메뉴 건너뛰기




Volumn 13, Issue 4, 2000, Pages 377-384

Molecular genetics of Alzheimer's disease: The role of β-amyloid and the presenilins

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2;

EID: 0033864011     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200008000-00003     Document Type: Review
Times cited : (74)

References (99)
  • 6
    • 0033616590 scopus 로고    scopus 로고
    • Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 - > Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4119-4124
    • Ancolio, K.1    Dumanchin, C.2    Barelli, H.3
  • 13
    • 0030889220 scopus 로고    scopus 로고
    • Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
    • (1997) Neurobiol Dis , vol.3 , pp. 325-337
    • Podlisny, M.B.1    Citron, M.2    Amarante, P.3
  • 16
    • 0032488995 scopus 로고    scopus 로고
    • The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
    • (1998) J Biol Chem , vol.273 , pp. 3205-3211
    • Capell, A.1    Grunberg, J.2    Pesold, B.3
  • 17
    • 0032568821 scopus 로고    scopus 로고
    • The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
    • (1998) J Biol Chem , vol.273 , pp. 16470-16475
    • Yu, G.1    Chen, F.2    Levesque, G.3
  • 21
    • 0031721511 scopus 로고    scopus 로고
    • Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
    • (1998) Nature Med , vol.4 , pp. 1177-1181
    • Buxbaum, J.D.1    Choi, E.K.2    Luo, Y.3
  • 34
    • 0031196094 scopus 로고    scopus 로고
    • Lack of interactions between amyloid precursor protein and hydrophilic domains of presenilin 1 and 2 using the yeast two hybrid system
    • (1997) J Mol Neurosci , vol.9 , pp. 49-54
    • Kim, S.S.1    Choi, Y.M.2    Suh, Y.H.3
  • 36
  • 41
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 46
  • 47
    • 0000792598 scopus 로고    scopus 로고
    • The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
    • (2000) J Biol Chem , vol.275 , pp. 3173-3178
    • Kimberly, W.T.1    Xia, W.2    Rahmati, T.3
  • 48
    • 0034621824 scopus 로고    scopus 로고
    • Photoactivated γ-secretase inhibitors directed to the active site covatently label presenilin 1
    • (2000) Nature , vol.405 , pp. 689-694
    • Li, Y.-M.1    Xu, M.2    Lai, M.-T.3
  • 50
  • 57
    • 0032461761 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg
    • (1998) Ann N Y Acad Sci , vol.855 , pp. 738-743
    • Roses, A.D.1
  • 60
    • 0032507032 scopus 로고    scopus 로고
    • The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics
    • (1998) JAMA , vol.279 , pp. 751-755
    • Tang, M.X.1    Stern, Y.2    Marder, K.3
  • 63
    • 0032563366 scopus 로고    scopus 로고
    • The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: Independent risk and linkage disequilibrium with the known APOE polymorphism
    • (1998) Neurosci Lett , vol.252 , pp. 95-98
    • Town, T.1    Paris, D.2    Fallin, D.3
  • 67
    • 0029128232 scopus 로고
    • LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amytoid precursor protein and mediates its degradation
    • (1995) Cell , vol.82 , pp. 331-340
    • Kounnas, M.Z.1    Moir, R.D.2    Rebeck, G.W.3
  • 72
  • 73
    • 0031911493 scopus 로고    scopus 로고
    • Apolipoprotein E genotype influences cognitive 'phenotype' in patients with Alzheimer's disease but not in healthy control subjects
    • (1998) Neurology , vol.50 , pp. 355-362
    • Smith, G.E.1    Bohac, D.L.2    Waring, S.C.3
  • 76
    • 0030752288 scopus 로고    scopus 로고
    • Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease
    • (1997) Neurology , vol.49 , pp. 56-61
    • Kang, D.E.1    Saitoh, T.2    Chen, X.3
  • 77
    • 0030028429 scopus 로고    scopus 로고
    • Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease
    • (1996) Lancet , vol.347 , pp. 509-512
    • Wragg, M.1    Hutton, M.2    Talbot, C.3
  • 81
    • 0031710443 scopus 로고    scopus 로고
    • The human FE65 gene: Genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type
    • (1998) Hum Genet , vol.103 , pp. 295-303
    • Hu, Q.1    Kukull, W.A.2    Bressler, S.L.3
  • 85
    • 0032547037 scopus 로고    scopus 로고
    • The butyrylcholinasterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations
    • (1998) Neurosci Lett , vol.249 , pp. 115-118
    • Crawford, F.1    Fallin, D.2    Suo, Z.3
  • 91
    • 0032547369 scopus 로고    scopus 로고
    • Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity
    • (1998) JAMA , vol.280 , pp. 614-618
    • Rogaeva, E.1    Premkumar, S.2    Song, Y.3
  • 93


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.