The genome sequence of the cyanobacterium Oscillatoria sp. PCC 6506 reveals several gene clusters responsible for the biosynthesis of toxins and secondary metabolites

Journal of Bacteriology

Volumn 192, Issue 19, 2010, Pages 5264-5265

  Méjean, Annick ^a,b   Mazmouz, Rabia ^a,b   Mann, Stéphane ^a   Calteau, Alexandra ^c   Médigue, Claudine ^c   Ploux, Olivier ^a  

^a CNRS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Genoscope   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANATOXIN A; CYLINDROSPERMOPSIN; CYTOTOXIN; HOMOANATOXIN A; NEUROTOXIN; UNCLASSIFIED DRUG; BACTERIAL TOXIN;

ARTICLE; CYANOBACTERIUM; GENE CLUSTER; GENE SEQUENCE; METABOLITE; NONHUMAN; OSCILLATORIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TOXIN SYNTHESIS; UNINDEXED SEQUENCE; BACTERIAL GENOME; GENETICS; MOLECULAR GENETICS; MULTIGENE FAMILY; PHYSIOLOGY;

OSCILLATORIA SP. PCC 6506;

BACTERIAL TOXINS; GENOME, BACTERIAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OSCILLATORIA;

EID: 77957373555     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00704-10     Document Type: Article

References (18)

1. Burns, B. P., M. L. Saker, M. C. Moffitt, and B. A. Neilan. 2004. Molecular detection of genes responsible for cyanobacterial toxin production in the genera Microcystis, Nodularia, and Cylindrospermopsis. Methods Mol. Biol. 268:213-222.
2. Cadel-Six, S., C. Peyraud-Thomas, L. Brient, N. Tandeau de Marsac, R. Rippka, and A. Méjean. 2007. Different genotypes of anatoxin-producing cyanobacteria coexist in the Tarn River, France. Appl. Environ. Microbiol. 73:7605-7614.
3. Cadel-Six, S., I. Iteman, C. Peyraud-Thomas, S. Mann, O. Ploux, and A. Méjean. 2009. Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria. Appl. Environ. Microbiol. 75:4909-4912.
4. Castenholz, R. W., R. Rippka, M. Herdman, and A. Wilmotte. 2001. Subsection III, order Oscillatoriales (Elenkin 1934), p. 539-562. In D. R. Boone, R. W. Castenholz, and G. M. Garrity (ed.), Bergey's manual of systematic bacteriology, 2nd ed., vol. 1. The Archaea and the deeply branching and phototrophic bacteria. Springer Verlag, New York, NY.
5. Chorus, I., and J. Bartram (ed.). 1999. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management. Spon Press, London, United Kingdom.
6. Herdman, M., I. Iteman, and R. Rippka. 2005. Catalogue of cyanobacterial strains, 2nd ed. Institut Pasteur, Paris, France.
7. Kalaitzis, J. A., F. M. Lauro, and B. A. Neilan. 2009. Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways. Nat. Prod. Rep. 26:1447-1465.
8. Ludwig, M., R. Schulz-Friedrich, and J. Appel. 2006. Occurrence of hydrogenases in cyanobacteria and anoxygenic photosynthetic bacteria: implications for the phylogenetic origin of cyanobacterial and algal hydrogenases. J. Mol. Evol. 63:758-768.
9. Mazmouz, R., F. Chapuis-Hugon, S. Mann, V. Pichon, A. Méjean, and O. Ploux. 2010. Biosynthesis of cylindrospermopsin and 7-epicylindrospermopsin in Oscillatoria PCC 6506; identification of the gene cluster and toxin analysis. Appl. Environ. Microbiol. 76:4943-4949.
10. Méjean, A., S. Mann, G. Vassiliadis, B. Lombard, D. Loew, and O. Ploux. 2010. In vitro reconstitution of the first steps of anatoxin-a biosynthesis in Oscillatoria PCC 6506: from free L-proline to acyl carrier protein bound dehydroproline. Biochemistry 49:103-113.
11. Méjean, A., S. Mann, T. Maldiney, G. Vassiliadis, O. Lequin, and O. Ploux. 2009. Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline. J. Am. Chem. Soc. 131: 7512-7513.
12. Mihali, T. K., R. Kellmann, J. Muenchhoff, K. D. Barrow, and B. A. Neilan. 2008. Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis. Appl. Environ. Microbiol. 74:716-722.
13. Mlouka, A., K. Comte, A. M. Castets, C. Bouchier, and N. Tandeau de Marsac. 2004. The gas vesicle gene cluster from Microcystis aeruginosa and DNA rearrangements that lead to loss of cell buoyancy. J. Bacteriol. 186: 2355-2365.
14. Rippka, R. 1988. Isolation and purification of cyanobacteria. Methods Enzymol. 167:3-27.
15. Tamagnini, P., E. Leitão, P. Oliveira, D. Ferreira, F. Pinto, D. J. Harris, T. Heidorn, and P. Lindblad. 2007. Cyanobacterial hydrogenases: diversity, regulation and applications. FEMS Microbiol. Rev. 31:692-720.
16. Vallenet, D., L. Labarre, Z. Rouy, V. Barbe, S. Bocs, S. Cruveiller, A. Lajus, G. Pascal, C. Scarpelli, and C. Médigue. 2006. MaGe: a microbial genome annotation system supported by synteny results. Nucleic Acids Res. 34: 53-65.
17. van Apeldoorn, M. E., H. P. van Egmond, G. J. Speijers, and G. J. Bakker. 2007. Toxins of cyanobacteria. Mol. Nutr. Food Res. 51:7-60.
18. Wonnacott, S., and T. Gallagher. 2006. The chemistry and pharmacology of anatoxin-a and related homotropanes with respect to nicotinic acetylcholine receptors. Mar. Drugs 4:228-254.