State of knowledge and concerns on cyanobacterial blooms and cyanotoxins

Environment International

Volumn 59, Issue , 2013, Pages 303-327

  Merel, Sylvain ^a,b   Walker, David ^b   Chicana, Ruth ^b   Snyder, Shane ^a   Baurès, Estelle ^c   Thomas, Olivier ^c  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Anatoxin; BMAA; Cylindrospermopsin; Drinking water treatment; Microcystin; Saxitoxin

Indexed keywords

ACTIVATED CARBON; AMINO ACIDS; BIOCHEMISTRY; CELL DEATH; CLARIFICATION; ECONOMIC AND SOCIAL EFFECTS; METABOLITES; MICROFILTRATION; NITROGEN FIXATION; OZONE WATER TREATMENT; OZONIZATION; POTABLE WATER; TOXIC MATERIALS; WATER RESOURCES;

ANATOXIN; BMAA; CYLINDROSPERMOPSIN; MICROCYSTINS; SAXITOXIN;

ACTIVATED CARBON TREATMENT;

2 AMINO 3 METHYLAMINOPROPIONIC ACID; ACTIVATED CARBON; ANATOXIN; APLYSIATOXIN; BACTERIAL TOXIN; CYANOTOXIN; CYLINDROSPERMOPSIN; DRINKING WATER; LYNGBYATOXIN; MICROCYSTIN; SAXITOXIN; SURFACE WATER; UNCLASSIFIED DRUG;

CYANOBACTERIUM; DRINKING WATER; ECONOMIC IMPACT; ENVIRONMENTAL FACTOR; LIGHT INTENSITY; NUTRIENT; OXIDATION; RESIDENCE TIME; SALINITY; SURFACE WATER; TOXICOLOGY; TOXIN; WATER TEMPERATURE; WATER TREATMENT;

ADSORPTION; AGING; ALLELOPATHY; AWARENESS; BACTERIAL OVERGROWTH; BIOSYNTHESIS; CELL DEATH; CHLORINATION; CYANOBACTERIUM; CYTOLYSIS; ECONOMIC ASPECT; ENVIRONMENTAL FACTOR; EVOLUTION; GENE CONTROL; LIGHT INTENSITY; MEMBRANE FILTER; NONHUMAN; NUTRIENT CONCENTRATION; NUTRIENT LIMITATION; OZONATION; PRIORITY JOURNAL; REVERSE OSMOSIS; REVIEW; SALINITY; WASTE COMPONENT REMOVAL; WASTE WATER MANAGEMENT; WATER FLOW; WATER SUPPLY; WATER TEMPERATURE;

BACTERIA (MICROORGANISMS); CYANOBACTERIA;

ANATOXIN; BMAA; CYLINDROSPERMOPSIN; DRINKING WATER TREATMENT; MICROCYSTIN; SAXITOXIN;

BACTERIAL TOXINS; CYANOBACTERIA; DRINKING WATER; ENVIRONMENTAL MONITORING; FRESH WATER; MICROCYSTINS; PEPTIDES, CYCLIC; URACIL; WATER MICROBIOLOGY;

EID: 84880800709     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2013.06.013     Document Type: Review

References (355)

1. Acero J.L., Rodriguez E., Meriluoto J. Kinetics of reactions between chlorine and the cyanobacterial toxins microcystins. Water Res 2005, 39:1628-1638.
2. Acero J.L., Rodríguez E., Majado M.E., Sordo A., Meriluoto J. Oxidation of microcystin-LR with chlorine and permanganate during drinking water treatment. J Water Supply Res Technol-AQUA 2008, 57:371-380.
3. 2. Water Res 2010, 44:278-286.
4. Al Momani F. Degradation of cyanobacteria anatoxin-a by advanced oxidation processes. Sep Purif Technol 2007, 57:85-93.
5. Al Momani F.A., Jarrah N. Treatment and kinetic study of cyanobacterial toxin by ozone. J Environ Sci Health A 2010, 45:719-731.
6. Al Momani F., Smith D.W., Gamal El-Din M. Degradation of cyanobacteria toxin by advanced oxidation processes. J Hazard Mater 2008, 150:238-249.
7. Almeida V.P.S., Cogo K., Tsai S.M., Moon D.H. Colorimetric test for the monitoring of microcystins in cyanobacterial culture and environmental samples from southeast-Brazil. Braz J Microbiol 2006, 37:192-198.
8. Al-Tebrineh J., Mihali T.K., Pomati F., Neilan B.A. Detection of saxitoxin-producing cyanobacteria and Anabaena circinalis in environmental water blooms by quantitative PCR. Appl Environ Microbiol 2010, 76:7836-7842.
9. An J., Carmichael W.W. Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins. Toxicon 1994, 32:1495-1507.
10. 2 photocatalysis of microcystin-LR. Toxicon 2008, 51:1103-1118.
11. Aranda-Rodriguez R., Kubwabo C., Benoit F.M. Extraction of 15 microcystins and nodularin using immunoaffinity columns. Toxicon 2003, 42:587-599.
12. Aráoz R., Guérineau V., Rippka R., Palibroda N., Herdman M., Laprevote O., et al. MALDI-TOF-MS detection of the low molecular weight neurotoxins anatoxin-a and homoanatoxin-a on lyophilized and fresh filaments of axenic Oscillatoria strains. Toxicon 2008, 51:1308-1315.
13. Aráoz R., Herdman M., Rippka R., Ledreux A., Molgó J., Changeux J.P., et al. A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes. Toxicon 2008, 52:163-174.
14. Aráoz R., Molgó J., Tandeau de Marsac N. Neurotoxic cyanobacterial toxins. Toxicon 2010, 56:813-828.
15. Aráoz R., Vilariño N., Botana L.M., Molgó J. Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors. Anal Bioanal Chem 2010, 397:1695-1704.
16. Arheimer B., Andréasson J., Fogelberg S., Johnsson H., Pers C.B., Persson K. Climate change impact on water quality: model results from southern Sweden. Ambio 2005, 34:559-566.
17. Azevedo S.M.F.O., Carmichael W.W., Jochimsen E.M., Rinehart K.L., Lau S., Shaw G.R., et al. Human intoxication by microcystins during renal dialysis treatment in Caruaru-Brazil. Toxicology 2002, 181-182:441-446.
18. Azevedo J., Osswald J., Guilhermino L., Vasconcelos V. Development and validation of an SPE-HPLC-FL method for the determination of anatoxin-a in water and trout (Oncorhyncus mykiss). Anal Lett 2011, 44:1431-1441.
19. Ballot A., Pflugmacher S., Wiegand C., Kotut K., Krienitz L. Cyanobacterial toxins in Lake Baringo, Kenya. Limnologica 2003, 33:2-9.
20. Ballot A., Fastner J., Wiedner C. Paralytic shellfish poisoning toxin-producing cyanobacterium Aphanizomenon gracile in Northeast Germany. Appl Environ Microbiol 2010, 76:1173-1180.
21. Banack S.A., Caller T.A., Stommel E.W. The cyanobacteria derived toxin β-n-methylamino-l-alanine and amyotrophic lateral sclerosis. Toxins 2010, 2:2837-2850.
22. Banack S.A., Downing T.G., Spácil Z., Purdie E.L., Metcalf J.S., Downing S., et al. Distinguishing the cyanobacterial neurotoxin β-n-methylamino-l-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB). Toxicon 2010, 56:868-879.
23. Banker R., Carmeli S., Hadas O., Teltsch B., Poral R., Sukenik A. Identification of cylindrospermopsin in Aphanizomenon ovalisporum (cyanophyceae) isolated from Lake Kinneret, Israel. J Phycol 1997, 33:613-616.
24. Banker R., Teltsch B., Sukenik A., Carmeli S. 7-epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from Lake Kinneret, Israel. J Nat Prod 2000, 63:387-389.
25. Banker R., Carmeli S., Werman M., Teltsch B., Porat R., Sukenik A. Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cylindrospermopsin. J Toxicol Environ Health A 2001, 62:281-288.
26. Barco M., Rivera J., Caixach J. Analysis of cyanobacterial hepatotoxins in water samples by microbore reversed-phase liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr A 2002, 959:103-111.
27. Barón-Sola Á., Ouahid Y., del Campo F.F. Detection of potentially producing cylindrospermopsin and microcystin strains in mixed populations of cyanobacteria by simultaneous amplification of cylindrospermopsin and microcystin gene regions. Ecotoxicol Environ Saf 2012, 75:102-108.
28. Bateman K.P., Thibault P., Douglas D.J., White R.L. Mass spectral analyses of microcystins from toxic cyanobacteria using on-line chromatographic and electrophoretic separations. J Chromatogr A 1995, 712:253-268.
29. Baxa D.V., Kurobe T., Ger K.A., Lehman P.W., Teh S.J. Estimating the abundance of toxic Microcystis in the San Francisco Estuary using quantitative real-time PCR. Harmful Algae 2010, 9:342-349.
30. Ben-Gigirey B., Rodríguez-Velasco M.L., Otero A., Vieites J.M., Cabado A.G. A comparative study for PSP toxins quantification by using MBA and HPLC official methods in shellfish. Toxicon 2012, 60:864-873.
31. Bláhová L., Oravec M., Marsálek B., Sejnohová L., Simek Z., Bláha L. The first occurrence of the cyanobacterial alkaloid toxin cylindrospermopsin in the Czech Republic as determined by immunochemical and LC/MS methods. Toxicon 2009, 53:519-524.
32. Blay P., Hui J., Chang J., Melanson J. Screening for multiple classes of marine biotoxins by liquid chromatography-high-resolution mass spectrometry. Anal Bioanal Chem 2011, 400:577-585.
33. Bogialli S., Bruno M., Curini R., Di Corcia A., Laganà A. Simple and rapid determination of anatoxin-a in lake water and fish muscle tissue by liquid-chromatography-tandem mass spectrometry. J Chromatogr A 2006, 1122:180-185.
34. Bouaïcha N., Maatouk I., Vincent G., Levi Y. A colorimetric and fluorometric microplate assay for the detection of microcystin-LR in drinking water without preconcentration. Food Chem Toxicol 2002, 40:1677-1683.
35. Bourke A.T.C., Hawes R.B., Neilson A., Stallman N.D. An outbreak of hepato-enteritis (the Palm Island mystery disease) possibly caused by algal intoxication. Toxicon 1983, 21:45-48.
36. Bourne D.G., Riddles P., Jones G.J., Smith W., Blakeley R.L. Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR. Environ Toxicol 2001, 16:523-534.
37. Bourne D.G., Blakeley R.L., Riddles P., Jones G.J. Biodegradation of the cyanobacterial toxin microcystin LR in natural water and biologically active slow sand filters. Water Res 2006, 40:1294-1302.
38. Brand L.E., Pablo J., Compton A., Hammerschlag N., Mash D.C. Cyanobacterial blooms and the occurrence of the neurotoxin, beta-n-methylamino-l-alanine (BMAA), in south Florida aquatic food webs. Harmful Algae 2010, 9:620-635.
39. Briand J.F., Jacquet S., Bernard C., Humbert J.F. Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems. Vet Res 2003, 34:361-377.
40. Brient L., Lengronne M., Bertrand E., Rolland D., Sipel A., Steinmann D., et al. A phycocyanin probe as a tool for monitoring cyanobacteria in freshwater bodies. J Environ Monit 2008, 10:248-255.
41. Brient L., Lengronne M., Bormans M., Fastner J. First occurrence of cylindrospermopsin in freshwater in France. Environ Toxicol 2009, 24:415-420.
42. Briley D.S., Knappe D.R.U. Optimizing ferric sulfate coagulation of algae with streaming current measurements. J Am Water Works Assoc 2002, 94:80-90.
43. Brooke S., Newcombe G., Nicholson B., Klass G. Decrease in toxicity of microcystins LA and LR in drinking water by ozonation. Toxicon 2006, 48:1054-1059.
44. Byth S. Palm Island mystery disease. Med J Aust 1980, 2:40-42.
45. Cadel-Six S., Iteman I., Peyraud-Thomas C., Mann S., Ploux O., Mejean A. Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria. Appl Environ Microbiol 2009, 75:4909-4912.
46. Campbell K., Huet A.C., Charlier C., Higgins C., Delahaut P., Elliott C.T. Comparison of ELISA and SPR biosensor technology for the detection of paralytic shellfish poisoning toxins. J Chromatogr B 2009, 877:4079-4089.
47. Campinas M., Rosa M.J. The ionic strength effect on microcystin and natural organic matter surrogate adsorption onto PAC. J Colloid Interface Sci 2006, 299:520-529.
48. Campinas M., Rosa M.J. Removal of microcystins by PAC/UF. Sep Purif Technol 2010, 71:114-120.
49. Campinas M., Rosa M.J. Evaluation of cyanobacterial cells removal and lysis by ultrafiltration. Sep Purif Technol 2010, 70:345-353.
50. Carmichael W.W., An J. Using an enzyme linked immunosorbent assay (ELISA) and a protein phosphatase inhibition assay (PPIA) for the detection of microcystins and nodularins. Nat Toxins 1999, 7:377-385.
51. Carrasco D., Moreno E., Paniagua T., Cd Hoyos, Wormer L., Sanchis D., et al. Anatoxin-a occurrence and potential cyanobacterial anatoxin-a producers in spanish reservoirs. J Phycol 2007, 43:1120-1125.
52. Cervantes Cianca R.C., Baptista M.S., da Silva L.P., Lopes V.R., Vasconcelos V.M. Reversed-phase HPLC/FD method for the quantitative analysis of the neurotoxin BMAA (β-N-methylamino-l-alanine) in cyanobacteria. Toxicon 2012, 59:379-384.
53. Chen J., Yan T., Xu J., He S., Zhao P., Yan X. Simultaneous determination of toxins in algae and water samples by high-performance liquid chromatography with triple quadrupole mass spectrometry. J Sep Sci 2012, 35:1094-1101.
54. Chiswell R.K., Shaw G.R., Eaglesham G., Smith M.J., Norris R.L., Seawright A.A., et al. Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii: effect of pH, temperature, and sunlight on decomposition. Environ Toxicol 1999, 14:155-161.
55. Chorus I. Germany: approaches to assessing and managing the cyanotoxin risk. Current approaches to cyanotoxin risk assessment, risk management and regulations in different countries 2005, 59-67. Umweltbundesamt, Berlin, Germany. I. Chorus (Ed.).
56. Chorus I. Current approaches to Cyanotoxin risk assessment, risk management and regulations in different countries 2012, Federal Environment Agency, Dessau-Roßlau, Germany.
57. Chorus I., Mur L.R. Preventative measures. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 235-273. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
58. Chow C.W.K., Panglisch S., House J., Drikas M., Burch M.D., Gimbel R. A study of membrane filtration for the removal of cyanobacterial cells. J Water Supply Res Technol-AQUA 1997, 46:324-334.
59. Chow C.W.K., House J., Velzeboer R.M.A., Drikas M., Burch M.D., Steffensen D.A. The effect of ferric chloride flocculation on cyanobacterial cells. Water Res 1998, 32:808-814.
60. Chow C.W.K., Drikas M., House J., Burch M.D., Velzeboer R.M.A. The impact of conventional water treatment processes on cells of the cyanobacterium Microcystis aeruginosa. Water Res 1999, 33:3253-3262.
61. Codd G.A., Lindsay J., Young F.M., Morrison L.F., Metcalf J.S. Harmful cyanobacteria: from mass mortalities to management measures. Harmful cyanobacteria 2005, 1-23. Springer, Dordrecht, Netherlands. J. Huisman, H.C.P. Matthijs, P.M. Visser (Eds.).
62. Cohen S.A. Analytical techniques for the detection of α-amino-β-methylaminopropionic acid. Analyst 2012, 137:1991-2005.
63. Cong L., Huang B., Chen Q., Lu B., Zhang J., Ren Y. Determination of trace amount of microcystins in water samples using liquid chromatography coupled with triple quadrupole mass spectrometry. Anal Chim Acta 2006, 569:157-168.
64. Cox P.A., Banack S.A., Murch S.J., Rasmussen U., Tien G., Bidigare R.R., et al. Diverse taxa of cyanobacteria produce beta-n-methylamino-l-alanine, a neurotoxic amino acid. Proc Natl Acad Sci U S A 2005, 102:5074-5078.
65. Dale B., Edwards M., Reid P.C. Climate change and harmful algal blooms. Ecology of harmful algae 2006, 367-378. Springer, New York, USA. E. Granéli, J.T. Turner (Eds.).
66. Daly R.I., Ho L., Brookes J.D. Effect of chlorination on Microcystis aeruginosa cell integrity and subsequent microcystin release and degradation. Environ Sci Technol 2007, 41:4447-4453.
67. Dawson R.M. The toxicology of microcystins. Toxicon 1998, 36:953-962.
68. DeGrasse S.L., van de Riet J., Hatfield R., Turner A. Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins. Toxicon 2011, 57:619-624.
69. del Campo F.F., Ouahid Y. Identification of microcystins from three collection strains of Microcystis aeruginosa. Environ Pollut 2010, 158:2906-2914.
70. Delgado L.F., Charles P., Glucina K., Morlay C. The removal of endocrine disrupting compounds, pharmaceutically activated compounds and cyanobacterial toxins during drinking water preparation using activated carbon-a review. Sci Total Environ 2012, 435:509-525.
71. Dell'Aversano C., Hess P., Quilliam M.A. Hydrophilic interaction liquid chromatography-mass spectrometry for the analysis of paralytic shellfish poisoning (PSP) toxins. J Chromatogr A 2005, 1081:190-201.
72. Dell'Aversano C., Eaglesham G.K., Quilliam M.A. Analysis of cyanobacterial toxins by hydrophilic interaction liquid chromatography-mass spectrometry. J Chromatogr A 2004, 1028:155-164.
73. Devic E., Li D.H., Dauta A., Henriksen P., Codd G.A., Marty J.L., et al. Detection of anatoxin-a(s) in environmental samples of cyanobacteria by using a biosensor with engineered acetylcholinesterases. Appl Environ Microbiol 2002, 68:4102-4106.
74. Diehnelt C.W., Peterman S.M., Budde W.L. Liquid chromatography-tandem mass spectrometry and accurate m/z measurements of cyclic peptide cyanobacteria toxins. TrAC Trends Anal Chem 2005, 24:622-634.
75. Dimitrakopoulos I.K., Kaloudis T.S., Hiskia A.E., Thomaidis N.S., Koupparis M.A. Development of a fast and selective method for the sensitive determination of anatoxin-a in lake waters using liquid chromatography-tandem mass spectrometry and phenylalanine-d(5) as internal standard. Anal Bioanal Chem 2010, 397:2245-2252.
76. Dittmann E., Wiegand C. Cyanobacterial toxins-occurrence, biosynthesis and impact on human affairs. Mol Nutr Food Res 2006, 50:7-17.
77. Dixon M.B., Falconet C., Ho L., Chow C.W.K., O'Neill B.K., Newcombe G. Nanofiltration for the removal of algal metabolites and the effects of fouling. Water Sci Technol 2010, 61:1189-1199.
78. Dixon M.B., Richard Y., Ho L., Chow C.W.K., O'Neill B.K., Newcombe G. A coagulation-powdered activated carbon-ultrafiltration-multiple barrier approach for removing toxins from two australian cyanobacterial blooms. J Hazard Mater 2011, 186:1553-1559.
79. Dixon M.B., Falconet C., Ho L., Chow C.W.K., O'Neill B.K., Newcombe G. Removal of cyanobacterial metabolites by nanofiltration from two treated waters. J Hazard Mater 2011, 188:288-295.
80. Donati C., Drikas M., Hayes R., Newcombe G. Microcystin-LR adsorption by powdered activated carbon. Water Res 1994, 28:1735-1742.
81. Dörr F.A., Rodríguez V., Molica R., Henriksen P., Krock B., Pinto E. Methods for detection of anatoxin-a(s) by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry. Toxicon 2010, 55:92-99.
82. dos Anjos F.M., Bittencourt-Oliveira MdC, Zajac M.P., Hiller S., Christian B., Erler K., et al. Detection of harmful cyanobacteria and their toxins by both PCR amplification and LC-MS during a bloom event. Toxicon 2006, 48:239-245.
83. Downing J.A., Watson S.B., McCauley E. Predicting cyanobacteria dominance in lakes. Can J Fish Aquat Sci 2001, 58:1905-1908.
84. Drikas M., Chow C.W.K., House J., Burch M.D. Using coagulation, flocculation, and settling to remove toxic cyanobacteria. J Am Water Works Assoc 2001, 93:100-111.
85. Dziga D., Wladyka B., Zielińska G., Meriluoto J., Wasylewski M. Heterologous expression and characterisation of microcystinase. Toxicon 2012, 59:578-586.
86. Eaglesham G.K., Norris R.L., Shaw G.R., Smith M.J., Chiswell R.K., Davis B.C., et al. Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes. Environ Toxicol 1999, 14:151-154.
87. El-Shehawy R., Gorokhova E., Fernández-Piñas F., del Campo F.F. Global warming and hepatotoxin production by cyanobacteria: what can we learn from experiments?. Water Res 2012, 46:1420-1429.
88. Esterhuizen M., Downing T.G. β-n-methylamino-l-alanine (BMAA) in novel South African cyanobacterial isolates. Ecotoxicol Environ Saf 2008, 71:309-313.
89. Faassen E.J., Gillissen F., Zweers H.A.J., Lurling M. Determination of the neurotoxins BMAA (beta-N-methylamino-L-alanine) and DAB (alpha-, gamma-diaminobutyric acid) by LC-MSMS in Dutch urban waters with cyanobacterial blooms. Amyotroph Lateral Scler 2009, 10:79-84.
90. Faassen E.J., Gillissen F., Lürling M. A comparative study on three analytical methods for the determination of the neurotoxin BMAA in cyanobacteria. PLoS One 2012, 7:e36667.
91. Falconer I.R. Tumor promotion and liver injury caused by oral consumption of cyanobacteria. Environ Toxicol Water Qual 1991, 6:177-184.
92. Falconer I.R. Measurement of toxins from blue-green algae in water and foodstuffs. Algal toxins in seafood and drinking water 1993, 165-175. Academic Press, London, UK. I.R. Falconer (Ed.).
93. Falconer I.R. An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water. Environ Toxicol 1999, 14:5-12.
94. Falconer I.R., Humpage A.R. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ Toxicol 2001, 16:192-195.
95. Fang X., Fan X., Tang Y., Chen J., Lu J. Liquid chromatography/quadrupole time-of-flight mass spectrometry for determination of saxitoxin and decarbamoylsaxitoxin in shellfish. J Chromatogr A 2004, 1036:233-237.
96. Fastner J., Heinze R., Humpage A.R., Mischke U., Eaglesham G.K., Chorus I. Cylindrospermopsin occurrence in two german lakes and preliminary assessment of toxicity and toxin production of Cylindrospermopsis raciborskii (cyanobacteria) isolates. Toxicon 2003, 42:313-321.
97. Fastner J., Rücker J., Stüken A., Preubel K., Nixdorf B., Chorus I., et al. Occurrence of the cyanobacterial toxin cylindrospermopsin in northeast Germany. Environ Toxicol 2007, 22:26-32.
98. Fawell J.K., Mitchell R.E., Everett D.J., Hill R.E. The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR. Hum Exp Toxicol 1999, 18:162-167.
99. Ferrão-Filho AdS, Soares M.C.S., Magalhães V.F., Azevedo S.M.F.O. Biomonitoring of cyanotoxins in two tropical reservoirs by cladoceran toxicity bioassays. Ecotoxicol Environ Saf 2009, 72:479-489.
100. Ferrão-Filho AdS, Soares M.C., Magalhães V.F., Azevedo S.M.F.O. A rapid bioassay for detecting saxitoxins using a Daphnia acute toxicity test. Environ Pollut 2010, 158:2084-2093.
101. Fischer W.J., Hitzfeld B.C., Tencalla F., Eriksson J.E., Mikhailov A., Dietrich D.R. Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (Oncorhynchus mykiss). Toxicol Sci 2000, 54:365-373.
102. Francis G. Poisonous Australian Lake. Nature 1878, 18:11-12.
103. Frias H.V., Mendes M.A., Cardozo K.H.M., Carvalho V.M., Tomazela D., Colepicolo P., et al. Use of electrospray tandem mass spectrometry for identification of microcystins during a cyanobacterial bloom event. Biochem Biophys Res Commun 2006, 344:741-746.
104. Fristachi A., Sinclair J.L. Occurrence of cyanobacterial harmful algal blooms workgroup report. Cyanobacterial harmful algal blooms: state of the science and research needs 2008, 45-103. Springer, New York, USA. K.H. Hudnell (Ed.).
105. Froscio S.M., Humpage A.R., Burcham P.C., Falconer I.R. Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environ Toxicol 2003, 18:243-251.
106. Froscio S.M., Humpage A.R., Wickramasinghe W., Shaw G., Falconer I.R. Interaction of the cyanobacterial toxin cylindrospermopsin with the eukaryotic protein synthesis system. Toxicon 2008, 51:191-198.
107. Furey A., Crowley J., Lehane M., James K.J. Liquid chromatography with electro spray ion-trap mass spectrometry for the determination of anatoxins in cyanobacteria and drinking water. Rapid Commun Mass Spectrom 2003, 17:583-588.
108. Gijsbertsen-Abrahamse A.J., Schmidt W., Chorus I., Heijman S.G.J. Removal of cyanotoxins by ultrafiltration and nanofiltration. J Membr Sci 2006, 276:252-259.
109. Graham D., Kisch H., Lawton L.A., Robertson P.K.J. The degradation of microcystin-LR using doped visible light absorbing photocatalysts. Chemosphere 2010, 78:1182-1185.
110. Gregor J., Marsálek B., Sípková H. Detection and estimation of potentially toxic cyanobacteria in raw water at the drinking water treatment plant by in vivo fluorescence method. Water Res 2007, 41:228-234.
111. Griffiths D.J., Saker M.L. The Palm Island mystery disease 20years on: a review of research on the cyanotoxin cylindrospermopsin. Environ Toxicol 2003, 18:78-93.
112. Grützmacher G., Böttcher G., Chorus I., Bartel H. Removal of microcystins by slow sand filtration. Environ Toxicol 2002, 17:386-394.
113. Gugger M., Lenoir S., Berger C., Ledreux A., Druart J.C., Humbert J.F., et al. First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 2005, 45:919-928.
114. Gupta N., Pant S.C., Vijayaraghavan R., Rao P.V.L. Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice. Toxicology 2003, 188:285-296.
115. Gurbuz F., Metcalf J.S., Karahan A.G., Codd G.A. Analysis of dissolved microcystins in surface water samples from Kovada Lake, Turkey. Sci Total Environ 2009, 407:4038-4046.
116. Hall T., Hart J., Croll B., Gregory R. Laboratory-scale investigations of algal toxin removal by water treatment. J Chart Inst Water Environ Manage 2000, 14:143-149.
117. Halme M., Rapinoja M.-L., Karjalainen M., Vanninen P. Verification and quantification of saxitoxin from algal samples using fast and validated hydrophilic interaction liquid chromatography-tandem mass spectrometry method. J Chromatogr B 2012, 880:50-57.
118. Harada K.-i, Oshikata M., Shimada T., Nagata A., Ishikawa N., Suzuki M., et al. High-performance liquid chromatographic separation of microcystins derivatized with a highly fluorescent dienophile. Nat Toxins 1997, 5:201-207.
119. Harada K.-i., Kondo F., Lawton L. Laboratory analysis of cyanotoxins. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 369-405. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
120. He X., Pelaez M., Westrick J.A., O'Shea K.E., Hiskia A., Triantis T., et al. Efficient removal of microcystin-LR by UV-C/H2O2 in synthetic and natural water samples. Water Res 2012, 46:1501-1510.
121. Heisler J., Glibert P.M., Burkholder J.M., Anderson D.M., Cochlan W., Dennison W.C., et al. Eutrophication and harmful algal blooms: a scientific consensus. Harmful Algae 2008, 8:3-13.
122. Henriksen P., Carmichael W.W., An J., Moestrup Ø. Detection of an anatoxin-a(s)-like anticholinesterase in natural blooms and cultures of cyanobacteria/blue-green algae from danish lakes and in the stomach contents of poisoned birds. Toxicon 1997, 35:901-913.
123. Heresztyn T., Nicholson B.C. Determination of cyanobacterial hepatotoxins directly in water using a protein phosphatase inhibition assay. Water Res 2001, 35:3049-3056.
124. Herranz S., Marazuela M.D., Moreno-Bondi M.C. Automated portable array biosensor for multisample microcystin analysis in freshwater samples. Biosens Bioelectron 2012, 33:50-55.
125. Herrmann A., Rosén J., Jansson D., Hellenäs K.-E. Evaluation of a generic multi-analyte method for detection of >100 representative compounds correlated to emergency events in 19 food types by ultrahigh-pressure liquid chromatography-tandem mass spectrometry. J Chromatogr A 2012, 1235:115-124.
126. Hilborn E.D., Carmichael W.W., Yuan M., Azevedo S.M.F.O. A simple colorimetric method to detect biological evidence of human exposure to microcystins. Toxicon 2005, 46:218-221.
127. Hilborn E.D., Carmichael W.W., Soares R.M., Yuan M., Servaites J.C., Barton H.A., et al. Serologic evaluation of human microcystin exposure. Environ Toxicol 2007, 22:459-463.
128. Himberg K., Keijola A.M., Hiisvirta L., Pyysalo H., Sivonen K. The effect of water treatment processes on the removal of hepatotoxins from Microcystis and Oscillatoria cyanobacteria: a laboratory study. Water Res 1989, 23:979-984.
129. Hisbergues M., Christiansen G., Rouhiainen L., Sivonen K., Börner T. PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera. Arch Microbiol 2003, 180:402-410.
130. Ho L., Meyn T., Keegan A., Hoefel D., Brookes J., Saint C.P., et al. Bacterial degradation of microcystin toxins within a biologically active sand filter. Water Res 2006, 40:768-774.
131. Ho L., Onstad G., von Gunten U., Rinck-Pfeiffer S., Craig K., Newcombe G. Differences in the chlorine reactivity of four microcystin analogues. Water Res 2006, 40:1200-1209.
132. Ho L., Hoefel D., Saint C.P., Newcombe G. Isolation and identification of a novel microcystin-degrading bacterium from a biological sand filter. Water Res 2007, 41:4685-4695.
133. Ho L., Slyman N., Kaeding U., Newcombe G. Optimizing PAC and chlorination practices for cylindrospermopsin removal. J Am Water Works Assoc 2008, 100:88-96.
134. Ho L., Lambling P., Bustamante H., Duker P., Newcombe G. Application of powdered activated carbon for the adsorption of cylindrospermopsin and microcystin toxins from drinking water supplies. Water Res 2011, 45:2954-2964.
135. Ho L., Sawade E., Newcombe G. Biological treatment options for cyanobacteria metabolite removal-a review. Water Res 2012, 46:1536-1548.
136. Ho L., Tang T., Monis P.T., Hoefel D. Biodegradation of multiple cyanobacterial metabolites in drinking water supplies. Chemosphere 2012, 87:1149-1154.
137. Ho L., Dreyfus J., Boyer J., Lowe T., Bustamante H., Duker P., et al. Fate of cyanobacteria and their metabolites during water treatment sludge management processes. Sci Total Environ 2012, 424:232-238.
138. Hoeger S.J., Dietrich D.R., Hitzfeld B.C. Effect of ozonation on the removal of cyanobacterial toxins during drinking water treatment. Environ Health Perspect 2002, 110:1127-1132.
139. Hrudey S., Burch M., Drikas M., Gregory R. Remedial measures. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 275-312. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
140. Huang W.J., Cheng B.L., Cheng Y.L. Adsorption of microcystin-LR by three types of activated carbon. J Hazard Mater 2007, 141:115-122.
141. Huang T.L., Zhao J.W., Chai B.B. Mechanism studies on chlorine and potassium permanganate degradation of microcystin-LR in water using high-performance liquid chromatography tandem mass spectrometry. Water Sci Technol 2008, 58:1079-1084.
142. Humpage A.R., Falconer I.R. Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male swiss albino mice: determination of no observed adverse effect level for deriving a drinking water guideline value. Environ Toxicol 2003, 18:94-103.
143. Humpage A.R., Fenech M., Thomas P., Falconer I.R. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat Res 2000, 472:155-161.
144. Humpage A.R., Magalhaes V.F., Froscio S.M. Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins. Anal Bioanal Chem 2010, 397:1655-1671.
145. Humpage A.R., Froscio S.M., Lau H.M., Murphy D., Blackbeard J. Evaluation of the Abraxis Strip Test for Microcystins™ for use with wastewater effluent and reservoir water. Water Res 2012, 46:1556-1565.
146. Ibelings B.W. Risks of toxic cyanobacterial blooms in recreational waters: guidelines in the netherlands. Current approaches to cyanotoxin risk assessment, risk management and regulations in different countries 2005, 85-91. Umweltbundesamt, Berlin, Germany. I. Chorus (Ed.).
147. Ibelings B.W., Chorus I. Accumulation of cyanobacterial toxins in freshwater "seafood" and its consequences for public health: a review. Environ Pollut 2007, 150:177-192.
148. James K.J., Sherlock I.R., Stack M.A. Anatoxin-a in irish freshwater and cyanobacteria, determined using a new fluorimetric liquid chromatographic method. Toxicon 1997, 35:963-971.
149. James K.J., Furey A., Sherlock I.R., Stack M.A., Twohig M., Caudwell F.B., et al. Sensitive determination of anatoxin-a, homoanatoxin-a and their degradation products by liquid chromatography with fluorimetric detection. J Chromatogr A 1998, 798:147-157.
150. James K.J., Crowley J., Hamilton B., Lehane M., Skulberg O., Furey A. Anatoxins and degradation products, determined using hybrid quadrupole time-of-flight and quadrupole ion-trap mass spectrometry: forensic investigations of cyanobacterial neurotoxin poisoning. Rapid Commun Mass Spectrom 2005, 19:1167-1175.
151. Ji Y., Huang J.-L., Fu J., Wu M.S., Cui C.W. Degradation of microcystin-RR in water by chlorine dioxide. J China Univ Min Technol 2008, 18:623-628.
152. Jochimsen E.M., Carmichael W.W., An J.S., Cardo D.M., Cookson S.T., Holmes C.E.M., et al. Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N Engl J Med 1998, 338:873-878.
153. Jöhnk K.D., Huisman J., Sharples J., Sommeijer B., Visser P.M., Stroom J.M. Summer heatwaves promote blooms of harmful cyanobacteria. Glob Chang Biol 2008, 14:495-512.
154. Johnson H.E., King S.R., Banack S.A., Webster C., Callanaupa W.J., Cox P.A. Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA. J Ethnopharmacol 2008, 118:159-165.
155. Jones G.J., Negri A.P. Persistence and degradation of cyanobacterial paralytic shellfish poisons (PSPs) in freshwaters. Water Res 1997, 31:525-533.
156. Jones G.J., Orr P.T. Release and degradation of microcystin following algicide treatment of a Microcystis aeruginosa bloom in a recreational lake, as determined by HPLC and protein phosphatase inhibition assay. Water Res 1994, 28:871-876.
157. Kaebernick M., Neilan B.A. Ecological and molecular investigations of cyanotoxin production. FEMS Microbiol Ecol 2001, 35:1-9.
158. Kalaitzis J.A., Chau R., Kohli G.S., Murray S.A., Neilan B.A. Biosynthesis of toxic naturally-occurring seafood contaminants. Toxicon 2010, 56:244-258.
159. Kaushik R., Balasubramanian R. Methods and approaches used for detection of cyanotoxins in environmental samples: a review. Crit Rev Environ Sci Technol 2013, 43:1349-1383.
160. Kaya K., Sano T. A photodetoxification mechanism of the cyanobacterial hepatotoxin microcystin-LR by ultraviolet irradiation. Chem Res Toxicol 1998, 11:159-163.
161. Kaya K., Sano T. Total microcystin determination using erythro-2-methyl-3-(methoxy-d3)-4-phenylbutyric acid (MMPB-d3) as the internal standard. Anal Chim Acta 1999, 386:107-112.
162. Kaya K., Sano T., Inoue H., Takagi H. Selective determination of total normal microcystin by colorimetry, LC/UV detection and/or LC/MS. Anal Chim Acta 2001, 450:73-80.
163. Kellmann R., Mills T., Neilan B.A. Functional modeling and phylogenetic distribution of putative cylindrospermopsin biosynthesis enzymes. J Mol Evol 2006, 62:267-280.
164. Kellmann R., Mihali T.K., Jeon Y.J., Pickford R., Pomati F., Neilan B.A. Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl Environ Microbiol 2008, 74:4044-4053.
165. Kenefick S.L., Hrudey S.E., Peterson H.G., Prepas E.E. Toxin release from Microcystis aeruginosa after chemical treatment. Water Sci Technol 1993, 27:433-440.
166. Khreich N., Lamourette P., Lagoutte B., Ronco C., Franck X., Creminon C., et al. A fluorescent immunochromatographic test using immunoliposomes for detecting microcystins and nodularins. Anal Bioanal Chem 2010, 397:1733-1742.
167. Kikuchi S., Kubo T., Kaya K. Cylindrospermopsin determination using 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) as the internal standard. Anal Chim Acta 2007, 583:124-127.
168. Konno H. Settling ang coagulation of slender type diatoms. Water Sci Technol 1993, 27:231-240.
169. Kosol S., Schmidt J., Kurmayer R. Variation in peptide net production and growth among strains of the toxic cyanobacterium Planktothrix spp. Eur J Phycol 2009, 44:49-62.
170. Krienitz L., Ballot A., Kotut K., Wiegand C., Pütz S., Metcalf J.S., et al. Contribution of hot spring cyanobacteria to the mysterious deaths of lesser flamingos at Lake Bogoria, Kenya. FEMS Microbiol Ecol 2003, 43:141-148.
171. Krüger T., Mönch B., Oppenhäuser S., Luckas B. LC-MS/MS determination of the isomeric neurotoxins BMAA (β-n-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Toxicon 2002, 55:547-557.
172. Krüger T., Christian B., Luckas B. Development of an analytical method for the unambiguous structure elucidation of cyclic peptides with special appliance for hepatotoxic desmethylated microcystins. Toxicon 2009, 54:302-312.
173. Kubo T., Kato N., Hosoya K., Kaya K. Effective determination method for a cyanobacterial neurotoxin, b-n-methylamino-l-alanine. Toxicon 2008, 51:1264-1268.
174. Kuiper-Goodman T., Falconer I., Fitzgerald J. Human health aspects. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 113-153. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
175. Kull T.P.J., Backlund P.H., Karlsson K.M., Meriluoto J.A.O. Oxidation of the cyanobacterial hepatotoxin microcystin-LR by chlorine dioxide: reaction kinetics, characterization, and toxicity of reaction products. Environ Sci Technol 2004, 38:6025-6031.
176. Kull T.P.J., Sjövall O.T., Tammenkoski M.K., Backlund P.H., Meriluoto J.A.O. Oxidation of the cyanobacterial hepatotoxin microcystin-LR by chlorine dioxide: influence of natural organic matter. Environ Sci Technol 2006, 40:1504-1510.
177. Kurmayer R., Christiansen G. The genetic basis of toxin production in cyanobacteria. Freshw Rev 2009, 2:31-50.
178. Kurmayer R., Kutzenberger T. Application of real-time PCR for quantification of microcystin genotypes in a population of the toxic cyanobacterium Microcystis sp. Appl Environ Microbiol 2003, 69:6723-6730.
179. Lajeunesse A., Segura P.A., Gélinas M., Hudon C., Thomas K., Quilliam M.A., et al. Detection and confirmation of saxitoxin analogues in freshwater benthic Lyngbya wollei algae collected in the St. Lawrence River (Canada) by liquid chromatography-tandem mass spectrometry. J Chromatogr A 2012, 1219:93-103.
180. Lam A.K., Prepas E.E., Spink D., Hrudey S.E. Chemical control of hepatotoxic phytoplankton blooms: implications for human health. Water Res 1995, 29:1845-1854.
181. Lambert T.W., Holmes C.F.B., Hrudey S.E. Adsorption of microcystin-LR by activated carbon and removal in full scale water treatment. Water Res 1996, 30:1411-1422.
182. Lawrence J.F., Niedzwiadek B. Quantitative determination of paralytic shellfish poisoning toxins in shellfish by using prechromatographic oxidation and liquid chromatography with fluorescence detection. J AOAC Int 2001, 84:1099-1108.
183. Lawrence J.F., Niedzwiadek B., Menard C., Lau B.P.Y., Lewis D., Kuper-Goodman T., et al. Comparison of liquid chromatography/mass spectrometry, ELISA, and phosphatase assay for the determination of microcystins in blue-green algae products. J AOAC Int 2001, 84:1035-1044.
184. Lawrence J.F., Niedzwiadek B., Menard C. Quantitative determination of paralytic shellfish poisoning toxins in shellfish using prechromatographic oxidation and liquid chromatography with fluorescence detection: Interlaboratory study. J AOAC Int 2004, 87:83-100.
185. Lawrence J.F., Niedzwiadek B., Menard C. Quantitative determination of paralytic shellfish poisoning toxins in shellfish using prechromatographic oxidation and liquid chromatography with fluorescence detection: collaborative study. J AOAC Int 2005, 88:1714-1732.
186. Lawton L.A., Edwards C. Conventional laboratory methods for cyanotoxins. Cyanobacterial harmful algal blooms: state of the science and research needs 2008, 513-537. Springer, New York, USA. K.H. Hudnell (Ed.).
187. Lawton L.A., Robertson P.K.J. Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters. Chem Soc Rev 1999, 28:217-224.
188. Lawton L.A., Edwards C., Codd G.A. Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 1994, 119:1525-1530.
189. 2 photocatalytic oxidation. Environ Sci Technol 1999, 33:771-775.
190. Lawton L.A., Chambers H., Edwards C., Nwaopara A.A., Healy M. Rapid detection of microcystins in cells and water. Toxicon 2010, 55:973-978.
191. Laycock M.V., Donovan M.A., Easy D.J. Sensitivity of lateral flow tests to mixtures of saxitoxins and applications to shellfish and phytoplankton monitoring. Toxicon 2010, 55:597-605.
192. Laycock M.V., Anderson D.M., Naar J., Goodman A., Easy D.J., Donovan M.A., et al. Laboratory desalination experiments with some algal toxins. Desalination 2012, 293:1-6.
193. Le Jeune A.H., Charpin M., Deluchat V., Briand J.F., Lenain J.F., Baudu M., et al. Effect of copper sulphate treatment on natural phytoplanktonic communities. Aquat Toxicol 2006, 80:267-280.
194. Lee J., Walker H.W. Mechanisms and factors influencing the removal of microcystin-LR by ultrafiltration membranes. J Membr Sci 2008, 320:240-247.
195. Li R., Carmichael W.W., Brittain S., Eaglesham G.K., Shaw G.R., Mahakhant A., et al. Isolation and identification of the cyanotoxin cylindrospermopsin and deoxy-cylindrospermopsin from a Thailand strain of Cylindrospermopsis raciborskii (cyanobacteria). Toxicon 2001, 39:973-980.
196. Li A., Tian Z., Li J., Yu R., Banack S.A., Wang Z. Detection of the neurotoxin BMAA within cyanobacteria isolated from freshwater in China. Toxicon 2010, 55:947-953.
197. Lindner P., Molz R., Yacoub-George E., Dürkop A., Wolf H. Development of a highly sensitive inhibition immunoassay for microcystin-LR. Anal Chim Acta 2004, 521:37-44.
198. Liu I., Lawton L.A., Robertson P.K.J. Mechanistic studies of the photocatalytic oxidation of microcystin-LR: an investigation of byproducts of the decomposition process. Environ Sci Technol 2003, 37:3214-3219.
199. 2. Appl Catal Environ 2005, 60:245-252.
200. Liu I., Lawton L.A., Bahnemann D.W., Liu L., Proft B., Robertson P.K.J. The photocatalytic decomposition of microcystin-LR using selected titanium dioxide materials. Chemosphere 2009, 76:549-553.
201. Locke S.J., Thibault P. Improvement in detection limits for the determination of paralytic shellfish poisoning toxins in shellfish tissues using capillary electrophoresis/electrospray mass spectrometry and discontinuous buffer systems. Anal Chem 1994, 66:3436-3446.
202. Ma M., Liu R., Liu H., Qu J. Chlorination of Microcystis aeruginosa suspension: cell lysis, toxin release and degradation. J Hazard Mater 2012, 217-218:279-285.
203. MacKintosh C., Beattie K.A., Klumpp S., Cohen P., Codd G.A. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2a from both mammals and higher plants. FEBS Lett 1990, 264:187-192.
204. Mathys W., Surholt B. Analysis of microcystins in freshwater samples using high performance liquid chromatography and an enzyme-linked immunosorbent assay. Int J Hyg Environ Health 2004, 207:601-605.
205. Matthijs H.C.P., Visser P.M., Reeze B., Meeuse J., Slot P.C., Wijn G., et al. Selective suppression of harmful cyanobacteria in an entire lake with hydrogen peroxide. Water Res 2012, 46:1460-1472.
206. McElhiney J., Lawton L.A. Detection of the cyanobacterial hepatotoxins microcystins. Toxicol Appl Pharmacol 2005, 203:219-230.
207. Mejean A., Mazmouz R., Mann S., Calteau A., Medigue C., Ploux O. The genome sequence of the cyanobacterium Oscillatoria sp. Pcc 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites. J Bacteriol 2010, 192:5264-5265.
208. Merel S., LeBot B., Clément M., Seux R., Thomas O. MS identification of microcystin-LR chlorination by-products. Chemosphere 2009, 74:832-839.
209. Merel S., Clément M., Thomas O. State of the art on cyanotoxins in water and their behaviour towards chlorine. Toxicon 2010, 55:677-691.
210. Merel S., Clément M., Mourot A., Fessard V., Thomas O. Characterization of cylindrospermopsin chlorination. Sci Total Environ 2010, 408:3433-3442.
211. Merel S., Villarín M., Chung K., Chicana R., Snyder S. Spatial and thematic distribution of research on cyanotoxins. Toxicon 2013, [in press].
212. Meriluoto J. Chromatography of microcystins. Anal Chim Acta 1997, 352:277-298.
213. Metcalf J.S., Bell S.G., Codd G.A. Production of novel polyclonal antibodies against the cyanobacterial toxin microcystin-LR and their application for the detection and quantification of microcystins and nodularin. Water Res 2000, 34:2761-2769.
214. Metcalf J.S., Barakate A., Codd G.A. Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin. FEMS Microbiol Lett 2004, 235:125-129.
215. Metcalf J.S., Banack S.A., Lindsay J., Morrison L.F., Cox P.A., Codd G.A. Co-occurrence of β-n-methylamino-l-alanine, a neurotoxic amino acid with other cyanobacterial toxins in british waterbodies, 1990-2004. Environ Microbiol 2008, 10:702-708.
216. Miao H., Tao W. The mechanisms of ozonation on cyanobacteria and its toxins removal. Sep Purif Technol 2009, 66:187-193.
217. Miao H.-F., Qin F., Tao G.-J., Tao W.-Y., Ruan W.-Q. Detoxification and degradation of microcystin-LR and -RR by ozonation. Chemosphere 2010, 79:355-361.
218. Moffitt M.C., Neilan B.A. Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins. Appl Environ Microbiol 2004, 70:6353-6362.
219. Molica R.J.R., Oliveira E.J.A., Carvalho P.V.V.C., Costa A.N.S.F., Cunha M.C.C., Melo G.L., et al. Occurrence of saxitoxins and an anatoxin-a(s)-like anticholinesterase in a Brazilian drinking water supply. Harmful Algae 2005, 4:743-753.
220. Montechiaro F., Giordano Effect of prolonged dark incubation on pigments and photosynthesis of the cave-dwelling cyanobacterium Phormidium autumnale (Oscillatoriales, Cyanobacteria). Phycologia 2006, 45:704-710.
221. Msagati T.A.M., Siame B.A., Shushu D.D. Evaluation of methods for the isolation, detection and quantification of cyanobacterial hepatotoxins. Aquat Toxicol 2006, 78:382-397.
222. Mur L.R., Skulberg M.O., Utkilen H. Cyanobacteria in the environment. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 15-40. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
223. Murch S.J., Cox P.A., Banack S.A., Steele J.C., Sacks O.W. Occurrence of β-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam. Acta Neurol Scand 2004, 110:267-269.
224. Nagai H., Yasumoto T., Hokama Y. Aplysiatoxin and debromoaplysiatoxin as the causative agents of a red alga Gracilaria coronopifolia poisoning in Hawaii. Toxicon 1996, 34:753-761.
225. Namikoshi M., Murakami T., Watanabe M.F., Oda T., Yamada J., Tsujimura S., et al. Simultaneous production of homoanatoxin-a, anatoxin-a, and a new non-toxic 4-hydroxyhomoanatoxin-a by the cyanobacterium Raphidiopsis mediterranea Skuja. Toxicon 2003, 42:533-538.
226. Neffling M.R., Spoof L., Meriluoto J. Rapid LC-MS detection of cyanobacterial hepatotoxins microcystins and nodularins-comparison of columns. Anal Chim Acta 2009, 653:234-241.
227. Neumann U., Weckesser J. Elimination of microcystin peptide toxins from water by reverse osmosis. Environ Toxicol Water Qual 1998, 13:143-148.
228. Newcombe G., Nicholson B. Water treatment options for dissolved cyanotoxins. J Water Supply Res Technol-AQUA 2004, 53:227-239.
229. Newcombe G., Cook D., Brooke S., Ho L., Slyman N. Treatment options for microcystin toxins: similarities and differences between variants. Environ Technol 2003, 24:299-308.
230. Nicholson B.C., Rositano J., Burch M.D. Destruction of cyanobacterial peptide hepatotoxins by chlorine and chloramine. Water Res 1994, 28:1297-1303.
231. Nicholson B.C., Shaw G.R., Morrall J., Senogles P.J., Woods T.A., Papageorgiou J., et al. Chlorination for degrading saxitoxins (paralytic shellfish poisons) in water. Environ Technol 2003, 24:1341-1348.
232. Nishiwaki-Matsushima R., Ohta T., Nishiwaki S., Suganuma M., Kohyama K., Ishikawa T., et al. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol 1992, 118:420-424.
233. Norris R.L., Eaglesham G.K., Pierens G., Shaw G.R., Smith M.J., Chiswell R.K., et al. Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii. Environ Toxicol 1999, 14:163-165.
234. O'Neil J.M., Davis T.W., Burford M.A., Gobler C.J. The rise of harmful cyanobacteria blooms: the potential roles of eutrophication and climate change. Harmful Algae 2012, 14:313-334.
235. Oehrle S.A., Southwell B., Westrick J. Detection of various freshwater cyanobacterial toxins using ultra-performance liquid chromatography tandem mass spectrometry. Toxicon 2010, 55:965-972.
236. Onodera H., Oshima Y., Henriksen P., Yasumoto T. Confirmation of anatoxin-a(s), in the cyanobacterium Anabaena lemmermannii, as the cause of bird kills in Danish lakes. Toxicon 1997, 35:1645-1648.
237. Onstad G.D., Strauch S., Meriluoto J., Codd G.A., von Gunten U. Selective oxidation of key functional groups in cyanotoxins during drinking water ozonation. Environ Sci Technol 2007, 41:4397-4404.
238. Orr P.T., Jones G.J. Relationship between microcystin production and cell division rates in nitrogen-limited microcystis aeruginosa cultures. Limnol Oceanogr 1998, 43:1604-1614.
239. Orr P.T., Jones G.J., Hamilton G.R. Removal of saxitoxins from drinking water by granular activated carbon, ozone and hydrogen peroxide-implications for compliance with the australian drinking water guidelines. Water Res 2004, 38:4455-4461.
240. Ortea P.M., Allis O., Healy B.M., Lehane M., Ní Shuilleabháin A., Furey A., et al. Determination of toxic cyclic heptapeptides by liquid chromatography with detection using ultra-violet, protein phosphatase assay and tandem mass spectrometry. Chemosphere 2004, 55:1395-1402.
241. Osborne N.J., Shaw G.R., Webb P.M. Health effects of recreational exposure to Moreton Bay, Australia waters during a Lyngbya majuscula bloom. Environ Int 2007, 33:309-314.
242. Osswald J., Rellán S., Gago A., Vasconcelos V. Toxicology and detection methods of the alkaloid neurotoxin produced by cyanobacteria, anatoxin-a. Environ Int 2007, 33:1070-1089.
243. Ostermaier V., Kurmayer R. Application of real-time PCR to estimate toxin production by the cyanobacterium Planktothrix sp. Appl Environ Microbiol 2010, 76:3495-3502.
244. Pablo J., Banack S.A., Cox P.A., Johnson T.E., Papapetropoulos S., Bradley W.G., et al. Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta Neurol Scand 2009, 120:216-225.
245. Paerl H.W., Paul V.J. Climate change: links to global expansion of harmful cyanobacteria. Water Res 2012, 46:1349-1363.
246. Paerl H.W., Hall N.S., Calandrino E.S. Controlling harmful cyanobacterial blooms in a world experiencing anthropogenic and climatic-induced change. Sci Total Environ 2011, 409:1739-1745.
247. Paerl H.W., Xu H., McCarthy M.J., Zhu G., Qin B., Li Y., et al. Controlling harmful cyanobacterial blooms in a hyper-eutrophic lake (Lake Taihu, China): the need for a dual nutrient (N & P) management strategy. Water Res 2011, 45:1973-1983.
248. Pan M., Mabry T.J., Cao P., Moini M. Identification of nonprotein amino acids from cycad seeds as N-ethoxycarbonyl ethyl ester derivatives by positive chemical-ionization gas chromatography-mass spectrometry. J Chromatogr A 1997, 787:288-294.
249. Pantelić D., Svirčev Z., Simeunović J., Vidović M., Trajković I. Cyanotoxins: characteristics, production and degradation routes in drinking water treatment with reference to the situation in Serbia. Chemosphere 2013, 91:421-441.
250. Park H.-D., Watanabe M.F., Harada K.-I., Nagai H., Suzuki M., Watanabe M., et al. Hepatotoxin (microcystin) and neurotoxin (anatoxin-a) contained in natural blooms and strains of cyanobacteria from Japanese freshwaters. Nat Toxins 1993, 1:353-360.
251. Park H.-D., Kim B., Kim E., Okino T. Hepatotoxic microcystins and neurotoxic anatoxin-a in cyanobacterial blooms from korean lakes. Environ Toxicol Water Qual 1998, 13:225-234.
252. Paul V.J. Global warming and cyanobacterial harmful algal blooms. Cyanobacterial harmful algal blooms: state of the science and research needs 2008, 239-257. Springer, New York, USA. K.H. Hudnell (Ed.).
253. 2 films with visible light-photoactivation for the removal of microcystin-LR. Appl Catal Environ 2010, 99:378-387.
254. Pelaez M., Nolan N.T., Pillai S.C., Seery M.K., Falaras P., Kontos A.G., et al. A review on the visible light active titanium dioxide photocatalysts for environmental applications. Appl Catal Environ 2012, 125:331-349.
255. Pelaez M., Falaras P., Kontos A.G., de la Cruz A.A., O'Shea K., Dunlop P.S.M., et al. A comparative study on the removal of cylindrospermopsin and microcystins from water with NF-TiO2-P25 composite films with visible and UV-vis light photocatalytic activity. Appl Catal Environ 2012, 121-122:30-39.
256. Pelander A., Ojanperä I., Sivonen K., Himberg K., Waris M., Niinivaara K., et al. Screening for cyanobacterial toxins in bloom and strain samples by thin layer chromatography. Water Res 1996, 30:1464-1470.
257. Pelander A., Ojanperä I., Lahti K., Niinivaara K., Vuori E. Visual detection of cyanobacterial hepatotoxins by thin-layer chromatography and application to water analysis. Water Res 2000, 34:2643-2652.
258. Pendleton P., Schumann R., Wong S.H. Microcystin-LR adsorption by activated carbon. J Colloid Interface Sci 2001, 240:1-8.
259. Peterson H.G., Hrudey S.E., Cantin I.A., Perley T.R., Kenefick S.L. Physiological toxicity, cell membrane damage and the release of dissolved organic carbon and geosmin by Aphanizomenon flos-aquae after exposure to water treatment chemicals. Water Res 1995, 29:1515-1523.
260. Pieterse A.J.H., Cloot A. Algal cells and coagulation, flocculation and sedimentation processes. Water Sci Technol 1997, 36:111-118.
261. Pietsch J., Bornmann K., Schimdt W. Relevance of intra- and extracellular cyanotoxins for drinking water treatment. Acta Hydrochim Hydrobiol 2002, 30:7-15.
262. Pouria S., de Andrade A., Barbosa J., Cavalcanti R.L., Barreto V.T.S., Ward C.J., et al. Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 1998, 352:21-26.
263. Qiao R.P., Li N., Qi X.H., Wang Q.S., Zhuang Y.Y. Degradation of microcystin-RR by UV radiation in the presence of hydrogen peroxide. Toxicon 2005, 45:745-752.
264. Rapala J., Erkomaa K., Kukkonen J., Sivonen K., Lahti K. Detection of microcystins with protein phosphatase inhibition assay, high-performance liquid chromatography-UV detection and enzyme-linked immunosorbent assay: comparison of methods. Anal Chim Acta 2002, 466:213-231.
265. Rapala J., Issakainen J., Salmela J., Hoppu K., Lahti K., Lepistö L. Finland: the network of monitoring cyanobacteria and their toxins (1998-2004). Current approaches to cyanotoxin risk assessment, risk management and regulations in different countries 2005, 47-53. Umweltbundesamt, Berlin, Germany. I. Chorus (Ed.).
266. Rawn D.F.K., Lau B.P.Y., Niedzwiadek B., Lawrence J.F. Improved method for the determination of anatoxin-a and two of its metabolites in blue-green algae using liquid chromatography with fluorescence detection. J AOAC Int 2005, 88:1741-1747.
267. Rellán S., Osswald J., Saker M., Gago-Martinez A., Vasconcelos V. First detection of anatoxin-a in human and animal dietary supplements containing cyanobacteria. Food Chem Toxicol 2009, 47:2189-2195.
268. Robertson P.K.J., Robertson J.M.C., Bahnemann D.W. Removal of microorganisms and their chemical metabolites from water using semiconductor photocatalysis. J Hazard Mater 2012, 211-212:161-171.
269. Robillot C., Hennion M.C. Issues arising when interpreting the results of the protein phosphatase 2a inhibition assay for the monitoring of microcystins. Anal Chim Acta 2004, 512:339-346.
270. Rodríguez E., Onstad G.D., Kull T.P.J., Metcalf J.S., Acero J.L., von Gunten U. Oxidative elimination of cyanotoxins: comparison of ozone, chlorine, chlorine dioxide and permanganate. Water Res 2007, 41:3381-3393.
271. Rodríguez E., Sordo A., Metcalf J.S., Acero J.L. Kinetics of the oxidation of cylindrospermopsin and anatoxin-a with chlorine, monochloramine and permanganate. Water Res 2007, 41:2048-2056.
272. Rodríguez E.M., Acero J.L., Spoof L., Meriluoto J. Oxidation of MC-LR and -RR with chlorine and potassium permanganate: toxicity of the reaction products. Water Res 2008, 42:1744-1752.
273. Rodríguez P., Alfonso A., Botana A.M., Vieytes M.R., Botana L.M. Comparative analysis of pre- and post-column oxidation methods for detection of paralytic shellfish toxins. Toxicon 2010, 56:448-457.
274. Rogers E.H., Zehr R.D., Gage M.I., Humpage A.R., Falconer I.R., Marr M., et al. The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation. Toxicon 2007, 49:855-864.
275. Rositano J., Nicholson B.C., Pieronne P. Destruction of cyanobacterial toxins by ozone. Ozone Sci Eng 1998, 20:223-238.
276. Rositano J., Newcombe G., Nicholson B., Sztajnbok P. Ozonation of NOM and algal toxins in four treated waters. Water Res 2001, 35:23-32.
277. Rücker J., Stüken A., Nixdorf B., Fastner J., Chorus I., Wiedner C. Concentrations of particulate and dissolved cylindrospermopsin in 21 Aphanizomenon-dominated temperate lakes. Toxicon 2007, 50:800-809.
278. Saker M.L., Thomas A.D., Norton J.H. Cattle mortality attributed to the toxic cyanobacterium Cylindrospermopsis raciborskii in an outback region of north Queensland. Environ Toxicol 1999, 14:179-182.
279. Saker M.L., Jungblut A.D., Neilan B.A., Rawn D.F.K., Vasconcelos V.M. Detection of microcystin synthetase genes in health food supplements containing the freshwater cyanobacterium Aphanizomenon flos-aquae. Toxicon 2005, 46:555-562.
280. Sano T., Nohara K., Shiraishi F., Kaya K. A method for micro-determination of total microcystin content in waterblooms of cyanobacteria (blue-green algae). Int J Environ Anal Chem 1992, 49:163-170.
281. Sarazin G., Quiblier-Llobéras C., Bertru G., Brient L., Vezie C., Bernard C., et al. First assessment of the toxical risk associated with fresh water cyanobacteria in France: the EFFLOCYA research program. J Water Sci 2002, 15:315-326.
282. Schembri M.A., Neilan B.A., Saint C.P. Identification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskii. Environ Toxicol 2001, 16:413-421.
283. Senogles P., Scott A., Shaw G. Effciency of UV treatment with and without titanium dioxide for the degradation of the cyanotoxin cylindrospermopsin. Resour Environ Biotechnol 2000, 3:71-85.
284. Senogles P., Shaw G., Smith M., Norris R., Chiswell R., Mueller J., et al. Degradation of the cyanobacterial toxin cylindrospermopsin, from cylindrospermopsis raciborskii, by chlorination. Toxicon 2000, 38:1203-1213.
285. Senogles P.-J., Scott J.A., Shaw G., Stratton H. Photocatalytic degradation of the cyanotoxin cylindrospermopsin, using titanium dioxide and UV irradiation. Water Res 2001, 35:1245-1255.
286. Senogles-Derham P.-J., Seawright A., Shaw G., Wickramisingh W., Shahin M. Toxicological aspects of treatment to remove cyanobacterial toxins from drinking water determined using the heterozygous p53 transgenic mouse model. Toxicon 2003, 41:979-988.
287. Sevilla E., Martin-Luna B., Vela L., Bes M.T., Fillat M.F., Peleato M.L. Iron availability affects mcyD expression and microcystin-LR synthesis in Microcystis aeruginosa PCC7806. Environ Microbiol 2008, 10:2476-2483.
288. Shan Y., Shi X., Dou A., Zou C., He H., Yang Q., et al. A fully automated system with on-line micro solid-phase extraction combined with capillary liquid chromatography-tandem mass spectrometry for high throughput analysis of microcystins and nodularin-R in tap water and lake water. J Chromatogr A 2011, 1218:1743-1748.
289. Sharma V.K., Triantis T.M., Antoniou M.G., He X., Pelaez M., Han C., et al. Destruction of microcystins by conventional and advanced oxidation processes: a review. Sep Purif Technol 2012, 91:3-17.
290. Shawwa A.R., Smith D.W. Kinetics of microcystin-LR oxidation by ozone. Ozone-Sci Eng 2001, 23:161-170.
291. Shephard G.S., Stockenström S., De Villiers D., Engelbrecht W.J., Sydenham E.W., Wessels G.F.S. Photocatalytic degradation of cyanobacterial microcystin toxins in water. Toxicon 1998, 36:1895-1901.
292. Shephard G.S., Stockenström S., de Villiers D., Engelbrecht W.J., Wessels G.F.S. Degradation of microcystin toxins in a falling film photocatalytic reactor with immobilized titanium dioxide catalyst. Water Res 2002, 36:140-146.
293. Shi H.-X., Qu J.-H., Wang A.-M., Ge J.-T. Degradation of microcystins in aqueous solution with in situ electrogenerated active chlorine. Chemosphere 2005, 60:326-333.
294. Shi H., Ding J., Timmons T., Adams C. pH effects on the adsorption of saxitoxin by powdered activated carbon. Harmful Algae 2012, 19:61-67.
295. Sivonen K., Jones G. Cyanobacterial toxins. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management 1999, 41-111. E & FN Spon, London, UK. I. Chorus, J. Bartram (Eds.).
296. Soares R.M., Yuan M., Servaites J.C., Delgado A., Magalhães V.F., Hilborn E.D., et al. Sublethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro, Brazil. Environ Toxicol 2006, 21:95-103.
297. Sorlini S., Collivignarelli C. Microcystin-LR removal from drinking water supplies by chemical oxidation and activated carbon adsorption. J Water Supply Res Technol-AQUA 2011, 60:403-411.
298. Spoof L., Meriluoto J. Rapid separation of microcystins and nodularin using a monolithic silica C18 column. J Chromatogr A 2002, 947:237-245.
299. Spoof L., Karlsson K., Meriluoto J. High-performance liquid chromatographic separation of microcystins and nodularin, cyanobacterial peptide toxins, on C18 and amide C16 sorbents. J Chromatogr A 2001, 909:225-236.
300. Spoof L., Vesterkvist P., Lindholm T., Meriluoto J. Screening for cyanobacterial hepatotoxins, microcystins and nodularin in environmental water samples by reversed-phase liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr A 2003, 1020:105-119.
301. Spoof L., Neffling M.R., Meriluoto J. Separation of microcystins and nodularins by ultra-performance liquid chromatography. J Chromatogr B 2009, 877:3822-3830.
302. Spoof L., Neffling M.R., Meriluoto J. Fast separation of microcystins and nodularins on narrow-bore reversed-phase columns coupled to a conventional HPLC system. Toxicon 2010, 55:954-964.
303. Steffensen D.A. Economic cost of cyanobacterial blooms. Cyanobacterial harmful algal blooms: state of the science and research needs 2008, 855-865. Springer, New York, USA. K.H. Hudnell (Ed.).
304. Stewart I., Seawright A.A., Shaw G.R. Cyanobacterial poisoning in livestock, wild mammals and birds-an overview. Cyanobacterial harmful algal blooms: state of the science and research needs 2008, 613-637. Springer, New York, USA. K.H. Hudnell (Ed.).
305. Stirling D.J., Quilliam M.A. First report of the cyanobacterial toxin cylindrospermopsin in New Zealand. Toxicon 2001, 39:1219-1222.
306. Sun F., Pei H.-Y., Hu W.-R., Ma C.-X. The lysis of Microcystis aeruginosa in AlCl3 coagulation and sedimentation processes. Chem Eng J 2012, 193-194:196-202.
307. Teixeira M.R., Rosa M.J. Microcystins removal by nanofiltration membranes. Sep Purif Technol 2005, 46:192-201.
308. Teixeira M.R., Rosa M.J. Comparing dissolved air flotation and conventional sedimentation to remove cyanobacterial cells of Microcystis aeruginosa: part I: the key operating conditions. Sep Purif Technol 2006, 52:84-94.
309. Teixeira M.R., Rosa M.J. Neurotoxic and hepatotoxic cyanotoxins removal by nanofiltration. Water Res 2006, 40:2837-2846.
310. Teixeira M.R., Rosa M.J. Integration of dissolved gas flotation and nanofiltration for M. Aeruginosa and associated microcystins removal. Water Res 2006, 40:3612-3620.
311. Teixeira MdG, Costa MdC, de Carvalho V.L., Pereira MdS, Hage E. Gastroenteritis epidemic in the area of the Itaparica Dam, Bahia, Brazil. Bull Pan Am Health Organ 1993, 27:244-253.
312. Teixeira M.R., Sousa V., Rosa M.J. Investigating dissolved air flotation performance with cyanobacterial cells and filaments. Water Res 2010, 44:3337-3344.
313. Tillett D., Dittmann E., Erhard M., von Dohren H., Borner T., Neilan B.A. Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system. Chem Biol 2000, 7:753-764.
314. Tillmanns A.R., Pick F.R., Aranda-Rodriguez R. Sampling and analysis of microcystins: implications for the development of standardized methods. Environ Toxicol 2007, 22:132-143.
315. Tong P., Zhang L., He Y., Tang S., Cheng J., Chen G. Analysis of microcystins by capillary zone electrophoresis coupling with electrospray ionization mass spectrometry. Talanta 2010, 82:1101-1106.
316. Tonk L., Visser P.M., Christiansen G., Dittmann E., Snelder E., Wiedner C., et al. The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity. Appl Environ Microbiol 2005, 71:5177-5181.
317. Törökné A., Asztalos M., Bánkiné M., Bickel H., Borbély G., Carmeli S., et al. Interlaboratory comparison trial on cylindrospermopsin measurement. Anal Biochem 2004, 332:280-284.
318. Triantis T., Tsimeli K., Kaloudis T., Thanassoulias N., Lytras E., Hiskia A. Development of an integrated laboratory system for the monitoring of cyanotoxins in surface and drinking waters. Toxicon 2010, 55:979-989.
319. Tsuji K., Watanuki T., Kondo F., Watanabe M.F., Suzuki S., Nakazawa H., et al. Stability of microcystins from cyanobacteria-ii. Effect of UV light on decomposition and isomerization. Toxicon 1995, 33:1619-1631.
320. Tsuji K., Watanuki T., Kondo F., Watanabe M.F., Nakazawa H., Suzuki M., et al. Stability of microcystins from cyanobacteria-iv. Effect of chlorination on decomposition. Toxicon 1997, 35:1033-1041.
321. Turner A., Hatfield R., Rapkova M., Higman W., Algoet M., Suarez-Isla B., et al. Comparison of AOAC 2005.06 LC official method with other methodologies for the quantitation of paralytic shellfish poisoning toxins in UK shellfish species. Anal Bioanal Chem 2011, 399:1257-1270.
322. Twist H., Codd G.A. Degradation of the cyanobacterial hepatotoxin, nodularin, under light and dark conditions. FEMS Microbiol Lett 1997, 151:83-88.
323. US EPA Impaired waters and total maximum daily loads [(updated March 6th, 2012; visited May 2nd, 2012)]. http://water.epa.gov/lawsregs/lawsguidance/cwa/tmdl/index.cfm.
324. US EPA Clean Water Act § 303(d) List of Impaired Waters [(updated May 2nd, 2012; visited May 2nd, 2012)]. http://yosemite.epa.gov/r10/water.nsf/91c5465a73ff369c882564f4007d6db0/250e807b6bf513f1882567dd0061e347!OpenDocument.
325. van Apeldoorn M.E., van Egmond H.P., Speijers G.J.A., Bakker G.J.I. Toxins of cyanobacteria. Mol Nutr Food Res 2007, 51:7-60.
326. Vasas G., Gáspár A., Páger C., Surányi G., Máthé C., Hamvas M.M., et al. Analysis of cyanobacterial toxins (anatoxin-a, cylindrospermopsin, microcystin-LR) by capillary electrophoresis. Electrophoresis 2004, 25:108-115.
327. Velzeboer R., Drikas M., Donati C., Burch M., Steffensen D. Release of geosmin by Anabaena circinalis following treatment with aluminium sulphate. Water Sci Technol 1995, 31:187-194.
328. Viaggiu E., Melchiorre S., Volpi F., Di Corcia A., Mancini R., Garibaldi L., et al. Anatoxin-a toxin in the cyanobacterium Planktothrix rubescens from a fishing pond in northern Italy. Environ Toxicol 2004, 19:191-197.
329. Villatte F., Schulze H., Schmid R.D., Bachmann T.T. A disposable acetylcholinesterase-based electrode biosensor to detect anatoxin-a(s) in water. Anal Bioanal Chem 2002, 372:322-326.
330. Vuori E., Pelander A., Himberg K., Waris M., Niinivaara K. Removal of nodularin from brackish water with reverse osmosis or vacuum distillation. Water Res 1997, 31:2922-2924.
331. Wang H., Ho L., Lewis D.M., Brookes J.D., Newcombe G. Discriminating and assessing adsorption and biodegradation removal mechanisms during granular activated carbon filtration of microcystin toxins. Water Res 2007, 41:4262-4270.
332. Wang J., Pang X., Ge F., Ma Z. An ultra-performance liquid chromatography-tandem mass spectrometry method for determination of microcystins occurrence in surface water in Zhejiang province, China. Toxicon 2007, 49:1120-1128.
333. Ward C.J., Beattie K.A., Lee E.Y.C., Codd G.A. Colorimetric protein phosphatase inhibition assay of laboratory strains and natural blooms of cyanobacteria: comparisons with high-performance liquid chromatographic analysis for microcystins. FEMS Microbiol Lett 1997, 153:465-473.
334. Warhurst A.M., Raggett S.L., McConnachie G.L., Pollard S.J., Chipofya V., Codd G.A. Adsorption of the cyanobacterial hepatotoxin microcystin-LR by a low-cost activated carbon from the seed husks of the pan-tropical tree, Moringa oleifera. Sci Total Environ 1997, 207:207-211.
335. Welker M., Bickel H., Fastner J. HPLC-PDA detection of cylindrospermopsin-opportunities and limits. Water Res 2002, 36:4659-4663.
336. Westrick J.A., Szlag D.C., Southwell B.J., Sinclair J. A review of cyanobacteria and cyanotoxins removal/inactivation in drinking water treatment. Anal Bioanal Chem 2010, 397:1705-1714.
337. WHO Guidelines for drinking-water quality. Addendum to volume 2, health criteria and other supporting information 1998, World Health Organization, Geneva. second ed.
338. Wiedner C., Rücker J., Brüggemann R., Nixdorf B. Climate change affects timing and size of populations of an invasive cyanobacterium in temperate regions. Oecologia 2007, 152:473-484.
339. Wirsing B., Flury T., Wiedner C., Neumann U., Weckesser J. Estimation of the microcystin content in cyanobacterial field samples from German lakes using the colorimetric protein-phosphatase inhibition assay and RP-HPLC. Environ Toxicol 1999, 14:23-29.
340. Wong C.K., Hung P., Ng E.A.L., Lee K.L.H., Wong G.T.C., Kam K.M. Operational application of a rapid antibody-based detection assay for first line screening of paralytic shellfish toxins in shellfish. Harmful Algae 2010, 9:636-646.
341. Wood S.A., Selwood A.I., Rueckert A., Holland P.T., Milne J.R., Smith K.F., et al. First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand. Toxicon 2007, 50:292-301.
342. Xagoraraki I., Harrington G.W., Zulliger K., Zeier B., Krick W., Karner D.A., et al. Inactivation kinetics of the cyanobacterial toxin microcystin-LR by free chlorine. J Environ Eng 2006, 132:818-823.
343. Xia Y., Deng J., Jiang L. Simple and highly sensitive detection of hepatotoxin microcystin-LR via colorimetric variation based on polydiacetylene vesicles. Sens Actuators B: Chem 2010, 145:713-719.
344. Yan H., Wang J., Chen J., Wei W., Wang H., Wang H. Characterization of the first step involved in enzymatic pathway for microcystin-RR biodegraded by Sphingopyxis sp. USTB-05. Chemosphere 2012, 87:12-18.
345. 2. Res Chem Intermed 2011, 37:47-60.
346. Yuan M., Carmichael W.W. Detection and analysis of the cyanobacterial peptide hepatotoxins microcystin and nodularin using SELDI-TOF mass spectrometry. Toxicon 2004, 44:561-570.
347. + ratio. J Am Soc Mass Spectrom 1999, 10:1138-1151.
348. Yuan M., Carmichael W.W., Hilborn E.D. Microcystin analysis in human sera and liver from human fatalities in Caruaru, Brazil 1996. Toxicon 2006, 48:627-640.
349. Zamyadi A., Ho L., Newcombe G., Daly R.I., Burch M., Baker P., et al. Release and oxidation of cell-bound saxitoxins during chlorination of Anabaena circinalis cells. Environ Sci Technol 2010, 44:9055-9061.
350. Zamyadi A., Ho L., Newcombe G., Bustamante H., Prévost M. Fate of toxic cyanobacterial cells and disinfection by-products formation after chlorination. Water Res 2012, 46:1524-1535.
351. Zamyadi A., Fan Y., Daly R.I., Prévost M. Chlorination of Microcystis aeruginosa: toxin release and oxidation, cellular chlorine demand and disinfection by-products formation. Water Res 2013, 47:1080-1090.
352. Zhang L., Ping X., Yang Z. Determination of microcystin-LR in surface water using high-performance liquid chromatography/tandem electrospray ionization mass detector. Talanta 2004, 62:191-198.
353. Zhou X., Meng Y., Ma H., Tao G. Method for determination of microcystin-leucine-arginine in water samples based on the quenching of the fluorescence of bioconjugates between CdSe/CdS quantum dots and microcystin-leucine-arginine antibody. Microchim Acta 2011, 173:259-266.
354. Zong W., Sun F., Sun X. Evaluation on the generative mechanism and biological toxicity of microcystin-LR disinfection by-products formed by chlorination. J Hazard Mater 2013, 252-253:293-299.
355. Zotou A., Jefferies T.M., Brough P.A., Gallagher T. Determination of anatoxin-a and homoanatoxin in blue-green-algal extracts by high-performence liquid-chromatography and gas-chromatography mass-spectrometry. Analyst 1993, 118:753-758.