-
1
-
-
44849116310
-
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
-
de Ferranti S., and Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin. Chem. 54 (2008) 945-955
-
(2008)
Clin. Chem.
, vol.54
, pp. 945-955
-
-
de Ferranti, S.1
Mozaffarian, D.2
-
2
-
-
33750590489
-
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk
-
Samad F., et al. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55 (2006) 2579-2587
-
(2006)
Diabetes
, vol.55
, pp. 2579-2587
-
-
Samad, F.1
-
3
-
-
0142164965
-
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
-
Chavez J.A., and Summers S.A. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419 (2003) 101-109
-
(2003)
Arch. Biochem. Biophys.
, vol.419
, pp. 101-109
-
-
Chavez, J.A.1
Summers, S.A.2
-
4
-
-
0032478314
-
Fatty acid-induced β cell apoptosis: a link between obesity and diabetes
-
Shimabukuro M., et al. Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 2498-2502
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
-
5
-
-
33845611051
-
Stress, visceral obesity, and metabolic complications
-
Kyrou I., et al. Stress, visceral obesity, and metabolic complications. Ann. N. Y. Acad. Sci. 1083 (2006) 77-110
-
(2006)
Ann. N. Y. Acad. Sci.
, vol.1083
, pp. 77-110
-
-
Kyrou, I.1
-
6
-
-
33846829811
-
Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk
-
Bergman R.N., et al. Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk. Am. J. Med. 120 (2007) S3-S8
-
(2007)
Am. J. Med.
, vol.120
-
-
Bergman, R.N.1
-
7
-
-
33748169268
-
Why visceral fat is bad: mechanisms of the metabolic syndrome
-
Bergman R.N., et al. Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity (Silver Spring) 14 (2006) 16S-19S
-
(2006)
Obesity (Silver Spring)
, vol.14
-
-
Bergman, R.N.1
-
8
-
-
45149106053
-
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism
-
Holland W.L., and Summers S.A. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr. Rev. 29 (2008) 381-402
-
(2008)
Endocr. Rev.
, vol.29
, pp. 381-402
-
-
Holland, W.L.1
Summers, S.A.2
-
9
-
-
0037203345
-
Lipoapoptosis: its mechanism and its diseases
-
Unger R.H., and Orci L. Lipoapoptosis: its mechanism and its diseases. Biochim. Biophys. Acta 1585 (2002) 202-212
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, pp. 202-212
-
-
Unger, R.H.1
Orci, L.2
-
10
-
-
0035163015
-
Pathogenesis of type 2 diabetes. Insulin resistance
-
Boden G. Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol. Metab. Clin. North Am. 30 (2001) 801-815
-
(2001)
Endocrinol. Metab. Clin. North Am.
, vol.30
, pp. 801-815
-
-
Boden, G.1
-
11
-
-
38549152194
-
Principles of bioactive lipid signalling: lessons from sphingolipids
-
Hannun Y.A., and Obeid L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9 (2008) 139-150
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
12
-
-
33846058198
-
LMSD: LIPID MAPS structure database
-
Sud M., et al. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 35 (2007) D527-D532
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Sud, M.1
-
13
-
-
34548329395
-
The metabolism and function of sphingolipids and glycosphingolipids
-
Lahiri S., and Futerman A.H. The metabolism and function of sphingolipids and glycosphingolipids. Cell. Mol. Life Sci. 64 (2007) 2270-2284
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 2270-2284
-
-
Lahiri, S.1
Futerman, A.H.2
-
14
-
-
33845346791
-
Inhibitors of sphingolipid metabolism enzymes
-
Delgado A., et al. Inhibitors of sphingolipid metabolism enzymes. Biochim. Biophys. Acta 1758 (2006) 1957-1977
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, pp. 1957-1977
-
-
Delgado, A.1
-
15
-
-
0037135626
-
The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind
-
Hannun Y.A., and Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277 (2002) 25847-25850
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25847-25850
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
16
-
-
0032868842
-
Ceramide and sphingomyelinases in the regulation of stress responses
-
Sawai H., and Hannun Y.A. Ceramide and sphingomyelinases in the regulation of stress responses. Chem. Phys. Lipids 102 (1999) 141-147
-
(1999)
Chem. Phys. Lipids
, vol.102
, pp. 141-147
-
-
Sawai, H.1
Hannun, Y.A.2
-
17
-
-
0033974782
-
Ceramide in the eukaryotic stress response
-
Hannun Y.A., and Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10 (2000) 73-80
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 73-80
-
-
Hannun, Y.A.1
Luberto, C.2
-
18
-
-
0034717903
-
Sphingolipid transport in eukaryotic cells
-
van Meer G., and Holthuis J.C. Sphingolipid transport in eukaryotic cells. Biochim. Biophys. Acta 1486 (2000) 145-170
-
(2000)
Biochim. Biophys. Acta
, vol.1486
, pp. 145-170
-
-
van Meer, G.1
Holthuis, J.C.2
-
19
-
-
37549038241
-
The contribution of sphingolipids to the pathogenesis of obesity
-
Samad F. The contribution of sphingolipids to the pathogenesis of obesity. Future Lipidol. 2 (2007) 625-639
-
(2007)
Future Lipidol.
, vol.2
, pp. 625-639
-
-
Samad, F.1
-
20
-
-
0037203317
-
Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses
-
Perry D.K. Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses. Biochim. Biophys. Acta 1585 (2002) 146-152
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, pp. 146-152
-
-
Perry, D.K.1
-
21
-
-
0035212942
-
Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption
-
Linn S.C., et al. Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. Biochem. Soc. Trans. 29 (2001) 831-835
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 831-835
-
-
Linn, S.C.1
-
22
-
-
33748746334
-
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis
-
Pewzner-Jung Y., et al. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis. J. Biol. Chem. 281 (2006) 25001-25005
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25001-25005
-
-
Pewzner-Jung, Y.1
-
23
-
-
0030963660
-
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide
-
Michel C., et al. Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J. Biol. Chem. 272 (1997) 22432-22437
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22432-22437
-
-
Michel, C.1
-
24
-
-
33845291120
-
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
-
Hait N.C., et al. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta 1758 (2006) 2016-2026
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, pp. 2016-2026
-
-
Hait, N.C.1
-
25
-
-
0037189475
-
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization
-
Sugiura M., et al. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J. Biol. Chem. 277 (2002) 23294-23300
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23294-23300
-
-
Sugiura, M.1
-
26
-
-
34848928974
-
The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells
-
Mitsutake S., et al. The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. Biochem. Biophys. Res. Commun. 363 (2007) 519-524
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.363
, pp. 519-524
-
-
Mitsutake, S.1
-
27
-
-
33749576963
-
The multigenic sphingomyelin synthase family
-
Tafesse F.G., et al. The multigenic sphingomyelin synthase family. J. Biol. Chem. 281 (2006) 29421-29425
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29421-29425
-
-
Tafesse, F.G.1
-
28
-
-
0242321186
-
Divergence and complexities in DAG signaling: looking beyond PKC
-
Yang C., and Kazanietz M.G. Divergence and complexities in DAG signaling: looking beyond PKC. Trends Pharmacol. Sci. 24 (2003) 602-608
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 602-608
-
-
Yang, C.1
Kazanietz, M.G.2
-
29
-
-
49649124877
-
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi
-
Villani M., et al. Sphingomyelin synthases regulate production of diacylglycerol at the Golgi. Biochem. J. 414 (2008) 31-41
-
(2008)
Biochem. J.
, vol.414
, pp. 31-41
-
-
Villani, M.1
-
30
-
-
35348871278
-
(Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology
-
Merrill Jr. A.H., et al. (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology. Trends Biochem. Sci. 32 (2007) 457-468
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 457-468
-
-
Merrill Jr., A.H.1
-
31
-
-
13444283465
-
Simulation and evaluation of sphingolipid metabolism in S. cerevisiae
-
Alvarez-Vasquez F., et al. Simulation and evaluation of sphingolipid metabolism in S. cerevisiae. Nature 433 (2005) 425-429
-
(2005)
Nature
, vol.433
, pp. 425-429
-
-
Alvarez-Vasquez, F.1
-
32
-
-
33749009744
-
The extended family of neutral sphingomyelinases
-
Clarke C.J., et al. The extended family of neutral sphingomyelinases. Biochemistry 45 (2006) 11247-11256
-
(2006)
Biochemistry
, vol.45
, pp. 11247-11256
-
-
Clarke, C.J.1
-
33
-
-
42249105215
-
The sphingolipid salvage pathway in ceramide metabolism and signaling
-
Kitatani K., et al. The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell. Signal. 20 (2008) 1010-1018
-
(2008)
Cell. Signal.
, vol.20
, pp. 1010-1018
-
-
Kitatani, K.1
-
34
-
-
33746271951
-
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry
-
Bielawski J., et al. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 39 (2006) 82-91
-
(2006)
Methods
, vol.39
, pp. 82-91
-
-
Bielawski, J.1
-
35
-
-
41449099770
-
Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics
-
Sullards M.C., et al. Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics. Methods Enzymol. 432 (2007) 83-115
-
(2007)
Methods Enzymol.
, vol.432
, pp. 83-115
-
-
Sullards, M.C.1
-
36
-
-
43049156529
-
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation
-
Panjarian S., et al. De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 86 (2008) 41-48
-
(2008)
Prostaglandins Other Lipid Mediat.
, vol.86
, pp. 41-48
-
-
Panjarian, S.1
-
37
-
-
33847376437
-
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas
-
Senkal C.E., et al. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol. Cancer Ther. 6 (2007) 712-722
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 712-722
-
-
Senkal, C.E.1
-
38
-
-
41949140023
-
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
-
Laviad E.L., et al. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. J. Biol. Chem. 283 (2008) 5677-5684
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 5677-5684
-
-
Laviad, E.L.1
-
39
-
-
0023836942
-
Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway
-
Merrill Jr. A.H., et al. Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Biochemistry 27 (1988) 340-345
-
(1988)
Biochemistry
, vol.27
, pp. 340-345
-
-
Merrill Jr., A.H.1
-
40
-
-
0021333971
-
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes
-
Williams R.D., et al. Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. Arch. Biochem. Biophys. 228 (1984) 282-291
-
(1984)
Arch. Biochem. Biophys.
, vol.228
, pp. 282-291
-
-
Williams, R.D.1
-
41
-
-
4444309565
-
The complex life of simple sphingolipids
-
Futerman A.H., and Hannun Y.A. The complex life of simple sphingolipids. EMBO Rep. 5 (2004) 777-782
-
(2004)
EMBO Rep.
, vol.5
, pp. 777-782
-
-
Futerman, A.H.1
Hannun, Y.A.2
-
42
-
-
33748047499
-
Bioactive sphingolipids in the modulation of the inflammatory response
-
El Alwani M., et al. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol. Ther. 112 (2006) 171-183
-
(2006)
Pharmacol. Ther.
, vol.112
, pp. 171-183
-
-
El Alwani, M.1
-
43
-
-
2442540272
-
Sphingolipid signalling: molecular basis and role in TNF-α-induced cell death
-
Malagarie-Cazenave S., et al. Sphingolipid signalling: molecular basis and role in TNF-α-induced cell death. Expert Rev. Mol. Med. 4 (2002) 1-15
-
(2002)
Expert Rev. Mol. Med.
, vol.4
, pp. 1-15
-
-
Malagarie-Cazenave, S.1
-
44
-
-
30344435318
-
Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation
-
Lamour N.F., and Chalfant C.E. Ceramide-1-phosphate: the "missing" link in eicosanoid biosynthesis and inflammation. Mol. Interv. 5 (2005) 358-367
-
(2005)
Mol. Interv.
, vol.5
, pp. 358-367
-
-
Lamour, N.F.1
Chalfant, C.E.2
-
45
-
-
0037401894
-
Intracellular signal transduction pathways activated by ceramide and its metabolites
-
Ruvolo P.P. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol. Res. 47 (2003) 383-392
-
(2003)
Pharmacol. Res.
, vol.47
, pp. 383-392
-
-
Ruvolo, P.P.1
-
46
-
-
33748765535
-
Sphingolipid-binding proteins
-
Snook C.F., et al. Sphingolipid-binding proteins. Biochim. Biophys. Acta 1761 (2006) 927-946
-
(2006)
Biochim. Biophys. Acta
, vol.1761
, pp. 927-946
-
-
Snook, C.F.1
-
47
-
-
33645278951
-
Sphingosine kinase: biochemical and cellular regulation and role in disease
-
Taha T.A., et al. Sphingosine kinase: biochemical and cellular regulation and role in disease. J. Biochem. Mol. Biol. 39 (2006) 113-131
-
(2006)
J. Biochem. Mol. Biol.
, vol.39
, pp. 113-131
-
-
Taha, T.A.1
-
48
-
-
0037203342
-
Ceramide in apoptosis: an overview and current perspectives
-
Pettus B.J., et al. Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta 1585 (2002) 114-125
-
(2002)
Biochim. Biophys. Acta
, vol.1585
, pp. 114-125
-
-
Pettus, B.J.1
-
49
-
-
43749120533
-
Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels
-
Siskind L.J., et al. Anti-apoptotic Bcl-2 family proteins disassemble ceramide channels. J. Biol. Chem. 283 (2008) 6622-6630
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 6622-6630
-
-
Siskind, L.J.1
-
50
-
-
18144404605
-
Positively charged ceramide is a potent inducer of mitochondrial permeabilization
-
Novgorodov S.A., et al. Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J. Biol. Chem. 280 (2005) 16096-16105
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16096-16105
-
-
Novgorodov, S.A.1
-
51
-
-
33845294390
-
A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death
-
Taha T.A., et al. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim. Biophys. Acta 1758 (2006) 2027-2036
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, pp. 2027-2036
-
-
Taha, T.A.1
-
52
-
-
34948813594
-
Autocrine and paracrine roles of sphingosine-1-phosphate
-
Alvarez S.E., et al. Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol. Metab. 18 (2007) 300-307
-
(2007)
Trends Endocrinol. Metab.
, vol.18
, pp. 300-307
-
-
Alvarez, S.E.1
-
53
-
-
33846811196
-
Regulation and functional roles of sphingosine kinases
-
Alemany R., et al. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch. Pharmacol. 374 (2007) 413-428
-
(2007)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.374
, pp. 413-428
-
-
Alemany, R.1
-
54
-
-
33846078397
-
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate
-
Maceyka M., et al. Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. Circ. Res. 100 (2007) 7-9
-
(2007)
Circ. Res.
, vol.100
, pp. 7-9
-
-
Maceyka, M.1
-
55
-
-
0037162037
-
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors
-
Kluk M.J., and Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 1582 (2002) 72-80
-
(2002)
Biochim. Biophys. Acta
, vol.1582
, pp. 72-80
-
-
Kluk, M.J.1
Hla, T.2
-
56
-
-
17344394207
-
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival
-
Van Brocklyn J.R., et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142 (1998) 229-240
-
(1998)
J. Cell Biol.
, vol.142
, pp. 229-240
-
-
Van Brocklyn, J.R.1
-
57
-
-
37249011266
-
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms
-
Subramanian P., et al. Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms. J. Lipid Res. 48 (2007) 2701-2708
-
(2007)
J. Lipid Res.
, vol.48
, pp. 2701-2708
-
-
Subramanian, P.1
-
58
-
-
12144287654
-
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
-
Pettus B.J., et al. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J. Biol. Chem. 279 (2004) 11320-11326
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11320-11326
-
-
Pettus, B.J.1
-
59
-
-
33744929865
-
Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes
-
Zhi L., et al. Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFα in primary human monocytes. J. Cell. Physiol. 208 (2006) 109-115
-
(2006)
J. Cell. Physiol.
, vol.208
, pp. 109-115
-
-
Zhi, L.1
-
60
-
-
22144486976
-
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators
-
Billich A., et al. Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators. Cell. Signal. 17 (2005) 1203-1217
-
(2005)
Cell. Signal.
, vol.17
, pp. 1203-1217
-
-
Billich, A.1
-
61
-
-
8644228563
-
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-κB-dependent mechanism
-
Lee H., et al. Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-κB-dependent mechanism. Am. J. Physiol. Cell Physiol. 287 (2004) C1657-C1666
-
(2004)
Am. J. Physiol. Cell Physiol.
, vol.287
-
-
Lee, H.1
-
62
-
-
4744347186
-
Sphingosine kinase-1 mediates TNF-α-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow
-
Chen X.L., et al. Sphingosine kinase-1 mediates TNF-α-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H1452-H1458
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.287
-
-
Chen, X.L.1
-
63
-
-
33846192839
-
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
-
Lavieu G., et al. Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?. Autophagy 3 (2007) 45-47
-
(2007)
Autophagy
, vol.3
, pp. 45-47
-
-
Lavieu, G.1
-
64
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
Lavieu G., et al. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J. Biol. Chem. 281 (2006) 8518-8527
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8518-8527
-
-
Lavieu, G.1
-
65
-
-
2442485884
-
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
-
Scarlatti F., et al. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 279 (2004) 18384-18391
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 18384-18391
-
-
Scarlatti, F.1
-
66
-
-
38349059779
-
Ageing-induced alterations in lipid/phospholipid profiles of rat brain and liver mitochondria: implications for mitochondrial energy-linked functions
-
Modi H.R., et al. Ageing-induced alterations in lipid/phospholipid profiles of rat brain and liver mitochondria: implications for mitochondrial energy-linked functions. J. Membr. Biol. 221 (2008) 51-60
-
(2008)
J. Membr. Biol.
, vol.221
, pp. 51-60
-
-
Modi, H.R.1
-
67
-
-
0034612304
-
Ceramide interaction with the respiratory chain of heart mitochondria
-
Di Paola M., et al. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry 39 (2000) 6660-6668
-
(2000)
Biochemistry
, vol.39
, pp. 6660-6668
-
-
Di Paola, M.1
-
68
-
-
33846267745
-
Life and death decisions of the pancreatic β-cell: the role of fatty acids
-
Newsholme P., et al. Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clin. Sci. (Lond.) 112 (2007) 27-42
-
(2007)
Clin. Sci. (Lond.)
, vol.112
, pp. 27-42
-
-
Newsholme, P.1
-
69
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
Kelpe C.L., et al. Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J. Biol. Chem. 278 (2003) 30015-30021
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30015-30021
-
-
Kelpe, C.L.1
-
70
-
-
0036326795
-
2+-dependent exocytosis in rat pancreatic β-cells
-
2+-dependent exocytosis in rat pancreatic β-cells. Diabetes 51 (2002) 2514-2521
-
(2002)
Diabetes
, vol.51
, pp. 2514-2521
-
-
Buschard, K.1
-
71
-
-
33748754785
-
Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet β-cells
-
Laychock S.G., et al. Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet β-cells. Endocrinology 147 (2006) 4705-4712
-
(2006)
Endocrinology
, vol.147
, pp. 4705-4712
-
-
Laychock, S.G.1
-
72
-
-
0038532298
-
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
-
Chavez J.A., et al. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J. Biol. Chem. 278 (2003) 10297-10303
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
-
73
-
-
4344614649
-
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford S., et al. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279 (2004) 36608-36615
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
-
74
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland W.L., et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5 (2007) 167-179
-
(2007)
Cell Metab.
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
-
75
-
-
34250303939
-
Key role for ceramides in mediating insulin resistance in human muscle cells
-
Pickersgill L., et al. Key role for ceramides in mediating insulin resistance in human muscle cells. J. Biol. Chem. 282 (2007) 12583-12589
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12583-12589
-
-
Pickersgill, L.1
-
76
-
-
33645842245
-
Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
-
Watt M.J., et al. Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues. Endocrinology 147 (2006) 2077-2085
-
(2006)
Endocrinology
, vol.147
, pp. 2077-2085
-
-
Watt, M.J.1
-
77
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α
-
Itani S.I., et al. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51 (2002) 2005-2011
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
-
78
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277 (2002) 50230-50236
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
-
79
-
-
2342621476
-
Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle
-
Straczkowski M., et al. Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes 53 (2004) 1215-1221
-
(2004)
Diabetes
, vol.53
, pp. 1215-1221
-
-
Straczkowski, M.1
-
80
-
-
0346729968
-
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
-
Adams II J.M., et al. Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53 (2004) 25-31
-
(2004)
Diabetes
, vol.53
, pp. 25-31
-
-
Adams II, J.M.1
-
81
-
-
0036479215
-
Ganglioside GM3 participates in the pathological conditions of insulin resistance
-
Tagami S., et al. Ganglioside GM3 participates in the pathological conditions of insulin resistance. J. Biol. Chem. 277 (2002) 3085-3092
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3085-3092
-
-
Tagami, S.1
-
82
-
-
13444251524
-
TNFα-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3
-
Kabayama K., et al. TNFα-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. Glycobiology 15 (2005) 21-29
-
(2005)
Glycobiology
, vol.15
, pp. 21-29
-
-
Kabayama, K.1
-
83
-
-
46649108016
-
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
-
Shah C., et al. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J. Biol. Chem. 283 (2008) 13538-13548
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13538-13548
-
-
Shah, C.1
-
84
-
-
47149096915
-
Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
-
Heilbronn L.K., and Campbell L.V. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr. Pharm. Des. 14 (2008) 1225-1230
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 1225-1230
-
-
Heilbronn, L.K.1
Campbell, L.V.2
-
85
-
-
41249098290
-
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
-
Wu D., et al. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J. Immunol. 179 (2007) 4829-4839
-
(2007)
J. Immunol.
, vol.179
, pp. 4829-4839
-
-
Wu, D.1
-
86
-
-
36048972285
-
Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug
-
Stover T.C., et al. Thermoresponsive and biodegradable linear-dendritic nanoparticles for targeted and sustained release of a pro-apoptotic drug. Biomaterials 29 (2008) 359-369
-
(2008)
Biomaterials
, vol.29
, pp. 359-369
-
-
Stover, T.C.1
-
87
-
-
42349096321
-
Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease
-
Chen Y., et al. Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal. Chem. 80 (2008) 2780-2788
-
(2008)
Anal. Chem.
, vol.80
, pp. 2780-2788
-
-
Chen, Y.1
-
88
-
-
0035487315
-
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Cζ, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
-
Cazzolli R., et al. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Cζ, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 50 (2001) 2210-2218
-
(2001)
Diabetes
, vol.50
, pp. 2210-2218
-
-
Cazzolli, R.1
-
89
-
-
44749085396
-
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
-
Skovbro M., et al. Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 51 (2008) 1253-1260
-
(2008)
Diabetologia
, vol.51
, pp. 1253-1260
-
-
Skovbro, M.1
|