5-HT(2A) receptor subtype is involved in the thermal hyperalgesic mechanism of serotonin in the periphery

Pain

Volumn 76, Issue 3, 1998, Pages 349-355

  Tokunaga, Atsushi ^a   Saika, Misako ^a   Senba, Emiko ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

5 HT(2A) receptor; Hyperalgesia; Ketanserin; Primary sensory neuron; Rat; Serotonin

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALPHA METHYLSEROTONIN; KETANSERIN; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 2A RECEPTOR; TROPISETRON; MESSENGER RNA; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; HISTOCHEMISTRY; HYPERALGESIA; INFLAMMATION; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; DOSE RESPONSE; HEAT; IN SITU HYBRIDIZATION; METABOLISM; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGY; SPINAL GANGLION; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; HEAT; HYPERALGESIA; IN SITU HYBRIDIZATION; MALE; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0031594975     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00066-9     Document Type: Article

References (40)

1. 2A receptors potentiates pain produced by inflammatory mediators. Neuropharmacology. 35:1996;99-110.
2. 2 receptors in nociceptive transmission. Brain Res. 543:1991;335-340.
3. 1B receptor subtypes in modulating spinal nociceptive transmission in mice. J. Pharmacol. Exp. Ther. 265:1993;378-385.
4. Armstrong D., Dry R.M.L., Keele C.A., Markham J.W. Observations on chemical excitants of cutaneous pain in man. J. Physiol. 120:1953;326-351.
5. Beck P.W., Handwerker H.O. Bradykinin and serotonin effects on various types of cutaneous nerve fibers. Pflügers Arch. 347:1974;209-222.
6. 1A receptors postsynaptic to serotoninergic neurones mediate spontaneous tailflicks in the rat J. Pharmacol. Exp. Ther. 264:1993;95-104.
7. Crisp, T., Stafinsky, J.L., Uram, M., Perni, V.C., Weaver, M.F. and Spanos, L.J., Serotonin contributes to the spinal antinociceptive effects of morphine, Pharmacol. Biochem. Behav., 39 (1991a) 591-595.
8. Crisp, T., Stafinsky, J.L., Spanos, L.J., Uram, M., Perni, V.C. and Donepudi, H.B., Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord, Gen. Pharmcol., 22 (1991b) 247-251.
9. 2 receptor antagonist. Agents Actions. 12:1982;388-397.
10. De Clerck F., Van Nueten J.M., Reneman R.S. Platelet-vessel wall interactions: implication of 5-hydroxytryptamine. A review, Agents Actions. 15:1984;612-626.
11. 2A receptors. Neurosci. Res. 29:1997;143-149.
12. 1B receptor in serotonergic neurons of anterior raphe nuclei in the rat brain. Synapse. 19:1995;18-28.
13. 3 receptor antagonists reduce c-fos expression in the trigeminal nuclear complex following noxious chemical stimulation of the rat nasal mucosa. Brain Res. 676:1995;336-342.
14. 3 antagonist on carrageenan-induced hyperalgesia in rats. Pain. 36:1989;249-255.
15. Giordano J. Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats. Eur. J. Pharmacol. 199:1991;233-236.
16. 3 receptor antagonists in the mouse. Neuropharmacology. 28:1989;423-427.
17. 3 receptor antagonists reduce inflammatory pain in the rats. Eur. J. Pharmacol. 170:1989;83-86.
18. Graziano F.M. Mast cells and mast cell products. Methods Enzymol. 162:1988;501-522.
19. Grubb B.D., McQueen D.S., Iggo A., Birrell G.J., Dutia M.B. A study of 5-HT-receptors associated with afferent nerves located in normal and inflamed rat ankle joints. Agents Actions. 25:1988;216-218.
20. Handwerker H.O. Influences of algogenic substances and prostaglandins on discharges of unmyelinated cutaneous nerve fibers identified as nociceptors. Adv. Pain Res. Ther. 1:1979;41-45.
21. Herbert M.K., Schmidt R.F. Activation of normal and inflamed fine articular afferent units by serotonin. Pain. 50:1992;79-88.
22. Holsapple M.P., Schnur M., Yim G.K.W. Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine. Agents Actions. 10:1980;368-373.
23. Horigome K., Pryor J.C., Bullock E.D., Johnson E.M. Jr. Mediator release from mast cells by nerve growth factor. J. Biol. Chem. 268:1993;14881-14887.
24. Hoyer D., Clerke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphery P.P. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
25. Lewin G.R., Rueff A.M., Mendell L.M. Peripheral and central mechanisms of NGF induced hyperalgesia. Eur. J. Neurosci. 6:1994;1903-1912.
26. 1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. Neurosci. Lett. 107:1989;227-232.
27. 1A receptor-mediated activity J. Pharmacol. Exp. Ther. 256:1991;973-982.
28. 1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour. NeuroReport. 3:1992;1061-1064.
29. Orwin J.M., Fozard J.R. Blockade of the flare response to intradermal 5-hydroxytryptamine in man by MDL 72.222, a selective antagonist at neuronal 5-hydroxytryptamine receptors. Eur. J. Clin. Pharmacol. 30:1986;209-212.
30. Page C.P. Platelets as inflammatory cells. Immunopharmacology. 17:1989;51-59.
31. Pierce P.A., Xie G.X., Levine J.D., Peroutka S.J. 5-Hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: a polymerase chain reaction study. Neuroscience. 70:1996;553-559.
32. Richardson B.P., Engel G., Donatsch P., Stadler P.A. Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature. 316:1985;126-131.
33. Rueff A., Dray A. Pharmacological characterization of the effects of 5-hydroxytryptamine and different prostaglandins on peripheral sensory neurons in vitro. Agents Actions. 38:1993;C13-C15.
34. Schmeiz M., Osiander G., Blunk J., Ringkamp M., Reeh P.W., Handwerker H.O. Intracutaneous injections of platelets cause acute pain and protracted hyperalgesia. Neurosci. Lett. 226:1997;171-174.
35. Sufka K.J., Schomburg F.M., Giordano J. Receptor mediation of 5-HT-induced inflammation and nociception in rats. Pharmacol. Biochem. Behav. 41:1992;53-56.
36. Taiwo Y.O., Levine J.D. Serotonin is a directly-acting hyperalgesic agent in the rat. Neuroscience. 48:1992;485-490.
37. Taiwo Y.O., Heller P.H., Levine J.D. Mediation of serotonin hyperalgesia by the cAMP second messenger system. Neuroscience. 48:1992;479-483.
38. 3 receptor mRNA. Proc. Natl. Acad. Sci. USA. 90:1993;1430-1434.
39. 1A receptor. Brain Res. 585:1992;212-218.
40. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.