The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: An eye on microglia

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Ridolfi, Elisa ^a   Barone, Cinzia ^a   Scarpini, Elio ^a   Galimberti, Daniela ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NONSTEROID ANTIINFLAMMATORY AGENT; PROGRANULIN; REACTIVE OXYGEN METABOLITE; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VALOSIN CONTAINING PROTEIN;

ALZHEIMER DISEASE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CHROMOSOME 17; CLINICAL FEATURE; CYTOKINE PRODUCTION; EFFECTOR CELL; ENVIRONMENTAL CHANGE; ENZYME ACTIVITY; FRONTOTEMPORAL DEMENTIA; GAP JUNCTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETICS; HAPLOINSUFFICIENCY; HUMAN; IMMUNOREACTIVITY; INCIDENCE; INNATE IMMUNITY; LOSS OF FUNCTION MUTATION; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONSENSE MUTATION; OXIDATIVE STRESS; PARKINSONISM; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SUBSTANTIA NIGRA PARS COMPACTA; TRAUMATIC BRAIN INJURY; ANIMAL; IMMUNOLOGY; INFLAMMATION; METABOLISM; FRONTOTEMPORAL LOBAR DEGENERATION;

ALZHEIMER DISEASE; ANIMALS; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MICROGLIA;

EID: 84881524358     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/939786     Document Type: Review

References (134)

1. Götz J., Ittner L. M., Schonrock N., Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy? Medical Journal of Australia 2006 185 7 381 384 2-s2.0-33749596351 (Pubitemid 44540801)
2. Alzheimer's Association, 2012 Alzheimer's disease facts and figures. Alzheimer's and Dementia 2012 8 2 131 168
3. Seltman R. E., Matthews B. R., Frontotemporal lobar degeneration: epidiemology, pathology, diagnosis and management. CNS Drugs 2012 26 10 841 870
4. Bellucci A., Bugiani O., Ghetti B., Spillantini M. G., Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation. Neurodegenerative Diseases 2011 8 4 221 229 2-s2.0-79955871342 10.1159/000322228
5. McKhann G. M., Knopman D. S., Chertkow H., Hyman B. T., Jack C. R. Jr., Kawas C. H., Klunk W. E., Koroshetz W. J., Manly J. J., Mayeux R., Mohs R. C., Morris J. C., Rossor M. N., Scheltens P., Carrillo M. C., Thies B., Weintraub S., Phelps C. H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia 2011 7 3 263 269 2-s2.0-79956142378 10.1016/j.jalz.2011.03.005
6. Albert M. S., DeKosky S. T., Dickson D., Dubois B., Feldman H. H., Fox N. C., Gamst A., Holtzman D. M., Jagust W. J., Petersen R. C., Snyder P. J., Carrillo M. C., Thies B., Phelps C. H., The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia 2011 7 3 270 279 2-s2.0-79956084514 10.1016/j.jalz.2011.03.008
7. Sperling R. A., Aisen P. S., Beckett L. A., Bennett D. A., Craft S., Fagan A. M., Iwatsubo T., Jack C. R. Jr., Kaye J., Montine T. J., Park D. C., Reiman E. M., Rowe C. C., Siemers E., Stern Y., Yaffe K., Carrillo M. C., Thies B., Morrison-Bogorad M., Wagster M. V., Phelps C. H., Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia 2011 7 3 280 292 2-s2.0-79956098248 10.1016/j.jalz.2011.03.003
8. Braak H., Braak E., Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica 1991 82 4 239 259 2-s2.0-0025863618
9. Jack C. R. Jr., Knopman D. S., Jagust W. J., Shaw L. M., Aisen P. S., Weiner M. W., Petersen R. C., Trojanowski J. Q., Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. The Lancet Neurology 2010 9 1 119 128 2-s2.0-72049130805 10.1016/S1474-4422(09)70299-6
10. Buchhave P., Minthon L., Zetterberg H., Wallin Å. K., Blennow K., Hansson O., Cerebrospinal fluid levels of β -amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Archives of General Psychiatry 2012 69 1 98 106 2-s2.0-84855304100 10.1001/archgenpsychiatry.2011.155
11. Bekris L. M., Yu C.-E., Bird T. D., Tsuang D. W., Review article: genetics of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology 2010 23 4 213 227 2-s2.0-78649232442 10.1177/0891988710383571
12. Hooli G Mohapatra B. V., Mattheisen M., Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology 2012 78 16 1250 1257
13. Sieben A., van Langenhove T., Engelborghs S., The genetics and neuropathology of frontotemporal lobar degeneration. Acta Neuropathologica 2012 124 3 353 372
14. Rascovsky K., Hodges J. R., Knopman D., Mendez M. F., Kramer J. H., Neuhaus J., van Swieten J. C., Seelaar H., Dopper E. G. P., Onyike C. U., Hillis A. E., Josephs K. A., Boeve B. F., Kertesz A., Seeley W. W., Rankin K. P., Johnson J. K., Gorno-Tempini M.-L., Rosen H., Prioleau-Latham C. E., Lee A., Kipps C. M., Lillo P., Piguet O., Rohrer J. D., Rossor M. N., Warren J. D., Fox N. C., Galasko D., Salmon D. P., Black S. E., Mesulam M., Weintraub S., Dickerson B. C., Diehl-Schmid J., Pasquier F., Deramecourt V., Lebert F., Pijnenburg Y., Chow T. W., Manes F., Grafman J., Cappa S. F., Freedman M., Grossman M., Miller B. L., Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011 134 9 2456 2477 2-s2.0-80052938441 10.1093/brain/awr179
15. Gorno-Tempini M. L., Hillis A. E., Weintraub S., Kertesz A., Mendez M., Cappa S. F., Ogar J. M., Rohrer J. D., Black S., Boeve B. F., Manes F., Dronkers N. F., Vandenberghe R., Rascovsky K., Patterson K., Miller B. L., Knopman D. S., Hodges J. R., Mesulam M. M., Grossman M., Classification of primary progressive aphasia and its variants. Neurology 2011 76 11 1006 1014 2-s2.0-79952823979 10.1212/WNL.0b013e31821103e6
16. Josephs K. A., Hodges J. R., Snowden J. S., MacKenzie I. R., Neumann M., Mann D. M., Dickson D. W., Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathologica 2011 122 2 137 153 2-s2.0-79960835044 10.1007/s00401-011-0839-6
17. Ferrari R., Thumma A., Momeni P., Molecular genetics of frontotemporal dementia. Acta Neuropathologica 2012 124 3 373 382
18. Sun L., Eriksen J. L., Recent insights into the involvement of progranulin in frontotemporal dementia. Current Neuropharmacology 2011 9 4 632 642 2-s2.0-82955249337
19. Tomiyama T., Nagata T., Shimada H., Teraoka R., Fukushima A., Kanemitsu H., Takuma H., Kuwano R., Imagawa M., Ataka S., Wada Y., Yoshioka E., Nishizaki T., Watanabe Y., Mori H., A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia. Annals of Neurology 2008 63 3 377 387 2-s2.0-41749096713 10.1002/ana.21321 (Pubitemid 351499867)
20. Iwatsubo T., Mann D. M. A., Odaka A., Suzuki N., Ihara Y., Amyloid β protein (A β) deposition: A β 42(43) precedes A β 40 in Down syndrome. Annals of Neurology 1995 37 3 294 299 2-s2.0-0028919919 10.1002/ana.410370305
21. Tandon A., Rogaeva E., Mullan M., St. George-Hyslop P. H., Molecular genetics of Alzheimer's disease: the role of β -amyloid and the presenilins. Current Opinion in Neurology 2000 13 4 377 384 2-s2.0-0033864011 10.1097/00019052-200008000-00003
22. Wisniewski K. E., Wisniewski H. M., Wen G. Y., Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Annals of Neurology 1985 17 3 278 282 2-s2.0-0021956826 (Pubitemid 15136603)
23. Baulac S., LaVoie M. J., Kimberly W. T., Strahle J., Wolfe M. S., Selkoe D. J., Xia W., Functional γ -secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ -secretase substrates. Neurobiology of Disease 2003 14 2 194 204 2-s2.0-0142250857 10.1016/S0969-9961(03)00123-2 (Pubitemid 37311284)
24. Kimberly W. T., LaVoie M. J., Ostaszewski B. L., Ye W., Wolfe M. S., Selkoe D. J., γ -Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. Proceedings of the National Academy of Sciences of the United States of America 2003 100 11 6382 6387 2-s2.0-0038652102 10.1073/pnas.1037392100 (Pubitemid 36666590)
25. Karlstrom H., Brooks W. S., Kwok J. B. J., Broe G. A., Kril J. J., McCann H., Halliday G. M., Schofield P. R., Variable phenotype of Alzheimer's disease with spastic paraparesis. Journal of Neurochemistry 2008 104 3 573 583 2-s2.0-38049110977 10.1111/j.1471-4159.2007.05038.x
26. Cruts M., van Duijn C. M., Backhovens H., van den Broeck M., Wehnert A., Serneels S., Sherrington R., Hutton M., Hardy J., St George-Hyslop P. H., Hofman A., van Broeckhoven C., Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. Human Molecular Genetics 1998 7 1 43 51 2-s2.0-6844255860 10.1093/hmg/7.1.43 (Pubitemid 28040736)
27. Goldman J. S., Farmer J. M., Wood E. M., Johnson J. K., Boxer A., Neuhaus J., Lomen-Hoerth C., Wilhelmsen K. C., Lee V. M.-Y., Grossman M., Miller B. L., Comparison of family histories in FTLD subtypes and related tauopathies. Neurology 2005 65 11 1817 1819 2-s2.0-33645078169 10.1212/01.wnl.0000187068. 92184.63
28. Baker M., Mackenzie I. R., Pickering-Brown S. M., Gass J., Rademakers R., Lindholm C., Snowden J., Adamson J., Sadovnick A. D., Rollinson S., Cannon A., Dwosh E., Neary D., Melquist S., Richardson A., Dickson D., Berger Z., Eriksen J., Robinson T., Zehr C., Dickey C. A., Crook R., McGowan E., Mann D., Boeve B., Feldman H., Hutton M., Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 2006 442 7105 916 919 2-s2.0-33746919083 10.1038/nature05016 (Pubitemid 44285946)
29. Rademakers R., Cruts M., van Broeckhoven C., The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Human Mutation 2004 24 4 277 295 2-s2.0-5044235577 10.1002/humu.20086 (Pubitemid 39336634)
30. Buée L., Delacourte A., Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain Pathology 1999 9 4 681 693 2-s2.0-0039575094 (Pubitemid 29470961)
31. Goedert M., Jakes R., Mutations causing neurodegenerative tauopathies. Biochimica et Biophysica Acta 2005 1739 2 240 250 2-s2.0-11144258263 10.1016/j.bbadis.2004.08.007 (Pubitemid 40021808)
32. Cruts M., Gijselinck I., van der Zee J., Engelborghs S., Wils H., Pirici D., Rademakers R., Vandenberghe R., Dermaut B., Martin J.-J., van Duijn C., Peeters K., Sciot R., Santens P., De Pooter T., Mattheijssens M., van den Broeck M., Cuijt I., Vennekens K., De Deyn P. P., Kumar-Singh S., van Broeckhoven C., Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 2006 442 7105 920 924 2-s2.0-33746910649 10.1038/nature05017 (Pubitemid 44285947)
33. Boeve B. F., Baker M., Dickson D. W., Parisi J. E., Giannini C., Josephs K. A., Hutton M., Pickering-Brown S. M., Rademakers R., Tang-Wai D., Jack C. R. Jr., Kantarci K., Shiung M. M., Golde T., Smith G. E., Geda Y. E., Knopman D. S., Petersen R. C., Frontotemporal dementia and parkinsonism associated with the IVS1+1G→A mutation in progranulin: a clinicopathologic study. Brain 2006 129 11 3103 3114 2-s2.0-33750576831 10.1093/brain/awl268 (Pubitemid 44684529)
34. DeJesus-Hernandez M., Mackenzie I. R., Boeve B. F., Boxer A. L., Baker M., Rutherford N. J., Nicholson A. M., Finch N. A., Flynn H., Adamson J., Kouri N., Wojtas A., Sengdy P., Hsiung G.-Y. R., Karydas A., Seeley W. W., Josephs K. A., Coppola G., Geschwind D. H., Wszolek Z. K., Feldman H., Knopman D. S., Petersen R. C., Miller B. L., Dickson D. W., Boylan K. B., Graff-Radford N. R., Rademakers R., Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011 72 2 245 256 2-s2.0-80054832080 10.1016/j.neuron.2011.09.011
35. Galimberti D., Fenoglio C., Serpente M., Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation. Biological Psychiatry 2013 10.1016/j.biopsych.2013.01.031
36. Mahley R. W., Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 1988 240 4852 622 630 2-s2.0-0024299370
37. Corder E. H., Saunders A. M., Strittmatter W. J., Schmechel D. E., Gaskell P. C., Small G. W., Roses A. D., Haines J. L., Pericak-Vance M. A., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993 261 5123 921 923 2-s2.0-0027194791 (Pubitemid 23275809)
38. Castano E. M., Prelli F., Wisniewski T., Golabek A., Kumar R. A., Soto C., Frangione B., Fibrillogenesis in alzheimer's disease of amyloid β peptides and apolipoprotein E. Biochemical Journal 1995 306 2 599 604 2-s2.0-0028986408
39. Ma J., Yee A., Brewer H. B. Jr., Das S., Potter H., Amyloid-associated proteins α 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β -protein into filaments. Nature 1994 372 6501 92 94 2-s2.0-0028173205 10.1038/372092a0
40. Wisniewski T., Castaño E. M., Golabek A., Vogel T., Frangione B., Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. The American Journal of Pathology 1994 145 5 1030 1035 2-s2.0-0027970307 (Pubitemid 24345650)
41. Pastor P., Roe C. M., Villegas A., Bedoya G., Chakraverty S., García G., Tirado V., Norton J., Ríos S., Martínez M., Kosik K. S., Lopera F., Goate A. M., Apolipoprotein E ε 4 modifies Alzheimer's disease onset in an E280A PS1 kindred. Annals of Neurology 2003 54 2 163 169 2-s2.0-0041865226 10.1002/ana.10636 (Pubitemid 36909615)
42. Roses A. D., Apolipoprotein E and Alzheimer's disease: a rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences 1996 802 50 57 2-s2.0-0030481305 10.1111/j.1749-6632. 1996.tb32598.x (Pubitemid 27055499)
43. van Deerlin V. M., Sleiman P. M. A., Martinez-Lage M., Chen-Plotkin A., Wang L.-S., Graff-Radford N. R., Dickson D. W., Rademakers R., Boeve B. F., Grossman M., Arnold S. E., Mann D. M. A., Pickering-Brown S. M., Seelaar H., Heutink P., van Swieten J. C., Murrell J. R., Ghetti B., Spina S., Grafman J., Hodges J., Spillantini M. G., Gilman S., Lieberman A. P., Kaye J. A., Woltjer R. L., Bigio E. H., Mesulam M., Al-Sarraj S., Troakes C., Rosenberg R. N., White C. L., Ferrer I., Lladó A., Neumann M., Kretzschmar H. A., Hulette C. M., Welsh-Bohmer K. A., Miller B. L., Alzualde A., De Munain A. L., McKee A. C., Gearing M., Levey A. I., Lah J. J., Hardy J., Rohrer J. D., Lashley T., MacKenzie I. R. A., Feldman H. H., Hamilton R. L., Dekosky S. T., van der Zee J., Kumar-Singh S., van Broeckhoven C., Mayeux R., Vonsattel J. P. G., Troncoso J. C., Kril J. J., Kwok J. B. J., Halliday G. M., Bird T. D., Ince P. G., Shaw P. J., Cairns N. J., Morris J. C., McLean C. A., Decarli C., Ellis W. G., Freeman S. H., Frosch M. P., Growdon J. H., Perl D. P., Sano M., Bennett D. A., Schneider J. A., Beach T. G., Reiman E. M., Woodruff B. K., Cummings J., Vinters H. V., Miller C. A., Chui H. C., Alafuzoff I., Hartikainen P., Seilhean D., Galasko D., Masliah E., Cotman C. W., Tũón M. T., Martínez M. C. C., Munoz D. G., Carroll S. L., Marson D., Riederer P. F., Bogdanovic N., Schellenberg G. D., Hakonarson H., Trojanowski J. Q., Lee V. M.-Y., Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 2010 42 3 234 239 2-s2.0-77649136250 10.1038/ng.536
44. Finch N., Carrasquillo M. M., Baker M., Rutherford N. J., Coppola G., Dejesus-Hernandez M., Crook R., Hunter T., Ghidoni R., Benussi L., Crook J., Finger E., Hantanpaa K. J., Karydas A. M., Sengdy P., Gonzalez J., Seeley W. W., Johnson N., Beach T. G., Mesulam M., Forloni G., Kertesz A., Knopman D. S., Uitti R., White C. L., Caselli R., Lippa C., Bigio E. H., Wszolek Z. K., Binetti G., MacKenzie I. R., Miller B. L., Boeve B. F., Younkin S. G., Dickson D. W., Petersen R. C., Graff-Radford N. R., Geschwind D. H., Rademakers R., TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology 2011 76 5 467 474 2-s2.0-79951494607 10.1212/WNL. 0b013e31820a0e3b
45. Galimberti D., Fenoglio C., Cortini F., Serpente M., Venturelli E., Villa C., Clerici F., Marcone A., Benussi L., Ghidoni R., Gallone S., Scalabrini D., Restelli I., Boneschi F. M., Cappa S., Binetti G., Mariani C., Rainero I., Giordana M. T., Bresolin N., Scarpini E., GRN variability contributes to sporadic frontotemporal lobar degeneration. Journal of Alzheimer's Disease 2010 19 1 171 177 2-s2.0-75149197665 10.3233/JAD-2010-1225
46. Cerami C., Scarpini E., Cappa S. F., Galimberti D., Frontotemporal lobar degeneration: current knowledge and future challenges. Journal of Neurology 2012 259 3 2278 2286 2-s2.0-84859931060 10.1007/s00415-012-6507-5
47. Czeh M., Gressens P., Kaindl A. M., The yin and yang of microglia. Developmental Neuroscience 2011 33 3-4 199 209 2-s2.0-80255129718 10.1159/000328989
48. Smith J. A., Das A., Ray S. K., Banik N. L., Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Research Bulletin 2012 87 1 10 20 2-s2.0-84155162481 10.1016/j.brainresbull.2011.10.004
49. Garden G. A., Möller T., Microglia biology in health and disease. Journal of Neuroimmune Pharmacology 2006 1 2 127 137 2-s2.0-33747463996 10.1007/s11481-006-9015-5 (Pubitemid 44257488)
50. Walter L., Neumann H., Role of microglia in neuronal degeneration and regeneration. Seminars in Immunopathology 2009 31 4 513 525 2-s2.0-73449145606 10.1007/s00281-009-0180-5
51. Graeber M. B., Streit W. J., Microglia: biology and pathology. Acta Neuropathologica 2010 119 1 89 105 2-s2.0-77649184973 10.1007/s00401-009-0622-0
52. Beauvillain C., Donnou S., Jarry U., Scotet M., Gascan H., Delneste Y., Guermonprez P., Jeannin P., Couez D., Neonatal and adult microglia cross-present exogenous antigens. GLIA 2008 56 1 69 77 2-s2.0-36448943918 10.1002/glia.20565 (Pubitemid 350172732)
53. Rubio-Perez J. M., Morillas-Ruiz J. M., A review: inflammatory process in Alzheimer's disease, role of cytokines. The Scientific World Journal 2012 2012 6 756357
54. Takami K., Terai K., Matsuo A., Walker D. G., McGeer P. L., Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains. Brain Research 1997 748 1-2 122 130 2-s2.0-0031044834 10.1016/S0006-8993(96)01274-7 (Pubitemid 27094890)
55. Breitner J. C. S., Welsh K. A., Helms M. J., Gaskell P. C., Gau B. A., Roses A. D., Pericak-Vance M. A., Saunders A. M., Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiology of Aging 1995 16 4 523 530 2-s2.0-0029160270 10.1016/0197-4580(95) 00049-K
56. Breitner J. C. S., Gau B. A., Welsh K. A., Plassman B. L., McDonald W. M., Helms M. J., Anthony J. C., Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology 1994 44 2 227 232 2-s2.0-0028289083 (Pubitemid 24070956)
57. Myllykangas-Luosujarvi R., Isomaki H., Alzheimer's disease and rheumatoid arthritis. British Journal of Rheumatology 1994 33 5 501 502 2-s2.0-0028301315
58. Rozemuller J. M., Eikelenboom P., Pals S. T., Stam F. C., Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family. Neuroscience Letters 1989 101 3 288 292 2-s2.0-0024394987 (Pubitemid 19159426)
59. Prasad K.N., La Rosa F.G., Prasad J.E., Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and β -amyloid. In Vitro Cellular and Developmental Biology 1998 34 3 265 274 2-s2.0-0032452164 (Pubitemid 29077080)
60. Lee Y.-J., Han S. B., Nam S.-Y., Oh K.-W., Hong J. T., Inflammation and Alzheimer's disease. Archives of Pharmacal Research 2010 33 10 1539 1556 2-s2.0-78449234130 10.1007/s12272-010-1006-7
61. von Bernhardi R., Glial cell dysregulation: a new perspective on Alzheimer disease. Neurotoxicity Research 2007 12 4 215 232 2-s2.0-41749116202 10.1007/BF03033906
62. Harry G. J., Lefebvre d'Hellencourt C., Bruccoleri A., Schmechel D., Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice. Brain, Behavior, and Immunity 2000 14 4 288 304 2-s2.0-0034527782 10.1006/brbi.2000.0606 (Pubitemid 32060520)
63. Ramírez G., Rey S., Von Bernhardi R., Proinflammatory stimuli are needed for induction of microglial cell-mediated A β PP244-C and A β -neurotoxicity in hippocampal cultures. Journal of Alzheimer's Disease 2008 15 1 45 59 2-s2.0-52449104934
64. Von Bernhardi R., Tichauer J. E., Eugenín J., Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. Journal of Neurochemistry 2010 112 5 1099 1114 2-s2.0-75949127404 10.1111/j.1471-4159.2009.06537.x
65. Salminen A., Ojala J., Kauppinen A., Kaarniranta K., Suuronen T., Inflammation in Alzheimer's disease: amyloid- β oligomers trigger innate immunity defence via pattern recognition receptors. Progress in Neurobiology 2009 87 3 181 194 2-s2.0-61349088546 10.1016/j.pneurobio.2009.01.001
66. Zhang W., Stanimirovic D., Current and future therapeutic strategies to target inflammation in stroke. Current Drug Targets 2002 1 2 151 166 2-s2.0-0142155220
67. Tan L., Schedl P., Song H.-J., Garza D., Konsolaki M., The Toll->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila. PLoS ONE 2008 3 12 e3966 2-s2.0-61449393535
68. Rosales-Corral S., Reiter R. J., Tan D.-X., Ortiz G. G., Lopez-Armas G., Functional aspects of redox control during neuroinflammation. Antioxidants and Redox Signaling 2010 13 2 193 247 2-s2.0-77953641852 10.1089/ars.2009.2629
69. Orellana J. A., Sáez P. J., Shoji K. F., Schalper K. A., Palacios-Prado N., Velarde V., Giaume C., Bennett M. V. L., Sáez J. C., Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxidants and Redox Signaling 2009 11 2 369 399 2-s2.0-58149100746 10.1089/ars.2008.2130
70. Cruz N. F., Ball K. K., Dienel G. A., Astrocytic gap junctional communication is reduced in amyloid- β -treated cultured astrocytes, but not in Alzheimer's disease transgenic mice. ASN Neuro 2010 2 4 e00041 2-s2.0-79955716348
71. Retamal M. A., Froger N., Palacios-Prado N., Ezan P., Sáez P. J., Sáez J. C., Giaume C., Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. Journal of Neuroscience 2007 27 50 13781 13792 2-s2.0-37249015389 10.1523/JNEUROSCI.2042-07.2007 (Pubitemid 350278255)
72. Orellana J. A., Shoji K. F., Abudara V., Ezan P., Amigou E., Sáez P. J., Jiang J. X., Naus C. C., Sáez J. C., Giaume C., Amyloid β -induced death in neurons involves glial and neuronal hemichannels. Journal of Neuroscience 2011 31 13 4962 4977 2-s2.0-79955739803 10.1523/JNEUROSCI.6417-10. 2011
73. Liao C.-K., Wang S.-M., Chen Y.-L., Wang H.-S., Wu J.-C., Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. International Journal of Biochemistry and Cell Biology 2010 42 5 762 770 2-s2.0-77649190701 10.1016/j.biocel.2010.01.016
74. Orellana J. A., Hernández D. E., Ezan P., Velarde V., Bennett M. V. L., Giaume C., Sáez J. C., Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. GLIA 2010 58 3 329 343 2-s2.0-75849165091 10.1002/glia.20926
75. Orellana J. A., Froger N., Ezan P., Jiang J. X., Bennett M. V. L., Naus C. C., Giaume C., Sáez J. C., ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. Journal of Neurochemistry 2011 118 5 826 840 2-s2.0-80051759671 10.1111/j.1471-4159.2011.07210.x
76. Koulakoff A., Mei X., Orellana J. A., Sáez J. C., Giaume C., Glial connexin expression and function in the context of Alzheimer's disease. Biochimica et Biophysica Acta 2011 1818 8 2048 2057 2-s2.0-80054988989 10.1016/j.bbamem.2011.10.001
77. Quintanilla R. A., Orellana J. A., von Bernhardi R., Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress. Archives of Medical Research 2012 43 8 632 644
78. Kalaria R. N., Microglia and Alzheimer's disease. Current Opinion in Hematology 1996 6 1 15 24 2-s2.0-0032904130 10.1097/00062752-199901000-00004 (Pubitemid 29069007)
79. Wisniewski H. M., Wegiel J., Wang K. C., Kujawa M., Lach B., Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Canadian Journal of Neurological Sciences 1989 16 4 535 542 2-s2.0-0024434236 (Pubitemid 19278365)
80. Wisniewski H. M., Wegiel J., Wang K. C., Lach B., Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathologica 1992 84 2 117 127 2-s2.0-0026685656 10.1007/BF00311383
81. Makar T. K., Nedergaard M., Preuss A., Gelbard A. S., Perumal A. S., Cooper A. J. L., Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. Journal of Neurochemistry 1994 62 1 45 53 2-s2.0-0027976087
82. Ramírez G., Toro R., Döbeli H., Von Bernhardi R., Protection of rat primary hippocampal cultures from A β cytotoxicity by pro-inflammatory molecules is mediated by astrocytes. Neurobiology of Disease 2005 19 1-2 243 254 2-s2.0-17444387480 10.1016/j.nbd.2005.01.007 (Pubitemid 40544742)
83. Tichauer J., Saud K., Von Bernhardi R., Modulation by astrocytes of microglial cell-mediated neuroinflammation: effect on the activation of microglial signaling pathways. NeuroImmunoModulation 2007 14 3-4 168 174 2-s2.0-37049017788 10.1159/000110642 (Pubitemid 350249113)
84. Tichauer J., von Bernhardi R., Relevance of TGFb Smad3 pathway modulation of scavenger receptor expression and microglial cell activation for Alzheimer disease. Journal of Neuroscience Research 2012 90 5 1970 1980
85. Arnaud L., Robakis N. K., Figueiredo-Pereira M. E., It may take inflammation, phosphorylation and ubiquitination to 'tangle' in Alzheimer's disease. Neurodegenerative Diseases 2006 3 6 313 319 2-s2.0-33845954777 (Pubitemid 46034207)
86. Checler F., Alves Da Costa C., Ancolio K., Chevallier N., Lopez-Perez E., Marambaud P., Role of the proteasome in Alzheimer's disease. Biochimica et Biophysica Acta 2000 1502 1 133 138 2-s2.0-0034718208 10.1016/S0925-4439(00) 00039-9 (Pubitemid 30433862)
87. Rockwell P., Yuan H., Magnusson R., Figueiredo-Pereira M. E., Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE2. Archives of Biochemistry and Biophysics 2000 374 2 325 333 2-s2.0-0034652238 10.1006/abbi.1999.1646 (Pubitemid 30120269)
88. Maldonado M. D., Reiter R. J., Pérez-San-Gregorio M. A., Melatonin as a potential therapeutic agent in psychiatric illness. Human Psychopharmacology 2009 24 5 391 400 2-s2.0-70149114138 10.1002/hup.1032
89. Lam Y. A., Pickart C. M., Alban A., Landon M., Jamieson C., Ramage R., Mayer R. J., Layfield R., Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America 2000 97 18 9902 9906 2-s2.0-0034730172
90. Nahreini P., Andreatta C., Prasad K. N., Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells. Cellular and Molecular Neurobiology 2001 21 5 509 521 2-s2.0-0035715799 10.1023/A: 1013819423394 (Pubitemid 34160989)
91. Permanne B., Adessi C., Saborio G. P., Fraga S., Frossard M.-J., van Dorpe J., Dewachter I., Banks W. A., van Leuven F., Soto C., Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. The FASEB Journal 2002 16 8 860 862 2-s2.0-0036615884
92. Combs C. K., Colleen Karlo J., Kao S.-C., Landreth G. E., β -amyloid stimulation of microglia anti monocytes results in TNF α -dependent expression of inducible nitric oxide synthase and neuronal apoptosis. Journal of Neuroscience 2001 21 4 1179 1188 2-s2.0-0035866060 (Pubitemid 32128763)
93. Ho G. J., Drego R., Hakimian E., Masliah E., Mechanisms of cell signaling and inflammation in Alzheimer's disease. Current Drug Targets 2005 4 2 247 256 2-s2.0-21044448540 10.2174/1568010053586237 (Pubitemid 40873107)
94. McGeer P. L., McGeer E. G., Inflammation and the degenerative diseases of aging. Annals of the New York Academy of Sciences 2004 1035 104 116 2-s2.0-14944352071 10.1196/annals.1332.007 (Pubitemid 40362329)
95. Bauer J., Strauss S., Schreiter-Gasser U., Ganter U., Schlegel P., Witt I., Yolk B., Berger M., Interleukin-6 and α -2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Letters 1991 285 1 111 114 2-s2.0-0025763298 10.1016/0014-5793(91)80737-N
96. Benveniste E. N., Sparacio S. M., Norris J. G., Grenett H. E., Fuller G. M., Induction and regulation of interleukin-6 gene expression in rat astrocytes. Journal of Neuroimmunology 1990 30 2-3 201 212 2-s2.0-0025000681 (Pubitemid 20362753)
97. Klegeris A., McGeer P. L., beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate. Journal of Neuroscience Research 1997 49 2 229 235 (Pubitemid 27332721)
98. Lee S. C., Liu W., Dickson D. W., Brosnan C. F., Berman J. W., Cytokine production by human fetal microglia and astrocytes: differential induction by lipopolysaccharide and IL-1 β Journal of Immunology 1993 150 7 2659 2667 2-s2.0-0027298505 (Pubitemid 23127515)
99. Selmaj K. W., Farooq M., Norton W. T., Raine C. S., Brosnan C. F., Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. Journal of Immunology 1990 144 1 129 135 2-s2.0-0025092159 (Pubitemid 20030466)
100. Heyser C. J., Masliah E., Samimi A., Campbell I. L., Gold L. H., Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proceedings of the National Academy of Sciences of the United States of America 1997 94 4 1500 1505 2-s2.0-0031028141 10.1073/pnas.94.4.1500 (Pubitemid 27087880)
101. Castell J. V., Gomez-Lechon M. J., David M., Andus T., Geiger T., Trullenque R., Fabra R., Heinrich P. C., Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Letters 1989 242 2 237 239 2-s2.0-0024581491 10.1016/0014-5793(89)80476-4 (Pubitemid 19020112)
102. Tan J., Town T., Paris D., Mori T., Suo Z., Crawford F., Mattson M. P., Flavell R. A., Mullan M., Microglial activation resulting from CD40-CD40l interaction after β-amyloid stimulation. Science 1999 286 5448 2352 2355 2-s2.0-0033579382 10.1126/science.286.5448.2352 (Pubitemid 30016899)
103. Horuk R., Martin A. W., Wang Z.-X., Schweitzer L., Gerassimides A., Guo H., Lu Z.-H., Hesselgesser J., Perez H. D., Kim J., Parker J., Hadley T. J., Peiper S. C., Expression of chemokine receptors by subsets of neurons in the central nervous system. Journal of Immunology 1997 158 6 2882 2890 2-s2.0-0031569227 (Pubitemid 127470549)
104. Xia M., Qin S., McNamara M., Mackay C., Hyman B. T., Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease. The American Journal of Pathology 1997 150 4 1267 1274 2-s2.0-0030951449 (Pubitemid 27152645)
105. Galimberti D., Schoonenboom N., Scheltens P., Fenoglio C., Bouwman F., Venturelli E., Guidi I., Blankenstein M. A., Bresolin N., Scarpini E., Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease. Archives of Neurology 2006 63 4 538 543 2-s2.0-33645731581 10.1001/archneur.63.4.538
106. Galimberti D., Venturelli E., Fenoglio C., Guidi I., Villa C., Bergamaschini L., Cortini F., Scalabrini D., Baron P., Vergani C., Bresolin N., Scarpini E., Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration. Journal of Neurology 2008 255 4 539 544 2-s2.0-42549130059 10.1007/s00415-008-0737-6
107. Wilms H., Sievers J., Dengler R., Bufler J., Deuschl G., Lucius R., Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. Journal of Neuroimmunology 2003 144 1-2 139 142 2-s2.0-0142226956 10.1016/j.jneuroim.2003.08.042 (Pubitemid 37329939)
108. Rogers J., Cooper N. R., Webster S., Schultz J., McGeer P. L., Styren S. D., Civin W. H., Brachova L., Bradt B., Ward P., Lieberburg I., Complement activation by β -amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America 1992 89 21 10016 10020 2-s2.0-0026447529 10.1073/pnas.89.21.10016
109. Shen Y., Meri S., Yin and Yang: complement activation and regulation in Alzheimer's disease. Progress in Neurobiology 2003 70 6 463 472 2-s2.0-0141991166 10.1016/j.pneurobio.2003.08.001 (Pubitemid 37249427)
110. Mukherjee P., Pasinetti G. M., The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease. Journal of Neuroimmunology 2000 105 2 124 130 2-s2.0-0034717942 10.1016/S0165-5728(99) 00261-1 (Pubitemid 30160749)
111. Bohlson S. S., Fraser D. A., Tenner A. J., Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Molecular Immunology 2007 44 1-3 33 43 2-s2.0-33750491279 10.1016/j.molimm.2006.06.021 (Pubitemid 44647109)
112. Masliah E., Mallory M., Hansen L., Alford M., Albright T., Terry R., Shapiro Sundsmo P. M., Saitoh T., Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease. Acta Neuropathologica 1991 83 1 12 20 2-s2.0-0025985434 10.1007/BF00294425
113. Tan J., Town T., Mori T., Wu Y., Saxe M., Crawford F., Mullan M., CD45 opposes β -amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. Journal of Neuroscience 2000 20 20 7587 7594 2-s2.0-0034667558
114. Zhu Y., Hou H., Rezai-Zadeh K., Giunta B., Ruscin A., Gemma C., Jin J., Dragicevic N., Bradshaw P., Rasool S., Glabe C. G., Ehrhart J., Bickford P., Mori T., Obregon D., Town T., Tan J., CD45 deficiency drives amyloid- β peptide oligomers and neuronal loss in alzheimer's disease mice. Journal of Neuroscience 2011 31 4 1355 1365 2-s2.0-79251560289 10.1523/JNEUROSCI.3268-10. 2011
115. Shaftel S. S., Kyrkanides S., Olschowka J. A., Miller J.-N. H., Johnson R. E., O'Banion M. K., Sustained hippocampal IL-1 β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. Journal of Clinical Investigation 2007 117 6 1595 1604 2-s2.0-34249899174 10.1172/JCI31450 (Pubitemid 46871344)
116. Chakrabarty P., Ceballos-Diaz C., Beccard A., Janus C., Dickson D., Golde T. E., Das P., IFN- γ promotes complement expression and attenuates amyloid plaque deposition in amyloid β precursor protein transgenic mice. Journal of Immunology 2010 184 9 5333 5343 2-s2.0-77954495173 10.4049/jimmunol.0903382
117. M T., Weitz, Town T., Microglia in Alzheimer's disease: it's all about context. International Journal of Alzheimer's Disease 2012 2012 314185
118. Cagnin A., Rossor M., Sampson E. L., MacKinnon T., Banati R. B., In vivo detection of microglial activation in frontotemporal dementia. Annals of Neurology 2004 56 6 894 897 2-s2.0-9644254411 10.1002/ana.20332 (Pubitemid 39578457)
119. Banati R. B., Newcombe J., Gunn R. N., Cagnin A., Turkheimer F., Heppner F., Price G., Wegner F., Giovannoni G., Miller D. H., Perkin G. D., Smith T., Hewson A. K., Bydder G., Kreutzberg G. W., Jones T., Cuzner M. L., Myers R., The peripheral benzodiazepine binding site in the brain in multiple sclerosis. Quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000 123 11 2321 2337 2-s2.0-0033768486
120. Naphade S. B., Kigerl K. A., Jakeman L. B., Kostyk S. K., Popovich P. G., Kuret J., Progranulin expression is upregulated after spinal contusion in mice. Acta Neuropathologica 2010 119 1 123 133 2-s2.0-77649192710 10.1007/s00401-009-0616-y
121. Tanaka Y., Matsuwaki T., Yamanouchi K., Nishihara M., Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice. Neuroscience 2013 231 2 49 60
122. Byrnes K. R., Washington P. M., Knoblach S. M., Hoffman E., Faden A. I., Delayed inflammatory mRNA and protein expression after spinal cord injury. Journal of Neuroinflammation 2011 8 5 130 144 2-s2.0-80053540582 10.1186/1742-2094-8-130
123. Wang Y., Moges H., Bharucha Y., Symes A., Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex. Experimental Neurology 2007 203 1 168 184 2-s2.0-33751398742 10.1016/j.expneurol.2006.08.006 (Pubitemid 44821175)
124. Yin F., Banerjee R., Thomas B., Zhou P., Qian L., Jia T., Ma X., Ma Y., Iadecola C., Beal M. F., Nathan C., Ding A., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. Journal of Experimental Medicine 2010 207 1 117 128 2-s2.0-76149118401 10.1084/jem.20091568
125. Yin F., Dumont M., Banerjee R., Ma Y., Li H., Lin M. T., Beal M. F., Nathan C., Thomas B., Ding A., Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. FASEB Journal 2010 24 12 4639 4647 2-s2.0-78149296002 10.1096/fj.10-161471
126. Martens L. H., Zhang J., Barmada S. J., Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. Journal of Clinical Investigation 2012 122 11 3955 3959
127. Brouwers N., Sleegers K., Engelborghs S., Maurer-Stroh S., Gijselinck I., van der Zee J., Pickut B. A., van den Broeck M., Mattheijssens M., Peeters K., Schymkowitz J., Rousseau F., Martin J.-J., Cruts M., De Deyn P. P., van Broeckhoven C., Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Neurology 2008 71 9 656 664 2-s2.0-52449110477 10.1212/01.wnl.0000319688.89790.7a
128. Cortini F., Fenoglio C., Guidi I., Venturelli E., Pomati S., Marcone A., Scalabrini D., Villa C., Clerici F., Dalla Valle E., Mariani C., Cappa S., Bresolin N., Scarpini E., Galimberti D., Novel exon 1 progranulin gene variant in Alzheimer's disease. European Journal of Neurology 2008 15 10 1111 1117 2-s2.0-51349151222 10.1111/j.1468-1331.2008.02266.x
129. Gliebus G., Rosso A., Lippa C. F., Progranulin and β -amyloid distribution: a case report of the brain from preclinical ps-1 mutation carrier. The American Journal of Alzheimer's Disease and other Dementias 2009 24 6 456 460 2-s2.0-70450284414 10.1177/1533317509346209
130. Pereson S., Wils H., Kleinberger G., McGowan E., Vandewoestyne M., van Broeck B., Joris G., Cuijt I., Deforce D., Hutton M., van Broeckhoven C., Kumar-Singh S., Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. Journal of Pathology 2009 219 2 173 181 2-s2.0-70349091081 10.1002/path.2580
131. Pickford F., Marcus J., Camargo L. M., Xiao Q., Graham D., Mo J.-R., Burkhardt M., Kulkarni V., Crispino J., Hering H., Hutton M., Progranulin is a chemoattractant for microglia and stimulates their endocytic activity. The American Journal of Pathology 2011 178 1 284 295 2-s2.0-79251482777 10.1016/j.ajpath.2010.11.002
132. Uberti D., Cantarella G., Facchetti F., Cafici A., Grasso G., Bernardini R., Memo M., TRAIL is expressed in the brain cells of Alzheimer's disease patients. NeuroReport 2004 15 4 579 581 2-s2.0-1842556406 10.1097/00001756- 200403220-00002 (Pubitemid 38457141)
133. Baba Y., Baker M. C., Le Ber I., Brice A., Maeck L., Kohlhase J., Yasuda M., Stoppe G., Bugiani O., Sperfeld A. D., Tsuboi Y., Uitti R. J., Farrer M. J., Ghetti B., Hutton M. L., Wszolek Z. K., Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation. Journal of Neural Transmission 2007 114 7 947 950 2-s2.0-34347359543 10.1007/s00702-007-0632-9 (Pubitemid 47013598)
134. C. H. Reynolds, J. C. Betts, W. P. Blackstock, A. R. Nebreda, and B. H. Anderton, "Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun Nterminal kinase and P38, and glycogen synthase kinase-3β, " Journal of Neurochemistry, vol. 74, no. 4, pp. 1587-1595, 2000. (Pubitemid 30163980)