The cancer-associated K351N mutation affects the ubiquitination and the translocation to mitochondria of p53 protein

Journal of Biological Chemistry

Volumn 286, Issue 46, 2011, Pages 39693-39702

  Muscolini, Michela ^a   Montagni, Elisa ^a   Palermo, Vanessa ^a   Di Agostino, Silvia ^b   Gu, Wei ^c   Abdelmoula Souissi, Salma ^d   Mazzoni, Cristina ^a   Blandino, Giovanni ^b   Tuosto, Loretta ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c Columbia University ^*  (United States)

^d UNIVERSITY OF SFAX   (Tunisia)

Author keywords

[No Author keywords available]

Indexed keywords

CIS-PLATIN; LIGASES; MITOCHONDRIAL MEMBRANES; NUCLEAR ACCUMULATION; NUCLEAR EXPORT; OVARIAN CARCINOMA CELL; P53 PROTEIN; POINT MUTATIONS; PRO-APOPTOTIC FUNCTION; STRESS-INDUCED; UBIQUITINATION;

CELL CULTURE; CELL MEMBRANES; OLIGOMERIZATION; OLIGOMERS; PLATINUM COMPOUNDS;

MITOCHONDRIA;

ASPARAGINE; CISPLATIN; DOXORUBICIN; LYSINE; MUTANT PROTEIN; PACLITAXEL; PROTEIN; PROTEIN BAX; PROTEIN MDM2; PROTEIN MSL2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CELL NUCLEUS; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OLIGOMERIZATION; OVARY CARCINOMA; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT; UBIQUITINATION;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MUTATION, MISSENSE; NUCLEAR EXPORT SIGNALS; OVARIAN NEOPLASMS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 81155154333     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279539     Document Type: Article

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