메뉴 건너뛰기




Volumn 105, Issue 2, 2000, Pages 124-130

The role of complement anaphylatoxin C5a in neurodegeneration: Implications in Alzheimer's disease

Author keywords

Alzheimer's disease; Anaphylatoxin; Apoptosis; Caspase; Inflammation

Indexed keywords

ANAPHYLATOXIN; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN);

EID: 0034717942     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00261-1     Document Type: Article
Times cited : (80)

References (62)
  • 1
    • 0032586748 scopus 로고    scopus 로고
    • 1A receptor causes suppression of anoxia-induced apoptosis via mitogen activated protein kinase in neuronal HN2-5 cells
    • 1A receptor causes suppression of anoxia-induced apoptosis via mitogen activated protein kinase in neuronal HN2-5 cells. J. Neurochem. 72:1999;1489-1496.
    • (1999) J. Neurochem. , vol.72 , pp. 1489-1496
    • Adayev, T.1    El-Sherif, Y.2    Barua, M.3    Penongton, N.J.4    Banerjee, P.5
  • 3
    • 0027310748 scopus 로고
    • Specific interactions of chemoattractant factor receptors with G-proteins
    • Amatruda T.T., Gerard N., Gerard C., Simon M. Specific interactions of chemoattractant factor receptors with G-proteins. J. Biol. Chem. 268:1993;10139-10144.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10139-10144
    • Amatruda, T.T.1    Gerard, N.2    Gerard, C.3    Simon, M.4
  • 4
    • 0030744875 scopus 로고    scopus 로고
    • Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
    • Barria A., Muller D., Derkach V., Griffith L.S., Soderling T.R. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science. 276:1997;2042-2048.
    • (1997) Science , vol.276 , pp. 2042-2048
    • Barria, A.1    Muller, D.2    Derkach, V.3    Griffith, L.S.4    Soderling, T.R.5
  • 5
    • 0028564917 scopus 로고
    • Mapping of the C5a receptor signal transduction network in human neutrophils
    • Buhl A.M., Avdi N., Worthen G.S., Johnson G.L. Mapping of the C5a receptor signal transduction network in human neutrophils. Proc. Natl. Acad. Sci. 91:1994;9190-9194.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 9190-9194
    • Buhl, A.M.1    Avdi, N.2    Worthen, G.S.3    Johnson, G.L.4
  • 7
    • 0026730122 scopus 로고
    • Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain
    • Campos-Gonzalez R., Kindy M.S. Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J. Neurochem. 59:1992;1955-1958.
    • (1992) J. Neurochem. , vol.59 , pp. 1955-1958
    • Campos-Gonzalez, R.1    Kindy, M.S.2
  • 8
    • 0032078872 scopus 로고    scopus 로고
    • A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II
    • Cheng H., Rojas-Soto M., Oguni A., Kennedy M.B. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron. 20:1998;895-904.
    • (1998) Neuron. , vol.20 , pp. 895-904
    • Cheng, H.1    Rojas-Soto, M.2    Oguni, A.3    Kennedy, M.B.4
  • 9
    • 0028903333 scopus 로고
    • Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase ii activity in cultured hippocampal neurons
    • Churn S.B., Limbrick D., Sombati S., DeLorenzo R.J. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase ii activity in cultured hippocampal neurons. J. Neurosci. 15:1995;3200-3214.
    • (1995) J. Neurosci. , vol.15 , pp. 3200-3214
    • Churn, S.B.1    Limbrick, D.2    Sombati, S.3    Delorenzo, R.J.4
  • 10
    • 0026715067 scopus 로고
    • Global forebrain ischemia induces a posttranslational modification of multifunctional calcium-and calmodulin-dependent kinase II
    • Churn S.B., Taft W.C., Billingsley M.S., Sankaran B., DeLorenzo R.J. Global forebrain ischemia induces a posttranslational modification of multifunctional calcium-and calmodulin-dependent kinase II. J. Neurochem. 59:1992;1221-1232.
    • (1992) J. Neurochem. , vol.59 , pp. 1221-1232
    • Churn, S.B.1    Taft, W.C.2    Billingsley, M.S.3    Sankaran, B.4    Delorenzo, R.J.5
  • 11
    • 0026738323 scopus 로고
    • Global forebrain ischemia results in decreased immunoreactivity of calcium/calmodulin-dependent protein kinase II
    • Churn S.B., Yaghmai A., Povlishock J., Rafiq A., DeLorenzo R.J. Global forebrain ischemia results in decreased immunoreactivity of calcium/calmodulin-dependent protein kinase II. J. Cerebral Blood Flow and Metab. 12:1992;784-793.
    • (1992) J. Cerebral Blood Flow and Metab. , vol.12 , pp. 784-793
    • Churn, S.B.1    Yaghmai, A.2    Povlishock, J.3    Rafiq, A.4    Delorenzo, R.J.5
  • 12
    • 0029245289 scopus 로고
    • A potential role for apoptosis in neurodegeneration and Alzheimer's disease
    • Cotman C.W., Anderson A.J. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10:1995;19-45.
    • (1995) Mol. Neurobiol. , vol.10 , pp. 19-45
    • Cotman, C.W.1    Anderson, A.J.2
  • 13
    • 0030868345 scopus 로고    scopus 로고
    • Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons
    • Du Y., Bales K.R., Dodel R.C., Hamilton-Byrd E., Horn J.W., Czilli D.L., Simmins L.K., Ni B., Paul S.M. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc. Natl. Acad. Sci. 94:1997;11657-11662.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 11657-11662
    • Du, Y.1    Bales, K.R.2    Dodel, R.C.3    Hamilton-Byrd, E.4    Horn, J.W.5    Czilli, D.L.6    Simmins, L.K.7    Ni, B.8    Paul, S.M.9
  • 14
    • 0029768088 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase pathway
    • Enselen H., Tokumistu H., Stork P.J., Davis R.J., Soderling T.R. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase pathway. Proc. Natl. Acad. Sci. USA. 93:1996;10803-10808.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10803-10808
    • Enselen, H.1    Tokumistu, H.2    Stork, P.J.3    Davis, R.J.4    Soderling, T.R.5
  • 16
    • 0028863749 scopus 로고
    • Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes
    • Gasque P., Chan P., Fontaine M., Ischenko A., Lamacz M., Götze O., Morgan P. Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. J. Immunol. 155:1995;4882-4889.
    • (1995) J. Immunol. , vol.155 , pp. 4882-4889
    • Gasque, P.1    Chan, P.2    Fontaine, M.3    Ischenko, A.4    Lamacz, M.5    Götze, O.6    Morgan, P.7
  • 17
    • 0027440120 scopus 로고
    • Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain
    • Gass P., Kiessling M., Bading H. Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain. Neurosci. Lett. 162:1993;39-42.
    • (1993) Neurosci. Lett. , vol.162 , pp. 39-42
    • Gass, P.1    Kiessling, M.2    Bading, H.3
  • 18
    • 0026078539 scopus 로고
    • The chemotactic receptor for human C5a anaphylatoxin
    • Gerard N.P., Gerard C. The chemotactic receptor for human C5a anaphylatoxin. Science. 349:1991;614-617.
    • (1991) Science , vol.349 , pp. 614-617
    • Gerard, N.P.1    Gerard, C.2
  • 19
    • 0026612964 scopus 로고
    • Neuronal Ca2+/calmodulin-dependent protein kinases
    • Hanson P.I., Schulman H. Neuronal Ca2+/calmodulin-dependent protein kinases. Annu. Rev. Biochem. 61:1992;559-601.
    • (1992) Annu. Rev. Biochem. , vol.61 , pp. 559-601
    • Hanson, P.I.1    Schulman, H.2
  • 20
    • 0029795542 scopus 로고    scopus 로고
    • The C5a chemoattractant receptor mediates mucosal defense to infection
    • Hoepken U.E., Lu B., Gerard N.P., Gerard C. The C5a chemoattractant receptor mediates mucosal defense to infection. Nature. 383:1996;86-89.
    • (1996) Nature , vol.383 , pp. 86-89
    • Hoepken, U.E.1    Lu, B.2    Gerard, N.P.3    Gerard, C.4
  • 21
    • 0019527376 scopus 로고
    • The structural basis for anaphylatoxin and chemotactic functions of C3A, C4a, and C5a
    • Hugli T.E. The structural basis for anaphylatoxin and chemotactic functions of C3A, C4a, and C5a. CRC Crit. Rev. Immunol. 1:1981;321-366.
    • (1981) CRC Crit. Rev. Immunol. , vol.1 , pp. 321-366
    • Hugli, T.E.1
  • 22
    • 0029930669 scopus 로고    scopus 로고
    • Complement factor C5A and epidermal growth factor trigger the activation of outward potassium currents in cultured murine microglia
    • Ilschner S., Nolte C., Kettenmann H. Complement factor C5A and epidermal growth factor trigger the activation of outward potassium currents in cultured murine microglia. Neuroscience. 73:1996;1109-1120.
    • (1996) Neuroscience , vol.73 , pp. 1109-1120
    • Ilschner, S.1    Nolte, C.2    Kettenmann, H.3
  • 23
    • 0028178458 scopus 로고
    • B-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
    • Jiang H., Burdick D., Glabe C.G., Cotman C.W., Tenner A.J. b-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immun. 152:1994;5050-5059.
    • (1994) J. Immun , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cotman, C.W.4    Tenner, A.J.5
  • 24
    • 0030868903 scopus 로고    scopus 로고
    • Alternative cleavage of Alzheimer's-associated presenilins during apoptosis by a caspase-3 family protease
    • Kim T., Pettingell W.H., Jung Y., Kovacs D.M., Tanzi R.E. Alternative cleavage of Alzheimer's-associated presenilins during apoptosis by a caspase-3 family protease. Science. 277:1997;373-376.
    • (1997) Science. , vol.277 , pp. 373-376
    • Kim, T.1    Pettingell, W.H.2    Jung, Y.3    Kovacs, D.M.4    Tanzi, R.E.5
  • 27
    • 0001273527 scopus 로고
    • Regional localization of cells containing C1q and C4 mRNAs in the frontal cortex during Alzheimer's disease
    • Lampert-Etchells M., Pasinetti G.M., Finch C.E., Johnson S.A. Regional localization of cells containing C1q and C4 mRNAs in the frontal cortex during Alzheimer's disease. Neurodegeneration. 2:1993;111-121.
    • (1993) Neurodegeneration , vol.2 , pp. 111-121
    • Lampert-Etchells, M.1    Pasinetti, G.M.2    Finch, C.E.3    Johnson, S.A.4
  • 28
    • 0027484754 scopus 로고
    • Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
    • Lee A., Whyte M.K.B., Haslett C. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J. Leukocyte Bio. 54:1993;283-288.
    • (1993) J. Leukocyte Bio. , vol.54 , pp. 283-288
    • Lee, A.1    Whyte, M.K.B.2    Haslett, C.3
  • 29
    • 0033026832 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase II is associated with N-methyl-D-aspartate receptor
    • Leonard A.S., Lim I.A., Hemsworth D.E., Horne M.C., Hell J.W. Calcium/calmodulin-dependent protein kinase II is associated with N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA. 96:1999;3239-3244.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3239-3244
    • Leonard, A.S.1    Lim, I.A.2    Hemsworth, D.E.3    Horne, M.C.4    Hell, J.W.5
  • 30
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemeri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:1997;479-489.
    • (1997) Cell. , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemeri, E.S.6    Wang, X.7
  • 31
    • 0028762647 scopus 로고
    • Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton S.A., Rosenberg P.A. Mechanisms of disease: excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330:1994;613-622.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 32
    • 0028891783 scopus 로고
    • Apoptosis, oncosis and necrosis: An overview of cell death
    • Manjo G., Joris I. Apoptosis, oncosis and necrosis: an overview of cell death. Am. J. Pathol. 146:1995;3-15.
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Manjo, G.1    Joris, I.2
  • 35
    • 0025755349 scopus 로고
    • The role of protein kinase C activation and inositol phosphate production in the regulation of cell-surface expression of MAC-1 by complement fragment C5a
    • Monk P., Bank P. The role of protein kinase C activation and inositol phosphate production in the regulation of cell-surface expression of MAC-1 by complement fragment C5a. Biochim. Biophys. Acta. 1092:1991;251-255.
    • (1991) Biochim. Biophys. Acta. , vol.1092 , pp. 251-255
    • Monk, P.1    Bank, P.2
  • 36
    • 0033198678 scopus 로고    scopus 로고
    • Complement anaphylatoxin receptors on neurons: New tricks for old receptors
    • Natsaf S., Stahel P.F., Davoust N., Barnum S.R. Complement anaphylatoxin receptors on neurons: new tricks for old receptors. Trends Neurosci. 22:1999;397-402.
    • (1999) Trends Neurosci. , vol.22 , pp. 397-402
    • Natsaf, S.1    Stahel, P.F.2    Davoust, N.3    Barnum, S.R.4
  • 37
    • 0342592138 scopus 로고    scopus 로고
    • Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton
    • Nolte C., Möller T., Walter T., Kettenmann H. Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton. Neuroscience. 73:1996;1091-1107.
    • (1996) Neuroscience. , vol.73 , pp. 1091-1107
    • Nolte, C.1    Möller, T.2    Walter, T.3    Kettenmann, H.4
  • 38
    • 0003056313 scopus 로고
    • Complement and β-amyloid neurotoxicity in vitro: A model for Alzheimer disease
    • Oda T., Lehrer-Graiwer J., Finch C.E., Pasinetti G.M. Complement and β-amyloid neurotoxicity in vitro: a model for Alzheimer disease. Alzheimer's Res. 1:1995;29-34.
    • (1995) Alzheimer's Res. , vol.1 , pp. 29-34
    • Oda, T.1    Lehrer-Graiwer, J.2    Finch, C.E.3    Pasinetti, G.M.4
  • 39
    • 0030782939 scopus 로고    scopus 로고
    • Excitotoxic neurodegeneration in Alzheimer disease - new hypothesis and new therapeutic strategies
    • Olney J.W., Wozniak D.F., Farber N.B. Excitotoxic neurodegeneration in Alzheimer disease - new hypothesis and new therapeutic strategies. Arch. Neurol. 54:1997;1234-1240.
    • (1997) Arch. Neurol. , vol.54 , pp. 1234-1240
    • Olney, J.W.1    Wozniak, D.F.2    Farber, N.B.3
  • 40
    • 0032889730 scopus 로고    scopus 로고
    • Expression of C5a receptor in mouse brain: Role in signal transduction and neurodegeneration
    • Osaka H., McGinty A., Hoepken U.E., Lu B., Gerard C., Pasinetti G.M. Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration. Neuroscience. 88:1998;1073-1082.
    • (1998) Neuroscience , vol.88 , pp. 1073-1082
    • Osaka, H.1    McGinty, A.2    Hoepken, U.E.3    Lu, B.4    Gerard, C.5    Pasinetti, G.M.6
  • 41
    • 0033562337 scopus 로고    scopus 로고
    • Complement-derived anaphylotoxin C5a Protects against glutamate-mediated neurotoxicity.
    • Osaka H., Mukherjee P., Aisen P.S., Pasinetti G.M. Complement-derived anaphylotoxin C5a Protects against glutamate-mediated neurotoxicity. J. Cell. Biochem. 73:1999;303-311.
    • (1999) J. Cell. Biochem. , vol.73 , pp. 303-311
    • Osaka, H.1    Mukherjee, P.2    Aisen, P.S.3    Pasinetti, G.M.4
  • 42
    • 0030250826 scopus 로고    scopus 로고
    • Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system
    • Pasinetti G.M. Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: the role of the complement system. Neurobiology of Aging. 17:1996;707-716.
    • (1996) Neurobiology of Aging , vol.17 , pp. 707-716
    • Pasinetti, G.M.1
  • 43
    • 0032190264 scopus 로고    scopus 로고
    • Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions
    • Pasinetti G.M. Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. J. Neurosci. Res. 54:1998;1-6.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 1-6
    • Pasinetti, G.M.1
  • 44
    • 0030175273 scopus 로고    scopus 로고
    • Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions
    • Pasinetti G.M., Tocco G., Sakhi S., Musleh W.D., DeSimoni M.G., Mascarucci P., Schreiber S., Baudry M., Finch C.E. Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions. Neurobiol. Dis. 3:1996;197-204.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 197-204
    • Pasinetti, G.M.1    Tocco, G.2    Sakhi, S.3    Musleh, W.D.4    Desimoni, M.G.5    Mascarucci, P.6    Schreiber, S.7    Baudry, M.8    Finch, C.E.9
  • 45
    • 0005261734 scopus 로고
    • Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro
    • Ray L.B., Sturgill T.W. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc. Natl. Acad. Sci. 84:1987;1502-1506.
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 1502-1506
    • Ray, L.B.1    Sturgill, T.W.2
  • 46
    • 0030782177 scopus 로고    scopus 로고
    • Cytochrome c: Can't live with it - can't live without it
    • Reed J.C. Cytochrome c: can't live with it - can't live without it. Cell. 91:1997;559-562.
    • (1997) Cell. , vol.91 , pp. 559-562
    • Reed, J.C.1
  • 47
    • 0001436241 scopus 로고
    • Immune-related mechanisms of Alzheimer's disease pathogenesis
    • In: Khachaturian, Z.S., Blass, J.B. (Eds.), Marcel Dekker, Inc., New York
    • Rogers, J., Civin, W.H., Styren, S.D., McGeer, P.L., 1992. Immune-related mechanisms of Alzheimer's disease pathogenesis. In: Khachaturian, Z.S., Blass, J.B. (Eds.), Alzheimer's Disease: New Treatment Strategies. Marcel Dekker, Inc., New York, pp. 147-163.
    • (1992) Alzheimer's Disease: New Treatment Strategies , pp. 147-163
    • Rogers, J.1    Civin, W.H.2    Styren, S.D.3    McGeer, P.L.4
  • 49
    • 0026069842 scopus 로고
    • Regulation of complement 5a receptor expression in U937 cells by phorbol ester
    • Rubin J., Titus L., Nanes M.S. Regulation of complement 5a receptor expression in U937 cells by phorbol ester. J. Leuk. Biol. 50:1991;502-508.
    • (1991) J. Leuk. Biol. , vol.50 , pp. 502-508
    • Rubin, J.1    Titus, L.2    Nanes, M.S.3
  • 50
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellualr signaling by proteolysis
    • Salvesen G.S., Dixit V.M. Caspases: intracellualr signaling by proteolysis. Cell. 91:1997;443-446.
    • (1997) Cell. , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 51
    • 0031930465 scopus 로고    scopus 로고
    • Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kianic acid-induced seizures
    • Sola C., Tusell J.M., Serratosa J. Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kianic acid-induced seizures. J. Neurochem. 70:1998;1600-1608.
    • (1998) J. Neurochem. , vol.70 , pp. 1600-1608
    • Sola, C.1    Tusell, J.M.2    Serratosa, J.3
  • 53
    • 0030842642 scopus 로고    scopus 로고
    • Complement and glutamate neurotoxicity: Genotypic influences of C5 in a mouse model of hippocampal neurodegeneration
    • Tocco G., Musleh W., Sakhi S., Schreiber S.S., Baudry M., Pasinetti G.M. Complement and glutamate neurotoxicity: genotypic influences of C5 in a mouse model of hippocampal neurodegeneration. Mol. Chem. Neuropathol. 31:1997;289-297.
    • (1997) Mol. Chem. Neuropathol. , vol.31 , pp. 289-297
    • Tocco, G.1    Musleh, W.2    Sakhi, S.3    Schreiber, S.S.4    Baudry, M.5    Pasinetti, G.M.6
  • 54
    • 0031031747 scopus 로고    scopus 로고
    • Aspartate residue 7 in amyloid β protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis
    • Velazquez P., Cribbs D.H., Poulos T.L., Tenner A.J. Aspartate residue 7 in amyloid β protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis. Nature Medicine. 3:1997;77-79.
    • (1997) Nature Medicine. , vol.3 , pp. 77-79
    • Velazquez, P.1    Cribbs, D.H.2    Poulos, T.L.3    Tenner, A.J.4
  • 56
    • 0020532691 scopus 로고
    • Expression of C5a-like biological activities by the fifth component of the human complement (C5) upon limited digestion with noncomplement enzymes without release of polypeptide fragments
    • Wetsel R.A., Kolb W.P. Expression of C5a-like biological activities by the fifth component of the human complement (C5) upon limited digestion with noncomplement enzymes without release of polypeptide fragments. J. Exp. Med. 157:1983;2029-2048.
    • (1983) J. Exp. Med. , vol.157 , pp. 2029-2048
    • Wetsel, R.A.1    Kolb, W.P.2
  • 57
    • 0021866561 scopus 로고
    • Anaphylatoxin C5a modulation of an alpha-adrenergic receptor system in the rat hypothalamus
    • Williams C., Schupf N., Hugli T. Anaphylatoxin C5a modulation of an alpha-adrenergic receptor system in the rat hypothalamus. J. Neuroimmunol. 9:1985;29-40.
    • (1985) J. Neuroimmunol. , vol.9 , pp. 29-40
    • Williams, C.1    Schupf, N.2    Hugli, T.3
  • 58
    • 0026725842 scopus 로고
    • Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) Gingivalis
    • Wingrove J.A., DiScipio R.G., Chen Z., Potempa J., Travis J., Hugli T.E. Activation of complement components C3 and C5 by a cysteine proteinase (gingipain-1) from Porphyromonas (Bacteroides) Gingivalis. J. Biol. Chem. 267:1992;18902-18907.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18902-18907
    • Wingrove, J.A.1    Discipio, R.G.2    Chen, Z.3    Potempa, J.4    Travis, J.5    Hugli, T.E.6
  • 59
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 60
    • 0031930313 scopus 로고    scopus 로고
    • Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque associated neurons and microglia in Alzheimer's disease
    • Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Vinters H.V., Frautschy S.A., Cole G. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque associated neurons and microglia in Alzheimer's disease. Amer. J. Pathol. 152:1998;379-389.
    • (1998) Amer. J. Pathol. , vol.152 , pp. 379-389
    • Yang, F.1    Sun, X.2    Beech, W.3    Teter, B.4    Wu, S.5    Sigel, J.6    Vinters, H.V.7    Frautschy, S.A.8    Cole, G.9
  • 62
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan J., Shaham S., Ledoux S., Ellis H.M., Horvitz H.M. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell. 75:1993;641-652.
    • (1993) Cell. , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.