-
1
-
-
1542619848
-
Cancer as a robust system: implications for anticancer therapy
-
Kitano H. Cancer as a robust system: implications for anticancer therapy. Nature Reviews Cancer 2004, 4:227-235.
-
(2004)
Nature Reviews Cancer
, vol.4
, pp. 227-235
-
-
Kitano, H.1
-
2
-
-
7644238181
-
Biological robustness
-
Kitano H. Biological robustness. Nature Reviews Genetics 2004, 5:826-837.
-
(2004)
Nature Reviews Genetics
, vol.5
, pp. 826-837
-
-
Kitano, H.1
-
3
-
-
70349330663
-
Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective
-
Huang S., Ernberg I., Kauffman S. Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective. Seminars in Cell & Developmental Biology 2009, 20:869-876.
-
(2009)
Seminars in Cell & Developmental Biology
, vol.20
, pp. 869-876
-
-
Huang, S.1
Ernberg, I.2
Kauffman, S.3
-
4
-
-
84858414016
-
Regulated noise in the epigenetic landscape of development and disease
-
Pujadas E., Feinberg A.P. Regulated noise in the epigenetic landscape of development and disease. Cell 2012, 148:1123-1131.
-
(2012)
Cell
, vol.148
, pp. 1123-1131
-
-
Pujadas, E.1
Feinberg, A.P.2
-
5
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves M., Maley C.C. Clonal evolution in cancer. Nature 2012, 481:306-313.
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
6
-
-
84860214990
-
Intra-tumour heterogeneity: a looking glass for cancer?
-
Marusyk A., Almendro V., Polyak K. Intra-tumour heterogeneity: a looking glass for cancer?. Nature Reviews Cancer 2012, 12:323-334.
-
(2012)
Nature Reviews Cancer
, vol.12
, pp. 323-334
-
-
Marusyk, A.1
Almendro, V.2
Polyak, K.3
-
7
-
-
77955062175
-
Increased entropy of signal transduction in the cancer metastasis phenotype
-
Teschendorff A.E., Severini S. Increased entropy of signal transduction in the cancer metastasis phenotype. BMC Systems Biology 2010, 4:104-116.
-
(2010)
BMC Systems Biology
, vol.4
, pp. 104-116
-
-
Teschendorff, A.E.1
Severini, S.2
-
8
-
-
84869186030
-
Differential network entropy reveals cancer system hallmarks
-
West J., Bianconi G., Severini S., Teschendorff A.E. Differential network entropy reveals cancer system hallmarks. Scientific Reports 2012, 2:802-809.
-
(2012)
Scientific Reports
, vol.2
, pp. 802-809
-
-
West, J.1
Bianconi, G.2
Severini, S.3
Teschendorff, A.E.4
-
9
-
-
84861863981
-
Molecular signaling network complexity is correlated with cancer patient survivability
-
Breitkreutz D., Hlatky L., Rietman E., Tuszynski J.A. Molecular signaling network complexity is correlated with cancer patient survivability. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:9209-9212.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 9209-9212
-
-
Breitkreutz, D.1
Hlatky, L.2
Rietman, E.3
Tuszynski, J.A.4
-
11
-
-
79958849271
-
Heterogeneity maintenance in glioblastoma: a social network
-
Bonavia R., Inda M.M., Cavenee W.K., Furnari F.B. Heterogeneity maintenance in glioblastoma: a social network. Cancer Research 2011, 71:4055-4060.
-
(2011)
Cancer Research
, vol.71
, pp. 4055-4060
-
-
Bonavia, R.1
Inda, M.M.2
Cavenee, W.K.3
Furnari, F.B.4
-
12
-
-
84866122803
-
Navigating cancer network attractors for tumor-specific therapy
-
Creixell P., Schoof E.M., Erler J.T., Linding R. Navigating cancer network attractors for tumor-specific therapy. Nature Biotechnology 2012, 30:842-848.
-
(2012)
Nature Biotechnology
, vol.30
, pp. 842-848
-
-
Creixell, P.1
Schoof, E.M.2
Erler, J.T.3
Linding, R.4
-
13
-
-
84870004129
-
Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment
-
Wu Y., Garmire L.X., Fan R. Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment. Integrative Biology 2012, 4:1478-1486.
-
(2012)
Integrative Biology
, vol.4
, pp. 1478-1486
-
-
Wu, Y.1
Garmire, L.X.2
Fan, R.3
-
14
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nature Reviews Cancer 2002, 2:442-454.
-
(2002)
Nature Reviews Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
16
-
-
84857789336
-
Understanding cancer stem cell heterogeneity and plasticity
-
Tang D.G. Understanding cancer stem cell heterogeneity and plasticity. Cell Research 2012, 22:457-472.
-
(2012)
Cell Research
, vol.22
, pp. 457-472
-
-
Tang, D.G.1
-
18
-
-
17844385816
-
Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence
-
Guck J., Schinkinger S., Lincoln B., Wottawah F., Ebert S., Romeyke M., et al. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophysical Journal 2005, 88:3689-3698.
-
(2005)
Biophysical Journal
, vol.88
, pp. 3689-3698
-
-
Guck, J.1
Schinkinger, S.2
Lincoln, B.3
Wottawah, F.4
Ebert, S.5
Romeyke, M.6
-
19
-
-
84869237943
-
Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells
-
Zhang W., Kai K., Choi D.S., Iwamoto T., Nguyen Y.H., Wong H., et al. Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:18707-18712.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 18707-18712
-
-
Zhang, W.1
Kai, K.2
Choi, D.S.3
Iwamoto, T.4
Nguyen, Y.H.5
Wong, H.6
-
20
-
-
0015074045
-
Differentiation of malignant to benign cells
-
Kauffman S. Differentiation of malignant to benign cells. Journal of Theoretical Biology 1971, 31:429-451.
-
(1971)
Journal of Theoretical Biology
, vol.31
, pp. 429-451
-
-
Kauffman, S.1
-
21
-
-
66149136501
-
The emergence of lineage-specific chromosomal topologies from coordinate gene regulation
-
Rajapakse I., Perlman M.D., Scalzo D., Kooperberg C., Groudine M., Kosak S.T. The emergence of lineage-specific chromosomal topologies from coordinate gene regulation. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:6679-6684.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 6679-6684
-
-
Rajapakse, I.1
Perlman, M.D.2
Scalzo, D.3
Kooperberg, C.4
Groudine, M.5
Kosak, S.T.6
-
22
-
-
84866369892
-
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
-
Buganim Y., Faddah D.A., Cheng A.W., Itskovich E., Markoulaki S., Ganz K., et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012, 150:1209-1222.
-
(2012)
Cell
, vol.150
, pp. 1209-1222
-
-
Buganim, Y.1
Faddah, D.A.2
Cheng, A.W.3
Itskovich, E.4
Markoulaki, S.5
Ganz, K.6
-
23
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
Lovén J., Hoke H.A., Lin C.Y., Lau A., Orlando D.A., Vakoc C.R., et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 2013, 153:320-334.
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Lovén, J.1
Hoke, H.A.2
Lin, C.Y.3
Lau, A.4
Orlando, D.A.5
Vakoc, C.R.6
-
24
-
-
84876216563
-
Master transcription factors and mediator establish super-enhancers at key cell identity genes
-
Whyte W.A., Orlando D.A., Hnisz D., Abraham B.J., Lin C.Y., Kagey M.H., et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 2013, 153:307-319.
-
(2013)
Cell
, vol.153
, pp. 307-319
-
-
Whyte, W.A.1
Orlando, D.A.2
Hnisz, D.3
Abraham, B.J.4
Lin, C.Y.5
Kagey, M.H.6
-
26
-
-
84877580262
-
Structure and dynamics of molecular networks: a novel paradigm of drug discovery. A comprehensive review
-
Csermely P., Korcsmaros T., Kiss H.J.M., London G., Nussinov R. Structure and dynamics of molecular networks: a novel paradigm of drug discovery. A comprehensive review. Pharmacology & Therapeutics 2013, 138:333-408.
-
(2013)
Pharmacology & Therapeutics
, vol.138
, pp. 333-408
-
-
Csermely, P.1
Korcsmaros, T.2
Kiss, H.J.M.3
London, G.4
Nussinov, R.5
-
28
-
-
32044451325
-
Cancer: a systems biology disease
-
Hornberg J.J., Bruggeman F.J., Westerhoff H.V., Lankelma J. Cancer: a systems biology disease. BioSystems 2006, 83:81-90.
-
(2006)
BioSystems
, vol.83
, pp. 81-90
-
-
Hornberg, J.J.1
Bruggeman, F.J.2
Westerhoff, H.V.3
Lankelma, J.4
-
32
-
-
54349091030
-
Protein co-evolution, co-adaptation and interactions
-
Pazos F., Valencia A. Protein co-evolution, co-adaptation and interactions. EMBO Journal 2008, 27:2648-2655.
-
(2008)
EMBO Journal
, vol.27
, pp. 2648-2655
-
-
Pazos, F.1
Valencia, A.2
-
33
-
-
84861112348
-
Rapid perturbation of free-energy landscapes: from in vitro to in vivo
-
Gelman H., Platkov M., Gruebele M. Rapid perturbation of free-energy landscapes: from in vitro to in vivo. Chemistry 2012, 18:6420-6427.
-
(2012)
Chemistry
, vol.18
, pp. 6420-6427
-
-
Gelman, H.1
Platkov, M.2
Gruebele, M.3
-
34
-
-
0034238006
-
Analysis of a "phase transition" from tumor growth to latency
-
Delsanto P.P., Romano A., Scalerandi M., Pescarmona G.P. Analysis of a "phase transition" from tumor growth to latency. Physical Review E 2000, 62:2547-2554.
-
(2000)
Physical Review E
, vol.62
, pp. 2547-2554
-
-
Delsanto, P.P.1
Romano, A.2
Scalerandi, M.3
Pescarmona, G.P.4
-
35
-
-
0038483826
-
Emergence of scaling in random networks
-
Barabasi A.L., Albert R. Emergence of scaling in random networks. Science 1999, 286:509-512.
-
(1999)
Science
, vol.286
, pp. 509-512
-
-
Barabasi, A.L.1
Albert, R.2
-
37
-
-
84873055344
-
MDM2, MDMX and p53 in oncogenesis and cancer therapy
-
Wade M., Li Y.C., Wahl G.M. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nature Reviews Cancer 2012, 13:83-96.
-
(2012)
Nature Reviews Cancer
, vol.13
, pp. 83-96
-
-
Wade, M.1
Li, Y.C.2
Wahl, G.M.3
-
38
-
-
84881233648
-
Dynamics of DNA damage induced by pathways of cancer
-
in press
-
Schwartz J.M., Tian K., Rajendran R., Doddananjaiah M., Krstic-Demonacos M. Dynamics of DNA damage induced by pathways of cancer. PLoS ONE 2013, 8. in press.
-
(2013)
PLoS ONE
, vol.8
-
-
Schwartz, J.M.1
Tian, K.2
Rajendran, R.3
Doddananjaiah, M.4
Krstic-Demonacos, M.5
-
39
-
-
16844363315
-
Modularity and evolutionary constraint on proteins
-
Fraser H.B. Modularity and evolutionary constraint on proteins. Nature Genetics 2005, 37:351-352.
-
(2005)
Nature Genetics
, vol.37
, pp. 351-352
-
-
Fraser, H.B.1
-
40
-
-
0037174670
-
Network motifs: simple building blocks of complex networks
-
Milo R., Shen-Orr S., Itzkovitz S., Kashtan N., Chklovskii D., Alon U. Network motifs: simple building blocks of complex networks. Science 2002, 298:824-827.
-
(2002)
Science
, vol.298
, pp. 824-827
-
-
Milo, R.1
Shen-Orr, S.2
Itzkovitz, S.3
Kashtan, N.4
Chklovskii, D.5
Alon, U.6
-
41
-
-
68749118345
-
Defining network topologies that can achieve biochemical adaptation
-
Ma W., Trusina A., El-Samad H., Lim W., Tang C. Defining network topologies that can achieve biochemical adaptation. Cell 2009, 138:760-773.
-
(2009)
Cell
, vol.138
, pp. 760-773
-
-
Ma, W.1
Trusina, A.2
El-Samad, H.3
Lim, W.4
Tang, C.5
-
43
-
-
59849125136
-
Dynamic modularity in protein interaction networks predicts breast cancer outcome
-
Taylor I.W., Linding R., Warde-Farley D., Liu Y., Pesquita C., Faria D., et al. Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nature Biotechnology 2009, 27:199-204.
-
(2009)
Nature Biotechnology
, vol.27
, pp. 199-204
-
-
Taylor, I.W.1
Linding, R.2
Warde-Farley, D.3
Liu, Y.4
Pesquita, C.5
Faria, D.6
-
44
-
-
33751208636
-
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
-
Horvath S., Zhang B., Carlson M., Lu K.V., Zhu S., Felciano R.M., et al. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:17402-17407.
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, pp. 17402-17407
-
-
Horvath, S.1
Zhang, B.2
Carlson, M.3
Lu, K.V.4
Zhu, S.5
Felciano, R.M.6
-
45
-
-
84875275699
-
Human diseases through the lens of network biology
-
Furlong L.I. Human diseases through the lens of network biology. Trends in Genetics 2012, 29:150-159.
-
(2012)
Trends in Genetics
, vol.29
, pp. 150-159
-
-
Furlong, L.I.1
-
46
-
-
80055081144
-
Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation
-
Mihalik á., Csermely P. Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. PLoS Computational Biology 2011, 7:e1002187.
-
(2011)
PLoS Computational Biology
, vol.7
-
-
Mihalik, á.1
Csermely, P.2
-
47
-
-
84878565203
-
System level mechanisms of adaptation, learning, memory formation and evolvability: the role of chaperone and other networks
-
in press
-
Gyurkó M.D., Soti C., Stetak A., Csermely P. System level mechanisms of adaptation, learning, memory formation and evolvability: the role of chaperone and other networks. Current Protein & Peptide Science 2013, 14. in press.
-
(2013)
Current Protein & Peptide Science
, vol.14
-
-
Gyurkó, M.D.1
Soti, C.2
Stetak, A.3
Csermely, P.4
-
48
-
-
33748706765
-
Global topological features of cancer proteins in the human interactome
-
Jonsson P.F., Bates P.A. Global topological features of cancer proteins in the human interactome. Bioinformatics 2006, 22:2291-2297.
-
(2006)
Bioinformatics
, vol.22
, pp. 2291-2297
-
-
Jonsson, P.F.1
Bates, P.A.2
-
49
-
-
34247622363
-
The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics
-
Yu H., Kim P.M., Sprecher E., Trifonov V., Gerstein M. The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics. PLoS Computational Biology 2007, 3:e59.
-
(2007)
PLoS Computational Biology
, vol.3
-
-
Yu, H.1
Kim, P.M.2
Sprecher, E.3
Trifonov, V.4
Gerstein, M.5
-
50
-
-
56449125182
-
Creative elements: network-based predictions of active centres in proteins and cellular and social networks
-
Csermely P. Creative elements: network-based predictions of active centres in proteins and cellular and social networks. Trends in Biochemical Sciences 2008, 33:569-576.
-
(2008)
Trends in Biochemical Sciences
, vol.33
, pp. 569-576
-
-
Csermely, P.1
-
51
-
-
0036408751
-
Intrinsic disorder in cell-signaling and cancer-associated proteins
-
Iakoucheva L.M., Brown C.J., Lawson J.D., Obradović Z., Dunker A.K. Intrinsic disorder in cell-signaling and cancer-associated proteins. Journal of Molecular Biology 2002, 323:573-584.
-
(2002)
Journal of Molecular Biology
, vol.323
, pp. 573-584
-
-
Iakoucheva, L.M.1
Brown, C.J.2
Lawson, J.D.3
Obradović, Z.4
Dunker, A.K.5
-
52
-
-
67650369989
-
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases
-
Uversky V.N., Oldfield C.J., Midic U., Xie H., Xue B., Vucetic S., et al. Unfoldomics of human diseases: linking protein intrinsic disorder with diseases. BMC Genomics 2009, 10:S7.
-
(2009)
BMC Genomics
, vol.10
-
-
Uversky, V.N.1
Oldfield, C.J.2
Midic, U.3
Xie, H.4
Xue, B.5
Vucetic, S.6
-
53
-
-
84872354783
-
Intrinsically disordered proteins and conformational noise: implications in cancer
-
Mahmoudabadi G., Rajagopalan K., Getzenberg R.H., Hannenhalli S., Rangarajan G., Kulkarni P. Intrinsically disordered proteins and conformational noise: implications in cancer. Cell Cycle 2013, 12:26-31.
-
(2013)
Cell Cycle
, vol.12
, pp. 26-31
-
-
Mahmoudabadi, G.1
Rajagopalan, K.2
Getzenberg, R.H.3
Hannenhalli, S.4
Rangarajan, G.5
Kulkarni, P.6
-
54
-
-
74549134502
-
Human cancer protein-protein interaction network: a structural perspective
-
Kar G., Gursoy A., Keskin O. Human cancer protein-protein interaction network: a structural perspective. PLoS Computational Biology 2009, 5:e1000601.
-
(2009)
PLoS Computational Biology
, vol.5
-
-
Kar, G.1
Gursoy, A.2
Keskin, O.3
-
55
-
-
79951534511
-
Mapping the disease protein interactome: toward a molecular medicine GPS to accelerate drug and biomarker discovery
-
Coulombe B. Mapping the disease protein interactome: toward a molecular medicine GPS to accelerate drug and biomarker discovery. Journal of Proteome Research 2011, 10:120-125.
-
(2011)
Journal of Proteome Research
, vol.10
, pp. 120-125
-
-
Coulombe, B.1
-
56
-
-
79959896639
-
Building protein-protein interaction networks with proteomics and informatics tools
-
Sardiu M.E., Washburn M.P. Building protein-protein interaction networks with proteomics and informatics tools. Journal of Biological Chemistry 2011, 286:23645-23651.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 23645-23651
-
-
Sardiu, M.E.1
Washburn, M.P.2
-
57
-
-
28444448000
-
Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues
-
Wachi S., Yoneda K., Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics 2005, 21:4205-4208.
-
(2005)
Bioinformatics
, vol.21
, pp. 4205-4208
-
-
Wachi, S.1
Yoneda, K.2
Wu, R.3
-
58
-
-
73549090972
-
Structure of protein interaction networks and their implications on drug design
-
Hase T., Tanaka H., Suzuki Y., Nakagawa S., Kitano H. Structure of protein interaction networks and their implications on drug design. PLoS Computational Biology 2009, 5:e1000550.
-
(2009)
PLoS Computational Biology
, vol.5
-
-
Hase, T.1
Tanaka, H.2
Suzuki, Y.3
Nakagawa, S.4
Kitano, H.5
-
59
-
-
79959744025
-
Do cancer proteins really interact strongly in the human proteinprotein interaction network?
-
Xia J., Sun J., Jia P., Zhao Z. Do cancer proteins really interact strongly in the human proteinprotein interaction network?. Computational Biology and Chemistry 2011, 35:121-125.
-
(2011)
Computational Biology and Chemistry
, vol.35
, pp. 121-125
-
-
Xia, J.1
Sun, J.2
Jia, P.3
Zhao, Z.4
-
60
-
-
84862817695
-
Crosstalk between transcription factors and microRNAs in human protein interaction network
-
Lin C.-C., Chen Y.-J., Chen C.-Y., Oyang Y.-J., Juan H.-F., Huang H.-C. Crosstalk between transcription factors and microRNAs in human protein interaction network. BMC Systems Biology 2012, 6:18-30.
-
(2012)
BMC Systems Biology
, vol.6
, pp. 18-30
-
-
Lin, C.-C.1
Chen, Y.-J.2
Chen, C.-Y.3
Oyang, Y.-J.4
Juan, H.-F.5
Huang, H.-C.6
-
61
-
-
77950223515
-
Signal transduction networks in cancer: quantitative parameters influence network topology
-
Klinke D.J. Signal transduction networks in cancer: quantitative parameters influence network topology. Cancer Research 2010, 70:1773-1782.
-
(2010)
Cancer Research
, vol.70
, pp. 1773-1782
-
-
Klinke, D.J.1
-
62
-
-
77955444349
-
Uniformly curated signaling pathways reveal tissue-specific cross-talks, novel pathway components, and drug target candidates
-
Korcsmáros T., Farkas I.J., Szalay M.S., Rovó P., Fazekas D., Spiró Z., et al. Uniformly curated signaling pathways reveal tissue-specific cross-talks, novel pathway components, and drug target candidates. Bioinformatics 2010, 26:2042-2050.
-
(2010)
Bioinformatics
, vol.26
, pp. 2042-2050
-
-
Korcsmáros, T.1
Farkas, I.J.2
Szalay, M.S.3
Rovó, P.4
Fazekas, D.5
Spiró, Z.6
-
63
-
-
79958026380
-
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
-
Mendoza M.C., Er E.E., Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends in Biochemical Sciences 2011, 36:320-328.
-
(2011)
Trends in Biochemical Sciences
, vol.36
, pp. 320-328
-
-
Mendoza, M.C.1
Er, E.E.2
Blenis, J.3
-
64
-
-
84864616734
-
Beyond "furballs" and "dumpling soups" - towards a molecular architecture of signaling complexes and networks
-
Lewitzky M., Simister P.C., Feller S.M. Beyond "furballs" and "dumpling soups" - towards a molecular architecture of signaling complexes and networks. FEBS Letters 2012, 586:2740-2750.
-
(2012)
FEBS Letters
, vol.586
, pp. 2740-2750
-
-
Lewitzky, M.1
Simister, P.C.2
Feller, S.M.3
-
65
-
-
84876296757
-
A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery
-
Nussinov R., Ma B., Tsai C.-J. A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery. Biochimica et Biophysica Acta 2013, 1834:820-829.
-
(2013)
Biochimica et Biophysica Acta
, vol.1834
, pp. 820-829
-
-
Nussinov, R.1
Ma, B.2
Tsai, C.-J.3
-
66
-
-
81155154333
-
The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein
-
Muscolini M., Montagni E., Palermo V., Di Agostino S., Gu W., Abdelmoula-Souissi S., et al. The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein. Journal of Biological Chemistry 2011, 286:39693-39702.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 39693-39702
-
-
Muscolini, M.1
Montagni, E.2
Palermo, V.3
Di Agostino, S.4
Gu, W.5
Abdelmoula-Souissi, S.6
-
67
-
-
84865599600
-
Endosomal crosstalk: meeting points for signaling pathways
-
Pálfy M., Reményi A., Korcsmáros T. Endosomal crosstalk: meeting points for signaling pathways. Trends in Cell Biology 2012, 22:447-456.
-
(2012)
Trends in Cell Biology
, vol.22
, pp. 447-456
-
-
Pálfy, M.1
Reményi, A.2
Korcsmáros, T.3
-
68
-
-
83255165727
-
High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
-
Fudenberg G., Getz G., Meyerson M., Mirny L.A. High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nature Biotechnology 2011, 29:1109-1113.
-
(2011)
Nature Biotechnology
, vol.29
, pp. 1109-1113
-
-
Fudenberg, G.1
Getz, G.2
Meyerson, M.3
Mirny, L.A.4
-
69
-
-
84861860413
-
Oncogene-mediated alterations in chromatin conformation
-
Rickman D.S., Soong T.D., Moss B., Mosquera J.M., Dlabal J., Terry S., et al. Oncogene-mediated alterations in chromatin conformation. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:9083-9088.
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. 9083-9088
-
-
Rickman, D.S.1
Soong, T.D.2
Moss, B.3
Mosquera, J.M.4
Dlabal, J.5
Terry, S.6
-
70
-
-
84870404918
-
Large-scale functional organization of long-range chromatin interaction networks
-
Sandhu K.S., Li G., Poh H.M., Quek Y.L., Sia Y.Y., Peh S.Q., et al. Large-scale functional organization of long-range chromatin interaction networks. Cell Reports 2012, 2:1207-1219.
-
(2012)
Cell Reports
, vol.2
, pp. 1207-1219
-
-
Sandhu, K.S.1
Li, G.2
Poh, H.M.3
Quek, Y.L.4
Sia, Y.Y.5
Peh, S.Q.6
-
71
-
-
33750370444
-
MicroRNA signatures in human cancers
-
Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nature Reviews Cancer 2006, 6:857-866.
-
(2006)
Nature Reviews Cancer
, vol.6
, pp. 857-866
-
-
Calin, G.A.1
Croce, C.M.2
-
72
-
-
36849078711
-
Let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F., Yao H., Zhu P., Zhang X., Pan Q., Gong C., et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
Zhang, X.4
Pan, Q.5
Gong, C.6
-
73
-
-
84864803503
-
The oncogenic role of miR-155 in breast cancer
-
Mattiske S., Suetani R.J., Neilsen P.M., Callen D.F. The oncogenic role of miR-155 in breast cancer. Cancer Epidemiology, Biomarkers & Prevention 2012, 21:1236-1243.
-
(2012)
Cancer Epidemiology, Biomarkers & Prevention
, vol.21
, pp. 1236-1243
-
-
Mattiske, S.1
Suetani, R.J.2
Neilsen, P.M.3
Callen, D.F.4
-
74
-
-
77951841445
-
Reprogramming of miRNA networks in cancer and leukemia
-
Volinia S., Galasso M., Costinean S., Tagliavini L., Gamberoni G., Drusco A., et al. Reprogramming of miRNA networks in cancer and leukemia. Genome Research 2010, 20:589-599.
-
(2010)
Genome Research
, vol.20
, pp. 589-599
-
-
Volinia, S.1
Galasso, M.2
Costinean, S.3
Tagliavini, L.4
Gamberoni, G.5
Drusco, A.6
-
75
-
-
43049156566
-
Human metabolic network reconstruction and its impact on drug discovery and development
-
Ma H., Goryanin I. Human metabolic network reconstruction and its impact on drug discovery and development. Drug Discovery Today 2008, 13:402-408.
-
(2008)
Drug Discovery Today
, vol.13
, pp. 402-408
-
-
Ma, H.1
Goryanin, I.2
-
76
-
-
79953661070
-
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect
-
Shlomi T., Benyamini T., Gottlieb E., Sharan R., Ruppin E. Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. PLoS Computational Biology 2011, 7:e1002018.
-
(2011)
PLoS Computational Biology
, vol.7
-
-
Shlomi, T.1
Benyamini, T.2
Gottlieb, E.3
Sharan, R.4
Ruppin, E.5
-
77
-
-
84870598190
-
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
-
Yang W., Zheng Y., Xia Y., Ji H., Chen X., Guo F., et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology 2012, 14:1295-1304.
-
(2012)
Nature Cell Biology
, vol.14
, pp. 1295-1304
-
-
Yang, W.1
Zheng, Y.2
Xia, Y.3
Ji, H.4
Chen, X.5
Guo, F.6
-
80
-
-
15044349115
-
The efficiency of multi-target drugs: the network approach might help drug design
-
Csermely P., Agoston V., Pongor S. The efficiency of multi-target drugs: the network approach might help drug design. Trends in Pharmacological Sciences 2005, 26:178-182.
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, pp. 178-182
-
-
Csermely, P.1
Agoston, V.2
Pongor, S.3
-
81
-
-
34548408283
-
Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signalling network
-
Awan A., Bari H., Yan F., Moksong S., Yang S., Chowdhury S., et al. Regulatory network motifs and hotspots of cancer genes in a mammalian cellular signalling network. IET Systems Biology 2007, 1:292-297.
-
(2007)
IET Systems Biology
, vol.1
, pp. 292-297
-
-
Awan, A.1
Bari, H.2
Yan, F.3
Moksong, S.4
Yang, S.5
Chowdhury, S.6
-
82
-
-
84861316184
-
MicroRNA dysregulation in prostate cancer: network analysis reveals preferential regulation of highly connected nodes
-
Budd W.T., Weaver D.E., Anderson J., Zehner Z.E. microRNA dysregulation in prostate cancer: network analysis reveals preferential regulation of highly connected nodes. Chemistry & Biodiversity 2012, 9:857-867.
-
(2012)
Chemistry & Biodiversity
, vol.9
, pp. 857-867
-
-
Budd, W.T.1
Weaver, D.E.2
Anderson, J.3
Zehner, Z.E.4
-
83
-
-
84884211557
-
TGF-? and NF-?B signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers
-
Freudlsperger C., Bian Y., Contag Wise S., Burnett J., Coupar J., Yang X., et al. TGF-? and NF-?B signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene 2013, 32:1549-1559.
-
(2013)
Oncogene
, vol.32
, pp. 1549-1559
-
-
Freudlsperger, C.1
Bian, Y.2
Contag Wise, S.3
Burnett, J.4
Coupar, J.5
Yang, X.6
-
84
-
-
80051728343
-
A systems pharmacology analysis of major chemotherapy combination regimens used in gastric cancer treatment: predicting potential new protein targets and drugs
-
Rosado J.O., Henriques J.P., Bonatto D. A systems pharmacology analysis of major chemotherapy combination regimens used in gastric cancer treatment: predicting potential new protein targets and drugs. Current Cancer Drug Targets 2011, 11:849-869.
-
(2011)
Current Cancer Drug Targets
, vol.11
, pp. 849-869
-
-
Rosado, J.O.1
Henriques, J.P.2
Bonatto, D.3
-
85
-
-
78650510609
-
MTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R., Efeyan A., Sabatini D.M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews Molecular Cell Biology 2011, 12:21-35.
-
(2011)
Nature Reviews Molecular Cell Biology
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
86
-
-
34548394483
-
Human protein-protein interaction networks and the value for drug discovery
-
Ruffner H., Bauer A., Bouwmeester T. Human protein-protein interaction networks and the value for drug discovery. Drug Discovery Today 2007, 12:709-716.
-
(2007)
Drug Discovery Today
, vol.12
, pp. 709-716
-
-
Ruffner, H.1
Bauer, A.2
Bouwmeester, T.3
-
87
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A., Ma L., Teruya-Feldstein J., Rojo F., Salmena L., Alimonti A., et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. Journal of Clinical Investigation 2008, 118:3065-3074.
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
-
88
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303:844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
-
89
-
-
84887623889
-
Network, nodes and nexus: systems approach to multitarget therapeutics
-
in press
-
Murthy D., Attri K.S., Gokhale R.S. Network, nodes and nexus: systems approach to multitarget therapeutics. Current Opinion in Biotechnology 2013, in press. 10.1016/j.copbio.2013.02.009.
-
(2013)
Current Opinion in Biotechnology
-
-
Murthy, D.1
Attri, K.S.2
Gokhale, R.S.3
-
90
-
-
84874629561
-
Therapeutic implications of targeting energy metabolism in breast cancer
-
Sakharkar M.K., Shashni B., Sharma K., Dhillon S.K., Ranjekar P.R., Sakharkar K.R. Therapeutic implications of targeting energy metabolism in breast cancer. PPAR Research 2013, 2013:109285.
-
(2013)
PPAR Research
, vol.2013
, pp. 109285
-
-
Sakharkar, M.K.1
Shashni, B.2
Sharma, K.3
Dhillon, S.K.4
Ranjekar, P.R.5
Sakharkar, K.R.6
-
91
-
-
76749148657
-
An integrative-omics approach to identify functional sub-networks in human colorectal cancer
-
Nibbe R.K., Koyutürk M., Chance M.R. An integrative-omics approach to identify functional sub-networks in human colorectal cancer. PLoS Computational Biology 2010, 6:e1000639.
-
(2010)
PLoS Computational Biology
, vol.6
-
-
Nibbe, R.K.1
Koyutürk, M.2
Chance, M.R.3
-
92
-
-
84877619075
-
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
-
Sadanandam A., Lyssiotis C.A., Homicsko K., Collisson E.A., Gibb W.J., Wullschleger S., et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine 2013, 19:619-625.
-
(2013)
Nature Medicine
, vol.19
, pp. 619-625
-
-
Sadanandam, A.1
Lyssiotis, C.A.2
Homicsko, K.3
Collisson, E.A.4
Gibb, W.J.5
Wullschleger, S.6
-
93
-
-
84860851412
-
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
-
Lee M.J., Ye A.S., Gardino A.K., Heijink A.M., Sorger P.K., MacBeath G., et al. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012, 149:780-794.
-
(2012)
Cell
, vol.149
, pp. 780-794
-
-
Lee, M.J.1
Ye, A.S.2
Gardino, A.K.3
Heijink, A.M.4
Sorger, P.K.5
MacBeath, G.6
-
95
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Current Opinion in Cell Biology 2005, 17:548-558.
-
(2005)
Current Opinion in Cell Biology
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
96
-
-
25444448993
-
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas
-
Bredel M., Bredel C., Juric D., Harsh G.R., Vogel H., Recht L.D., et al. Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Research 2005, 65:8679-8689.
-
(2005)
Cancer Research
, vol.65
, pp. 8679-8689
-
-
Bredel, M.1
Bredel, C.2
Juric, D.3
Harsh, G.R.4
Vogel, H.5
Recht, L.D.6
-
97
-
-
77957859044
-
Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect
-
Resendis-Antonio O., Checa A., Encarnación S. Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect. PLoS ONE 2010, 5:e12383.
-
(2010)
PLoS ONE
, vol.5
-
-
Resendis-Antonio, O.1
Checa, A.2
Encarnación, S.3
-
98
-
-
80355129300
-
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation
-
Vazquez A., Markert E.K., Oltvai Z.N. Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS ONE 2011, 6:e25881.
-
(2011)
PLoS ONE
, vol.6
-
-
Vazquez, A.1
Markert, E.K.2
Oltvai, Z.N.3
|