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Volumn 259, Issue 11, 2012, Pages 2278-2286

Frontotemporal lobar degeneration: Current knowledge and future challenges

Author keywords

C9ORF72; Frontotemporal lobar degeneration; Genetics; Progranulin (GRN); Risk factor; Tau

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN; PROGRANULIN; TAU PROTEIN;

EID: 84868204382     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6507-5     Document Type: Review
Times cited : (33)

References (103)
  • 3
    • 80052938441 scopus 로고    scopus 로고
    • Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
    • Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456-2477
    • (2011) Brain , vol.134 , pp. 2456-2477
    • Rascovsky, K.1    Hodges, J.R.2    Knopman, D.3    Mendez, M.F.4    Kramer, J.H.5    Neuhaus, J.6
  • 5
    • 78751579187 scopus 로고    scopus 로고
    • Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management
    • Piguet O, Hornberger M, Mioshi E, Hodges JR (2011) Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management. Lancet Neurol 10:162-172
    • (2011) Lancet Neurol , vol.10 , pp. 162-172
    • Piguet, O.1    Hornberger, M.2    Mioshi, E.3    Hodges, J.R.4
  • 6
    • 29144489408 scopus 로고    scopus 로고
    • Progressive, isolated language disturbance: Its significance in a 65-year-old-man. A case report with implications for treatment and review of literature
    • DOI 10.1016/j.jns.2005.09.006, PII S0022510X05003333
    • Scarpini E, Galimberti D, Guidi I, Bresolin N, Scheltens P (2006) Progressive, isolated language disturbance: its significance in a 65 year-old-man. A case report with implications for treatment and review of literature. J Neurol Sci 240:45-51 (Pubitemid 41814952)
    • (2006) Journal of the Neurological Sciences , vol.240 , Issue.1-2 , pp. 45-51
    • Scarpini, E.1    Galimberti, D.2    Guidi, I.3    Bresolin, N.4    Scheltens, P.5
  • 7
    • 15044355712 scopus 로고    scopus 로고
    • Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration
    • DOI 10.1097/01.wnn.0000152225.05377.ab
    • Rankin KP, Kramer JH, Miller BL (2005) Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol 18:28-36 (Pubitemid 40381367)
    • (2005) Cognitive and Behavioral Neurology , vol.18 , Issue.1 , pp. 28-36
    • Rankin, K.P.1    Kramer, J.H.2    Miller, B.L.3
  • 12
    • 0037062609 scopus 로고    scopus 로고
    • The prevalence of frontotemporal dementia
    • Ratnavalli E, Brayne C, Dawson K, Hodges JR (2002) The prevalence of frontotemporal dementia. Neurology 58:1615-1621 (Pubitemid 34602891)
    • (2002) Neurology , vol.58 , Issue.11 , pp. 1615-1621
    • Ratnavalli, E.1    Brayne, C.2    Dawson, K.3    Hodges, J.R.4
  • 16
    • 34447108549 scopus 로고    scopus 로고
    • Progranulin and frontotemporal lobar degeneration
    • DOI 10.1007/s00401-007-0241-6
    • Pickering-Brown SM (2007) The complex aetiology of fronto-temporal lobar degeneration. Exp Neurol 114:39-47 (Pubitemid 47029058)
    • (2007) Acta Neuropathologica , vol.114 , Issue.1 , pp. 39-47
    • Pickering-Brown, S.M.1
  • 17
    • 80054832080 scopus 로고    scopus 로고
    • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    • DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72:245-256
    • (2011) Neuron , vol.72 , pp. 245-256
    • DeJesus-Hernandez, M.1    Mackenzie, I.R.2    Boeve, B.F.3    Boxer, A.L.4    Baker, M.5    Rutherford, N.J.6
  • 18
    • 80054837386 scopus 로고    scopus 로고
    • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
    • Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72:257-268
    • (2011) Neuron , vol.72 , pp. 257-268
    • Renton, A.E.1    Majounie, E.2    Waite, A.3    Simón-Sánchez, J.4    Rollinson, S.5    Gibbs, J.R.6
  • 19
    • 83555166183 scopus 로고    scopus 로고
    • A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: A gene identification study
    • Gijselinck I, Van Langenhove T, van der Zee J, Sleegers K, Philtjens S, Kleinberger G et al (2012) A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study. Lancet Neurol 11(1):54-65
    • (2012) Lancet Neurol , vol.11 , Issue.1 , pp. 54-65
    • Gijselinck, I.1    Van Langenhove, T.2    Van Der Zee, J.3    Sleegers, K.4    Philtjens, S.5    Kleinberger, G.6
  • 24
    • 0036892302 scopus 로고    scopus 로고
    • Tau gene mutations: Dissecting the pathogenesis of FTDP-17
    • DOI 10.1016/S1471-4914(02)02440-1
    • Ingram EM, Spillantini MG (2002) Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends Mol Med 8:555-562 (Pubitemid 35408213)
    • (2002) Trends in Molecular Medicine , vol.8 , Issue.12 , pp. 555-562
    • Ingram, E.M.1    Spillantini, M.G.2
  • 25
    • 5044235577 scopus 로고    scopus 로고
    • The role of tau (MAPT) in frontotemporal dementia and related tauopathies
    • DOI 10.1002/humu.20086
    • Rademakers R, Cruts M, van Broeckhoven C (2004) The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Hum Mutat 24:277-295 (Pubitemid 39336634)
    • (2004) Human Mutation , vol.24 , Issue.4 , pp. 277-295
    • Rademakers, R.1    Cruts, M.2    Van Broeckhoven, C.3
  • 28
    • 0039575094 scopus 로고    scopus 로고
    • Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease
    • Buée L, Delacourte A (1999) Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease. Brain Pathol 9:681-693 (Pubitemid 29470961)
    • (1999) Brain Pathology , vol.9 , Issue.4 , pp. 681-693
    • Buee, L.1    Delacourte, A.2
  • 29
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3:519-526
    • (1989) Neuron , vol.3 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 30
    • 0142139311 scopus 로고    scopus 로고
    • Tau protein in familial and sporadic diseases
    • DOI 10.1385/NMM:4:1-2:37
    • Yancopoulou D, Spillantini MG (2003) Tau protein in familial and sporadic diseases. Neuromol Med 4:37-48 (Pubitemid 37315184)
    • (2003) NeuroMolecular Medicine , vol.4 , Issue.1-2 , pp. 37-48
    • Yancopoulou, D.1    Spillantini, M.G.2
  • 32
    • 33847194237 scopus 로고    scopus 로고
    • Hereditary frontotemporal dementia caused by Tau gene mutations
    • van Swieten J, Spillantini MG (2007) Hereditary frontotemporal dementia caused by Tau gene mutations. Brain Pathol 17:63-73
    • (2007) Brain Pathol , vol.17 , pp. 63-73
    • Van Swieten, J.1    Spillantini, M.G.2
  • 33
    • 51449089054 scopus 로고    scopus 로고
    • Mutations in progranulin (GRN) within the spectrum of clinical and pathological pheno-types of frontotemporal dementia
    • van Swieten JC, Heutink P (2008) Mutations in progranulin (GRN) within the spectrum of clinical and pathological pheno-types of frontotemporal dementia. Lancet Neurol 7:965-974
    • (2008) Lancet Neurol , vol.7 , pp. 965-974
    • Van Swieten, J.C.1    Heutink, P.2
  • 34
    • 42249085980 scopus 로고    scopus 로고
    • Refining frontotemporal dementia with parkinsonism linked to chromosome 17: Introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)
    • DOI 10.1001/archneur.65.4.460
    • Boeve BF, Hutton M (2008) Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN). Arch Neurol 65:460-464 (Pubitemid 351549953)
    • (2008) Archives of Neurology , vol.65 , Issue.4 , pp. 460-464
    • Boeve, B.F.1    Hutton, M.2
  • 38
    • 33645089933 scopus 로고    scopus 로고
    • A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD
    • van der Zee J, Rademakers R, Engelborghs S, Gijselinck I, Bogaerts V, Vandenberghe R et al (2006) A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD. Brain 129:841-852
    • (2006) Brain , vol.129 , pp. 841-852
    • Van Der Zee, J.1    Rademakers, R.2    Engelborghs, S.3    Gijselinck, I.4    Bogaerts, V.5    Vandenberghe, R.6
  • 41
    • 0242320195 scopus 로고    scopus 로고
    • Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis
    • DOI 10.1007/s00109-003-0474-3
    • He Z, Bateman A (2003) Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med 81:600-612 (Pubitemid 37357675)
    • (2003) Journal of Molecular Medicine , vol.81 , Issue.10 , pp. 600-612
    • He, Z.1    Bateman, A.2
  • 46
    • 33750599059 scopus 로고    scopus 로고
    • Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia
    • DOI 10.1093/brain/awl267
    • Snowden JS, Pickering-Brown SM, Mackenzie IR, Richardson AM, Varma A, Neary D, Mann DM (2006) Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia. Brain 129:3091-3102 (Pubitemid 44684528)
    • (2006) Brain , vol.129 , Issue.11 , pp. 3091-3102
    • Snowden, J.S.1    Pickering-Brown, S.M.2    Mackenzie, I.R.3    Richardson, A.M.T.4    Varma, A.5    Neary, D.6    Mann, D.M.A.7
  • 47
    • 76149123541 scopus 로고    scopus 로고
    • The spectrum of mutations in progranulin: A collaborative study screening 545 cases of neurodegeneration
    • Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E et al (2010) The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Arch Neurol 67:161-170
    • (2010) Arch Neurol , vol.67 , pp. 161-170
    • Yu, C.E.1    Bird, T.D.2    Bekris, L.M.3    Montine, T.J.4    Leverenz, J.B.5    Steinbart, E.6
  • 48
    • 70350618915 scopus 로고    scopus 로고
    • Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic mild cognitive impairment converted to Alzheimer's disease
    • Carecchio M, Fenoglio C, De Riz M, Guidi I, Comi C, Cortini F et al (2009) Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic mild cognitive impairment converted to Alzheimer's disease. J Neurol Sci 287:291-293
    • (2009) J Neurol Sci , vol.287 , pp. 291-293
    • Carecchio, M.1    Fenoglio, C.2    De Riz, M.3    Guidi, I.4    Comi, C.5    Cortini, F.6
  • 51
    • 80053974001 scopus 로고    scopus 로고
    • Heterosexual pedophilia in a frontotemporal dementia patient with a mutation in the progranulin gene
    • Rainero I, Rubino E, Negro E, Gallone S, Galimberti D, Gentile S et al (2011) Heterosexual pedophilia in a frontotemporal dementia patient with a mutation in the progranulin gene. Biol Psychiatry 70:43-44
    • (2011) Biol Psychiatry , vol.70 , pp. 43-44
    • Rainero, I.1    Rubino, E.2    Negro, E.3    Gallone, S.4    Galimberti, D.5    Gentile, S.6
  • 52
    • 84455193367 scopus 로고    scopus 로고
    • From genotype to phenotype: Two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder
    • Cerami C, Marcone A, Galimberti D, Villa C, Scarpini E, Cappa SF (2011) From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder. J Alzheimers Dis 27(4):791-797
    • (2011) J Alzheimers Dis , vol.27 , Issue.4 , pp. 791-797
    • Cerami, C.1    Marcone, A.2    Galimberti, D.3    Villa, C.4    Scarpini, E.5    Cappa, S.F.6
  • 53
    • 54449085260 scopus 로고    scopus 로고
    • Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
    • Ghidoni R, Benussi L, Glionna M, Franzoni M, Binetti G (2008) Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration. Neurology 71:1235-1239
    • (2008) Neurology , vol.71 , pp. 1235-1239
    • Ghidoni, R.1    Benussi, L.2    Glionna, M.3    Franzoni, M.4    Binetti, G.5
  • 54
    • 64849103956 scopus 로고    scopus 로고
    • Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
    • Finch N, Baker M, Crook R, Swanson K, Kuntz K, Surtees R et al (2009) Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Brain 132:583-591
    • (2009) Brain , vol.132 , pp. 583-591
    • Finch, N.1    Baker, M.2    Crook, R.3    Swanson, K.4    Kuntz, K.5    Surtees, R.6
  • 55
    • 0034605478 scopus 로고    scopus 로고
    • Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22
    • Hosler BA, Siddique T, Sapp PC, Sailor W, Huang MC, Hossain A et al (2000) Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. JAMA 284:1664-1669
    • (2000) JAMA , vol.284 , pp. 1664-1669
    • Hosler, B.A.1    Siddique, T.2    Sapp, P.C.3    Sailor, W.4    Huang, M.C.5    Hossain, A.6
  • 56
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    • Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J et al (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323:1208-1211
    • (2009) Science , vol.323 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobágyi, T.3    De Vos, K.J.4    Nishimura, A.L.5    Sreedharan, J.6
  • 59
    • 79953034868 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis
    • Rollinson S, Mead S, Snowden J, Richardson A, Rohrer J, Halliwell N (2011) Frontotemporal lobar degeneration genome wide association study replication confirms a risk locus shared with amyotrophic lateral sclerosis. Neurobiol Aging 32:758e1-758e7
    • (2011) Neurobiol Aging , vol.32
    • Rollinson, S.1    Mead, S.2    Snowden, J.3    Richardson, A.4    Rohrer, J.5    Halliwell, N.6
  • 60
    • 1842483843 scopus 로고    scopus 로고
    • Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
    • DOI 10.1038/ng1332
    • Watts GD, Wymer J, Kovach MJ, Mehta SG, Mumm S, Darvish D et al (2004) Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin containing protein. Nat Genet 36:377-381 (Pubitemid 38437260)
    • (2004) Nature Genetics , vol.36 , Issue.4 , pp. 377-381
    • Watts, G.D.J.1    Wymer, J.2    Kovach, M.J.3    Mehta, S.G.4    Mumm, S.5    Darvish, D.6    Pestronk, A.7    Whyte, M.P.8    Kimonis, V.E.9
  • 61
    • 56449111307 scopus 로고    scopus 로고
    • VCP disease associated with myopathy, Paget disease of bone and fronto-temporal dementia: Review of a unique disorder
    • Kimonis VE, Fulchiero E, Vesa J, Watts G (2008) VCP disease associated with myopathy, Paget disease of bone and fronto-temporal dementia: review of a unique disorder. Biochim Bio-phys Acta 1782:744-748
    • (2008) Biochim Bio-phys Acta , vol.1782 , pp. 744-748
    • Kimonis, V.E.1    Fulchiero, E.2    Vesa, J.3    Watts, G.4
  • 66
    • 77649252528 scopus 로고    scopus 로고
    • Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
    • Pesiridis G, Lee VMY, Trojanowski JQ (2009) Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Hum Mol Gen 18:R156-R162
    • (2009) Hum Mol Gen , vol.18
    • Pesiridis, G.1    Lee, V.M.Y.2    Trojanowski, J.Q.3
  • 70
    • 67349155310 scopus 로고    scopus 로고
    • Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation
    • Chiò A, Restagno G, Brunetti M, Ossola I, Calvo A, Mora G et al (2009) Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation. Neurobiol Aging 30:1272-1275
    • (2009) Neurobiol Aging , vol.30 , pp. 1272-1275
    • Chiò, A.1    Restagno, G.2    Brunetti, M.3    Ossola, I.4    Calvo, A.5    Mora, G.6
  • 73
    • 80052580969 scopus 로고    scopus 로고
    • Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    • Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N et al (2011) Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature 477:211-215
    • (2011) Nature , vol.477 , pp. 211-215
    • Deng, H.X.1    Chen, W.2    Hong, S.T.3    Boycott, K.M.4    Gorrie, G.H.5    Siddique, N.6
  • 80
    • 0031597685 scopus 로고    scopus 로고
    • The apolipoprotein E ε4 allele is not a significant risk factor for frontotemporal dementia
    • DOI 10.1002/ana.410440122
    • Geschwind D, Karrim J, Nelson SF, Miller B (1998) The apo-lipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia. Ann Neurol 44:134-138 (Pubitemid 28323665)
    • (1998) Annals of Neurology , vol.44 , Issue.1 , pp. 134-138
    • Geschwind, D.1    Karrim, J.2    Nelson, S.F.3    Miller, B.4
  • 82
    • 0036219387 scopus 로고    scopus 로고
    • Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes
    • Short RA, Graff-Radford NR, Adamson J, Baker M, Hutton M (2002) Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes. Arch Neurol 59:611-615 (Pubitemid 34289965)
    • (2002) Archives of Neurology , vol.59 , Issue.4 , pp. 611-615
    • Short, R.A.1    Graff-Radford, N.R.2    Adamson, J.3    Baker, M.4    Hutton, M.5
  • 90
    • 56049083010 scopus 로고    scopus 로고
    • Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP-43-positive frontotemporal dementia
    • Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ et al (2008) Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP-43-positive frontotemporal dementia. Human Mol Genet 17:3631-3642
    • (2008) Human Mol Genet , vol.17 , pp. 3631-3642
    • Rademakers, R.1    Eriksen, J.L.2    Baker, M.3    Robinson, T.4    Ahmed, Z.5    Lincoln, S.J.6
  • 93
    • 67650908424 scopus 로고    scopus 로고
    • MCP-1 A-2518G polymorphism: Effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels
    • Galimberti D, Venturelli E, Villa C, Fenoglio C, Clerici F, Marcone A et al (2009) MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels. J Alzheimers Dis 17:125-133
    • (2009) J Alzheimers Dis , vol.17 , pp. 125-133
    • Galimberti, D.1    Venturelli, E.2    Villa, C.3    Fenoglio, C.4    Clerici, F.5    Marcone, A.6
  • 94
    • 57449108081 scopus 로고    scopus 로고
    • The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration
    • Venturelli E, Villa C, Fenoglio C, Clerici F, Marcone A, Ghidoni R et al (2009) The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration. Eur J Neurol 16:37-42
    • (2009) Eur J Neurol , vol.16 , pp. 37-42
    • Venturelli, E.1    Villa, C.2    Fenoglio, C.3    Clerici, F.4    Marcone, A.5    Ghidoni, R.6
  • 96
    • 79953276507 scopus 로고    scopus 로고
    • BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease
    • Venturelli E, Villa C, Fenoglio C, Clerici F, Marcone A, Benussi L et al (2011) BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease. J Alzheimers Dis 23:701-707
    • (2011) J Alzheimers Dis , vol.23 , pp. 701-707
    • Venturelli, E.1    Villa, C.2    Fenoglio, C.3    Clerici, F.4    Marcone, A.5    Benussi, L.6
  • 99
    • 79960740814 scopus 로고    scopus 로고
    • UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting
    • Stefani F, Zhang L, Taylor S, Donovan J, Rollinson S, Doyotte A et al (2011) UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Curr Biol 21(14):1245-1250
    • (2011) Curr Biol , vol.21 , Issue.14 , pp. 1245-1250
    • Stefani, F.1    Zhang, L.2    Taylor, S.3    Donovan, J.4    Rollinson, S.5    Doyotte, A.6
  • 102
    • 78649796276 scopus 로고    scopus 로고
    • Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
    • Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ et al (2010) Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. Am J Hum Genet 87:890-897
    • (2010) Am J Hum Genet , vol.87 , pp. 890-897
    • Carrasquillo, M.M.1    Nicholson, A.M.2    Finch, N.3    Gibbs, J.R.4    Baker, M.5    Rutherford, N.J.6
  • 103
    • 68149131822 scopus 로고    scopus 로고
    • A decade of genetic counseling in frontotemporal dementia affected families: Few counselling requests and much familial opposition to testing
    • Riedijk SR, Niermeijer MFN, Dooijes D, Tibben A (2009) A decade of genetic counseling in frontotemporal dementia affected families: few counselling requests and much familial opposition to testing. J Genet Counsel 18:350-356
    • (2009) J Genet Counsel , vol.18 , pp. 350-356
    • Riedijk, S.R.1    Niermeijer, M.F.N.2    Dooijes, D.3    Tibben, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.