism and physiological effects. Proc. Nutr. Soc. N. Z. 20: 1-21.
118. Setchell, K.D.R. (1998) Phytoestrogens: biochemistry, physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr. 68:1333S-1346S.
119. Setchell, K.D.R. & Adlercreutz, H. (1988) Mammalian lignans and phytooestrogens. Recent studies on their formation, metabolism and biological role in health and disease. In: Role of the Gut Flora in Toxicity and Cancer (Rowland, I. R., ed.), pp. 315-345, Academic Press, London, UK.
120. Setchell, K.D.R., Borriello, S. P., Hulme, P., Kirk, D. N. & Axelson, M. (1984) Non-steroidal oestrogens of dietary origin: possible roles in hormone dependent disease. Am. J. Clin. Nutr. 40: 569-578.
121. Setchell, K.D.R., Gosselin, S. J., Welsh, M. B., Johnston, J. O., Balistreri, W. F., Kramer, L. W., Dresser, B. L. & Tarr, M. J. (1987a) Dietary estrogens - a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93: 225-233.
122. Setchell, K.D.R., Lawson, A. M., Mitchell, F. L., Adlercreutz, H., Kirk, D. N. & Axelson, M. (1980) Lignans in man and animal species. Nature (Lond.) 287: 740-742.
123. Setchell, K.D.R., Nechemias-Zimmer, L., Cal, J. & Heubi, J. E. (1997) Exposure of infants to phytoestrogens from soy infant formulas. Lancet 350: 23-27.
124. Setchell, K.D.R., Nechemias-Zimmer, L., Cai, J. & Heubi, J. E. (1998) The isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life. Am. J. Clin. Nutr. 68: 1453S-1461S.
125. Setchell, K D.R., Welsh, M. B. & Lim, C. K. (1987b) HPLC analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical, and thermospray mass spectrometric detection. J. Chromatogr. 386: 315-323.
126. Sharma, O. P., Adlercreutz, H., Strandberg, J. D., Zirkin, B. R., & Coffey, D. S. (1992) Soy of dietary source plays a preventative role against the pathogenesis of prostatitis in rats. J. Steroid Biochem. Mol. Biol. 43: 557-564.
127. Sharpe, R. M. & Skakkebaek, N. E. (1993) Are oestrogens involved in falling sperm counts and disorders in the male reproductive tract? Lancet 341: 1392-1395.
128. Shimizu, H., Ross, R. K., Bernstein, L., Pike, M. C. & Henderson, B. E. (1990) Serum estrogen-levels in postmenopausal women - comparison of American whites and Japanese in Japan. Br. J. Cancer 62: 451-453.
129. Shultz, T. D., Bonorden, W. R. & Seaman, W. R. (1991) Effect of short term flaxseed consumption on lignan and sex hormone metabolism in men. Nutr. Res. 11: 1089-1100.
130. Shutt, D. A. & Cox, R. I. (1972) Steroid and phytoestrogen binding to sheep uterine receptors in vitro. J. Endocrinol. 52: 299-310.
131. Sirtori, C. R., Even, R. & Lovati, M. R. (1993) Soyabean diet and plasma cholesterol: from therapy to molecular mechanisms. Ann. N.Y. Acad. Sci. 676: 188-201.
132. Slavin, J. L. (1996) Phytoestrogens in breast milk - another advantage of breast-feeding? Clin. Chem. 42: 841-842.
133. Stampfer, M. J., Colditz, G. A., Willett, W. C., et al. (1991) Postmenopausal estrogen therapy and cardiovascular disease. N. Engl. J. Med. 325: 756-762.
134. Sturdee, D. W. (1997) Clinical symptoms of estrogen deficiency. Curr. Obstet. Gynaecol. 7: 190-196.
135. Tetsuka, M., Anderson, R. A. & Hillier, S. G. (1997) Distribution of messenger RNA's encoding oestrogen receptor isoforms in female reproductive tissues. J. Endocrinol. 152: (suppl.) OC (oral communication)20.
136. Tobais, J. H., Cook, D. G., Chambers, T. J., Dalzell, N. (1994) A comparison of bone mineral density between Caucasian, Asian and Afro-Caribbean women. Clin. Sci. (Lond.) 87: 587-591.
137. Tsutsumi, N., Kawashima, K., Nagata, H., Ujiie, A. & Endo, H. (1995) Effects of KCA-012 on bone metabolism in organ culture. Jpn. J. Pharmacol. 67: 169-171.
138. Walz, E. (1931) Isoflavon- und saponin-glucoside in Soja-hispida. Justus Liebigs Ann. Chem. 489: 118-155.
139. Wang, D. Y., Key, T.J.A., Pike, M. C., Boreham, J. & Chen, J. (1991) Serum hormone levels in British and rural Chinese females. Breast Cancer Res. Treat. 18: S41-S45.
140. Wei, H., Bowen, R., Cai, Q., Barnes, S. & Wang, Y. (1995) Antioxidant and antiproliferative effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med. 208: 124-130.
141. Wilcox, G., Wahlqvist, M. L., Burger, H. G. & Medley, G. (1990) Oestrogen effects of plant derived foods in postmenopasual women. Br. Med. J. 301: 905-906.
142. Wilcox, J. N. & Blumenthal, B. F. (1995) Thrombotic mechanisms in atherosclerosis: potential impact of soy protein. J. Nutr. 125: 631S-638S.
143. Willy, P. J. & Mangelsdorf, D. J. (1998) Nuclear orphan receptors: the search for novel ligands and signalling pathways In: Hormones and Signalling, Vol. 1 (O'Malley, B. W., ed.), pp. 307-358. Academic Press, New York, NY.
144. Wu, A. H., Ziegler, R. G., Hornross, P. L., Nomura, A.M.Y., West, D. W., Kolonel, L. N., Rosenthal, J. F., Hoover, R. N. & Pike, M. C. (1996a) Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol. Biomark. Prev. 5: 901-906.
145. Wu, A. H., Ziegler, R. G., Pike, M. C., Nomura, A.M.Y., West, D. W., Kolonel, L. N., Hornross, P. L., Rosenthal, J. F. & Hoover, R. N . (1996b) Menstrual and reproductive factors and risk of breast cancer. Br. J. Cancer 73: 680-686.
146. Yoshida, K., Tsukamoto, T., Torii, H., Doi, T., Naeshiro, I., Uemura, I. & Tanayama, S. (1985) Metabolism of Ipriflavone (TC-80) in rats. Radioisotopes 34: 612-617.
147. Yuan, M.-J., Wang, Q.-S., Ross, R. K., Henderson, B. E. & Yu, M. C. (1995) Diet and breast cancer in Shanghai and Tianjin, China. Br. J. Cancer 71: 1353-1358.
148. Zhou, Y. & Lee, A. S. (1998) Mechanism for the suppression of the mammalian stress response by genistein, an anticancer phytoestrogen from soy. J. Natl. Cancer Inst. 90: 381-388.
149. Zumoff, B. (1993) Biological and endocrinological insights into the possible breast cancer risk from postmenopausal estrogen replacement therapy. Steroids 58: 196-204.