Sphingosine kinase 1 is regulated by peroxisome proliferator-activated receptor α in response to free fatty acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity

Journal of Biological Chemistry

Volumn 288, Issue 31, 2013, Pages 22193-22206

  Ross, Jessica S ^a   Hu, Wei ^a   Rosen, Bess ^c   Snider, Ashley J ^b,f   Obeid, Lina M ^d,e   Cowart, L Ashley ^a,f  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b University Family Medicine   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e Northport Veterans Affairs Medical Center   (United States)

^f RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIET-INDUCED OBESITY; FREE FATTY ACID; INTERLEUKIN-6; PARACRINE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; SKELETAL MUSCLE; SPHINGOSINE KINASE;

CYTOLOGY; ENZYMES; MUSCLE; PALMITIC ACID; SPHINGOSINES;

NUTRITION;

FATTY ACID; INTERLEUKIN 6; MESSENGER RNA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; SPHINGOSINE KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; LIPID METABOLISM; MALE; MOUSE; MULTICENTER STUDY; NONHUMAN; OBESITY; PARACRINE SIGNALING; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; SKELETAL MUSCLE; TRANSCRIPTION REGULATION;

IL-6; LIPOTOXICITY; OBESITY; PPARΑ; SKELETAL MUSCLE; SPHINGOLIPID; SPHINGOSINE KINASE 1; SPHINGOSINE-1-PHOSPHATE;

ANIMALS; BASE SEQUENCE; CELL LINE; DIET; DNA PRIMERS; FATTY ACIDS, NONESTERIFIED; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; OBESITY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PPAR GAMMA; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION;

EID: 84881224197     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.477786     Document Type: Article

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