The peripheral benzodiazepine binding site in the brain in multiple sclerosis. Quantitative in vivo imaging of microglia as a measure of disease activity

Brain

Volumn 123, Issue 11, 2000, Pages 2321-2337

  Banati, R B ^a,h   Newcombe, J ^c   Gunn, R N ^a   Cagnin, A ^a   Turkheimer, F ^a   Heppner, F ^b,i   Price, G ^e   Wegner, F ^g   Giovannoni, G ^c   Miller, D H ^c   Perkin, G D ^b   Smith, T ^c,d   Hewson, A K ^c,f   Bydder, G ^a   Kreutzberg, G W ^h   Jones, T ^a   Cuzner, M L ^c   Myers, R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g Paul Flechsig Institute   (Germany)

^h MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

ⁱ UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

EAE; Inflammation; Microglia; Mitochondrial benzodiazepine receptor; Multiple sclerosis; Peripheral benzodiazepine receptor; PET; PK11195

Indexed keywords

BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ADULT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CLINICAL ARTICLE; DISEASE ACTIVITY; FEMALE; GRAY MATTER; HUMAN; IN VIVO STUDY; MALE; MICROGLIA; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0033768486     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/123.11.2321     Document Type: Article

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