Confirmation of anatoxin-a(s), in the cyanobacterium Anabaena lemmermannii, as the cause of bird kills in Danish lakes

Toxicon

Volumn 35, Issue 11, 1997, Pages 1645-1648

  Onodera, Hideyuki ^a   Oshima, Yasukatsu ^a   Henriksen, Peter ^b   Yasumoto, Takeshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANATOXIN A;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CHOLINESTERASE INHIBITION; CIRCULAR DICHROISM; CYANOBACTERIUM; DENMARK; DRUG IDENTIFICATION; DRUG ISOLATION; LAKE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ANABAENA; ANIMALS; BACTERIAL TOXINS; BIRDS; DENMARK; MALE; MARINE TOXINS; MICE; MICROCYSTINS; NEUROTOXINS;

ANABAENA FLOS-AQUAE; ANABAENA LEMMERMANNII; ANIMALIA; AVES; CYANOBACTERIA; FLOS;

EID: 0030779288     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(97)00038-X     Document Type: Article

References (15)

1. Alam, M., Ikawa, M., Sasner, J. J. Jr and Sawyer, P. J. (1973) Purification of Aphanizomenon flos-aquae toxin and its chemical and physiological properties. Toxicon 11, 65-72.
2. Carmichael, W. W. (1994) The toxins of cyanobacteria. Scientific American 270, 78-86.
3. Carmichael, W. W. and Gorham, P. R. (1978) Anatoxins from clones of Anabaena flos-aquae isolated from lakes of western Canada. Mitteilungen. Internationale Vereinigung für Theoretische und Angewandte Limnologie 21, 285-295.
4. Carmichael, W. W., Mahmood, N. A. and Hyde, E. G. (1990) Natural toxins from cyanobacteria (blue - green algae). In Marine Toxins: ACS Symposium Series 418, ed. S. Hall and G. Strichartz, pp. 87-106. American Chemical Society, Washington, DC.
5. Cook, W. O., Beasley, V. R., Lovell, R. A., Dahlem, A. M., Hooser, S. B., Mahmood, N. A. and Carmichael, W. W. (1989) Consistent inhibition of peripheral cholinesterases by neurotoxins from the freshwater cyanobacterium Anabaena flos-aquae: studies of ducks, swine, mice and a steer. Environmental Toxicology and Chemistry 8, 915-922.
6. Devlin, J. P., Edwards, O. E., Gorham, P. R., Hunter, N. R., Pike, R. K. and Stavric, B. (1977) Anatoxin-a, a toxic alkaloid from Anabaena flos-aquae NRC 44-1. Canadian Journal of Chemistry 55, 1367-1371.
7. Harada, K.-I., Kimura, Y., Ogawa, K., Suzuki, M., Dahlem, A. M., Beasley, V. R. and Carmichael, W. W. (1989) A new procedure for the analysis and purification of naturally occurring anatoxin-a from the blue - green alga Anabaena flos-aquae. Toxicon 27, 1289-1296.
8. Henriksen, P., Carmichael, W. W., An, J. and Moestrup, Ø. (1997) Detection of an anatoxin-a(s)-like anticholinesterase in natural blooms and cultures of cyanobacteria/blue - green algae from Danish lakes and in the stomach contents of poisoned birds. Toxicon (submitted).
9. Humpage, A. R., Rositano, J., Bretag, A. H., Brown, R., Baker, P. D., Nicholson, B. C. and Steffensen, D. A. (1994) Paralytic shellfish poisons from Australian blue - green algal (cyanobacterial) blooms. Australian Journal of Marine and Freshwater Research 45, 761-771.
10. Jackim, E. and Gentile, J. (1968) Toxins of a blue - green alga: similarity to saxitoxin. Science 162, 915-916.
11. Mahmood, N. A. and Carmichael, W. W. (1986) The pharmacology of anatoxin-a(s), a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17. Toxicon 24, 425-434.
12. Mahmood, N. A., Carmichael, W. W. and Pfahler, D. (1988) Anticholinesterase poisonings in dogs from a cyanobacterial (blue - green algae) bloom dominated by Anabaena flos-aquae. American Journal of Veterinary Research 49, 500-503.
13. Matsunaga, S., Moore, R. E., Niemczura, W. P. and Carmichael, W. W. (1989) Anatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquae. Journal of the American Chemistry Society 111, 8021-8023.
14. Onodera, H., Oshima, Y., Watanabe, M. F., Watanabe, M., Bolch, C. J., Blackburn, S. and Yasumoto, T. (1996) Screening of paralytic shellfish toxins in freshwater cyanobacteria and chemical confirmation of the toxins in cultured Anabaena circinalis from Australia. In Harmful and Toxic Algal Blooms, ed. T. Yasumoto, Y. Oshima and Y. Fukuyo, pp. 563-566. IOC-UNESCO, Paris.
15. Oshima, Y. (1995) Postcolumn derivatization liquid Chromatographic method for paralytic shellfish toxins. Journal of the AOAC International 78, 528-532.