Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria

Applied and Environmental Microbiology

Volumn 75, Issue 14, 2009, Pages 4909-4912

  Cadel Six, Sabrina ^a   Iteman, Isabelle ^a   Peyraud Thomas, Caroline ^a   Mann, Stéphane ^b   Ploux, Olivier ^b   Méjean, Annick ^a,b,c  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANATOXIN; CODING SEQUENCES; OSCILLATORIA; POLYKETIDE SYNTHASE;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; STRAIN;

ENZYMES;

ANATOXIN A; BACTERIAL TOXIN; HOMOANATOXIN A; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

CYANOBACTERIUM; ENZYME ACTIVITY; GENOME; IDENTIFICATION METHOD; TOXIN;

ARTICLE; BACTERIAL GENOME; BACTERIAL STRAIN; CYANOBACTERIUM; GENE IDENTIFICATION; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATORIA;

BACTERIAL TOXINS; BICYCLO COMPOUNDS, HETEROCYCLIC; DNA, BACTERIAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OSCILLATORIA; POLYKETIDE SYNTHASES; SEQUENCE ANALYSIS, DNA; TROPANES;

CYANOBACTERIA; OSCILLATORIA; OSCILLATORIA SP.;

EID: 67650497679     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02478-08     Document Type: Article

References (22)

1. Aráoz, R., H. O. Nghiêm, R. Rippka, N. Palibroda, N. Tandeau de Marsac, and M. Herdman. 2005. Neurotoxins in axenic oscillatorian cyanobacteria: coexistence of anatoxin-a and homoanatoxin-a determined by ligand-binding assay and GC/MS. Microbiology 151:1263-1273.
2. Cadel-Six, S., C. Peyraud-Thomas, L. Brient, N. Tandeau de Marsac, R. Rippka, and A. Méjean. 2007. Different genotypes of anatoxin-producing cyanobacteria coexist in the Tarn River, France. Appl. Environ. Microbiol. 73:7605-7614.
3. Carmichael, W. W., D. F. Biggs, and M. A. Peterson. 1979. Pharmacology of anatoxin-a, produced by the freshwater cyanophyte Anabaena flos-aquae NRC-44-1. Toxicon 17:229-236.
4. Chorus, I., and J. Bartram (ed.). 1999. Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management. Spon Press, London, United Kingdom.
5. Donadio, S., P. Monciardini, and M. Sosio. 2007. Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat. Prod. Rep. 24:1073-1109.
6. Edwards, C., K. Beattie, C. Scrimgeour, and G. Codd. 1992. Identification of anatoxin-a in benthic cyanobacteria (blue-green algae) and in associated dog poisoning at Loch Insh, Scotland. Toxicon 30:1165-1175.
7. Gugger, M., S. Lenoir, C. Berger, A. Ledreux, J. C. Druart, J. F. Humbert, C. Guette, and C. Bernard. 2005. First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 45:919-928.
8. Gunn, G. J., A. G. Rafferty, G. C. Rafferty, N. Cockburn, C. Edwards, K. A. Beattie, and G. A. Codd. 1992. Fatal canine neurotoxicosis attributed to blue-green algae (cyanobacteria). Vet. Rec. 130:301-302.
9. Hemscheidt, T., J. Rapala, K. Sivonen, and O. M. Skulberg. 1995. Biosynthesis of anatoxin-a in Anabaena flos-aquae and homoanatoxin-a in Oscillatoria formosa. J. Chem. Soc. Chem. Commun. 13:1361-1362.
10. Herdman, M., I. Iteman, and R. Rippka. 2005. Catalogue of cyanobacterial strains, 2nd ed. Institut Pasteur, Paris, France.
11. Mihali, T. K., R. Kellmann, J. Muenchhoff, K. D. Barrow, and B. A. Neilan. 2008. Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis. Appl. Environ. Microbiol. 74:716-722.
12. Mlouka, A., K. Comte, A. M. Castets, C. Bouchier, and N. Tandeau de Marsac. 2004. The gas vesicle gene cluster from Microcystis aeruginosa and DNA rearrangements that lead to loss of cell buoyancy. J. Bacteriol. 186: 2355-2365.
13. Moffitt, M. C., and B. A. Neilan. 2001. On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genus Nodularia. FEMS Microbiol. Lett. 196:207-214.
14. Moffitt, M. C., and B. A. Neilan. 2003. Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations. J. Mol. Evol. 56:446-457.
15. Pearson, L. A., and B. A. Neilan. 2008. The molecular genetics of cyanobacterial toxicity as a basis for monitoring water quality and public health risk. Curr. Opin. Biotechnol. 19:281-288.
16. Rippka, R. 1988. Isolation and purification of cyanobacteria. Methods Enzymol. 167:3-27.
17. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. Siebert, P. D., A. Chenchik, D. E. Kellogg, K. A. Lukyanov, and S. A. Lukyanov. 1995. An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res. 23:1087-1088.
19. Sivonen, K., K. Himberg, R. Luukkainen, S. I. Niemelä, G. K. Poon, and G. A. Codd. 1989. Preliminary characterization of neurotoxic cyanobacteria blooms and strains from Finland. Toxic. Assess. 4:339-352.
20. van Apeldoorn, M. E., H. P. van Egmond, G. J. Speijers, and G. J. Bakker. 2007. Toxins of cyanobacteria. Mol. Nutr. Food Res. 51:7-60.
21. Wonnacott, S., and T. Gallagher. 2006. The chemistry and pharmacology of anatoxin-a and related homotropanes with respect to nicotinic acetylcholine receptors. Mar. Drugs 4:228-254.
22. Wood, S. A., A. I. Selwood, A. Rueckert, P. T. Holland, J. R. Milne, K. F. Smith, B. Smits, L. F. Watts, and C. S. Cary. 2007. First report of homo-anatoxin-a and associated dog neurotoxicosis in New Zealand. Toxicon 50:292-301.