Oxidative stress-mediated signaling pathways: A review

Journal of Food, Agriculture and Environment

Volumn 11, Issue 2, 2013, Pages 132-139

  Yin, Jie ^a,b,d   Ren, Wenkai ^b,d   Wu, Xiaosong ^c   Yang, Guan ^e   Wang, Jing ^b,d   Li, Tiejun ^b   Ding, Jiannan ^a   Cai, Lichuang ^a   Su, Dingding ^f  

^a INSTITUTE OF APPLIED CHEMISTRY   (China)

^b AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

^c HUNAN AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^e WASHINGTON STATE UNIVERSITY   (United States)

^f Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop   (China)

Author keywords

Molecular mechanism; Oxidative stress; Signalling

Indexed keywords

CALCIUM; CATALASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450; CYTOKINE; E1A ASSOCIATED P300 PROTEIN; EPIDERMAL GROWTH FACTOR; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROTROPHIN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR SOX9; UNINDEXED DRUG; VASCULOTROPIN;

APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CELL SURVIVAL; DOWN REGULATION; GENE EXPRESSION; HUMAN; INFLAMMATION; METABOLISM; NONHUMAN; ONCOGENE MYB; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

EID: 84880274893     PISSN: 14590255     EISSN: 14590263     Source Type: Journal    
DOI: None     Document Type: Article

References (103)

1. Reuter, S., Gupta, S.C., Chaturvedi, M.M. and Aggarwal, B.B. 2010. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol. Med. 49(11):1603-1616.
2. Pi, J., Zhang, Q., Fu, J., Woods, C.G., Hou, Y., Corkey, B.E., Collins, S., and Andersen, M.E. 2010. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol. Appl. Pharmacol. 244(1):77-83.
3. Kanninen, K., White, A.R., Koistinaho, J. and Malm, T. 2011. Targeting glycogen dynthase kinase-3beta for therapeutic benefit against oxidative stress in Alzheimer's disease: Involvement of the Nrf2-ARE pathway. Int. J. Alzheimer's Dis. 2011:985085.
4. Durackova, Z. 2008. Some current insights into oxidative stress. Physiological Research 59(4):459-469.
5. Wortham, M., He, L., Gyamfi, M., Copple, B.L. and Wan, Y.J.Y. 2008. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Digestive Diseases and Sciences 53(10):2761-2774.
6. Sies, H. 1991. Oxidative stress: from basic research to clinical application. Am. J. Med. 91(3C):31S-38S.
7. Sykiotis, G. P., Habeos, I.G., Samuelson, A.V. and Bohmann, D. 2011. The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation. Curr. Opin. Clin. Nutr. Metab. Care 14(1):41-48.
8. Benhar, M., Engelberg, D. and Levitzki, A. 2002. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 3(5):420-425.
9. Pantano, C., Reynaert, N.L., van der Vliet, A. and Janssen-Heininger, Y.M. 2006. Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid. Redox Signal 8(9-10):1791-1806.
10. Hussain, S. P., Hofseth, L. J. and Harris, C. C. 2003. Radical causes of cancer. Nat. Rev. Cancer 3(4):276-285.
11. Meira, L. B., Bugni, J.M., Green, S.L., Lee, C.W., Pang, B., Borenshtein, D., Rickman, B.H., Rogers, A.B., Moroski-Erkul, C.A., McFaline, J.L., Schauer, D.B., Dedon, P.C., Fox, J.G. and Samson, L.D. 2008. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J. Clin. Invest. 118(7):2516-2525.
12. Das, P. M. and Singal, R. 2004. DNA methylation and cancer. J. Clin. Oncol. 22(22):4632-4642.
13. Klaunig, J. E. and Kamendulis, L. M. 2004. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44:239-267.
14. Jomova, K., Baros, S. and Valko, M. 2012. Redox active metal-induced oxidative stress in biological systems. Transition Metal Chemistry 37(2):127-134.
15. Parke, D. V. and Sapota, A. 1996. Chemical toxicity and reactive oxygen species. Int. J. Occup. Med. Environ. Health 9(4):331-340.
16. St-Pierre, J., Buckingham, J.A., Roebuck, S.J. and Brand, M.D.2002. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 277(47):44784-44790.
17. Fridlyand, L. E. and Philipson, L. H. 2004. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53(8):1942-1948.
18. Obrosova, I. G. and Kador, P. F. 2011. Aldose reductase/polyol inhibitors for diabetic retinopathy. Curr. Pharm. Biotechnol. 12(3):373-385.
19. 2+) signaling on molecular pathways of neuropathic pain in diabetes: Focus on TRP channels. Neurochem. Res. 37(10):2065-2075.
20. Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M. and Mazur, M.2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160(1):1-40.
21. Karihtala, P. and Soini, Y. 2007. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS 115(2):81-103.
22. Corpas, F. J., Barroso, J. B. and del Rio, L. A. 2001. Peroxisomes as a source of reactive oxygen species and nitric oxide signal molecules in plant cells. Trends in Plant Science 6(4):145-150.
23. Corpas, F. J., Fernandez-Ocana, A., Carreras, A., Valderrama, R., Luque, F., Esteban, F.J., Rodriguez-Serrano, M., Chaki, M., Pedrajas, J.R., Sandalio, L.M., del Rio, L.A. and Barroso, J.B. 2006. The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves. Plant Cell Physiol. 47(7):984-994.
24. Aruoma, O. I., Grootveld, M. and Bahorun, T. 2006. Free radicals in biology and medicine: from inflammation to biotechnology. Biofactors 27(1-4):1-3.
25. Li, Y., Huang, T.T., Carlson, E.J., Melov, S., Ursell, P.C., Olson, J.L., Noble, L.J., Yoshimura, M.P., Berger, C., Chan, P.H., Wallace, D.C. and Epstein, C.J. 1995. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11(4):376-381.
26. Melov, S., Doctrow, S.R., Schneider, J.A., Haberson, J., Patel, M., Coskun, P.E., Huffman, K., Wallace, D.C. and Malfroy, B. 2001. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21(21):8348-8353.
27. Mates, J. M. and Sanchez-Jimenez, F. M. 2000. Role of reactive oxygen species in apoptosis: Implications for cancer therapy. Int. J. Biochem. Cell Biol. 32(2):157-170.
28. Ray, G. and Husain, S. A. 2002. Oxidants, antioxidants and carcinogenesis. Indian J. Exp. Biol. 40(11):1213-1232.
29. Valko, M., Izakovic, M., Mazur, M., Rhodes, C.J. and Telser, J. 2004. Role of oxygen radicals in DNA damage and cancer incidence. Mol. Cell Biochem. 266(1-2):37-56.
30. Schrader, M. and Fahimi, H. D. 2006. Peroxisomes and oxidative stress. Biochim. Biophys. Acta 1763(12):1755-1766.
31. Chu, F. F., Esworthy, R.S., Chu, P.G., Longmate, J.A., Huycke, M.M., Wilczynski, S. and Doroshow, J.H. 2004. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res. 64(3):962-968.
32. Neumann, C. A., Krause, D.S., Carman, C.V., Das, S., Dubey, D.P., Abraham, J.L., Bronson, R.T., Fujiwara, Y., Orkin, S.H. and Van Etten, R.A. 2003. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424(6948):561-565.
33. Winterbourn, C. C. 1995. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicology Letters 82-83:969-974.
34. Klaunig, J. E., Wang, Z., Pu, X. and Zhou, S. 2011. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol. Appl. Pharmacol. 254(2):86-99.
35. Sies, H. 1993. Strategies of antioxidant defense. Eur. J. Biochem. 215(2):213-219.
36. Marnett, L. J. 2000. Oxyradicals and DNA damage. Carcinogenesis 21(3):361-70.
37. McMahon, M., Thomas, N., Itoh, K., Yamamoto, M. and Hayes, J.D. 2004. Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron. J. Biol. Chem. 279(30):31556-31567.
38. Chan, K., Han, X. D. and Kan, Y. W. 2001. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl Acad. Sci. U. S. A. 98(8):4611-4616.
39. Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P. and Kensler, T.W. 2001. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America 98(6):3410-3415.
40. Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J.D. and Yamamoto, M. 2002. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294(1-2):1-12.
41. Chen, Q., Dowhan, D.H., Liang, D., Moore, D.D. and Overbeek, P.A. 2002. CREB-binding protein/p300 co-activation of crystallin gene expression. J. Biol. Chem. 277(27):24081-24089.
42. Hedge, S. P., Kumar, A., Kurschner, C. and Shapiro, L.H. 1998. c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. Mol. Cell Biol. 18(5):2729-2737.
43. Stewart, D., Killeen, E., Naquin, R., Alam, S. and Alam, J. 2003. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J. Biol. Chem. 278(4):2396-2402.
44. Kobayashi, A., Kang, M.I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K. and Yamamoto, M. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell Biol. 24(16):7130-7139.
45. Zhang, D. D., Lo, S.C., Sun, Z., Habib, G.M., Lieberman, M.W. and Hannink, M. 2005. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280(34):30091-30099.
46. Yuan, X., Xu, C., Pan, Z., Keum, Y.S., Kim, J.H., Shen, G., Yu, S., Oo, K.T., Ma, J. and Kong, A.N. 2006. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Mol. Carcinog. 45(11):841-850.
47. Itoh, K., Igarashi, K., Hayashi, N., Nishizawa, M. and Yamamoto, M. 1995. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol. Cell Biol. 15(8):4184-4193.
48. Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K. and Cobb, M.H. 2001. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr. Rev. 22(2):153-183.
49. Martindale, J. L. and Holbrook, N. J. 2002. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell Physiol. 192(1):1-15.
50. Chatterjee, S. and Fisher, A. B. 2004. ROS to the rescue. Am. J. Physiol. Lung Cell Mol. Physiol. 287(4):L704-705.
51. Haagenson, K. K. and Wu, G. S. 2010. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Cancer Metastasis Rev. 29(1):143-149.
52. Brown, M. D. and Sacks, D. B. 2008. Compartmentalised MAPK pathways. Handb. Exp. Pharmacol. 186:205-235.
53. Moriyama, M., Moriyama, H., Ueda, A., Nishibata, Y., Okura, H., Ichinose, A., Matsuyama, A. and Hayakawa, T. 2012. Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. BMC Cell Biol. 13(1):21.
54. Wu, W. S., Zhao, Y.S., Shi, Z., Chang, S.Y., Nie, G., Duan, X.L., Zhao, S.M., Wu, Q., Yang, Z.L., Zhao, B. and Chang, Y.Z. 2012. Mitochondrial ferritin attenuates beta-amyloid-induced neurotoxicity: Reduction in oxidative damage through the Erk/P38 MAPK pathways. Antioxid. Redox Signal 18(2):158-169.
55. Park, S. K., Dahmer, M. K. and Quasney, M. W. 2012. MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes. Cell Physiol. Biochem. 30(2):334-346.
56. Liu, C. M., Sun, Y.Z., Sun, J.M., Ma, J.Q. and Cheng, C. 2012. Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-kappaB pathway. Biochim. Biophys. Acta 1820(10):1693-1703.
57. Weng, C. J., Chen, M.J., Yeh, C.T. and Yen, G.C. 2011. Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity. New Biotechnol. 28(6):767-777.
58. Cheng, Y. Y., Yang, J.S., Tsai, S.C., Liaw, C.C., Chung, J.G., Huang, L.J., Lee, K.H., Lu, C.C., Chien, H.C., Tsuzuki, M. and Kuo, S.C. 2012. The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells. Oncol. Rep. 28(4):1482-1490.
59. Son, Y., Cheong, Y.K., Kim, N.H., Chung, H.T., Kang, D.G. and Pae, H.O. 2011. Mitogen-activated protein kinases and reactive oxygen species: How can ROS activate MAPK pathways? J. Signal Transduct. 2011:792639.
60. Choi, B. H., Hur, E.M., Lee, J.H., Jun, D.J. and Kim, K.T. 2006. Protein kinase Cdelta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J. Cell Sci. 119(Pt 7):1329-1340.
61. Zhou, J. Y., Liu, Y. and Wu, G. S. 2006. The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death. Cancer Res. 66(9):4888-4894.
62. Thannickal, V. J. and Fanburg, B. L. 2000. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 279(6):L1005-1028.
63. Nagai, H., Noguchi, T., Takeda, K. and Ichijo, H. 2007. Pathophysiological roles of ASK1-MAP kinase signaling pathways. J. Biochem. Mol. Biol. 40(1):1-6.
64. Yang, Q., Kim, Y.S., Lin, Y., Lewis, J., Neckers, L. and Liu, Z.G. 2006. Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK. EMBO Rep. 7(6):622-627.
65. Wang, D., Kreutzer, D. A. and Essigmann, J. M. 1998. Mutagenicity and repair of oxidative DNA damage: Insights from studies using defined lesions. Mutat. Res. 400(1-2):99-115.
66. Waris, G. and Ahsan, H. 2006. Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinog. 5:14.
67. Morgan, M. J. and Liu, Z. G. 2011. Crosstalk of reactive oxygen species and NF-kappaB signaling. Cell Res. 21(1):103-115.
68. Gloire, G., Legrand-Poels, S. and Piette, J. 2006. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem. Pharmacol. 72(11):1493-1505.
69. Takada, Y. and Aggarwal, B.B. 2004. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J. Biol. Chem. 279(6):4750-4759.
70. Hayden, M.S. and Ghosh, S. 2004. Signaling to NF-kappaB. Genes Dev. 18(18):2195-2224.
71. Kil, I. S., Kim, S. Y. and Park, J. W. 2008. Glutathionylation regulates IkappaB. Biochem. Biophys. Res. Commun. 373(1):169-73.
72. Reynaert, N. L., van der Vliet, A., Guala, A.S., McGovern, T., Hristova, M., Pantano, C., Heintz, N.H., Heim, J., Ho, Y.S., Matthews, D.E., Wouters, E.F. and Janssen-Heininger, Y.M. 2006. Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc. Natl Acad. Sci. U. S. A. 103(35):13086-13091.
73. Mellor, H. and Parker, P. J. 1998. The extended protein kinase C superfamily. Biochemical Journal 332(Pt 2):281-292.
74. Duquesnes, N., Lezoualc'h, F. and Crozatier, B. 2011. PKC-delta and PKC-epsilon: foes of the same family or strangers? J. Mol. Cell Cardiol. 51(5):665-673.
75. Rosse, C., Linch, M., Kermorgant, S., Cameron, A.J., Boeckeler, K. and Parker, P.J. 2010. PKC and the control of localized signal dynamics. Nat. Rev. Mol. Cell Biol. 11(2):103-112.
76. Kong, S. S., Liu, J.J., Yu, X.J., Lu, Y. and Zang, W.J. 2012. Protection against ischemia-induced oxidative stress conferred by vagal stimulation in the rat heart: Involvement of the AMPK-PKC pathway. Int. J. Mol. Sci. 13(11):14311-14325.
77. Jin, M., Kumar, A. and Kumar, S. 2012. Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: Role of oxidative stress-mediated PKC/MEK/Nrf2 pathway. PLoS One 7(4):35505.
78. Lin, D. B. and Takemoto, D. J. 2005. Oxidative activation of protein kinase C gamma through the C1 domain-Effects on gap junctions. Journal of Biological Chemistry 280(14):13682-13693.
79. Shin, E.J., Duong, C.X., Nguyen, X.K., Li, Z., Bing, G., Bach, J.H., Park, D.H., Nakayama, K., Ali, S.F., Kanthasamy, A.G., Cadet, J.L., Nabeshima, T. and Kim, H.C. 2012. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cdelta. Behav. Brain Res. 232(1):98-113.
80. Klaunig, J. E., Kamendulis, L. M. and Hocevar, B. A. 2010. Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 38(1):96-109.
81. Giorgi, C., Agnoletto, C., Baldini, C., Bononi, A., Bonora, M., Marchi, S., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., Zavan, B. and Pinton, P. 2010. Redox control of protein kinase C: Cell-and disease-specific aspects. Antioxid. Redox. Signal 13(7):1051-1085.
82. DelCarlo, M. and Loeser, R. F. 2006. Chondrocyte cell death mediated by reactive oxygen species-dependent activation of PKC-betaI. Am. J. Physiol. Cell Physiol. 290(3):C802-811.
83. Wang, Y., Biswas, G., Prabu, S.K. and Avadhani, N.G. 2006. Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytes. Biochem. Pharmacol. 72(7):881-892.
84. Cosentino-Gomes, D., Rocco-Machado, N. and Meyer-Fernandes, J. R. 2012. Cell Signaling through protein kinase C oxidation and activation. International Journal of Molecular Sciences 13(9):10697-U1522.
85. Becerra-Diaz, M., Valderrama-Carvajal, H. and Terrazas, L. I. 2011. Signal Transducers and Activators of Transcription (STAT) family members in helminth infections. Int. J. Biol. Sci. 7(9):1371-1381.
86. Sun, X., Wu, S. and Xing, D. 2010. The reactive oxygen species-Src-Stat3 pathway provokes negative feedback inhibition of apoptosis induced by high-fluence low-power laser irradiation. FEBS J. 277(22):4789-4802.
87. Kurdi, M. and Booz, G. W. 2007. Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: Parthenolide targets JAK1 activation by generating ROS. Journal of Cellular Physiology 212(2):424-431.
88. Smith, J.K., Patil, C.N., Patlolla, S., Gunter, B.W., Booz, G.W. and Duhe, R.J. 2012. Identification of a redox-sensitive switch within the JAK2 catalytic domain. Free Radical Biology and Medicine 52(6):1101-1110.
89. Lo, R. K., Cheung, H. and Wong, Y. H. 2003. Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK-and ERK-dependent mechanism. J. Biol. Chem. 278(52):52154-52165.
90. Su, W. P., Lo, Y.C., Yan, J.J., Liao, I.C., Tsai, P.J., Wang, H.C., Yeh, H.H., Lin, C.C., Chen, H.H., Lai, W.W. and Su, W.C. 2012. Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells. Carcinogenesis 33(11):2065-2075.
91. Krauss, S., Zhang, C. Y. and Lowell, B. B. 2005. The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell Biol. 6(3):248-261.
92. Jezek, P., Zackova, M., Ruzicka, M., Skobisova, E. and Jaburek, M. 2004. Mitochondrial uncoupling proteins-Facts and fantasies. Physiological Research 53:S199-S211.
93. Ruzicka, M., Skobisova, E., Dlaskova, A., Santorova, J., Smolkova, K., Spacek, T., Zackova, M., Modriansky, M. and Jezek, P. 2005. Recruitment of mitochondrial uncoupling protein UCP2 after lipopolysaccharide induction. Int. J. Biochem. Cell Biol. 37(4):809-821.
94. Feige, J. N., Gelman, L., Michalik, L., Desvergne, B. and Wahli, W. 2006. From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Progress in Lipid Research 45(2):120-159.
95. Marion-Letellier, R., Dechelotte, P., Iacucci, M. and Ghosh, S. 2009. Dietary modulation of peroxisome proliferator-activated receptor gamma. Gut. 58(4):586-593.
96. Zhang, T., Wang, F., Xu, H.X., Yi, L., Qin, Y., Chang, H., Mi, M.T. and Zhang, Q.Y. 2013. Activation of nuclear factor erythroid 2-related factor 2 and PPARgamma plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury. Br. J. Nutr. 109(2):223-235.
97. Martin, H. L., Mounsey, R.B., Mustafa, S., Sathe, K. and Teismann, P. 2012. Pharmacological manipulation of peroxisome proliferator-activated receptor gamma (PPARgamma) reveals a role for anti-oxidant protection in a model of Parkinson's disease. Exp. Neurol. 235(2):528-538.
98. Yang, Y., Qin, X.C., Liu, S.H., Li, J.J., Zhu, X.H., Gao, T.M. and Wang, X.M. 2011. Peroxisome proliferator-activated receptor gamma is inhibited by histone deacetylase 4 in cortical neurons under oxidative stress. Journal of Neurochemistry 118(3):429-439.
99. Girnun, G. D., Domann, F.E., Moore, S.A. and Robbins, M.E.C. 2002. Identification of a functional peroxisome proliferator-activated receptor response element in the rat catalase promoter. Molecular Endocrinology 16(12):2793-2801.
100. Yu, X., Shao, X.G., Sun, H., Li, Y.N., Yang, J., Deng, Y.C. and Huang, Y.G. 2008. Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus. Brain Research 1200:146-158.
101. Chung, S. S., Kim, M., Youn, B.S., Lee, N.S., Park, J.W., Lee, I.K., Lee, Y.S., Kim, J.B., Cho, Y.M., Lee, H.K. and Park, K.S. 2009. Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Mol. Cell Biol. 29(1):20-30.
102. Gupte, A. A., Liu, J.Z., Ren, Y., Minze, L.J., Wiles, J.R., Collins, A.R., Lyon, C.J., Pratico, D., Finegold, M.J., Wong, S.T., Webb, P., Baxter, J.D., Moore, D.D. and Hsueh, W.A.2010. Rosiglitazone attenuates age-and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology 52(6):2001-11.
103. Maiese, K., Chong, Z.Z., Wang, S. and Shang, Y.C. 2012. Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade. Int. J. Mol. Sci. 13(11):13830-13866.