Identification of a redox-sensitive switch within the JAK2 catalytic domain

Free Radical Biology and Medicine

Volumn 52, Issue 6, 2012, Pages 1101-1110

  Smith, John K ^a,b   Patil, Chetan N ^a   Patlolla, Srikant ^a   Gunter, Barak W ^a   Booz, George W ^a   Duhé, Roy J ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b William Carey University   (United States)

Author keywords

Islet; Cysteine; Cytokines; Diabetes; Free radicals; Janus kinase; Redox

Indexed keywords

DITHIOTHREITOL; JANUS KINASE 2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ANIMALS; CATALYTIC DOMAIN; CELL LINE; CYSTEINE; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DITHIOTHREITOL; ENZYME ACTIVATION; HYDROGEN PEROXIDE; INSULIN-SECRETING CELLS; JANUS KINASE 2; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; STAT5 TRANSCRIPTION FACTOR;

MURINAE;

EID: 84862819547     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.12.025     Document Type: Article

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