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+ channel
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+ channel (dGNaC1) that is present in gonads and in the early embryo of Drosophila. Expressed in Xenopus oocytes, dGNaC1 has a constitutive channel activity. Because of the localization and the electrophysiological properties, the authors suggest that dGNaC1 might be involved in gametogenesis and embryonic development.
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Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons
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+ channel that is further activated by mutations causing neurodegeneration with the C. elegans degenerins. The authors propose an involvement of RPK in embryonal development. PPK is a silent channel present in multiple dendritic neurones: it is therefore proposed to be involved in proprioception.
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A proton gated cation channel involved in acid sensing
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+-gated cation channel that is transiently activated when the extracellular pH is decreased rapidly to below pH 6.9.
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41
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A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells
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of special interest. This paper reports the cloning of MDEG2, a splice variant of ASIC2 (MDEG) that is inactive when expressed alone. The authors show that the ASIC2b mRNA apparently colocalizes with ASIC2a (MDEG) in brain and with ASIC3 (DRASIC) in sensory neurones. Coexpression of ASIC2b (MDEG2) with ASIC2a (MDEG) or ASIC3 (DRASIC) causes important changes in the selectivity or kinetics of the channel indicating that heteromultimeric channels are formed.
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Lingueglia E, de Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. of special interest J Biol Chem. 272:1997;29778-29783 This paper reports the cloning of MDEG2, a splice variant of ASIC2 (MDEG) that is inactive when expressed alone. The authors show that the ASIC2b mRNA apparently colocalizes with ASIC2a (MDEG) in brain and with ASIC3 (DRASIC) in sensory neurones. Coexpression of ASIC2b (MDEG2) with ASIC2a (MDEG) or ASIC3 (DRASIC) causes important changes in the selectivity or kinetics of the channel indicating that heteromultimeric channels are formed.
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J Biol Chem
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Lingueglia, E.1
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Bassilana, F.3
Heurteaux, C.4
Sakai, H.5
Waldmann, R.6
Lazdunski, M.7
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42
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0030826633
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+ channel specific sensory neurons
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+ channel from sensory neurones (DRASIC) that has a biphasic desensitization kinetic: a transient current is followed by a sustained current. Because of the sustained component, DRASIC is proposed to be involved in the perception of pain caused by acids: however, the DRASIC subunit requires pH values below 4 for activation of the sustained current.
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+ channel from sensory neurones (DRASIC) that has a biphasic desensitization kinetic: a transient current is followed by a sustained current. Because of the sustained component, DRASIC is proposed to be involved in the perception of pain caused by acids: however, the DRASIC subunit requires pH values below 4 for activation of the sustained current.
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J Biol Chem
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Waldmann, R.1
Bassilana, F.2
De Weille, J.3
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Lazdunski, M.6
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43
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BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
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Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci USA. 94:1997;1459-1464.
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Corey, D.P.5
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44
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0030723559
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+ channel with novel properties
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of special interest. This paper reports that ASIC1 and MDEG colocalize in the brain and that both subunits form a heteromultimeric channel with novel properties. Coexpression of mutant subunits and coimmunoprecipitation were used to show that both subunits associate to a heteromultimeric channel.
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+ channel with novel properties. of special interest J Biol Chem. 272:1997;28819-28822 This paper reports that ASIC1 and MDEG colocalize in the brain and that both subunits form a heteromultimeric channel with novel properties. Coexpression of mutant subunits and coimmunoprecipitation were used to show that both subunits associate to a heteromultimeric channel.
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J Biol Chem
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Bassilana, F.1
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Lazdunski, M.6
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46
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The capsaicin receptor: A heat-activated ion channel in the pain pathway
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of outstanding interest. This paper reports the expression cloning of a cation channel from sensory neurones that is activated by capsaicin, the pungent ingredient of hot chilli peppers. This channel is also activated by heat, suggesting that it is one of the mediators of noxious thermal stimuli.
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Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. of outstanding interest Nature. 389:1997;816-824 This paper reports the expression cloning of a cation channel from sensory neurones that is activated by capsaicin, the pungent ingredient of hot chilli peppers. This channel is also activated by heat, suggesting that it is one of the mediators of noxious thermal stimuli.
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Caterina, M.J.1
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