Reversed-phase HPLC/FD method for the quantitative analysis of the neurotoxin BMAA (β-N-methylamino-l-alanine) in cyanobacteria

Toxicon

Volumn 59, Issue 3, 2012, Pages 379-384

  Cervantes Cianca, R C ^a,b   Baptista, M S ^a   Da Silva, Luís Pinto ^c   Lopes, V R ^a,c   Vasconcelos, V M ^a,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF VIGO   (Spain)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

AQC derivatization; BMAA; Cyanobacteria; Estuaries; Methanol elution

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; ACETONITRILE; HYDROCHLORIC ACID; METHANOL; TRICHLOROACETIC ACID;

ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYANOBACTERIUM; DERIVATIZATION; ELUTION; EXTRACTION; FLUORESCENCE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; NONHUMAN; PHASE SEPARATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROTEIN HYDROLYSIS; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRENGTH; TOXIN ANALYSIS;

AMINO ACIDS, DIAMINO; AMINOQUINOLINES; CARBAMATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; NEUROTOXINS; NOSTOC; WATER MICROBIOLOGY;

CYANOBACTERIA; NOSTOC;

EID: 84856069786     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2011.12.010     Document Type: Article

References (28)

1. Banack S.A., Johnson H.E., Cheng R., Cox P.A. Production of theneurotoxin BMAA by a marine cyanobacterium. Mar. Drugs 2007, 5:180-196.
2. Banack S.A., Caller T., Stommel E.W. The cyanobacteria derived toxin beta-N-methylamino-l-alanine and amyotrophic lateral sclerosis. Toxins 2010, 2:2837-2850.
3. Banack S.A.S.A., Downing T.G., Spácil Z., Purdie E.L., Metcalf J.S., Downing S., Esterhuizen M., Codd G.A., Cox P.A. Distinguishing the cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) from its structural isomer 2,4-diaminobutyric acid (2,4-DAB). Toxicon 2010, 56(6):868-879.
4. Bartolomeo M.P., Maisano F. Validation of a reversed phase-HPLC method for quantitative amino acid analysis. J. Biomol. Technol. 2006, 17:131-137.
5. Bidlingmeyer B.A., Cohen S.A., Tarvin T.L. Rapid analysis of amino acid using pre-column derivatization. J. Chromatogr. 1984, 336:93-104.
6. Cervantes C.R.C., Pallares M.A., Barbosa D.R., Vidal A.L., Leão M.J.M., Gago-Martínez A. Application of precolumn oxidation HPLC method with fluorescence detection to evaluate saxitoxin levels in discrete brain regions of rats. Toxicon 2007, 49(1):89-99.
7. Cervantes C.R., Duran B.R., Faro L., Vidal A.L., Gago M.A., Pallares A.M. Differential changes of neuroactive amino acids in samples obtained from discrete rat brain regions after systemic administration of saxitoxin. Neurochem. Int. 2009, 54(5-6):308-313.
8. Codd G.A., Metcalf J.S., Ward C.J., Beattie K.A., Poon G.K. Analysis of cyanobacterial toxins by physicochemical and biochemical methods. J. AOAC 2001, 84:1626-1635.
9. Cohen S.A., Michaud D.P. Synthesis of a fluorescent derivatizing reagent, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, and its application for the analysis of hydrolysate amino acids via high-performance liquid chromatography. Anal. Biochem. 1993, 211(2):279-287.
10. Cohen S.A., Strydom D.J. Comparison of amino acid analyses by phenylisothiocyanate and 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate precolumn derivatization. Anal. Biochem. 1994, 222(1):19-28.
11. Cohen S.A. Amino acid analysis using precolumnderivatizationwith 6-Aminoquinolyl-N-hydroxysuccinimidyl carbamate. Methods in Molecular Biology 2001, 39-47. Humana Press Inc., Totowa. C. Cooper, N. Packer, K. Williams (Eds.).
12. Cohen S.A. Quantitation of amino aids and amines by chromatography methods and protocols 2005, 246. Elsevier, B.V. I. Molnar-Perl (Ed.).
13. Cox P.A., Banack S.A., Murch S.J., Rasmussen U., Tien G., Bidigare R.R., Metcalfe J.S., Morrison L.F., Codd G.A., Bergman B. Diverse taxa ofcyanobacteriaproduce beta-N-methylamino-l-alanine, a neurotoxicaminoacid. Proc. Natl. Acad. Sci. USA. 2005, 102:5074-5078.
14. Eriksson J., Jonason S., Papaefthimiou D., Rasmussen U., Bergman B. Improving derivatization efficiency of BMAA utilizing AccQ-Tag in a complex cyanobacterial matrix. Amino Acids 2009, 36:43-48.
15. Esterhuizen M., Downing T.G. β-N-methylamino-l-alanine (BMAA) in novel South African cyanobacterial isolates. Ecotox. Environ. Safe. 2008, 71:309-313.
16. FDA Guidance for Industry Bioanalytical Method Validation 2001, U.S. Department of Health and Human Services.
17. González A., Herrador M.A. A practical guide to analytical method validation, including measurement uncertainty and accuracy profiles. Trends Anal. Chem. 2007, 26:227-238.
18. Heinrikson R.L., Meredith S.C. Amino acid analysis by reversed-phase high performance liquid chromatography: precolumn derivatization with phenylisothiocyanate. Anal. Biochem. 1984, 136:65-74.
19. Hou S., He H., Zhang W., Xie H., Zhang X. Determination of soil amino acids by high performance liquid chromatography-electro spray ionization-mass spectrometry derivatized with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Talanta 2009, 80(2):440-447.
20. Krüger T., Mönch B., Opnehäuser B., Luckas B. LC-MS/MS determination of the isomeric neurotoxins BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius. Toxicon 2010, 55:547-557.
21. Li A., Tia Z., Li J., Yu R., Banack S.A., Wang Z. Detection of the neurotoxin BMAA within cyanobacteria isolated from freshwater in China. Toxicon 2010, 55(5):947-953.
22. Liu H.J., Chang B.Y., Yan H.W., Yu F.H., Liu X.X. Determination of amino-acids in food and feed by derivatization with 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate and reversed phase liquid-chromatographic separation. J. AOAC Int. 1994, 78(3):736-744.
23. Lopes V., Fernández N., Martins R., Vasconcelos V. Primary screening of the bioactivity of brackish water cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos. Mar. Drugs 2010, 8:471-482.
24. Metcalf J.S., Codd G.A. Cyanobacteria, neurotoxins and water resources: are there implications for human neurodegenerative disease?. Amyotroph. Lateral Scler. 2009, 10:74-78.
25. Sarwar G., Botting H.G. Evaluation of liquid chromatographic analysis of nutritionally important amino acids in food and physiological samples. J. Chromatogr. 1993, 615(1):1-22.
26. Spácil Z., Eriksson J., Jonassons R., Rasmussen U., Llaq L.L., Bergman B. Analytical protocol for identification of BMAA and DAB in biological samples. Analyst 2010, 135(1):127-132.
27. Thompson M., Ellison S.L.R., Wood R. Harmonized guidelines for single-laboratory validation of methods of analysis (IUPAC technical report). Pure Appl. Chem. 2002, 47:835-855.
28. Wamorkar V., Manjunath S.Y., Varma M.M. Development and validation of UV spectroscopic method for determination of metoclopramide hydrochloride in bulk and tablet formulation. Int. J. Pharm. Pharmaceutic. Sci. 2007, 3(3):171-174.