Acid-sensing ion channels (ASICs): Therapeutic targets for neurological diseases and their regulation

BMB Reports

Volumn 46, Issue 6, 2013, Pages 295-304

  Kweon, Hae Jin ^a   Suh, Byung Chang ^a  

^a Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

Acid sensing ion channels; Acidosis; G protein coupled receptors; Modulation; Pain; pH

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL BLOCKING AGENT; G PROTEIN COUPLED RECEPTOR;

ARTICLE; CHEMISTRY; HUMAN; ISCHEMIA; METABOLISM; MULTIPLE SCLEROSIS; NERVE CELL; PATHOLOGY; PH; PHYSIOLOGY; SEIZURE; SIGNAL TRANSDUCTION;

ACID SENSING ION CHANNEL BLOCKERS; ACID SENSING ION CHANNELS; HUMANS; HYDROGEN-ION CONCENTRATION; ISCHEMIA; MULTIPLE SCLEROSIS; NEURONS; RECEPTORS, G-PROTEIN-COUPLED; SEIZURES; SIGNAL TRANSDUCTION;

EID: 84880597393     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2013.46.6.121     Document Type: Article

References (109)

1. Basbaum, A. I., Bautista, D. M., Scherrer, G. and Julius, D. (2009) Cellular and molecular mechanisms of pain. Cell 139, 267-284.
2. Steen, K. H., Issberner, W. and Reeh, P. W. (1995) Pain due to experimental acidosis in human skin: evidence for non-adapting nociceptor excitation. Neurosci. Lett. 199, 29-32.
3. Jones, N. G., Slater, R., Cadiou, H., McNaughton, P. and McMahon, S. B. (2004) Acid-induced pain and its modulation in humans. J. Neurosci. 24, 10974-10979.
4. Steen, K. H., Reeh, P. W., Anton, F. and Handwerker, H. O. (1992) Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J. Neurosci. 12, 86-95.
5. Smith, M. L., Von Hanwehr, R. and Siesjo, B. K. (1986) Changes in extraand intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats. J. Cereb. Blood Flow Metab. 6, 574-583.
6. Zha, X. M. (2013) Acid-sensing ion channels: trafficking and synaptic function. Mol. Brain 6, 1.
7. Wemmie, J. A., Price, M. P. and Welsh, M. J. (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends. Neurosci. 29, 578-586.
8. Miesenbock, G., De Angelis, D. A. and Rothman, J. E. (1998) Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394, 192-195.
9. Magnotta, V. A., Heo, H. Y., Dlouhy, B. J., Dahdaleh, N. S., Follmer, R. L., Thedens, D. R., Welsh, M. J. and Wemmie, J. A. (2012) Detecting activity-evoked pH changes in human brain. Proc. Natl. Acad. Sci. U. S. A. 109, 8270-8273.
10. Jasti, J., Furukawa, H., Gonzales, E. B. and Gouaux, E. (2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449, 316-323.
11. Noel, J., Salinas, M., Baron, A., Diochot, S., Deval, E. and Lingueglia, E. (2010) Current perspectives on acid-sensing ion channels: new advances and therapeutic implications. Exp. Rev. Clin. Pharmacol. 3, 331-346.
12. Lingueglia, E., de Weille, J. R., Bassilana, F., Heurteaux, C., Sakai, H., Waldmann, R. and Lazdunski, M. (1997) A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J. Biol. Chem. 272, 29778-29783.
13. Yu, Y., Chen, Z., Li, W. G., Cao, H., Feng, E. G., Yu, F., Liu, H., Jiang, H. and Xu, T. L. (2010) A nonproton ligand sensor in the acid-sensing ion channel. Neuron 68, 61-72.
14. Bohlen, C. J., Chesler, A. T., Sharif-Naeini, R., Medzihradszky, K. F., Zhou, S., King, D., Sanchez, E. E., Burlingame, A. L., Basbaum, A. I. and Julius, D. (2011) A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature 479, 410-414.
15. Li, W. G., Yu, Y., Huang, C., Cao, H. and Xu, T. L. (2011) Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride. J. Biol. Chem. 286, 42635-42646.
16. Sherwood, T. W., Lee, K. G., Gormley, M. G. and Askwith, C. C. (2011) Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J. Neurosci. 31, 9723-9734.
17. Hoagland, E. N., Sherwood, T. W., Lee, K. G., Walker, C. J. and Askwith, C. C. (2010) Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. J. Biol. Chem. 285, 41852-41862.
18. Yermolaieva, O., Leonard, A. S., Schnizler, M. K., Abboud, F. M. and Welsh, M. J. (2004) Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a. Proc. Natl. Acad. Sci. U.S.A. 101, 6752-6757.
19. Xiong, Z. G., Zhu, X. M., Chu, X. P., Minami, M., Hey, J., Wei, W. L., MacDonald, J. F., Wemmie, J. A., Price, M. P., Welsh, M. J. and Simon, R. P. (2004) Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 118, 687-698.
20. Samways, D. S., Harkins, A. B. and Egan, T. M. (2009) Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry. Cell Calcium 45, 319-325.
21. Pignataro, G., Simon, R. P. and Xiong, Z. G. (2007) Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 130, 151-158.
22. Gao, J., Duan, B., Wang, D. G., Deng, X. H., Zhang, G. Y., Xu, L. and Xu, T. L. (2005) Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 48, 635-646.
23. Chen, X. and Grunder, S. (2007) Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J. Physiol. 579, 657-670.
24. Escoubas, P., De Weille, J. R., Lecoq, A., Diochot, S., Waldmann, R., Champigny, G., Moinier, D., Menez, A. and Lazdunski, M. (2000) Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. J. Biol. Chem. 275, 25116-25121.
25. Diochot, S., Baron, A., Rash, L. D., Deval, E., Escoubas, P., Scarzello, S., Salinas, M. and Lazdunski, M. (2004) A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J. 23, 1516-1525.
26. Voilley, N., de Weille, J., Mamet, J. and Lazdunski, M. (2001) Nonsteroid Anti-Inflammatory Drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J. Neurosci. 21, 8026-8033.
27. Dube, G. R., Lehto, S. G., Breese, N. M., Baker, S. J., Wang, X., Matulenko, M. A., Honore, P., Stewart, A. O., Moreland, R. B. and Brioni, J. D. (2005) Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Pain 117, 88-96.
28. Diochot, S., Baron, A., Salinas, M., Douguet, D., Scarzello, S., Dabert-Gay, A. S., Debayle, D., Friend, V., Alloui, A., Lazdunski, M. and Lingueglia, E. (2012) Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature 490, 552-555.
29. +into heteromeric proton-gated channels sensitive to Gd. J. Biol. Chem. 275, 28519-28525.
30. Wang, W., Duan, B., Xu, H., Xu, L. and Xu, T. L. (2006) Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead. J. Biol Chem. 281, 2497-2505.
31. Staruschenko, A., Dorofeeva, N. A., Bolshakov, K. V. and Stockand, J. D. (2007) Subunit-dependent cadmium and nickel inhibition of acid-sensing ion channels. J. Neurobiol. 67, 97-107.
32. 2+ in cultured hypothalamic neurons of the rat. Neuroscience 145, 631-641.
33. 2+ ions. Brain Res. 900, 277-281.
34. Chu, X. P., Wemmie, J. A., Wang, W. Z., Zhu, X. M., Saugstad, J. A., Price, M. P., Simon, R. P. and Xiong, Z. G. (2004) Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J. Neurosci. 24, 8678-8689.
35. + are coactivators of acid-sensing ion channels. J. Biol. Chem. 276, 35361-35367.
36. + channel on ischemia-sensing neurons. Nat. Neurosci. 4, 869-870.
37. Smith, E. S., Cadiou, H. and McNaughton, P. A. (2007) Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience 145, 686-698.
38. Duan, B., Wang, Y. Z., Yang, T., Chu, X. P., Yu, Y., Huang, Y., Cao, H., Hansen, J., Simon, R. P., Zhu, M. X., Xiong, Z. G. and Xu, T. L. (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J. Neurosci. 31, 2101-2112.
39. Sherwood, T., Franke, R., Conneely, S., Joyner, J., Arumugan, P. and Askwith, C. (2009) Identification of protein domains that control proton and calcium sensitivity of ASIC1a. J. Biol. Chem. 284, 27899-27907.
40. Cadiou, H., Studer, M., Jones, N. G., Smith, E. S., Ballard, A., McMahon, S. B. and McNaughton, P. A. (2007) Modulation of acid-sensing ion channel activity by nitric oxide. J. Neurosci. 27, 13251-13260.
41. Askwith, C. C., Cheng, C., Ikuma, M., Benson, C., Price, M. P. and Welsh, M. J. (2000) Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 26, 133-141.
42. Sherwood, T. W. and Askwith, C. C. (2008) Endogenous arginine-phenylalanine-amide-related peptides alter steadystate desensitization of ASIC1a. J. Biol. Chem. 283, 1818-1830.
43. Alijevic, O. and Kellenberger, S. (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J. Biol. Chem. 287, 36059-36070.
44. Wemmie, J. A., Askwith, C. C., Lamani, E., Cassell, M. D., Freeman, J. H. Jr., and Welsh, M. J. (2003) Acid-sensing ion channel 1 is localized in brain Rregions with high synaptic density and contributes to fear conditioning. J. Neurosci. 23, 5496-5502.
45. de la Rosa, D. A., Krueger, S. R., Kolar, A., Shao, D., Fitzsimonds, R. M. and Canessa, C. M. (2003) Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J. Physiol. 546, 77-87.
46. Zha, X. M., Costa, V., Harding, A. M., Reznikov, L., Benson, C. J. and Welsh, M. J. (2009) ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J. Neurosci. 29, 8438-8446.
47. Wemmie, J. A., Chen, J., Askwith, C. C., Hruska-Hageman, A. M., Price, M. P., Nolan, B. C., Yoder, P. G., Lamani, E., Hoshi, T., Freeman, J. H.Jr., and Welsh, M. J. (2002) The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34, 463-477.
48. Wu, P. Y., Huang, Y. Y., Chen, C. C., Hsu, T. T., Lin, Y. C., Weng, J. Y., Chien, T. C., Cheng, I. H. and Lien, C. C. (2013) Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J. Neurosci. 33, 1828-1832.
49. Chu, X. P. and Xiong, Z. G. (2013) Acid-sensing ion channels in pathological conditions. Adv. Exp. Med. Biol. 961, 419-431.
50. Ahn, Y. J., Kim, H., Lim, H., Lee, M., Kang, Y., Moon, S., Kim, H. S. and Kim, H. H. (2012) AMP-activated protein kinase: implications on ischemic diseases. BMB Rep. 45, 489-495.
51. Choi, D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
52. Wahlgren, N. G. and Ahmed, N. (2004) Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approaches. Cerebrovasc Dis. 17(Suppl 1), 153-166.
53. Xiong, Z. G., Pignataro, G., Li, M., Chang, S. Y. and Simon, R. P. (2008) Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr. Opin. Pharmacol. 8, 25-32.
54. Somjen, G. G. (1984) Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression. Brain Res. 311, 186-188.
55. Mitchell, W. G. and Grubbs, R. C. (1956) Inhibition of audiogenic seizures by carbon dioxide. Science 123, 223-224.
56. 2+-induces seizures in combined entorhinal cortex-hippocampal slices. Exp. Brain Res. 101, 44-52.
57. Ziemann, A. E., Schnizler, M. K., Albert, G. W., Severson, M. A., Howard, M. A. 3rd, Welsh, M. J. and Wemmie, J. A. (2008) Seizure termination by acidosis depends on ASIC1a. Nat. Neurosci. 11, 816-822.
58. Friese, M. A., Craner, M. J., Etzensperger, R., Vergo, S., Wemmie, J. A., Welsh, M. J., Vincent, A. and Fugger, L. (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat. Med. 13, 1483-1489.
59. Krishtal, O. A. and Pidoplichko, V. I. (1981) A receptor for protons in the membrane of sensory neurons may participate in nociception. Neuroscience 6, 2599-2601.
60. Ikeuchi, M., Kolker, S. J., Burnes, L. A., Walder, R. Y. and Sluka, K. A. (2008) Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice. Pain 137, 662-669.
61. Allen, N. J. and Attwell, D. (2002) Modulation of ASIC channels in rat cerebellar purkinje neurons by ischaemia-related signals. J. Physiol. 543, 521-529.
62. Deval, E., Noel, J., Lay, N., Alloui, A., Diochot, S., Friend, V., Jodar, M., Lazdunski, M. and Lingueglia, E. (2008) ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J. 27, 3047-3055.
63. Delmas, P., Hao, J. and Rodat-Despoix, L. (2011) Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nat. Rev. Neurosci. 12, 139-153.
64. Chen, C. C. and Wong, C. W. (2013) Neurosensory mechanotransduction through acid-sensing ion channels. J. Cell. Mol. Med. 17, 337-349.
65. Price, M. P., Lewin, G. R., Mcllwrath, S. L., Cheng, C., Xie, J., Heppenstall, P. A., Stucky, C. L., Mannsfeldt, A. G., Brennan, T. J., Drummond, H. A., Qiao, J., Benson, C. J., Tarr, D. E., Hrstka, R. F., Yang, B., Williamson, R. A. and Welsh, M. J. (2000) The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407, 1007-1011.
66. Drew, L. J., Rohrer, D. K., Price, M. P., Blaver, K. E., Cockayne, D. A., Cesare, P. and Wood, J. N. (2004) Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J. Physiol. 556, 691-710.
67. Farooqui, A. A., Ong, W. Y. and Horrocks, L. A. (2006) Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol. Rev. 58, 591-620.
68. Liu, L. and Rittenhouse, A. R. (2000) Effects of arachidonic acid on unitary calcium currents in rat sympathetic neurons. J. Physiol. 525, 391-404.
69. Chyb, S., Raghu, P. and Hardie, R. C. (1999) Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 397, 255-259.
70. Meves, H. (2008) Arachidonic acid and ion channels: an update. Br. J. pharmacol. 155, 4-16.
71. Nelson, L. S., Kim, K., Memmott, J. E. and Li, C. (1998) FMRFamide-related gene family in the nematode, Caenorhabditis elegans. Brain. Res. Mol. Brain. Res. 58, 103-111.
72. Schneider, L. E. and Taghert, P. H. (1988) Isolation and characterization of a Drosophila gene that encodes multiple neuropeptides related to Phe-Met-Arg-Phe-NH2 (FMRFamide). Proc. Natl. Acad. Sci. U. S. A. 85, 1993-1997.
73. Gayton, R. J. (1982) Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin-Arg6-Phe7. Nature 298, 275-276.
74. Hauser, K. F., Foldes, J. K. and Turbek, C. S. (1999) Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp. Neurolo. 160, 361-375.
75. Babini, E., Paukert, M., Geisler, H. S. and Grunder, S. (2002) Alternative splicing and interaction with diand polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1). J. Biol. Chem. 277, 41597-41603.
76. Sherwood, T. W. and Askwith, C. C. (2009) Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death. J. Neurosci. 29, 14371-14380.
77. 2. Science 273, 956-959.
78. Suh, B. C. and Hille, B. (2002) Recovery from muscarinic modulation of M current channels requires Phosphatidylinositol 4,5-Bisphosphate synthesis. Neuron 35, 507-520.
79. 2 gate KCNQ ion channels. Science 314, 1454-1457.
80. 2+ channels by membrane phosphatidylinositol 4,5-bisphosphate. Neuron 67, 224-238.
81. Rohacs, T. and Nilius, B. (2007) Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers. Archiv. 455, 157-168.
82. Rohacs, T., Lopes, C. M., Jin, T., Ramdya, P. P., Molnar, Z. and Logothetis, D. E. (2003) Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc. Natl. Acad. Sci. U. S. A. 100, 745-750.
83. Zhang, Z., Okawa, H., Wang, Y. and Liman, E. R. (2005) Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J. Biol. Chem. 280, 39185-39192.
84. 2 is a necessary cofactor for ion channel function: how and why? Annu. Rev. Biophys. 37, 175-195.
85. + channel. J. Gen. Physiol. 130, 399-413.
86. Li, T., Yang, Y. and Canessa, C. M. (2012) Impact of recovery from desensitization on acid-sensing ion channel-1a (ASIC1a) current and response to high frequency stimulation. J. Biol. Chem. 287, 40680-40689.
87. Dorofeeva, N. A., Karpushev, A. V., Nikolaev M. V., Bolshakov, K. V. and Stockand, J. D. (2009) Muscarinic M1 modulation of acid-sensing ion channels. Neuroreport 20, 1386-1391.
88. Duan, B., Liu, D. S., Huang, Y., Zeng, W. Z., Wang, X., Yu, H., Zhu, M. X., Chen, Z. Y. and Xu, T. L. (2012) PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J. Neurosci. 32, 6351-6363.
89. Ahluwalia, J., Urban, L., Capogna, M., Bevan, S. and Nagy, I. (2000) Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100, 685-688.
90. Hohmann, A. G. and Herkenham, M. (1999) Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study. Neuroscience 90, 923-931.
91. Liu, Y. Q., Qiu, F., Qiu, C. Y., Cai, Q., Zou, P., Wu, H. and Hu, W. P. (2012) Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons. PLoS One 7, e45531.
92. Chai, S., Li, M., Lan, J., Xiong, Z. G., Saugstad, J. A., and Simon, R. P. (2007) A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J. Biol. Chem. 282, 22668-22677.
93. 2 receptors in rat dorsal root ganglion neurons. Neuropharmacology 63, 494-500.
94. Mamet, J., Baron, A., Lazdunski, M. and Voilley, N. (2002) ProInflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J. Neurosci. 22, 10662-10670.
95. 2A receptor subtype is involved in the thermal hyperalgesic mechanism of serotonin in the periphery. Pain 76, 349-355.
96. Lin, S. Y., Chang, W. J., Lin, C. S., Huang, C. Y., Wang, H. F. and Sun, W. H. (2011) Serotonin receptor 5-HT2B mediates serotonin-induced mechanical hyperalgesia. J. Neurosci. 31, 1410-1418.
97. Lingueglia, E. (2007) Acid-sensing ion channels in sensory perception. J. Biol. Chem. 282, 17325-17329.
98. Duggan, A., Garcia-Anoveros, J., and Corey, D. P. (2002) The PDZ domain protein PICK1 and the sodium channels BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J. Biol. Chem. 277, 5203-5208.
99. Lin, C. C., Chen, W. N., Chen, C. J., Lin, Y. W., Zimmer, A. and Chen, C. C. (2012) An antinociceptive role for substance P in acid-induced chronic muscle pain. PNAS 109, E76-E83.
100. +-gated channels in mouse sensory neurons. Proc. Natl. Acad. Sci. U. S. A. 99, 2338-2343.
101. Sutherland, S. P., Benson, C. J., Adelman, J. P. and McCleskey, E. W. (2001) Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc. Natl. Acad. Sci. U. S. A. 98, 711-716.
102. Waldmann, R., Champigny, G., Bassilana, F., Heurteaux, C. and Lazdunski, M. (1997) A proton-gated cation channel involved in acid-sensing. Nature 386, 173-177.
103. +-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr. Opin. Neurobiol. 8, 418-424.
104. Baron, A., Voilley, N., Lazdunski, M. and Lingueglia, E. (2008) Acid sensing ion channels in dorsal spinal cord neurons. J. Neurosci. 28, 1498-1508.
105. Ettaiche, M., Deval, E., Cougnon, M., Lazdunski, M. and Voilley, N. (2006) Silencing acid-sensing ion channel 1a alters cone-mediated retinal function. J. Neurosci. 26, 5800-5809.
106. Walder, R. Y., Rasmussen, L. A., Rainier, J. D., Light, A. R., Wemmie, J. A. and Sluka, K. A. (2010) ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury. J. Pain 11, 210-218.
107. Ettaiche, M., Guy, N., Hofman, P., Lazdunski, M. and Waldmann, R. (2004) Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. J. Neurosci. 24, 1005-1012.
108. Ugawa, S., Minami, Y., Guo, W., Saishin, Y., Takatsuji, K., Yamamoto, T., Tohyama, M. and Shimada, S. (1998) Receptor that leaves a sour taste in the mouth. Nature 395, 555-556.
109. Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W. and Abboud, F. M. (2009) The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64, 885-897.