Type 2 diabetes - An introduction to the development and use of animal models

ILAR Journal

Volumn 47, Issue 3, 2006, Pages 181-185

  Kaplan, Jay R ^a   Wagner, Janice D ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

"Thrifty gene" hypothesis; Animal models; Insulin resistance; Sex differences; Type 2 diabetes

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; TRIACYLGLYCEROL;

ADIPOCYTE; ADRENERGIC SYSTEM; BODY FAT DISTRIBUTION; BRAIN SIZE; CAT; CELL METABOLISM; COMORBIDITY; DISEASE COURSE; DISEASE MODEL; DISEASE PREDISPOSITION; DNA MODIFICATION; DYSLIPIDEMIA; EDITORIAL; EPIDEMIOLOGICAL DATA; FEMALE; HEREDITY; HYPERTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN RESISTANCE; LIFESTYLE; MALE; MEDICAL LITERATURE; MENTAL STRESS; MOUSE; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRIMATE; RAT; RODENT; SEX DIFFERENCE; SPECIES DIFFERENCE; SWINE; WEIGHT GAIN;

ANIMALIA; PRIMATES; RODENTIA;

EID: 33745590659     PISSN: 10842020     EISSN: None     Source Type: Journal    
DOI: 10.1093/ilar.47.3.181     Document Type: Editorial

References (40)

1. Barthold SW, Elliott RW, eds. 2004. Advances in Diabetes Through Animal-related Research. ILAR J 45:227-386.
2. Bellinger DA, Merricks EP, Nichols TC. 2006. Swine models of type 2 diabetes mellitus: Insulin resistance, glucose tolerance, and cardiovascular complications. ILAR J 47:243-258.
3. Björntorp P. 1999. Neuroendocrine perturbations as a cause of insulin resistance. Diabetes Metab Res Rev 15:427-441.
4. Brunner EJ, Hemingway H, Walker BR, Page M, Clarke P, Juneja M, Shipley MJ, Kumari M, Andrew R, Seckl JR, Papadopoulos A, Checkley S, Rumley A, Lowe GD, Stansfeld SA, Marmot MG. 2002. Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: Nested case-control study. Circulation 106:2659-2665.
5. Bruns CM, Kemnitz JW. 2004. Sex hormones, insulin sensitivity, and diabetes mellitus. ILAR J 45:160-169.
6. Cefalu WT. 2006. Animal models of type 2 diabetes: Clinical presentation and pathophysiological relevance to the human condition. ILAR J 47: 186-198.
7. CDC [Centers for Disease Control and Prevention]. 2005. National diabetes fact sheet: General information and national estimates on diabetes in the United States. 2005. Atlanta: US Department of Health and Human Services, CDC.
8. Chrousos GP. 2000. The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuroendocrine and target tissue-related causes. Int J Obes 24(Suppl 2): S50-S55.
9. Colagiuiri S, Miller JB. 2002. The "carnivore connection" - Evolutionary aspects of insulin resistance. Eur J Clin Nutr 56(Suppl 1):S30-S35.
10. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J. 2005. Origins and evolution of the Western diet: Health implications for the 21st century. Am J Clin Nutr 81:341-354.
11. Deckelbaum RJ, Williams CL. 2001. Childhood obesity: The health issue. Obes Res 9:239S-243S.
12. DeFronzo RA. 1999. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131:281-303.
13. DeFronzo RA. 2004. Pathogenesis of type 2 diabetes mellitus. Med Clin N Am 88:787-835.
14. DeLeo V, Musacchio MC, Morgante G, LaMarca A, Petraglia F. 2003. Polycystic ovary syndrome and type 2 diabetes mellitus. Minerva Ginecol 55:53-62.
15. Gonzales JA, Szeto A, Mendez AJ, Zaias J, Paredes J, Caperton CV, Llabre MM, Levine JE, Goldberg RB, Schneiderman N, McCabe PM. 2005. Effect of behavioral interventions on insulin sensitivity and atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Psychosom Med 67:172-178.
16. Grundy SM. 2005. A constellation of complications: The metabolic syndrome. Clin Cornerstone 7:36-45.
17. Hansen L, Pedersen O. 2005. Genetics of type 2 diabetes mellitus: Status and perspectives. Diabetes Obes Metab 7:122-135.
18. Henson MS, O'Brien TD. 2006. Feline models of type 2 diabetes mellitus. ILAR J 47:234-242.
19. Huxley R, Barzi F, Woodward M. 2006. Excess risk of fatal coronary heart disease associated with diabetes in men and women: Meta-analysis of 37 prospective cohort studies. BMJ 332:73-78.
20. IDF [International Diabetes Federation]. 2005. The IDF consensus worldwide definition of the metabolic syndrome. Available online (http://www.idf.org/webdata/docs/IDF_Metasyndrome_definition.pdf).
21. Juutilainen A, Kortelainen S, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. 2004. Gender difference in the impact of type 2 diabetes on coronary heart disease risk. Diabetes Care 27:2898-2904.
22. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E, Heart and Estrogen/Progestin Replacement Study. 2003. Glycemic effects of postmenopausal hormone therapy: The Heart and Estrogen/Progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 138: 1-9.
23. Kaplan JR, Adams MR, Clarkson TB, Manuck SB, Shively CA, Williams JK. 1996. Psychosocial factors, sex differences, and atherosclerosis: Lessons from animal models. Psychosom Med 58:598-611.
24. Kaplan JR, Manuck SB. 2004. Ovarian dysfunction, stress, and disease: A primate continuum. ILAR J 47:89-115.
25. Kinder LS, Carnethon MR, Palaniappan LP, King AC, Fortmann SP. 2004. Depression and the metabolic syndrome in young adults: Findings from the Third National Health and Nutrition Examination Survey. Psychosom Med 66:316-322.
26. Leonard WR, Robertson ML, Snodgrass JJ, Kuzawa CW. 2003. Metabolic correlates of hominid brain evolution. Compar Biochem Physiol Pt A 136:5-15.
27. Lohff JC, Christian PJ, Marion SL, Arrandale A, Hoyer PB. 2005. Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause. Comp Med 55:523-527.
28. Margolis KL, Bonds DE, Rodabough RJ, Tinker L, Phillips ES, Allen C, Bassford T, Burke G, Torrens J, Howard BV, for the Women's Health Initiative Investigators. 2004. Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: Results from the Women's Health Initiative Hormone Trial. Diabetologia 47:1175-1187.
29. Matveyenko A, Butler PC. 2006. IAPP transgenic rodents as models for type 2 diabetes. ILAR J 47:225-233.
30. Muldoon MF, Mackey RH, Korytkowski MT, Flory JD, Pollock BG, Manuck SB. 2006. The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers. J Clin Endocrinol Metab 91:718-721.
31. Neel JV. 1999. The "thrifty genotype" in 1998. Nutr Rev 57:S2-S9.
32. Neubauer N, Kulkarni RN. 2006. Molecular approaches to study control of glucose homeostasis. ILAR J 47:199-211.
33. Ratcliffe HL, Luginbuhl H. 1971. The domestic pig: A model for experimental atherosclerosis. Atherosclerosis 13:133-136.
34. Reaven GM. 2005. The insulin resistance syndrome: Definition and dietary approaches to treatment. Annu Rev Nutr 25:391-406.
35. Rosmond R. 2003. Stress induced disturbances of the HPA axis: A pathway to type 2 diabetes? Med Sci Monit 9:RA35-RA39.
36. Shafrir E, Ziv E, Kalman R. 2006. Nutritionally induced diabetes in desert rodents as models of type 2 diabetes: Acomys cahirinus (spiny mice) and Psammomys obesus (desert gerbil). ILAR J 47:212-224.
37. Unwin N, Shaw J, Zimmet P, Alberti KG. 2002. Impaired glucose tolerance and impaired fasting glycaemia: The current status on definition and intervention. Diabet Med 19:708-723.
38. Vasudevan AR, Garber AJ. 2005. Insulin resistance syndrome. A review. Minerva Endocrinol 30:101-119.
39. Wagner JD, Kavanagh K, Ward GM, Auerbach BJ, Harwood HJ Jr, Kaplan JR. 2006. Old World nonhuman primate models of type 2 diabetes mellitus. ILAR J 47:259-271.
40. Zimmet P, Thomas CR. 2003. Genotype, obesity and cardiovascular disease - Has technical and social advancement outstripped evolution? J Intern Med 254:114-125.