Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence

Biophysical Journal

Volumn 88, Issue 5, 2005, Pages 3689-3698

  Guck, Jochen ^a,b   Schinkinger, Stefan ^a,b   Lincoln, Bryan ^a,b   Wottawah, Falk ^a,b   Ebert, Susanne ^a   Romeyke, Maren ^a   Lenz, Dominik ^a   Erickson, Harold M ^c,d   Ananthakrishnan, Revathi ^a,b   Mitchell, Daniel ^d   Kas, Josef ^a,b   Ulvick, Sydney ^d   Bilby, Curt ^d  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d Evacyte Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CELL SURFACE; CYTOSKELETON; ELASTICITY; FIBROBLAST; FORCE; HUMAN; HUMAN CELL; LASER; MALIGNANT TRANSFORMATION; METASTASIS; MICROFLUIDICS; MOUSE; NONHUMAN; STRENGTH;

EID: 17844385816     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.104.045476     Document Type: Article

References (53)

1. Aaronson, S. A., and G. J. Todaro. 1968a. Basis for the acquisition of malignant potential by mouse cells cultivated in vitro. Science. 162: 1024-1026.
2. Aaronson, S. A., and G. J. Todaro. 1968b. Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40. J. Cell. Physiol 72:141-148.
3. Ashkin, A. 1970. Acceleration and trapping of particles by radiation pressure. Phys. Rev. Lett. 24:156-159.
4. Ashkin, A., and J. M. Dziedzic. 1973. Radiation pressure on a free liquid surface. Phys. Rev. Lett. 30:139-142.
5. Barer, R., and S. Joseph. 1954. Refractometry of living cells, Part I. Basic principles. Q. J. Microsc. Sci. 95:399-423.
6. Barer, R., and S. Joseph. 1955a. Refractometry of living cells, Part II. The immersion medium. Q. J. Microsc. Sci. 96:1-26.
7. Barer, R., and S. Joseph. 1955b. Refractometry of living cells, Part III. Technical and optical methods. Q. J. Microsc. Sci. 96:423-447.
8. Ben-Ze'ev, A. 1985. The cytoskeleton in cancer cells. Biochim. Biophys. Acta. 780:197-212.
9. Bosch, F. H., J. M. Werre, L. Schipper, B. Roerdinkholder-Stoelwinder, T. Huls, F. L. Willekens, G. Wichers, and M. R. Halie. 1994. Determinants of red blood cell deformability in relation to cell age. Eur. J. Haematol. 52:35-41.
10. Caraway, N. P., C. V. Fanning, E. M. Wojcik, G. A. Staerkel, R. S. Benjamin, and N. G. Ordonez. 1993. Cytology of malignant melanoma of soft parts: fine-needle aspirates and exfoliative specimens. Diagn. Cytopathol. 9:632-638.
11. Carlson, R. H. G., C. V. Gabel, S. S. Chan, R. H. Austin, J. P. Brody, and J. W. Winkelman. 1997. Self-sorting of white blood cells in a lattice. Phys. Rev. Lett. 79:2149-2152.
12. Cunningham, C. C., J. B. Gorlin, D. J. Kwiatkowski, J. H. Hartwig, P. A. Janmey, H. R. Byers, and T. P. Stossel. 1992. Actin-binding protein requirement for cortical stability and efficient locomotion. Science. 255: 325-327.
13. Elson, E. L. 1988. Cellular mechanics as an indicator of cytoskeletal structure and function. Annu. Rev. Biophys. Biophys. Chem. 17:397-430.
14. Epstein, J. B., L. Zhang, and M. Rosin. 2002. Advances in the diagnosis of oral premalignant and malignant lesions. J. Can. Dent. Assoc. 68:617-621.
15. Fu, A. Y., H. P. Chou, C. Spence, F. H. Arnold, and S. R. Quake. 2002. An integrated microfabricated cell sorter. Anal. Chem. 74:2451-2457.
16. Fuchs, E., and D. W. Cleveland. 1998. A structural scaffolding of intermediate filaments in health and disease. Science. 279:514-519.
17. Gardel, M. L., M. T. Valentine, J. C. Crocker, A. R. Bausch, and D. A. Weitz. 2003. Microrheology of entangled F-actin solutions. Phys. Rev. Lett. 91:158302.
18. Gerstner, A., W. Laffers, F. Bootz, and A. Tamok. 2000. Immunophenotyping of peripheral blood leukocytes by laser scanning cytometry. J. Immunol. Methods. 246:175-185.
19. Guck, J., R. Ananthakrishnan, H. Mahmood, T. J. Moon, C. C. Cunningham, and J. Käs. 2001. The optical stretcher: a novel laser tool to micromanipulate cells. Biophys. J. 81:767-784.
20. Guck, J., R. Ananthakrishnan, T. J. Moon, C. C. Cunningham, and J. Käs. 2000. Optical deformability of soft biological dielectrics. Phys. Rev. Lett. 84:5451-5454.
21. Himelstein, B. P., R. Canete-Soler, E. J. Bernhard, D. W. Dilks, and R. J. Muschel. 1994. Metalloproteinases in tumor progression: the contribution of MMP-9. Invasion Metastasis. 14:246-258.
22. Hochmuth, R. M. 2000. Micropipette aspiration of living cells. J. Biomech. 33:15-22.
23. Janmey, P. A., U. Euteneuer, P. Traub, and M. Schliwa. 1991. Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J. Cell Biol. 113:155-160.
24. Johnson, M. D., J. A. Torri, M. E. Lippman, and R. B. Dickson. 1999. Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness. Exp. Cell Res. 247: 105-113.
25. Katsantonis, J., A. Tosca, S. B. Koukouritaki, P. A. Theodoropoulos, A. Gravanis, and C. Stournaras. 1994. Differences in the G/total actin ratio and microfilament stability between normal and malignant human keratinocytes. Cell Biochem. Funct. 12:267-274.
26. Kirfel, J., T. M. Magin, and J. Reichelt. 2003. Keratins: a structural scaffold with emerging functions. Cell. Mol. Life Sci. 60:56-71.
27. Kundu, T., J. Bereiter-Hahn, and I. Karl. 2000. Cell property determination from the acoustic microscope generated voltage versus frequency curves. Biophys. J. 78:2270-2279.
28. Lekka, M., P. Laidler, D. Gil, J. Lekki, Z. Stachura, and A. Z. Hrynkiewicz. 1999. Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy. Eur. Biophys. J. 28:312-316.
29. Lodish, H. B., A. Berk, S. L. Zipursky, P. Matsudaira, D. Baltimore, and J. E. Darnell. 2000. Molecular Cell Biology. W.H. Freeman and Company, New York.
30. Mahaffy, R. E., C. K. Shih, F. C. MacKintosh, and J. Käs. 2000. Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. Phys. Rev. Lett. 85:880-883.
31. Moustakas, A., and C. Stournaras. 1999. Regulation of actin organisation by TGF-beta in H-ras-transformed fibroblasts. J. Cell Sci. 112:1169-1179.
32. Olins, A. L., H. Herrmann, P. Lichter, and D. E. Olins. 2000. Retinoic acid differentiation of HL-60 cells promotes cytoskeletal polarization. Exp. Cell Res. 254:130-142.
33. Rao, K. M., and H. J. Cohen. 1991. Actin cytoskeletal network in aging and cancer. Mutat. Res. 256:139-148.
34. Raz, A., and B. Geiger. 1982. Altered organization of cell-substrate contacts and membrane-associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities. Cancer Res. 42:5183-5190.
35. Rotsch, C., K. Jacobson, and M. Radmacher. 1999. Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy. Proc. Natl. Acad. Sci. USA. 96:921-926.
36. Rotsch, C., and M. Radmacher. 2000. Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study. Biophys. J. 78:520-535.
37. Sherman, M. E., and R. J. Kurman. 1996. The role of exfoliative cytology and histopathology in screening and triage. Obstet. Gynecol. Clin. North Am. 23:641-655.
38. Sleep, J., D. Wilson, R. Simmons, and W. Gratzer. 1999. Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study. Biophys. J. 77:3085-3095.
39. Soule, H. D., J. Vazguez, A. Long, S. Albert, and M. Brennan. 1973. A human cell line from a pleural effusion derived from a breast carcinoma. J. Natl. Cancer Inst. 51:1409-1416.
40. Tait, L., H. D. Soule, and J. Russo. 1990. Ultrastructural and immunocytochemical characterization of an immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50:6087-6094.
41. Thoumine, O., and A. Ott. 1997. Comparison of the mechanical properties of normal and transformed fibroblasts. Biorheology. 34:309-326.
42. Unger, M. A., H. P. Chou, T. Thorsen, A. Scherer, and S. R. Quake. 2000. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science. 288:113-116.
43. Wang, N1, J. P. Butler, and D. E. Ingber. 1993. Mechanotransduction across the cell surface and through the cytoskeleton. Science. 260:1124-1127.
44. Wang, N., and D. Stamenovic. 2000. Contribution of intermediate filaments to cell stiffness, stiffening, and growth. Am. J. Physiol. Cell Physiol. 279:C188-CI94.
45. Wang, Q., D. Lee, V. Sysounthone, R. A. S. Chandraratna, S. Christakos, R. Korah, and R. Wieder. 2001. 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function-and cell-specific additive effects. Breast Cancer Res. Treat. 67:157-168.
46. Ward, K. A., W. I. Li, S. Zimmer, and T. Davis. 1991. Viscoelastic properties of transformed cells: role in tumor cell progression and metastasis formation. Biorheology. 28:301-313.
47. Wilhelm, J., and E. Frey. 2003. Elasticity of stiff polymer networks. Phys. Rev. Lett. 91:108103.
48. Williamson, J. R., R. A. Gardner, C. W. Boylan, G. L. Carroll, K. Chang, J. S. Marvel, B. Gonen, C. Kilo, R. Tran-Son-Tay, and S. P. Sutera. 1985. Microrheologic investigation of erythrocyte deformability in diabetes mellitus. Blood. 65:283-288.
49. Wirtz, H. R., and L. G. Dobbs. 1990. Calcium mobilization and exocytosis after one mechanical stretch of lung epithelial cells. Science. 250:1266-1269.
50. Worthen, G. S., B. Schwab 3rd, E. L. Elson, and G. P. Downey. 1989. Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science. 245:183-186.
51. Wottawah, F., S. Schinkinger, B. Lincoln, R. Ananthakrishnan, M. Romeyke, J. Guck, and J. Käs. 2005. Optical rheology of biological cells. Phys. Rev. Lett. 94:098103.
52. Wyckoff, J. B., J. G. Jones, J. S. Condeelis, and J. E. Segall. 2000. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res. 60:2504-2511.
53. Zahalak, G. I., W. B. McConnaughey, and E. L. Elson. 1990. Determination of cellular mechanical properties by cell poking, with an application to leukocytes. J. Biomech. Eng. 112:283-294.